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Learn12368-1-AP
antibody from Proteintech Group
Targeting: PINX1
FLJ20565, Gno1, LPTL, LPTS, MGC8850, Pxr1
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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [8]
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- Validations
- Western blot [1]
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- Product number
- 12368-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12368-1-AP, RRID:AB_2164405
- Product name
- PINX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PINX1 antibody (Cat. #12368-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Insufficient PINX1 expression stimulates telomerase activation by direct inhibition of EBV LMP1-NF-κB axis during nasopharyngeal carcinoma development.
The clinical significance of PINX1 expression in papillary thyroid carcinoma.
The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway.
PinX1 suppresses tumorigenesis by negatively regulating telomerase/telomeres in colorectal carcinoma cells and is a promising molecular marker for patient prognosis.
The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas.
PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway.
Anthracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitination and degradation.
Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma.
Liu Y, Gong P, Zhou N, Zhang J, He C, Wang S, Peng H
Biochemical and biophysical research communications 2019 Jun 18;514(1):127-133
Biochemical and biophysical research communications 2019 Jun 18;514(1):127-133
The clinical significance of PINX1 expression in papillary thyroid carcinoma.
Kang J, Han K, Kim HJ, Park JH, Kong JS, Park S, Myung JK
Human pathology 2018 Nov;81:176-183
Human pathology 2018 Nov;81:176-183
The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway.
Tian XP, Jin XH, Li M, Huang WJ, Xie D, Zhang JX
Molecular cancer 2017 Apr 4;16(1):74
Molecular cancer 2017 Apr 4;16(1):74
PinX1 suppresses tumorigenesis by negatively regulating telomerase/telomeres in colorectal carcinoma cells and is a promising molecular marker for patient prognosis.
Qian D, Cheng J, Ding X, Chen X, Chen X, Guan Y, Zhang B, Wang J, Er P, Qiu M, Zeng X, Guo Y, Wang H, Zhao L, Xie D, Yuan Z, Wang P, Pang Q
OncoTargets and therapy 2016;9:4821-31
OncoTargets and therapy 2016;9:4821-31
The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas.
Tian XP, Qian D, He LR, Huang H, Mai SJ, Li CP, Huang XX, Cai MY, Liao YJ, Kung HF, Zeng YX, Xie D
Cancer letters 2014 Oct 10;353(1):104-14
Cancer letters 2014 Oct 10;353(1):104-14
PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway.
Liu JY, Qian D, He LR, Li YH, Liao YJ, Mai SJ, Tian XP, Liu YH, Zhang JX, Kung HF, Zeng YX, Zhou FJ, Xie D
Molecular cancer 2013 Nov 23;12(1):148
Molecular cancer 2013 Nov 23;12(1):148
Anthracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitination and degradation.
Zhang B, Qian D, Ma HH, Jin R, Yang PX, Cai MY, Liu YH, Liao YJ, Deng HX, Mai SJ, Zhang H, Zeng YX, Lin MC, Kung HF, Xie D, Huang JJ
Oncogene 2012 Jan 5;31(1):1-12
Oncogene 2012 Jan 5;31(1):1-12
Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma.
Cai MY, Zhang B, He WP, Yang GF, Rao HL, Rao ZY, Wu QL, Guan XY, Kung HF, Zeng YX, Xie D
Cancer science 2010 Jun;101(6):1543-9
Cancer science 2010 Jun;101(6):1543-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PINX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PINX1. This antibody recognizes human, mouse, rat antigen. The PINX1 antibody has been validated for the following applications: ELISA, WB analysis.
