10144-2-AP

antibody from Proteintech Group

Targeting: STAT1 ISGF-3, STAT91

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

10144-2-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10144-2-AP, RRID:AB_2286875

Product name

STAT1 antibody

Antibody type

Polyclonal

Description

KD/KO validated STAT1 antibody (Cat. #10144-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: FC, IF, IP, WB, ELISA.

Reactivity

Human, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance.

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CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways.

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The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.

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Establishment of incontinence-associated dermatitis rat models and assessment of the therapeutic effects of zinc oxide, painless skin protective film and silicone dressing.

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Experimental and therapeutic medicine 2021 Oct;22(4):1058

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Polygalaxanthone III downregulates inflammation in the lipopolysaccharide-stimulated RAW264.7 macrophages: A quantibody array analysis.

Wu Y, Fu H, Yang X, Leng F, Huang Y, Deng H, Xiang Q, Zhang S
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Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Li Z, Xu Q, Huangfu N, Chen X, Zhu J
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Tumour microenvironment-based molecular profiling reveals ideal candidates for high-grade serous ovarian cancer immunotherapy.

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Cell proliferation 2021 Mar;54(3):e12979

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Serum proteome profiling provides a deep understanding of the 'gut-liver axis' in relation to liver injury and regeneration.

Leng L, Ma J, Lv L, Gao D, Li M, Wang Y, Zhu Y
Acta biochimica et biophysica Sinica 2021 Mar 2;53(3):372-380

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Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.

Zhou Z, Li Y, Ma X, Cao B, Peng T, Sheng Y, Peng H, Li R, Cao Y, Xi R, Li F, Wang M, Sun H, Zhang G, Zhang H, Hu K, Xiao W, Wang F
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421

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Baicalein Delays H₂O₂-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.

Gao L, Zheng WG, Wu XK, Du GH, Qin XM
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335

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Evaluation of piggyBac-mediated anti-CD19 CAR-T cells after ex vivo expansion with aAPCs or magnetic beads.

Yang LR, Li L, Meng MY, Wang WJ, Yang SL, Zhao YY, Wang RQ, Gao H, Tang WW, Yang Y, Yang LL, Liao LW, Hou ZL
Journal of cellular and molecular medicine 2021 Jan;25(2):686-700

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Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.

Luo N, Yang C, Zhu Y, Chen Q, Zhang B
Journal of agricultural and food chemistry 2021 Jan 20;69(2):655-667

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MAGE-C3 promotes cancer metastasis by inducing epithelial-mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma.

Wu Q, Zhang W, Wang Y, Min Q, Zhang H, Dong D, Zhan Q
Cancer communications (London, England) 2021 Dec;41(12):1354-1372

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Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression.

Liu C, Qu J, Wu M, Huang X, Li L
Ecotoxicology and environmental safety 2021 Dec 1;225:112792

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The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.

Yan Z, Zhan J, Qi W, Lin J, Huang Y, Xue X, Pan X
Frontiers in pharmacology 2020;11:1195

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Curcumin prevents osteocyte apoptosis by inhibiting M1-type macrophage polarization in mice model of glucocorticoid-associated osteonecrosis of the femoral head.

Jin S, Meng C, He Y, Wang X, Zhang Q, Wang Z, Huang W, Wang H
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Sep;38(9):2020-2030

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IL-27 Rα⁺ cells promoted allorejection via enhancing STAT1/3/5 phosphorylation.

Zhao S, Liang T, Zhang C, Shi D, Jiang W, Su C, Hou G
Journal of cellular and molecular medicine 2020 Sep;24(18):10756-10767

---

CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway.

Chen Y, Shao Z, Jiang E, Zhou X, Wang L, Wang H, Luo X, Chen Q, Liu K, Shang Z
Journal of cellular physiology 2020 Sep;235(9):5995-6009

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Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.

Zhang M, Fu M, Li M, Hu H, Gong S, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292

---

m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.

Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana TM
The EMBO journal 2020 Oct 15;39(20):e104514

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miR-142-5p/DAX1-dependent regulation of P450c17 contributes to triclosan-mediated testosterone suppression.

Duan P, Huang X, Ha M, Li L, Liu C
The Science of the total environment 2020 May 15;717:137280

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Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.

Fan Z, Chen X, Liu L, Zhu C, Xu J, Yin X, Sheng Y, Zhu Z, Wen L, Zuo X, Zheng X, Zhang Y, Xu J, Huang H, Zhou F, Sun L, Luo J, Zhang D, Chen X, Cui Y, Hao Y, Cui Y, Zhang X, Chen R
Arthritis & rheumatology (Hoboken, N.J.) 2020 Jun;72(6):985-996

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TRIM59 suppresses NO production by promoting the binding of PIAS1 and STAT1 in macrophages.

Su X, Zhang Q, Yue J, Wang Y, Zhang Y, Yang R
International immunopharmacology 2020 Dec;89(Pt A):107030

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TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.

Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Investigative ophthalmology & visual science 2020 Dec 1;61(14):24

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Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis.

Hu J, Yang Z, Wu H, Wang D
International immunopharmacology 2020 Aug;85:106620

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Silica particles disorganize the polarization of pulmonary macrophages in mice.

Zhao Y, Hao C, Bao L, Wang D, Li Y, Qu Y, Ding M, Zhao A, Yao W
Ecotoxicology and environmental safety 2020 Apr 15;193:110364

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USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression.

Han B, Sun Y, Yang D, Zhang H, Mo S, Chen X, Lu H, Mao X, Hu J
Aging 2020 Apr 15;12(8):6990-7005

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Severe Fever With Thrombocytopenia Syndrome Virus-Induced Macrophage Differentiation Is Regulated by miR-146.

Zhang L, Fu Y, Wang H, Guan Y, Zhu W, Guo M, Zheng N, Wu Z
Frontiers in immunology 2019;10:1095

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Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.

Zhang YZ, Zhang ZM, Zhou LT, Zhu J, Zhang XH, Qi W, Ding S, Xu Q, Han X, Zhao YM, Song XY, Zhao TY, Ye L
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418

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MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.

Yuan J, Tan L, Yin Z, Zhu W, Tao K, Wang G, Shi W, Gao J
Cell death & disease 2019 Jun 11;10(6):454

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IL-27 Promotes Human Placenta-Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4⁺IL-10⁺IFN-γ⁺ T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease.

Yi J, Chen Z, Xu F, Wang Z, Zhang A, Liu T, Zhao N, Xiong Y, Jiang G, Ma J, Luan X
Journal of immunology (Baltimore, Md. : 1950) 2019 Feb 15;202(4):1124-1136

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Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8).

Li J, Zhou Y, Du G, Qin X, Gao L
European journal of pharmacology 2019 Dec 15;865:172789

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MicroRNA-204-5p suppresses IL6-mediated inflammatory response and chemokine generation in HK-2 renal tubular epithelial cells by targeting IL6R.

Li H, Wang J, Liu X, Cheng Q
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Apr;97(2):109-117

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Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis.

Wu J, Wang A, Wang X, Li G, Jia P, Shen G, Chen B, Yuan Y, Zhang H, Yang F, Xu Y
Bone 2019 Apr;121:16-28

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Alcohol attenuates anti-HCV function of IFN-λ1 through up-regulation of PLASy expression in human hepatic cells.

Ran M, Huang J, Liang H, Jiang J, Liang B, Ning C, Zang N, Liao W, Liu H, Qin F, Yang Q, Ho W, Ye L, Chen H
Journal of medical virology 2018 Jun;90(6):1112-1120

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Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.

Wang H, Xin X, Wang M, Han L, Li J, Hao Y, Zheng C, Shen C
Archives of virology 2018 Jun;163(6):1429-1438

---

PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.

Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, He M, Yao Y, Man M, Wang J
Cell death & disease 2018 Jan 22;9(2):71

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MicroRNA gga-miR-130b Suppresses Infectious Bursal Disease Virus Replication via Targeting of the Viral Genome and Cellular Suppressors of Cytokine Signaling 5.

Fu M, Wang B, Chen X, He Z, Wang Y, Li X, Cao H, Zheng SJ
Journal of virology 2018 Jan 1;92(1)

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The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression.

Kueck T, Cassella E, Holler J, Kim B, Bieniasz PD
eLife 2018 Aug 22;7

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l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.

Leng YP, Ma YS, Li XG, Chen RF, Zeng PY, Li XH, Qiu CF, Li YP, Zhang Z, Chen AF
British journal of pharmacology 2018 Apr;175(8):1157-1172

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Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis.

Liu Q, Du Y, Li K, Zhang W, Feng X, Hao J, Li H, Liu S
Mediators of inflammation 2017;2017:3038514

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Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection.

Fu Y, Zhang L, Zhang F, Tang T, Zhou Q, Feng C, Jin Y, Wu Z
PLoS pathogens 2017 Sep;13(9):e1006611

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Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.

Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704

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Global quantitative proteomic analysis profiles host protein expression in response to Sendai virus infection.

Zhu SL, Chen X, Wang LJ, Wan WW, Xin QL, Wang W, Xiao G, Zhang LK
Proteomics 2017 Mar;17(5)

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Quantitative Proteomic analysis on Activated Hepatic Stellate Cells reversion Reveal STAT1 as a key regulator between Liver Fibrosis and recovery.

Zhang H, Chen F, Fan X, Lin C, Hao Y, Wei H, Lin W, Jiang Y, He F
Scientific reports 2017 Mar 21;7:44910

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Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.

Igbe I, Shen XF, Jiao W, Qiang Z, Deng T, Li S, Liu WL, Liu HW, Zhang GL, Wang F
Oncotarget 2017 Dec 26;8(69):113734-113748

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6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.

Wonganan O, He YJ, Shen XF, Wongkrajang K, Suksamrarn A, Zhang GL, Wang F
Toxicology and applied pharmacology 2017 Dec 1;336:31-39

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IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations.

Xu F, Yi J, Wang Z, Hu Y, Han C, Xue Q, Zhang X, Luan X
Immunologic research 2017 Aug;65(4):903-912

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IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis.

Shen P, Li Q, Ma J, Tian M, Hong F, Zhai X, Li J, Huang H, Shi C
BMC microbiology 2017 Aug 23;17(1):185

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iTRAQ-based Proteomic Analysis of Porcine Kidney Epithelial PK15 cells Infected with Pseudorabies virus.

Yang S, Pei Y, Zhao A
Scientific reports 2017 Apr 4;7:45922

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Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone.

Huang B, Wang W, Li Q, Wang Z, Yan B, Zhang Z, Wang L, Huang M, Jia C, Lu J, Liu S, Chen H, Li M, Cai D, Jiang Y, Jin D, Bai X
Nature communications 2016 Dec 14;7:13885

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Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake.

Yang X, Yao H, Chen Y, Sun L, Li Y, Ma X, Duan S, Li X, Xiang R, Han J, Duan Y
The Journal of biological chemistry 2015 Sep 4;290(36):21788-99

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IL-27 alleviates the bleomycin-induced pulmonary fibrosis by regulating the Th17 cell differentiation.

Dong Z, Lu X, Yang Y, Zhang T, Li Y, Chai Y, Lei W, Li C, Ai L, Tai W
BMC pulmonary medicine 2015 Feb 18;15:13

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Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F
Kidney international 2014 Oct;86(4):712-25

---

Up-regulation of intestinal epithelial cell derived IL-7 expression by keratinocyte growth factor through STAT1/IRF-1, IRF-2 pathway.

Cai YJ, Wang WS, Yang Y, Sun LH, Teitelbaum DH, Yang H
PloS one 2013;8(3):e58647

---

Identification and analysis of glycogen synthase kinase 3 beta1 interactome.

Gao X, Wang JY, Gao LM, Yin XF, Liu L
Cell biology international 2013 Aug;37(8):768-79

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

PC-3 cells were subjected to SDS PAGE followed by western blot with 10144-2-AP(STAT1 antibody) at dilution of 1:600

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The STAT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human STAT1. This antibody recognizes human,mouse,rat antigen. The STAT1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

10144-2-AP.pdf

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