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- Antibody Data
- Antigen structure
- References [39]
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- Western blot [2]
- Immunocytochemistry [1]
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- Product number
- ABIN151776 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Egl Nine Homolog 2 (C. Elegans) (EGLN2) (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- C-Term
- Vial size
- 0.1 mg
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor.
Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.
Changes in Hypoxia-Inducible Factor-1 (HIF-1) and Regulatory Prolyl Hydroxylase (PHD) Enzymes Following Hypoxic-Ischemic Injury in the Neonatal Rat.
PHD1 regulates p53-mediated colorectal cancer chemoresistance.
Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27.
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells.
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.
Chronic hypoxemia in late gestation decreases cardiomyocyte number but does not change expression of hypoxia-responsive genes.
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α.
The role of prolyl hydroxylase domain protein (PHD) during rosiglitazone-induced adipocyte differentiation.
HIF-1α is upregulated in human mesenchymal stem cells.
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids.
Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
A mechanism for induction of a hypoxic response by vaccinia virus.
Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia.
Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients.
Low expression of prolyl hydroxylase 2 is associated with tumor grade and poor prognosis in patients with colorectal cancer.
Prolyl hydroxylase domain protein 3 targets Pax2 for destruction.
Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes.
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.
Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.
HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury.
Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms.
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential.
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.
The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys.
Hypoxia-inducible factors in the first trimester human lung.
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Dynamic HIF1A regulation during human placental development.
Previous or ongoing schistosome infections do not compromise the efficacy of the attenuated cercaria vaccine.
Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung.
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
Takada M, Zhuang M, Inuzuka H, Zhang J, Zurlo G, Zhang J, Zhang Q
Oncotarget 2017 Jan 24;8(4):6787-6795
Oncotarget 2017 Jan 24;8(4):6787-6795
Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.
Zhang L, Peng S, Dai X, Gan W, Nie X, Wei W, Hu G, Guo J
Cancer letters 2017 Apr 1;390:11-20
Cancer letters 2017 Apr 1;390:11-20
Changes in Hypoxia-Inducible Factor-1 (HIF-1) and Regulatory Prolyl Hydroxylase (PHD) Enzymes Following Hypoxic-Ischemic Injury in the Neonatal Rat.
Chu HX, Jones NM
Neurochemical research 2016 Mar;41(3):515-22
Neurochemical research 2016 Mar;41(3):515-22
PHD1 regulates p53-mediated colorectal cancer chemoresistance.
Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M
EMBO molecular medicine 2015 Oct;7(10):1350-65
EMBO molecular medicine 2015 Oct;7(10):1350-65
Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27.
Högel H, Miikkulainen P, Bino L, Jaakkola PM
Molecular cancer 2015 Jul 30;14:143
Molecular cancer 2015 Jul 30;14:143
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG Jr, Liu XS, Zhang Q
The EMBO journal 2015 Dec 2;34(23):2953-70
The EMBO journal 2015 Dec 2;34(23):2953-70
Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells.
Yogev O, Lagos D, Enver T, Boshoff C
PLoS pathogens 2014 Sep;10(9):e1004400
PLoS pathogens 2014 Sep;10(9):e1004400
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.
Henze AT, Garvalov BK, Seidel S, Cuesta AM, Ritter M, Filatova A, Foss F, Dopeso H, Essmann CL, Maxwell PH, Reifenberger G, Carmeliet P, Acker-Palmer A, Acker T
Nature communications 2014 Nov 25;5:5582
Nature communications 2014 Nov 25;5:5582
Chronic hypoxemia in late gestation decreases cardiomyocyte number but does not change expression of hypoxia-responsive genes.
Botting KJ, McMillen IC, Forbes H, Nyengaard JR, Morrison JL
Journal of the American Heart Association 2014 Jul 28;3(4)
Journal of the American Heart Association 2014 Jul 28;3(4)
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q
Genes & development 2014 Jul 1;28(13):1429-44
Genes & development 2014 Jul 1;28(13):1429-44
High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α.
Tan JT, Prosser HC, Vanags LZ, Monger SA, Ng MK, Bursill CA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jan;28(1):206-17
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jan;28(1):206-17
The role of prolyl hydroxylase domain protein (PHD) during rosiglitazone-induced adipocyte differentiation.
Kim J, Kwak HJ, Cha JY, Jeong YS, Rhee SD, Cheon HG
The Journal of biological chemistry 2014 Jan 31;289(5):2755-64
The Journal of biological chemistry 2014 Jan 31;289(5):2755-64
HIF-1α is upregulated in human mesenchymal stem cells.
Palomäki S, Pietilä M, Laitinen S, Pesälä J, Sormunen R, Lehenkari P, Koivunen P
Stem cells (Dayton, Ohio) 2013 Sep;31(9):1902-9
Stem cells (Dayton, Ohio) 2013 Sep;31(9):1902-9
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids.
Durán RV, MacKenzie ED, Boulahbel H, Frezza C, Heiserich L, Tardito S, Bussolati O, Rocha S, Hall MN, Gottlieb E
Oncogene 2013 Sep 19;32(38):4549-56
Oncogene 2013 Sep 19;32(38):4549-56
Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.
Rawluszko AA, Bujnicka KE, Horbacka K, Krokowicz P, Jagodziński PP
BMC cancer 2013 Nov 6;13:526
BMC cancer 2013 Nov 6;13:526
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
Scholz CC, Cavadas MA, Tambuwala MM, Hams E, Rodríguez J, von Kriegsheim A, Cotter P, Bruning U, Fallon PG, Cheong A, Cummins EP, Taylor CT
Proceedings of the National Academy of Sciences of the United States of America 2013 Nov 12;110(46):18490-5
Proceedings of the National Academy of Sciences of the United States of America 2013 Nov 12;110(46):18490-5
A mechanism for induction of a hypoxic response by vaccinia virus.
Mazzon M, Peters NE, Loenarz C, Krysztofinska EM, Ember SW, Ferguson BJ, Smith GL
Proceedings of the National Academy of Sciences of the United States of America 2013 Jul 23;110(30):12444-9
Proceedings of the National Academy of Sciences of the United States of America 2013 Jul 23;110(30):12444-9
Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia.
Kunze R, Zhou W, Veltkamp R, Wielockx B, Breier G, Marti HH
Stroke 2012 Oct;43(10):2748-56
Stroke 2012 Oct;43(10):2748-56
Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients.
Peurala E, Koivunen P, Bloigu R, Haapasaari KM, Jukkola-Vuorinen A
Breast cancer research and treatment 2012 May;133(1):179-88
Breast cancer research and treatment 2012 May;133(1):179-88
Low expression of prolyl hydroxylase 2 is associated with tumor grade and poor prognosis in patients with colorectal cancer.
Xie G, Zheng L, Ou J, Huang H, He J, Li J, Pan F, Liang H
Experimental biology and medicine (Maywood, N.J.) 2012 Jul;237(7):860-6
Experimental biology and medicine (Maywood, N.J.) 2012 Jul;237(7):860-6
Prolyl hydroxylase domain protein 3 targets Pax2 for destruction.
Yan B, Jiao S, Zhang HS, Lv DD, Xue J, Fan L, Wu GH, Fang J
Biochemical and biophysical research communications 2011 Jun 3;409(2):315-20
Biochemical and biophysical research communications 2011 Jun 3;409(2):315-20
Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes.
Pyott SM, Schwarze U, Christiansen HE, Pepin MG, Leistritz DF, Dineen R, Harris C, Burton BK, Angle B, Kim K, Sussman MD, Weis M, Eyre DR, Russell DW, McCarthy KJ, Steiner RD, Byers PH
Human molecular genetics 2011 Apr 15;20(8):1595-609
Human molecular genetics 2011 Apr 15;20(8):1595-609
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.
Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T
Cancer research 2010 Jan 1;70(1):357-66
Cancer research 2010 Jan 1;70(1):357-66
Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.
Wiley M, Sweeney KR, Chan DA, Brown KM, McMurtrey C, Howard EW, Giaccia AJ, Blader IJ
The Journal of biological chemistry 2010 Aug 27;285(35):26852-60
The Journal of biological chemistry 2010 Aug 27;285(35):26852-60
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.
Hyvärinen J, Hassinen IE, Sormunen R, Mäki JM, Kivirikko KI, Koivunen P, Myllyharju J
The Journal of biological chemistry 2010 Apr 30;285(18):13646-57
The Journal of biological chemistry 2010 Apr 30;285(18):13646-57
HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury.
Schödel J, Klanke B, Weidemann A, Buchholz B, Bernhardt W, Bertog M, Amann K, Korbmacher C, Wiesener M, Warnecke C, Kurtz A, Eckardt KU, Willam C
The American journal of pathology 2009 May;174(5):1663-74
The American journal of pathology 2009 May;174(5):1663-74
Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms.
Schultz K, Murthy V, Tatro JB, Beasley D
American journal of physiology. Lung cellular and molecular physiology 2009 Jun;296(6):L921-7
American journal of physiology. Lung cellular and molecular physiology 2009 Jun;296(6):L921-7
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ
Cancer cell 2009 Jun 2;15(6):527-38
Cancer cell 2009 Jun 2;15(6):527-38
The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential.
Lee K A, Lynd JD, O'Reilly S, Kiupel M, McCormick JJ, LaPres JJ
Molecular cancer research : MCR 2008 May;6(5):829-42
Molecular cancer research : MCR 2008 May;6(5):829-42
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.
Takeda K, Aguila HL, Parikh NS, Li X, Lamothe K, Duan LJ, Takeda H, Lee FS, Fong GH
Blood 2008 Mar 15;111(6):3229-35
Blood 2008 Mar 15;111(6):3229-35
The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.
Mikhaylova O, Ignacak ML, Barankiewicz TJ, Harbaugh SV, Yi Y, Maxwell PH, Schneider M, Van Geyte K, Carmeliet P, Revelo MP, Wyder M, Greis KD, Meller J, Czyzyk-Krzeska MF
Molecular and cellular biology 2008 Apr;28(8):2701-17
Molecular and cellular biology 2008 Apr;28(8):2701-17
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys.
Li N, Yi F, Sundy CM, Chen L, Hilliker ML, Donley DK, Muldoon DB, Li PL
American journal of physiology. Renal physiology 2007 Jan;292(1):F207-16
American journal of physiology. Renal physiology 2007 Jan;292(1):F207-16
Hypoxia-inducible factors in the first trimester human lung.
Groenman F, Rutter M, Caniggia I, Tibboel D, Post M
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 Apr;55(4):355-63
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 Apr;55(4):355-63
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Khan Z, Michalopoulos GK, Stolz DB
The American journal of pathology 2006 Oct;169(4):1251-69
The American journal of pathology 2006 Oct;169(4):1251-69
Dynamic HIF1A regulation during human placental development.
Ietta F, Wu Y, Winter J, Xu J, Wang J, Post M, Caniggia I
Biology of reproduction 2006 Jul;75(1):112-21
Biology of reproduction 2006 Jul;75(1):112-21
Previous or ongoing schistosome infections do not compromise the efficacy of the attenuated cercaria vaccine.
Kariuki TM, Van Dam GJ, Deelder AM, Farah IO, Yole DS, Wilson RA, Coulson PS
Infection and immunity 2006 Jul;74(7):3979-86
Infection and immunity 2006 Jul;74(7):3979-86
Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.
McMahon S, Charbonneau M, Grandmont S, Richard DE, Dubois CM
The Journal of biological chemistry 2006 Aug 25;281(34):24171-81
The Journal of biological chemistry 2006 Aug 25;281(34):24171-81
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung.
Asikainen TM, Schneider BK, Waleh NS, Clyman RI, Ho WB, Flippin LA, Günzler V, White CW
Proceedings of the National Academy of Sciences of the United States of America 2005 Jul 19;102(29):10212-7
Proceedings of the National Academy of Sciences of the United States of America 2005 Jul 19;102(29):10212-7
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL
Molecular cell 2005 Feb 18;17(4):503-12
Molecular cell 2005 Feb 18;17(4):503-12
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