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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [36]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- ABIN252118 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) (Large Subunit), (Small Subunit), (active) antibody
- Antibody type
- Polyclonal
- Description
- Unpurified
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- Large Subunit, Small Subunit, active
- Vial size
- 0.05 mL
- Storage
- Store at -20°C. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma.
Histone deacetylase inhibitor quisinostat activates caspase signaling and upregulates p53 acetylation to inhibit the proliferation of HepG2 cells.
Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the Retinal Pigment Epithelium and Photoreceptor After Sodium Iodate Injury.
Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye.
Cymbopogon citratus and Camellia sinensis extracts selectively induce apoptosis in cancer cells and reduce growth of lymphoma xenografts in vivo.
Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis.
Ursolic Acid Triggers Apoptosis in Human Osteosarcoma Cells via Caspase Activation and the ERK1/2 MAPK Pathway.
Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling.
Dodecyl gallate induces apoptosis by upregulating the caspase-dependent apoptotic pathway and inhibiting the expression of anti-apoptotic Bcl-2 family proteins in human osteosarcoma cells.
Neural differentiation and synaptogenesis in retinal development.
Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.
Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis.
Prenatal alcohol exposure inducing the apoptosis of mossy cells in hippocampus of SMS2-/- mice.
The cytotoxic nature of Acanthopanax sessiliflorus stem bark extracts in human breast cancer cells.
Apocytolysis, a proposed mechanism of blister formation in epidermolysis bullosa simplex.
Peripheral noxious stimulation reduces withdrawal threshold to mechanical stimuli after spinal cord injury: role of tumor necrosis factor alpha and apoptosis.
Modulation of hippocampal neuroplasticity by Fas/CD95 regulatory protein 2 (Faim2) in the course of bacterial meningitis.
Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye.
Oncolytic activity of avian influenza virus in human pancreatic ductal adenocarcinoma cell lines.
Death receptor 5 and neuroproliferation.
Apoptosis in extracorporeal preserved inguinal fat flaps of the rat.
Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.
Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy.
Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice.
Sphingomyelin induces cathepsin D-mediated apoptosis in intestinal epithelial cells and increases inflammation in DSS colitis.
Pathways of macrophage apoptosis within the interface membrane in aseptic loosening of prostheses.
Interferon-γ exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways.
CLSI-derived hematology and biochemistry reference intervals for healthy adults in eastern and southern Africa.
Differential role of the Fas/Fas ligand apoptotic pathway in inflammation and lung fibrosis associated with reovirus 1/L-induced bronchiolitis obliterans organizing pneumonia and acute respiratory distress syndrome.
A computational screen for type I polyketide synthases in metagenomics shotgun data.
Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.
Murine FLIP transgene expressed on thyroid epithelial cells promotes resolution of granulomatous experimental autoimmune thyroiditis in DBA/1 mice.
Expression of transgenic FLIP on thyroid epithelial cells inhibits induction and promotes resolution of granulomatous experimental autoimmune thyroiditis in CBA/J mice.
Caspases: pharmacological manipulation of cell death.
Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation.
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Liu PF, Hu YC, Kang BH, Tseng YK, Wu PC, Liang CC, Hou YY, Fu TY, Liou HH, Hsieh IC, Ger LP, Shu CW
PloS one 2017;12(7):e0180620
PloS one 2017;12(7):e0180620
Histone deacetylase inhibitor quisinostat activates caspase signaling and upregulates p53 acetylation to inhibit the proliferation of HepG2 cells.
Li F, Wang T, Wang Z, Chen X, Liu R
Molecular medicine reports 2017 Nov;16(5):6094-6101
Molecular medicine reports 2017 Nov;16(5):6094-6101
Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the Retinal Pigment Epithelium and Photoreceptor After Sodium Iodate Injury.
Xiao J, Yao J, Jia L, Lin C, Zacks DN
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1801-1810
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1801-1810
Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye.
Chi W, Hua X, Chen X, Bian F, Yuan X, Zhang L, Wang X, Chen D, Deng R, Li Z, Liu Y, de Paiva CS, Pflugfelder SC, Li DQ
Journal of autoimmunity 2017 Jun;80:65-76
Journal of autoimmunity 2017 Jun;80:65-76
Cymbopogon citratus and Camellia sinensis extracts selectively induce apoptosis in cancer cells and reduce growth of lymphoma xenografts in vivo.
Philion C, Ma D, Ruvinov I, Mansour F, Pignanelli C, Noel M, Saleem A, Arnason J, Rodrigues M, Singh I, Ropat J, Pandey S
Oncotarget 2017 Dec 19;8(67):110756-110773
Oncotarget 2017 Dec 19;8(67):110756-110773
Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis.
Gao Y, Yang H, Fan Y, Li L, Fang J, Yang W
Mediators of inflammation 2016;2016:1320365
Mediators of inflammation 2016;2016:1320365
Ursolic Acid Triggers Apoptosis in Human Osteosarcoma Cells via Caspase Activation and the ERK1/2 MAPK Pathway.
Wu CC, Cheng CH, Lee YH, Chang IL, Chen HY, Hsieh CP, Chueh PJ
Journal of agricultural and food chemistry 2016 Jun 1;64(21):4220-6
Journal of agricultural and food chemistry 2016 Jun 1;64(21):4220-6
Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling.
Matzke-Ogi A, Jannasch K, Shatirishvili M, Fuchs B, Chiblak S, Morton J, Tawk B, Lindner T, Sansom O, Alves F, Warth A, Schwager C, Mier W, Kleeff J, Ponta H, Abdollahi A, Orian-Rousseau V
Gastroenterology 2016 Feb;150(2):513-25.e10
Gastroenterology 2016 Feb;150(2):513-25.e10
Dodecyl gallate induces apoptosis by upregulating the caspase-dependent apoptotic pathway and inhibiting the expression of anti-apoptotic Bcl-2 family proteins in human osteosarcoma cells.
Cheng CH, Cheng YP, Chang IL, Chen HY, Wu CC, Hsieh CP
Molecular medicine reports 2016 Feb;13(2):1495-500
Molecular medicine reports 2016 Feb;13(2):1495-500
Neural differentiation and synaptogenesis in retinal development.
Fan WJ, Li X, Yao HL, Deng JX, Liu HL, Cui ZJ, Wang Q, Wu P, Deng JB
Neural regeneration research 2016 Feb;11(2):312-8
Neural regeneration research 2016 Feb;11(2):312-8
Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.
Magarin M, Pohl T, Lill A, Schulz H, Blaschke F, Heuser A, Thierfelder L, Donath S, Drenckhahn JD
Journal of molecular and cellular cardiology 2016 Aug;97:1-14
Journal of molecular and cellular cardiology 2016 Aug;97:1-14
Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis.
Seko Y, Fujimura T, Yao T, Taka H, Mineki R, Okumura K, Murayama K
Scientific reports 2015 Sep 8;5:13737
Scientific reports 2015 Sep 8;5:13737
Prenatal alcohol exposure inducing the apoptosis of mossy cells in hippocampus of SMS2-/- mice.
Wang L, Wu L, Wang X, Deng J, Ma Z, Fan W, He W, Deng J
Environmental toxicology and pharmacology 2015 Nov;40(3):975-82
Environmental toxicology and pharmacology 2015 Nov;40(3):975-82
The cytotoxic nature of Acanthopanax sessiliflorus stem bark extracts in human breast cancer cells.
Thamizhiniyan V, Young-Woong C, Young-Kyoon K
Saudi journal of biological sciences 2015 Nov;22(6):752-9
Saudi journal of biological sciences 2015 Nov;22(6):752-9
Apocytolysis, a proposed mechanism of blister formation in epidermolysis bullosa simplex.
El-Hawary MS, Abdel-Halim MR, Sayed SS, Abdelkader HA
Archives of dermatological research 2015 May;307(4):371-7
Archives of dermatological research 2015 May;307(4):371-7
Peripheral noxious stimulation reduces withdrawal threshold to mechanical stimuli after spinal cord injury: role of tumor necrosis factor alpha and apoptosis.
Garraway SM, Woller SA, Huie JR, Hartman JJ, Hook MA, Miranda RC, Huang YJ, Ferguson AR, Grau JW
Pain 2014 Nov;155(11):2344-59
Pain 2014 Nov;155(11):2344-59
Modulation of hippocampal neuroplasticity by Fas/CD95 regulatory protein 2 (Faim2) in the course of bacterial meningitis.
Tauber SC, Harms K, Falkenburger B, Weis J, Sellhaus B, Nau R, Schulz JB, Reich A
Journal of neuropathology and experimental neurology 2014 Jan;73(1):2-13
Journal of neuropathology and experimental neurology 2014 Jan;73(1):2-13
Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye.
Zhang X, De Paiva CS, Su Z, Volpe EA, Li DQ, Pflugfelder SC
Experimental eye research 2014 Jan;118:117-24
Experimental eye research 2014 Jan;118:117-24
Oncolytic activity of avian influenza virus in human pancreatic ductal adenocarcinoma cell lines.
Kasloff SB, Pizzuto MS, Silic-Benussi M, Pavone S, Ciminale V, Capua I
Journal of virology 2014 Aug;88(16):9321-34
Journal of virology 2014 Aug;88(16):9321-34
Death receptor 5 and neuroproliferation.
Niu Y, Li Y, Zang J, Huang H, Deng J, Cui Z, Yu D, Deng J
Cellular and molecular neurobiology 2012 Mar;32(2):255-65
Cellular and molecular neurobiology 2012 Mar;32(2):255-65
Apoptosis in extracorporeal preserved inguinal fat flaps of the rat.
Herold C, Rennekampff HO, Ohm L, Strauss S, Linkner J, Reimers K, Allmeling C, Vaske B, Vogt PM
Apoptosis : an international journal on programmed cell death 2012 Apr;17(4):400-9
Apoptosis : an international journal on programmed cell death 2012 Apr;17(4):400-9
Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.
Krajewska M, You Z, Rong J, Kress C, Huang X, Yang J, Kyoda T, Leyva R, Banares S, Hu Y, Sze CH, Whalen MJ, Salmena L, Hakem R, Head BP, Reed JC, Krajewski S
PloS one 2011;6(9):e24341
PloS one 2011;6(9):e24341
Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy.
Anand S, Wilson C, Hasan T, Maytin EV
Cancer research 2011 Sep 15;71(18):6040-50
Cancer research 2011 Sep 15;71(18):6040-50
Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice.
Csak T, Dolganiuc A, Kodys K, Nath B, Petrasek J, Bala S, Lippai D, Szabo G
Hepatology (Baltimore, Md.) 2011 Jun;53(6):1917-31
Hepatology (Baltimore, Md.) 2011 Jun;53(6):1917-31
Sphingomyelin induces cathepsin D-mediated apoptosis in intestinal epithelial cells and increases inflammation in DSS colitis.
Fischbeck A, Leucht K, Frey-Wagner I, Bentz S, Pesch T, Kellermeier S, Krebs M, Fried M, Rogler G, Hausmann M, Humpf HU
Gut 2011 Jan;60(1):55-65
Gut 2011 Jan;60(1):55-65
Pathways of macrophage apoptosis within the interface membrane in aseptic loosening of prostheses.
Yang F, Wu W, Cao L, Huang Y, Zhu Z, Tang T, Dai K
Biomaterials 2011 Dec;32(35):9159-67
Biomaterials 2011 Dec;32(35):9159-67
Interferon-γ exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways.
Zhang X, Chen W, De Paiva CS, Corrales RM, Volpe EA, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC
Investigative ophthalmology & visual science 2011 Aug 9;52(9):6279-85
Investigative ophthalmology & visual science 2011 Aug 9;52(9):6279-85
CLSI-derived hematology and biochemistry reference intervals for healthy adults in eastern and southern Africa.
Karita E, Ketter N, Price MA, Kayitenkore K, Kaleebu P, Nanvubya A, Anzala O, Jaoko W, Mutua G, Ruzagira E, Mulenga J, Sanders EJ, Mwangome M, Allen S, Bwanika A, Bahemuka U, Awuondo K, Omosa G, Farah B, Amornkul P, Birungi J, Yates S, Stoll-Johnson L, Gilmour J, Stevens G, Shutes E, Manigart O, Hughes P, Dally L, Scott J, Stevens W, Fast P, Kamali A
PloS one 2009;4(2):e4401
PloS one 2009;4(2):e4401
Differential role of the Fas/Fas ligand apoptotic pathway in inflammation and lung fibrosis associated with reovirus 1/L-induced bronchiolitis obliterans organizing pneumonia and acute respiratory distress syndrome.
Lopez AD, Avasarala S, Grewal S, Murali AK, London L
Journal of immunology (Baltimore, Md. : 1950) 2009 Dec 15;183(12):8244-57
Journal of immunology (Baltimore, Md. : 1950) 2009 Dec 15;183(12):8244-57
A computational screen for type I polyketide synthases in metagenomics shotgun data.
Foerstner KU, Doerks T, Creevey CJ, Doerks A, Bork P
PloS one 2008;3(10):e3515
PloS one 2008;3(10):e3515
Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.
Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA
Molecular and cellular biology 2008 Jun;28(12):3943-51
Molecular and cellular biology 2008 Jun;28(12):3943-51
Murine FLIP transgene expressed on thyroid epithelial cells promotes resolution of granulomatous experimental autoimmune thyroiditis in DBA/1 mice.
Fang Y, Wei Y, Demarco V, Chen K, Sharp GC, Braley-Mullen H
The American journal of pathology 2007 Mar;170(3):875-87
The American journal of pathology 2007 Mar;170(3):875-87
Expression of transgenic FLIP on thyroid epithelial cells inhibits induction and promotes resolution of granulomatous experimental autoimmune thyroiditis in CBA/J mice.
Fang Y, DeMarco VG, Sharp GC, Braley-Mullen H
Endocrinology 2007 Dec;148(12):5734-45
Endocrinology 2007 Dec;148(12):5734-45
Caspases: pharmacological manipulation of cell death.
Lavrik IN, Golks A, Krammer PH
The Journal of clinical investigation 2005 Oct;115(10):2665-72
The Journal of clinical investigation 2005 Oct;115(10):2665-72
Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation.
Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J, Naito M, Salvesen GS, Reed JC, Fiskum G, Krajewski S
Experimental neurology 2004 Oct;189(2):261-79
Experimental neurology 2004 Oct;189(2):261-79
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM
Cell death and differentiation 2004 Apr;11(4):424-38
Cell death and differentiation 2004 Apr;11(4):424-38
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
