TBATA

This gene encodes a protein that regulates thymic epithelial cell proliferation and thymus size. It has been identified as a ligand for the class I human leukocyte antigen (HLA-I) in thymus. Studies of the orthologous mouse protein suggest that it may also play a role in spermatid differentiation, as well as in neuronal morphogenesis and synaptic plasticity. Polymorphisms in this gene are associated with susceptibility for multiple sclerosis (MS). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Description

Thymus, brain and testes associated

Tissue specificity

Tissue enriched (lymphoid tissue)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

10 (70771239 - 70785401)

Ensembl ID

ENSG00000166220  (ver. 103.38)

Orthologs

Mouse Tbata: ENSMUSG00000020096

UniProt

Q96M53

neXtProt

NX_Q96M53

Human splice variants
Mouse splice variants

Protein structure