ARHGAP22

This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Description

Rho GTPase activating protein 22

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (48446036 - 48656265)

Ensembl ID

ENSG00000128805  (ver. 103.38)

Orthologs

Mouse Arhgap22: ENSMUSG00000063506

UniProt

Q7Z5H3

neXtProt

NX_Q7Z5H3

Human splice variants
Mouse splice variants

Protein structure