BS8060

antibody from Bioworld Technology, Inc

Targeting: INSIG2

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8060

Provider

Bioworld Technology, Inc

Product name

INSIG2 polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human INSIG2.

Description

INSIG-1 and INSIG-2 play distinct roles in a negative-feedback mechanism for cholesterol synthesis. INSIG-1 localizes to the endoplasmic reticulum (ER) and binds the sterol-sensing domain of SREBP cleavage-activating protein (SCAP). Sterol induces INSIG-1 binding to SCAP. INSIG-2, another ER protein, binds SCAP in a sterol-regulated manner. Thus, INSIG-1 and INSIG-2 block the export of SCAP from the ER and ultimately inhibit cholesterol synthesis by preventing the proteolytic processing of SREBPs by Golgi enzymes. The critical role of INSIG-1 and INSIG-2 in cholesterol metabolism may be exploited as a therapeutic effect for hypercholesterolemia.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.