KCNH4

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008]

Description

Potassium voltage-gated channel subfamily H member 4

Tissue specificity

Tissue enriched (brain)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Voltage-gated ion channels

Chromosome

17 (42156891 - 42181142)

Ensembl ID

ENSG00000089558  (ver. 103.38)

Orthologs

Mouse Kcnh4: ENSMUSG00000035355

UniProt

Q9UQ05

neXtProt

NX_Q9UQ05

Human splice variants
Mouse splice variants

Protein structure