Tissue expression
Cell line expression
Protein structure
PSMB3
Proteasome 20S subunit beta 3HC10-II, MGC4147
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]
Top validated antibodies |
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Proteintech Group | 15983-1-AP | Polyclonal |
WB
EL
ICC
IHC |
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NovoPro Bioscience Inc. | 114383 | Polyclonal |
WB
EL
ICC
IHC |
||
Invitrogen Antibodies | 15983-1-AP | Polyclonal |
WB
ICC
IHC
|
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antibodies-online | ABIN4347834 | Polyclonal |
WB
ICC
IHC
|
||
FineTest Biotech | FNab06872 | Polyclonal |
WB
EL
ICC
IHC |
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