GDF10

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016]

Description

Growth differentiation factor 10

Tissue specificity

Tissue enhanced (lung, retina)

Subcell location

Vesicles

Predicted location

Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

10 (47300197 - 47313577)

Ensembl ID

ENSG00000266524  (ver. 103.38)

Orthologs

Mouse Gdf10: ENSMUSG00000021943

UniProt

P55107

neXtProt

NX_P55107

Human splice variants
Mouse splice variants

Protein structure