BS7849

antibody from Bioworld Technology, Inc

Targeting: BGN DSPG1, SLRR1A

Immunohistochemistry

Antibody data

Submit

Validation data

Product number: BS7849 - Provider product page
Provider: Bioworld Technology, Inc
Product name: BGN polyclonal antibody
Antibody type: Polyclonal
Antigen: Recombinant full length Human BGN.
Description: Biglycan, a class I small leucine rich proteoglycan (SLRP) present in the extracellular matrix, influences bone cell differentiation and proliferation. Biglycan contains two chondroitin sulfate glucosaminoglycan (GAG) chains attached near its amino terminus, whereas a closely related SLRP, decorin, contains only one. Biglycan deficient specimens possess diminished capacity to produce bone cells precursors, a lessened response to TGFÉÇ, reduced collagen synthesis, and increased apoptosis. Patients with rheumatoid arthritis express increased immunity to biglycan whereas osteoarthritis patients do not, suggesting that higher immunity to SLRPs may play a role in the pathogenesis of inflammatory rheumatic diseases.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

BGN protein structure - BS7849 shown in red.