BS8088

antibody from Bioworld Technology, Inc
Targeting: AATF BFR2, CHE-1, CHE1, DED
Provider product page for BS8088
Western blot
Immunohistochemistry

Antibody data

Product number
BS8088 - Provider product page
Provider
Bioworld Technology, Inc
Product name
AATF polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human AATF.
Description
Che-1, also known as apoptosis-antagonizing transcription factor (AATF), is a widely expressed nuclear protein that belongs to the AATF family. Hyperphosphorylated during the G1/S phase transition, Che-1 may function as a general inhibitor of the histone deacetylase HDAC1. Che-1 binding to the pocket region of Rb may displace HDAC1 from Rb/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Displacement of HDAC1 from Sp1 bound to the p21 promoter leads to increased expression of Che-1. It also antagonizes PAR4 (prostate apoptosis response 4) mediated induction of aberrant amyloid peptide production in Alzheimer£ªs disease (AD), also known as presenile and senile dementia. PAR4 is a leucine zipper protein that is pro-apoptotic and associated with neuronal degeneration in AD. Che-1 interaction with PAR4 suggests that it might directly or indirectly participate in regulation of PAR4 activity. Che-1 also co-localizes with PAR4 in both cytoplasmic and nuclear compartments, and interacts directly and selectively with PAR4 via the leucine zipper domain in neural cells.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
AATF protein structure - BS8088 shown in red.