GTF3C6

RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. [supplied by OMIM, Mar 2008]

Description

General transcription factor IIIC subunit 6

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (110958706 - 110967890)

Ensembl ID

ENSG00000155115  (ver. 103.38)

Orthologs

Mouse Gtf3c6: ENSMUSG00000019837

UniProt

Q969F1

neXtProt

NX_Q969F1

Human splice variants
Mouse splice variants

Protein structure