14887-1-AP

antibody from Proteintech Group

Targeting: HSPA9 GRP75, HSPA9B, mot-2, mthsp75, PBP74

Provider product page for 14887-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [16]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 14887-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14887-1-AP, RRID:AB_2120458
Product name: GRP75 antibody
Antibody type: Polyclonal
Description: KD/KO validated GRP75 antibody (Cat. #14887-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HSPA9 protein structure - 14887-1-AP shown in red.

Submitted references A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.

Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15

Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation.

Pinho BR, Almeida LM, Duchen MR, Oliveira JMA
Life sciences 2021 Nov 15;285:120009

LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding.

Shin CS, Meng S, Garbis SD, Moradian A, Taylor RW, Sweredoski MJ, Lomenick B, Chan DC
Nature communications 2021 Jan 11;12(1):265

N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.

Scott GK, Mahoney S, Scott M, Loureiro A, Lopez-Ramirez A, Tanner JJ, Ellerby LM, Benz CC
Amino acids 2021 Dec;53(12):1927-1939

Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population.

Sun D, Yao S, Wu F, Deng W, Ma Y, Jin L, Wang J, Wang X
Frontiers in genetics 2020;11:577795

ATF4 Mediates Mitochondrial Unfolded Protein Response in Alveolar Epithelial Cells.

Jiang D, Cui H, Xie N, Banerjee S, Liu RM, Dai H, Thannickal VJ, Liu G
American journal of respiratory cell and molecular biology 2020 Oct;63(4):478-489

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.

Wang P, Deng J, Dong J, Liu J, Bigio EH, Mesulam M, Wang T, Sun L, Wang L, Lee AY, McGee WA, Chen X, Fushimi K, Zhu L, Wu JY
PLoS genetics 2019 May;15(5):e1007947

Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology.

Ide M, Ohnishi T, Toyoshima M, Balan S, Maekawa M, Shimamoto-Mitsuyama C, Iwayama Y, Ohba H, Watanabe A, Ishii T, Shibuya N, Kimura Y, Hisano Y, Murata Y, Hara T, Morikawa M, Hashimoto K, Nozaki Y, Toyota T, Wada Y, Tanaka Y, Kato T, Nishi A, Fujisawa S, Okano H, Itokawa M, Hirokawa N, Kunii Y, Kakita A, Yabe H, Iwamoto K, Meno K, Katagiri T, Dean B, Uchida K, Kimura H, Yoshikawa T
EMBO molecular medicine 2019 Dec;11(12):e10695

LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response.

Zurita Rendón O, Shoubridge EA
Molecular and cellular biology 2018 Oct 15;38(20)

TP53-induced glycolysis and apoptosis regulator is indispensable for mitochondria quality control and degradation following damage.

Feng J, Luo L, Liu Y, Fu S, Chen J, Duan X, Xiang L, Zhang Y, Wu J, Fan J, Wen Q, Zhang Y, Yang J, Peng J, Zhao M, Yang L
Oncology letters 2018 Jan;15(1):155-160

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.

Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH
The Journal of biological chemistry 2018 Dec 21;293(51):19797-19811

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.

Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger HG, Quirós PM, López-Otín C, Rugarli EI, Langer T
The Journal of cell biology 2016 Jan 18;212(2):157-66

ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.

Xie Q, Su J, Jiao B, Shen L, Ma L, Qu X, Yu C, Jiang X, Xu Y, Sun L
International journal of oncology 2016 Dec;49(6):2507-2519

DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.

Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker M, Decker T, Lamkemeyer T, Rugarli EI, Langer T
Cell metabolism 2014 Jul 1;20(1):158-71

Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.

Ho KY, Yeh TS, Huang HH, Hung KF, Chai CY, Chen WT, Tsai SM, Chang NC, Chien CY, Wang HM, Wu YJ
International journal of molecular sciences 2013 Jul 11;14(7):14439-59

An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.

Su CC, Su JH, Lin JJ, Chen CC, Hwang WI, Huang HH, Wu YJ
Marine drugs 2011 Dec;9(12):2622-42

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 14887-1-AP(GRP75 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The GRP75 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GRP75. This antibody recognizes human,mouse,rat antigen. The GRP75 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Appendix: 14887-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 14887-1-AP(GRP75 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 14887-1-AP(GRP75 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue