Ab177880

antibody from Aladdin Scientific Corporation

Targeting: IL3RA CD123

ELISA (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Functional assay (Data presented on provider website)

Antibody Data

Product number

Ab177880

Provider

Aladdin Scientific Corporation

Product name

Talacotuzumab (anti-IL-3Ra)

Antibody type

Recombinant

Description

Talacotuzumab (anti-IL-3Ra) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab (anti-IL-3Ra) has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab (anti-IL-3Ra) inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab (anti-IL-3Ra) has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab (anti-IL-3Ra) is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models.

Reactivity

Human

Conjugate

Unconjugated

Vial size

10mg,1mg,5mg

Concentration

Lot by Lot

Storage

Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.