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- Antibody Data
- Antigen structure
- References [39]
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- Product number
- 13130-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13130-1-AP, RRID:AB_2157558
- Product name
- ORAI1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ORAI1 antibody (Cat. #13130-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cortisol modulates calcium release-activated calcium channel gating in fish hepatocytes.
The protective effects of curcumin in cerebral ischemia and reperfusion injury through PKC-θ signaling.
Effect of MgCl2 and GdCl3 on ORAI1 Expression and Store-Operated Ca2+ Entry in Megakaryocytes.
Direct control of store-operated calcium channels by ultrafast laser.
Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca2+ Entry in Megakaryocytes.
Reversal of phosphate-induced ORAI1 expression, store-operated Ca2+ entry and osteogenic signaling by MgCl2 in human aortic smooth muscle cells.
Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice.
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Stimulation of ORAI1 expression, store-operated Ca2+ entry, and osteogenic signaling by high glucose exposure of human aortic smooth muscle cells.
Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation.
Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p.
Upregulation of Orai1 and STIM1 expression as well as store-operated Ca2+ entry in ovary carcinoma cells by placental growth factor.
FUN14 domain-containing 1 promotes breast cancer proliferation and migration by activating calcium-NFATC1-BMI1 axis.
Effects of ORAI calcium release-activated calcium modulator 1 (ORAI1) on neutrophil activity in dairy cows with subclinical hypocalcemia1.
Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin.
CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A.
AMP-activated kinase is a regulator of fibroblast growth factor 23 production.
Interplay between ER Ca(2+) Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca(2+) Entry.
The calcium channel proteins ORAI3 and STIM1 mediate TGF-β induced Snai1 expression.
SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation.
ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.
Effects of Hyperglycemia on Vascular Smooth Muscle Ca2+ Signaling.
Epigallocatechin-3-gallate (EGCG) up-regulates miR-15b expression thus attenuating store operated calcium entry (SOCE) into murine CD4+ T cells and human leukaemic T cell lymphoblasts.
Inhibition of store-operated Ca(2+) entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.
Cationic liposomes suppress intracellular calcium ion concentration increase via inhibition of PI3 kinase pathway in mast cells.
NFAT5-sensitive Orai1 expression and store-operated Ca2+ entry in megakaryocytes.
NFκB-sensitive Orai1 expression in the regulation of FGF23 release.
SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
Store-operated Ca(2+) entry in rhabdomyosarcoma cells.
Expression profiling of human basophils: modulation by cytokines and secretagogues.
Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3.
1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
TGFβ1 and SGK1-sensitive store-operated Ca2+ entry and Orai1 expression in endometrial Ishikawa cells.
Enhanced Ca²⁺ entry and Na+/Ca²⁺ exchanger activity in dendritic cells from AMP-activated protein kinase-deficient mice.
The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes.
Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions.
Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1).
Functional interactions among STIM1, Orai1 and TRPC1 on the activation of SOCs in HL-7702 cells.
Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation.
Das C, Rout MK, Wildering WC, Vijayan MM
Scientific reports 2021 May 5;11(1):9621
Scientific reports 2021 May 5;11(1):9621
The protective effects of curcumin in cerebral ischemia and reperfusion injury through PKC-θ signaling.
Mo Y, Yue E, Shi N, Liu K
Cell cycle (Georgetown, Tex.) 2021 Mar-Mar;20(5-6):550-560
Cell cycle (Georgetown, Tex.) 2021 Mar-Mar;20(5-6):550-560
Effect of MgCl2 and GdCl3 on ORAI1 Expression and Store-Operated Ca2+ Entry in Megakaryocytes.
Zhou K, Zhu X, Ma K, Liu J, Nürnberg B, Gawaz M, Lang F
International journal of molecular sciences 2021 Mar 24;22(7)
International journal of molecular sciences 2021 Mar 24;22(7)
Direct control of store-operated calcium channels by ultrafast laser.
Cheng P, Tian X, Tang W, Cheng J, Bao J, Wang H, Zheng S, Wang Y, Wei X, Chen T, Feng H, Xue T, Goda K, He H
Cell research 2021 Jul;31(7):758-772
Cell research 2021 Jul;31(7):758-772
Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca2+ Entry in Megakaryocytes.
Pelzl L, Sahu I, Ma K, Heinzmann D, Bhuyan AAM, Al-Maghout T, Sukkar B, Sharma Y, Marini I, Rigoni F, Artunc F, Cao H, Gutti R, Voelkl J, Pieske B, Gawaz M, Bakchoul T, Lang F
Scientific reports 2020 Feb 3;10(1):1728
Scientific reports 2020 Feb 3;10(1):1728
Reversal of phosphate-induced ORAI1 expression, store-operated Ca2+ entry and osteogenic signaling by MgCl2 in human aortic smooth muscle cells.
Zhu X, Ma K, Zhou K, Voelkl J, Alesutan I, Leibrock C, Nürnberg B, Lang F
Biochemical and biophysical research communications 2020 Feb 26;523(1):18-24
Biochemical and biophysical research communications 2020 Feb 26;523(1):18-24
Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice.
Angenendt A, Steiner R, Knörck A, Schwär G, Konrad M, Krause E, Lis A
Aging 2020 Feb 12;12(4):3266-3286
Aging 2020 Feb 12;12(4):3266-3286
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Lin T, Luo W, Li Z, Zhang L, Zheng X, Mai L, Yang W, Guan G, Su Z, Liu P, Li Z, Xie Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
Stimulation of ORAI1 expression, store-operated Ca2+ entry, and osteogenic signaling by high glucose exposure of human aortic smooth muscle cells.
Ma K, Sukkar B, Zhu X, Zhou K, Cao H, Voelkl J, Alesutan I, Nürnberg B, Lang F
Pflugers Archiv : European journal of physiology 2020 Aug;472(8):1093-1102
Pflugers Archiv : European journal of physiology 2020 Aug;472(8):1093-1102
Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation.
Fang B, Zhao Q, Ling W, Zhang Y, Ou M
American journal of translational research 2019;11(12):7591-7603
American journal of translational research 2019;11(12):7591-7603
Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p.
Zhang S, Al-Maghout T, Cao H, Pelzl L, Salker MS, Veldhoen M, Cheng A, Lang F, Singh Y
Frontiers in immunology 2019;10:1737
Frontiers in immunology 2019;10:1737
Upregulation of Orai1 and STIM1 expression as well as store-operated Ca2+ entry in ovary carcinoma cells by placental growth factor.
Abdelazeem KNM, Droppova B, Sukkar B, Al-Maghout T, Pelzl L, Zacharopoulou N, Ali Hassan NH, Abdel-Fattah KI, Stournaras C, Lang F
Biochemical and biophysical research communications 2019 May 7;512(3):467-472
Biochemical and biophysical research communications 2019 May 7;512(3):467-472
FUN14 domain-containing 1 promotes breast cancer proliferation and migration by activating calcium-NFATC1-BMI1 axis.
Wu L, Zhang D, Zhou L, Pei Y, Zhuang Y, Cui W, Chen J
EBioMedicine 2019 Mar;41:384-394
EBioMedicine 2019 Mar;41:384-394
Effects of ORAI calcium release-activated calcium modulator 1 (ORAI1) on neutrophil activity in dairy cows with subclinical hypocalcemia1.
Zhang B, Guo H, Yang W, Li M, Zou Y, Loor JJ, Xia C, Xu C
Journal of animal science 2019 Jul 30;97(8):3326-3336
Journal of animal science 2019 Jul 30;97(8):3326-3336
Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin.
Sukkar B, Hauser S, Pelzl L, Hosseinzadeh Z, Sahu I, Al-Maghout T, Bhuyan AAM, Zacharopoulou N, Stournaras C, Schöls L, Lang F
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):278-289
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):278-289
CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A.
Sharma A, Ramena G, Yin Y, Premkumar L, Elble RC
PloS one 2018;13(5):e0196512
PloS one 2018;13(5):e0196512
AMP-activated kinase is a regulator of fibroblast growth factor 23 production.
Glosse P, Feger M, Mutig K, Chen H, Hirche F, Hasan AA, Gaballa MMS, Hocher B, Lang F, Föller M
Kidney international 2018 Sep;94(3):491-501
Kidney international 2018 Sep;94(3):491-501
Interplay between ER Ca(2+) Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca(2+) Entry.
Nelson HA, Leech CA, Kopp RF, Roe MW
International journal of molecular sciences 2018 May 19;19(5)
International journal of molecular sciences 2018 May 19;19(5)
The calcium channel proteins ORAI3 and STIM1 mediate TGF-β induced Snai1 expression.
Bhattacharya A, Kumar J, Hermanson K, Sun Y, Qureshi H, Perley D, Scheidegger A, Singh BB, Dhasarathy A
Oncotarget 2018 Jun 29;9(50):29468-29483
Oncotarget 2018 Jun 29;9(50):29468-29483
SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation.
Zhu ZD, Yu T, Liu HJ, Jin J, He J
Cell death & disease 2018 Jan 19;9(2):50
Cell death & disease 2018 Jan 19;9(2):50
ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.
Diercks BP, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, Rosche A, Krüger A, Kaufmann U, Vaeth M, Failla AV, Zobiak B, Kandil FI, Schetelig D, Ruthenbeck A, Meier C, Lodygin D, Flügel A, Ren D, Wolf IMA, Feske S, Guse AH
Science signaling 2018 Dec 18;11(561)
Science signaling 2018 Dec 18;11(561)
Effects of Hyperglycemia on Vascular Smooth Muscle Ca2+ Signaling.
El-Najjar N, Kulkarni RP, Nader N, Hodeify R, Machaca K
BioMed research international 2017;2017:3691349
BioMed research international 2017;2017:3691349
Epigallocatechin-3-gallate (EGCG) up-regulates miR-15b expression thus attenuating store operated calcium entry (SOCE) into murine CD4+ T cells and human leukaemic T cell lymphoblasts.
Zhang S, Al-Maghout T, Bissinger R, Zeng N, Pelzl L, Salker MS, Cheng A, Singh Y, Lang F
Oncotarget 2017 Oct 27;8(52):89500-89514
Oncotarget 2017 Oct 27;8(52):89500-89514
Inhibition of store-operated Ca(2+) entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.
Huang W, Ren C, Huang G, Liu J, Liu W, Wang L, Zhu B, Feng X, Shi J, Li J, Xia X, Jia W, Chen J, Chen Y, Jiang X
Oncology letters 2017 Feb;13(2):921-929
Oncology letters 2017 Feb;13(2):921-929
Cationic liposomes suppress intracellular calcium ion concentration increase via inhibition of PI3 kinase pathway in mast cells.
Inoh Y, Haneda A, Tadokoro S, Yokawa S, Furuno T
Biochimica et biophysica acta. Biomembranes 2017 Dec;1859(12):2461-2466
Biochimica et biophysica acta. Biomembranes 2017 Dec;1859(12):2461-2466
NFAT5-sensitive Orai1 expression and store-operated Ca2+ entry in megakaryocytes.
Sahu I, Pelzl L, Sukkar B, Fakhri H, Al-Maghout T, Cao H, Hauser S, Gutti R, Gawaz M, Lang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Aug;31(8):3439-3448
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Aug;31(8):3439-3448
NFκB-sensitive Orai1 expression in the regulation of FGF23 release.
Zhang B, Yan J, Umbach AT, Fakhri H, Fajol A, Schmidt S, Salker MS, Chen H, Alexander D, Spichtig D, Daryadel A, Wagner CA, Föller M, Lang F
Journal of molecular medicine (Berlin, Germany) 2016 May;94(5):557-66
Journal of molecular medicine (Berlin, Germany) 2016 May;94(5):557-66
SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
Chan CM, Aw JT, Webb SE, Miller AL
Zygote (Cambridge, England) 2016 Dec;24(6):880-889
Zygote (Cambridge, England) 2016 Dec;24(6):880-889
Store-operated Ca(2+) entry in rhabdomyosarcoma cells.
Schmid E, Stagno MJ, Yan J, Stournaras C, Lang F, Fuchs J, Seitz G
Biochemical and biophysical research communications 2016 Aug 12;477(1):129-136
Biochemical and biophysical research communications 2016 Aug 12;477(1):129-136
Expression profiling of human basophils: modulation by cytokines and secretagogues.
MacGlashan D Jr
PloS one 2015;10(5):e0126435
PloS one 2015;10(5):e0126435
Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3.
Schmid E, Yan J, Nurbaeva MK, Russo A, Yang W, Faggio C, Shumilina E, Lang F
PloS one 2014;9(2):e88637
PloS one 2014;9(2):e88637
1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
Borst O, Münzer P, Schmid E, Schmidt EM, Russo A, Walker B, Yang W, Leibrock C, Szteyn K, Schmidt S, Elvers M, Faggio C, Shumilina E, Kuro-o M, Gawaz M, Lang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 May;28(5):2108-19
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 May;28(5):2108-19
TGFβ1 and SGK1-sensitive store-operated Ca2+ entry and Orai1 expression in endometrial Ishikawa cells.
Schmidt S, Schneider S, Yang W, Liu G, Schmidt EM, Schmid E, Mia S, Brucker S, Stournaras C, Wallwiener D, Brosens JJ, Lang F
Molecular human reproduction 2014 Feb;20(2):139-47
Molecular human reproduction 2014 Feb;20(2):139-47
Enhanced Ca²⁺ entry and Na+/Ca²⁺ exchanger activity in dendritic cells from AMP-activated protein kinase-deficient mice.
Nurbaeva MK, Schmid E, Szteyn K, Yang W, Viollet B, Shumilina E, Lang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jul;26(7):3049-58
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jul;26(7):3049-58
The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes.
Borst O, Schmidt EM, Münzer P, Schönberger T, Towhid ST, Elvers M, Leibrock C, Schmid E, Eylenstein A, Kuhl D, May AE, Gawaz M, Lang F
Blood 2012 Jan 5;119(1):251-61
Blood 2012 Jan 5;119(1):251-61
Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions.
Eylenstein A, Schmidt S, Gu S, Yang W, Schmid E, Schmidt EM, Alesutan I, Szteyn K, Regel I, Shumilina E, Lang F
The Journal of biological chemistry 2012 Jan 20;287(4):2719-30
The Journal of biological chemistry 2012 Jan 20;287(4):2719-30
Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1).
Eylenstein A, Gehring EM, Heise N, Shumilina E, Schmidt S, Szteyn K, Münzer P, Nurbaeva MK, Eichenmüller M, Tyan L, Regel I, Föller M, Kuhl D, Soboloff J, Penner R, Lang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Jun;25(6):2012-21
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Jun;25(6):2012-21
Functional interactions among STIM1, Orai1 and TRPC1 on the activation of SOCs in HL-7702 cells.
Zhang ZY, Pan LJ, Zhang ZM
Amino acids 2010 Jun;39(1):195-204
Amino acids 2010 Jun;39(1):195-204
Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation.
Braun A, Varga-Szabo D, Kleinschnitz C, Pleines I, Bender M, Austinat M, Bösl M, Stoll G, Nieswandt B
Blood 2009 Feb 26;113(9):2056-63
Blood 2009 Feb 26;113(9):2056-63
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ORAI1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ORAI1. This antibody recognizes human, mouse, rat, zebrafish antigen. The ORAI1 antibody has been validated for the following applications: ELISA, WB analysis.
