DNAH3

This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]

Description

Dynein axonemal heavy chain 3

Tissue specificity

Tissue enhanced (brain, fallopian tube, testis)

Subcell location

Nuclear membrane, Intermediate filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

16 (20933111 - 21159441)

Ensembl ID

ENSG00000158486  (ver. 103.38)

Orthologs

Mouse Dnah3: ENSMUSG00000052273

UniProt

Q8TD57

neXtProt

NX_Q8TD57

Human splice variants
Mouse splice variants

Protein structure