TMX4

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017]

Description

Thioredoxin related transmembrane protein 4

Tissue specificity

Low tissue specificity

Subcell location

Nuclear membrane

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (7977346 - 8019805)

Ensembl ID

ENSG00000125827  (ver. 103.38)

Orthologs

Mouse Tmx4: ENSMUSG00000034723

UniProt

Q9H1E5

neXtProt

NX_Q9H1E5

Human splice variants
Mouse splice variants

Protein structure