Antibody data
- Antibody Data
- Antigen structure
- References [45]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 21920-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21920-1-AP, RRID:AB_11232223
- Product name
- NMDAR2B/GRIN2B antibody
- Antibody type
- Polyclonal
- Description
- NMDAR2B/GRIN2B antibody (Cat. #21920-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice.
Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity.
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.
Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine.
Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate cortex.
Early and Delayed Impact of Nanosilver on the Glutamatergic NMDA Receptor Complex in Immature Rat Brain.
Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus.
Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model.
Phosphorylation of GluN2B subunits of N-methyl-d-aspartate receptors in the frontal association cortex involved in morphine-induced conditioned place preference in mice.
A high-throughput screen identifies inhibitors of lung cancer stem cells.
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca2+-Activin A circuit in chronic cerebral hypoperfusion rats.
Enriched Environment Promotes Cognitive Function Recovery following Cerebral Ischemic Injury via Upregulating GABAergic and Glutamatergic Systems in the Contralateral Hippocampus.
Effects of Xiaoyaosan on Depressive-Like Behaviors in Rats With Chronic Unpredictable Mild Stress Through HPA Axis Induced Astrocytic Activities.
Involvement of NMDAR/PSD-95/nNOS-NO-cGMP pathway in embryonic exposure to BPA induced learning and memory dysfunction of rats.
Up-regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine.
STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
EphrinB/EphB Signaling Contributes to the Synaptic Plasticity of Chronic Migraine Through NR2B Phosphorylation.
CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion.
SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors.
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice.
TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system.
Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy.
Inhibition of CB1 receptor ameliorates spatial learning and memory impairment in mice with traumatic brain injury.
Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X.
CAMK2-Dependent Signaling in Neurons Is Essential for Survival.
The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors.
NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model.
Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS2 nanoflowers.
N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression.
Effects of intrathecal bupivacaine on the NR2B/CaMKIIα/CREB signaling pathway in the rat lumbar spinal cord.
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex.
HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons.
Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats.
Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age.
Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice.
Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease.
Beneficial Effects of a CaMKIIα Inhibitor TatCN21 Peptide in Global Cerebral Ischemia.
Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction.
Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.
A lasting effect of postnatal sevoflurane anesthesia on the composition of NMDA receptor subunits in rat prefrontal cortex.
NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.
Dopamine D3 receptor-regulated NR2B subunits of N-methyl-d-aspartate receptors in the nucleus accumbens involves in morphine-induced locomotor activity.
Chang Y, Yao Y, Ma R, Wang Z, Hu J, Wu Y, Jiang X, Li L, Li G
Frontiers in neuroscience 2021;15:620176
Frontiers in neuroscience 2021;15:620176
Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity.
Qi CC, Chen XX, Gao XR, Xu JX, Liu S, Ge JF
Frontiers in aging neuroscience 2021;13:633495
Frontiers in aging neuroscience 2021;13:633495
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q
Molecular neurodegeneration 2021 Sep 22;16(1):66
Molecular neurodegeneration 2021 Sep 22;16(1):66
Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.
Peng X, Wang J, Peng J, Jiang H, Le K
Journal of molecular neuroscience : MN 2021 Sep 22;
Journal of molecular neuroscience : MN 2021 Sep 22;
Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine.
Zhang X, You L, Zhang X, Wang F, Wang Y, Zhou J, Liu C, Qu F
Chinese medicine 2021 Oct 2;16(1):97
Chinese medicine 2021 Oct 2;16(1):97
Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate cortex.
Xiao Y, Xie L, Xu QY, Chen L, Chen H, Xu GY, Zhang PA
Journal of neurophysiology 2021 May 1;125(5):1787-1797
Journal of neurophysiology 2021 May 1;125(5):1787-1797
Early and Delayed Impact of Nanosilver on the Glutamatergic NMDA Receptor Complex in Immature Rat Brain.
Dąbrowska-Bouta B, Sulkowski G, Sałek M, Frontczak-Baniewicz M, Strużyńska L
International journal of molecular sciences 2021 Mar 17;22(6)
International journal of molecular sciences 2021 Mar 17;22(6)
Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus.
Wang C, Shu Y, Xu L, Liu Q, Zhang B, Zhang H
Toxicology and industrial health 2021 Jun;37(6):303-313
Toxicology and industrial health 2021 Jun;37(6):303-313
Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model.
Wang Y, Pan Q, Tian R, Wen Q, Qin G, Zhang D, Chen L, Zhang Y, Zhou J
The journal of headache and pain 2021 Jul 27;22(1):84
The journal of headache and pain 2021 Jul 27;22(1):84
Phosphorylation of GluN2B subunits of N-methyl-d-aspartate receptors in the frontal association cortex involved in morphine-induced conditioned place preference in mice.
Chen G, Han W, Li A, Wang J, Xiao J, Huang X, Nazir KA, Shang Q, Qian H, Qiao C, Liu X, Li T
Neuroscience letters 2021 Jan 10;741:135470
Neuroscience letters 2021 Jan 10;741:135470
A high-throughput screen identifies inhibitors of lung cancer stem cells.
She X, Gao Y, Zhao Y, Yin Y, Dong Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug;140:111748
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug;140:111748
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca2+-Activin A circuit in chronic cerebral hypoperfusion rats.
Zhang X, Shi X, Wang J, Xu Z, He J
Aging 2021 Aug 30;13(16):20748-20761
Aging 2021 Aug 30;13(16):20748-20761
Enriched Environment Promotes Cognitive Function Recovery following Cerebral Ischemic Injury via Upregulating GABAergic and Glutamatergic Systems in the Contralateral Hippocampus.
Wang Y, Wu J, Xie H, Wang L, Wang C, Wu Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:8850119
Evidence-based complementary and alternative medicine : eCAM 2020;2020:8850119
Effects of Xiaoyaosan on Depressive-Like Behaviors in Rats With Chronic Unpredictable Mild Stress Through HPA Axis Induced Astrocytic Activities.
Song M, Zhang J, Li X, Liu Y, Wang T, Yan Z, Chen J
Frontiers in psychiatry 2020;11:545823
Frontiers in psychiatry 2020;11:545823
Involvement of NMDAR/PSD-95/nNOS-NO-cGMP pathway in embryonic exposure to BPA induced learning and memory dysfunction of rats.
Yu H, Ma L, Liu D, Wang Y, Pei X, Duan Z, Ma M, Zhang Y
Environmental pollution (Barking, Essex : 1987) 2020 Nov;266(Pt 1):115055
Environmental pollution (Barking, Essex : 1987) 2020 Nov;266(Pt 1):115055
Up-regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine.
Zhou X, Liang J, Wang J, Fei Z, Qin G, Zhang D, Zhou J, Chen L
Journal of neurochemistry 2020 Nov;155(4):370-389
Journal of neurochemistry 2020 Nov;155(4):370-389
STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
Gruszczynska-Biegala J, Strucinska K, Maciag F, Majewski L, Sladowska M, Kuznicki J
Cells 2020 Jan 9;9(1)
Cells 2020 Jan 9;9(1)
EphrinB/EphB Signaling Contributes to the Synaptic Plasticity of Chronic Migraine Through NR2B Phosphorylation.
Wang J, Fei Z, Liang J, Zhou X, Qin G, Zhang D, Zhou J, Chen L
Neuroscience 2020 Jan 21;428:178-191
Neuroscience 2020 Jan 21;428:178-191
CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion.
Xian H, Jiang Y, Zhang H, Ma SB, Zhao R, Cong R
Neuroscience 2020 Jan 15;425:29-38
Neuroscience 2020 Jan 15;425:29-38
SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors.
He QL, Deng HS, Xu LS, Zhu JJ, Ni HD, Wang TT, Wang YG, Shen H, Pan H, Yao M
Neuroscience letters 2020 Jan 1;714:134595
Neuroscience letters 2020 Jan 1;714:134595
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice.
Qi F, Liu T, Zhang X, Gao X, Li Z, Chen L, Lin C, Wang L, Wang ZJ, Tang H, Chen Z
Neuropharmacology 2020 Jan 1;162:107783
Neuropharmacology 2020 Jan 1;162:107783
TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.
Zhang H, Tian X, Lu X, Xu D, Guo Y, Dong Z, Li Y, Ma Y, Chen C, Yang Y, Yang M, Yang Y, Liu F, Zhou R, He M, Xiao F, Wang X
The Journal of clinical investigation 2019 Sep 3;129(9):3864-3876
The Journal of clinical investigation 2019 Sep 3;129(9):3864-3876
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Wang X, Luo C, Mao XY, Li X, Yin JY, Zhang W, Zhou HH, Liu ZQ
Brain research 2019 Sep 15;1719:30-39
Brain research 2019 Sep 15;1719:30-39
Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system.
Chen K, Sun D, Qu S, Chen Y, Wang J, Zhou L, Jose PA, Yang Y, Zeng C
Clinical science (London, England : 1979) 2019 May 31;133(9):1097-1113
Clinical science (London, England : 1979) 2019 May 31;133(9):1097-1113
Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy.
Wen Y, Wu K, Xie Y, Dan W, Zhan Y, Shi Q
Biochemical and biophysical research communications 2019 Mar 26;511(1):79-86
Biochemical and biophysical research communications 2019 Mar 26;511(1):79-86
Inhibition of CB1 receptor ameliorates spatial learning and memory impairment in mice with traumatic brain injury.
Xu X, Jiang S, Xu E, Wu X, Zhao R
Neuroscience letters 2019 Mar 23;696:127-131
Neuroscience letters 2019 Mar 23;696:127-131
Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X.
So LY, Munger SJ, Miller JE
Behavioural brain research 2019 Mar 15;360:103-112
Behavioural brain research 2019 Mar 15;360:103-112
CAMK2-Dependent Signaling in Neurons Is Essential for Survival.
Kool MJ, Proietti Onori M, Borgesius NZ, van de Bree JE, Elgersma-Hooisma M, Nio E, Bezstarosti K, Buitendijk GHS, Aghadavoud Jolfaei M, Demmers JAA, Elgersma Y, van Woerden GM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 10;39(28):5424-5439
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 10;39(28):5424-5439
The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors.
Lu X, Zhang Q, Wang T
Biochemical and biophysical research communications 2019 Aug 13;516(1):63-67
Biochemical and biophysical research communications 2019 Aug 13;516(1):63-67
NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model.
Wang XY, Zhou HR, Wang S, Liu CY, Qin GC, Fu QQ, Zhou JY, Chen LX
The journal of headache and pain 2018 Nov 6;19(1):102
The journal of headache and pain 2018 Nov 6;19(1):102
Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS2 nanoflowers.
Bai D, Li Q, Wang J, Zhao J, Deng X, Yuan L, Wu P
Toxicology research 2018 Nov 1;7(6):1267-1279
Toxicology research 2018 Nov 1;7(6):1267-1279
N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression.
Huang LE, Guo SH, Thitiseranee L, Yang Y, Zhou YF, Yao YX
Scientific reports 2018 May 18;8(1):7848
Scientific reports 2018 May 18;8(1):7848
Effects of intrathecal bupivacaine on the NR2B/CaMKIIα/CREB signaling pathway in the rat lumbar spinal cord.
Zhao L, Zhang Y, Yang F, Zhu D, Li N, Zhao L, Li N, Yu J, Ma H
Molecular medicine reports 2018 Mar;17(3):4508-4514
Molecular medicine reports 2018 Mar;17(3):4508-4514
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex.
Li Y, Wang L, Zhang X, Huang M, Li S, Wang X, Chen L, Jiang B, Yang Y
Neuropharmacology 2018 Jan;128:207-220
Neuropharmacology 2018 Jan;128:207-220
HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons.
Liu X, Zhang L, Jin L, Tan Y, Li W, Tang J
Molecular pain 2018 Jan-Dec;14:1744806918778490
Molecular pain 2018 Jan-Dec;14:1744806918778490
Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats.
Cao M, Fang J, Wang X, Wang Y, Duan K, Ye F, Ouyang W, Tong J
Brain research 2018 Apr 1;1684:21-29
Brain research 2018 Apr 1;1684:21-29
Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age.
Tang Y, Wang X, Zhang S, Duan S, Qing W, Chen G, Ye F, Le Y, Ouyang W
PloS one 2017;12(8):e0182471
PloS one 2017;12(8):e0182471
Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice.
Zhang S, Wang X, Ai S, Ouyang W, Le Y, Tong J
PloS one 2017;12(11):e0188273
PloS one 2017;12(11):e0188273
Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease.
Hui S, Yang Y, Peng WJ, Sheng CX, Gong W, Chen S, Xu PP, Wang Z
Neural regeneration research 2017 Oct;12(10):1680-1686
Neural regeneration research 2017 Oct;12(10):1680-1686
Beneficial Effects of a CaMKIIα Inhibitor TatCN21 Peptide in Global Cerebral Ischemia.
Ahmed ME, Dong Y, Lu Y, Tucker D, Wang R, Zhang Q
Journal of molecular neuroscience : MN 2017 Jan;61(1):42-51
Journal of molecular neuroscience : MN 2017 Jan;61(1):42-51
Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction.
Wen Y, Fu P, Wu K, Si K, Xie Y, Dan W, Zhan Y, Shi Q
Neurochemical research 2017 Aug;42(8):2154-2166
Neurochemical research 2017 Aug;42(8):2154-2166
Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.
Tang L, Zhang Y, Chen G, Xiong Y, Wang X, Zhu B
Neurochemical research 2017 Apr;42(4):1211-1218
Neurochemical research 2017 Apr;42(4):1211-1218
A lasting effect of postnatal sevoflurane anesthesia on the composition of NMDA receptor subunits in rat prefrontal cortex.
Zhang X, Shen F, Xu D, Zhao X
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2016 Nov;54:62-69
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2016 Nov;54:62-69
NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.
Zhang Y, Chen G, Gao B, Li Y, Liang S, Wang X, Wang X, Zhu B
Scientific reports 2016 Nov 23;6:37713
Scientific reports 2016 Nov 23;6:37713
Dopamine D3 receptor-regulated NR2B subunits of N-methyl-d-aspartate receptors in the nucleus accumbens involves in morphine-induced locomotor activity.
Liu XS, Hou Y, Yan TL, Guo YY, Han W, Guan FL, Chen T, Li T
CNS neuroscience & therapeutics 2014 Sep;20(9):823-9
CNS neuroscience & therapeutics 2014 Sep;20(9):823-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 21920-1-AP(GRIN2B antibody) at dilution of 1:5000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-GRIN2B (IP:21920-1-AP, 3ug; Detection:21920-1-AP 1:2000) with mouse brain tissue lysate 6000ug.
- Sample type
- tissue
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NMDAR2B antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human NMDAR2B. This antibody recognizes human,mouse,rat antigen. The NMDAR2B antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 21920-1-AP(GRIN2B antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue