SYT8

This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Description

Synaptotagmin 8

Tissue specificity

Tissue enhanced (esophagus, skin , urinary bladder)

Subcell location

Nucleoli fibrillar center, Endoplasmic reticulum

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

11 (1828307 - 1837521)

Ensembl ID

ENSG00000149043  (ver. 103.38)

Orthologs

Mouse Syt8: ENSMUSG00000031098

UniProt

Q8NBV8

neXtProt

NX_Q8NBV8

Human splice variants
Mouse splice variants

Protein structure