Antibody data

Product number
11-10033 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-DLL4 Antibody
Antibody type
Polyclonal
Description
Dll4 (Delta-like 4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. It is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring stalk cells to become tip cells during angiogenesis. Dll4-Notch signaling is mediated either by direct cell-cell contact or by Dll4 Containing exosomes from a distance. DLL4 signaling is extensively critical for tumor angiogenesis. Blockage of DLL4 signaling inhibits tumor growth by deregulating angiogenesis and promoting non productive angiogenesis. Additionally, DLL4 has been shown to help regulate the cellular actions of VEGF.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant DLL4 p
rotein (amino acids 423-650) was us
ed as the immunogen for this antibo
dy.
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
DLL4 protein structure - 11-10033 shown in red.