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antibody from Atlas Antibodies
Targeting: NLRP3
AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCU, MWS, NALP3, PYPAF1
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Immunohistochemistry [5]
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- Product number
- HPA012878 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA012878, RRID:AB_1846752
- Product name
- Anti-NLRP3
- Antibody type
- Polyclonal
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Antigen sequence
FKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMI
DFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKW
GSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI
CKMKKDYRKKYR- Isotype
- IgG
- Vial size
- 100 µl
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Submitted references Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages.
Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1 Production
Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.
Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.
Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.
L'homme L, Esser N, Riva L, Scheen A, Paquot N, Piette J, Legrand-Poels S
Journal of lipid research 2013 Nov;54(11):2998-3008
Journal of lipid research 2013 Nov;54(11):2998-3008
Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1 Production
Haneklaus M, Gerlic M, Kurowska-Stolarska M, Rainey A, Pich D, McInnes I, Hammerschmidt W, O'Neill L, Masters S
The Journal of Immunology 2012 October;189(8):3795-3799
The Journal of Immunology 2012 October;189(8):3795-3799
Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.
Abdul-Sater AA, Saïd-Sadier N, Padilla EV, Ojcius DM
Microbes and infection 2010 Aug;12(8-9):652-661
Microbes and infection 2010 Aug;12(8-9):652-661
Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.
Saïd-Sadier N, Padilla E, Langsley G, Ojcius DM
PloS one 2010 Apr 2;5(4):e10008
PloS one 2010 Apr 2;5(4):e10008
Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.
Abdul-Sater AA, Koo E, Häcker G, Ojcius DM
The Journal of biological chemistry 2009 Sep 25;284(39):26789-96
The Journal of biological chemistry 2009 Sep 25;284(39):26789-96
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human tonsil shows moderate cytoplasmic positivity in germinal and non-germinal center cells.
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human lung shows moderate cytoplasmic positivity in macrophages.
- Sample type
- HUMAN
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human tonsil shows moderate cytoplasmic positivity in non - germinal center cells.
- Sample type
- HUMAN
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human skeletal muscle shows no positivity in myocytes as expected.
- Sample type
- HUMAN
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human spleen shows cytoplasmic positivity in lymphoid cells.
- Sample type
- HUMAN
