MALRD1

This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the APOE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2017]

Description

MAM and LDL receptor class A domain containing 1

Tissue specificity

Tissue enriched (intestine)

Subcell location

Golgi apparatus

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

10 (19048801 - 19790401)

Ensembl ID

ENSG00000204740  (ver. 103.38)

Orthologs

Mouse Malrd1: ENSMUSG00000075520

UniProt

Q5VYJ5

neXtProt

NX_Q5VYJ5

Human splice variants
Mouse splice variants

Protein structure