60225-1-Ig

antibody from Proteintech Group

Targeting: PIK3R1 GRB1, p85, p85-ALPHA

Provider product page for 60225-1-Ig

Western blot

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Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [61]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 60225-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#60225-1-Ig, RRID:AB_11042594
Product name: PI3 kinase p85 Alpha antibody
Antibody type: Monoclonal
Description: PI3 Kinase p85 Alpha antibody (Cat. #60225-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, pig, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat, Porcine
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 4G3C11
Vial size: 20ul, 150ul

PIK3R1 protein structure - 60225-1-Ig shown in red.

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Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.

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Photobiomodulation Promotes Repair Following Spinal Cord Injury by Regulating the Transformation of A1/A2 Reactive Astrocytes.

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Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.

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A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.

Cao T, Tang M, Jiang P, Zhang B, Wu X, Chen Q, Zeng C, Li N, Zhang S, Cai H
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Yu Y, Jiang L, Li J, Lei L, Li H
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Liu X, Yang J, Yang C, Huang X, Han M, Kang F, Li J
Cancer cell international 2021 Nov 25;21(1):622

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Huang B, Lu Y, Gui M, Guan J, Lin M, Zhao J, Mao Q, Lin J
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Chen H, Pan R, Li H, Zhang W, Ren C, Lu Q, Chen H, Zhang X, Nie Y
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Daphnoretin induces reactive oxygen species-mediated apoptosis in melanoma cells.

Wang H, Hu X, Li M, Pan Z, Li D, Zheng Q
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Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.

Peng MF, Tian S, Song YG, Li CX, Miao MS, Ren Z, Li M
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Parthenolide inhibits the tumor characteristics of renal cell carcinoma.

Liu D, Han Y, Liu L, Ren X, Zhang H, Fan S, Qin T, Li L
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Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.

Sun Z, Zhang L, Li L, Shao C, Liu J, Zhou M, Wang Z
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Ma RR, Zhang H, Chen HF, Zhang GH, Tian YR, Gao P
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The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.

Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X, Li Y, Zhou L, He H, Yu C, Liu J, Dang Y, Xia Y, He Q, Jin H, Li Y, Hu Y, Miao Y, Yue Z, Hu B
Autophagy 2021 Apr;17(4):980-1000

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Zhang H, Hui J, Yang J, Deng J, Fan D
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Hepatitis B virus upregulates cellular inhibitor of apoptosis protein 2 expression via the PI3K/AKT/NF-κB signaling pathway in liver cancer.

Lian J, Zou Y, Huang L, Cheng H, Huang K, Zeng J, Chen L
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miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia.

Wang Y, Zhang J, Su Y, Wang C, Zhang G, Liu X, Chen Q, Lv M, Chang Y, Peng J, Hou M, Huang X, Zhang X
Molecular therapy. Nucleic acids 2020 Jun 5;20:764-776

CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.

Chen Y, Tang J, Lu T, Liu F
Thoracic cancer 2020 Jul;11(7):1848-1860

Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.

Li T, Liu T, Chen X, Li L, Feng M, Zhang Y, Wan L, Zhang C, Yao W
Journal of neuroinflammation 2020 Jul 14;17(1):211

Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis.

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Arteriosclerosis, thrombosis, and vascular biology 2020 Feb;40(2):335-349

Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling.

Zheng J, Qu D, Wang C, Ding L, Zhou W
BMC pregnancy and childbirth 2020 Feb 10;20(1):87

MiR-155 promotes interleukin-1β-induced chondrocyte apoptosis and catabolic activity by targeting PIK3R1-mediated PI3K/Akt pathway.

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Zhai R, Xu H, Hu F, Wu J, Kong X, Sun X
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Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs.

Li H, Liu S, Hu Y, Zhao B, Sun Y, Xu D
Ecotoxicology and environmental safety 2020 Apr 1;192:110267

A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation.

Ye Z, Zhang S, Liu Y, Wang S, Zhang J, Huang R
Mediators of inflammation 2019;2019:8709583

Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling.

Guo Y, Pei X
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7517431

Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway.

Zhang Y, Yang S, Cui X, Yang J, Zheng M, Jia J, Han F, Yang X, Wang J, Guo Z, Chang B, Chang B
Journal of diabetes research 2019;2019:4709715

Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway.

Wang X, Han Y, Liu J, Zhang Y, Cheng K, Guo J, Guo Q, Liu S, Sun H, Hua Y, Zhang G, Xu S, Guo F, Yang Z
Mediators of inflammation 2019;2019:4312016

TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.

Wu X, Li S, Wang K, Hua W, Li S, Song Y, Zhang Y, Yang S, Yang C
Inflammation 2019 Oct;42(5):1575-1584

Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy.

Dong X, Yang Y, Zhou Y, Bi X, Zhao N, Zhang Z, Li L, Hang Q, Zhang R, Chen D, Cao P, Yin Z, Luo L
Cell death and differentiation 2019 Oct;26(10):2086-2099

Minimally modified low-density lipoprotein upregulates the ET_B and α₁ receptors in mouse mesenteric arteries in vivo by activating the PI3K/Akt pathway.

Zeng ZS, Lin J, Xu CB, Cao L, Chen C, Li J
The Journal of pharmacy and pharmacology 2019 Jun;71(6):937-944

Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.

Wang J, Wan D, Wan G, Wang J, Zhang J, Zhu H
Annals of translational medicine 2019 Dec;7(23):756

The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway.

Ou B, Tao W, Yang S, Feng J, Wang J, Yang T, Wu H, Huang Y, Tan L, Huang W, Feng Z, Mei Z
Evidence-based complementary and alternative medicine : eCAM 2018;2018:7290170

Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.

Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788

Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.

Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, Zhang Y, Lu S, Liu P
Cancer medicine 2018 Apr;7(4):1546-1559

Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells.

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Scientific reports 2017 Oct 16;7(1):13248

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Zhou P, Tu L, Lin X, Hao X, Zheng Q, Zeng W, Zhang X, Zheng Y, Wang L, Li S
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Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.

Chen X, Zhao X, Cai H, Sun H, Hu Y, Huang X, Kong W, Kong W
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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 60225-1-Ig(PIK3R1 antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The P85a; PIK3R1 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human P85a; PIK3R1. This antibody recognizes human, mouse antigen. The P85a; PIK3R1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 60225-1-Ig.pdf

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