LMO1

This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]

Description

LIM domain only 1

Tissue specificity

Tissue enhanced (brain, skeletal muscle, tongue)

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

11 (8224309 - 8268716)

Ensembl ID

ENSG00000166407  (ver. 103.38)

Orthologs

Mouse Lmo1: ENSMUSG00000036111

UniProt

P25800

neXtProt

NX_P25800

Human splice variants
Mouse splice variants

Protein structure