WFDC12

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]

Description

WAP four-disulfide core domain 12

Tissue specificity

Tissue enriched (skin)

Predicted location

Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

20 (45123425 - 45124465)

Ensembl ID

ENSG00000168703  (ver. 103.38)

Orthologs

Mouse Wfdc12: ENSMUSG00000042845

UniProt

Q8WWY7

neXtProt

NX_Q8WWY7

Human splice variants
Mouse splice variants

Protein structure