DEFB107A

Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 107, DEFB107A and DEFB107B, in tail-to-tail orientation. This gene, DEFB107A, represents the more centromeric copy. [provided by RefSeq, Oct 2014]

Description

Defensin beta 107A

Tissue specificity

Tissue enriched (epididymis)

Predicted location

Secreted in male reproductive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

8 (7811720 - 7815716)

Ensembl ID

ENSG00000186572  (ver. 103.38)

Orthologs

-

UniProt

Q8IZN7

neXtProt

NX_Q8IZN7

Human splice variants

Protein structure