HSPA1B

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

Description

Heat shock protein family A (Hsp70) member 1B

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

6 (31827738 - 31830254)

Ensembl ID

ENSG00000204388  (ver. 103.38)

Orthologs

-

UniProt

P0DMV9

neXtProt

NX_P0DMV9

Human splice variants

Protein structure