GP5

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]). [supplied by OMIM, Nov 2010]

Description

Glycoprotein V platelet

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Cytosol

Predicted location

Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (194394821 - 194398354)

Ensembl ID

ENSG00000178732  (ver. 103.38)

Orthologs

Mouse Gp5: ENSMUSG00000047953

UniProt

P40197

neXtProt

NX_P40197

Human splice variants
Mouse splice variants

Protein structure