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Western blot
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- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Flow cytometry [1]
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- Product number
- 304202 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#304202, RRID:AB_314418
- Product name
- Purified anti-human CD45RO
- Antibody type
- Monoclonal
- Antigen
- CD45RO
- Description
- CD45RO is a 180 kD single chain membrane glycoprotein. It is a splice variant of tyrosine phosphatase CD45, lacking the A, B, and C determinants. The CD45RO isoform is expressed on activated and memory T cells, some B cell subsets, activated monocytes/macrophages, and granulocytes. CD45RO enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1 and CD22. CD45 isoform expression can change in response to cytokines.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients.
Interplay between CD45RA+ regulatory T cells and TNF-alpha in the regulation of human Th17 differentiation.
Active systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1.
Upregulation of CCL20 and recruitment of CCR6+ gastric infiltrating lymphocytes in Helicobacter pylori gastritis.
IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy.
Weiss L, Letimier FA, Carriere M, Maiella S, Donkova-Petrini V, Targat B, Benecke A, Rogge L, Levy Y
Proceedings of the National Academy of Sciences of the United States of America 2010 Jun 8;107(23):10632-7
Proceedings of the National Academy of Sciences of the United States of America 2010 Jun 8;107(23):10632-7
Interplay between CD45RA+ regulatory T cells and TNF-alpha in the regulation of human Th17 differentiation.
Baba N, Rubio M, Sarfati M
International immunology 2010 Apr;22(4):237-44
International immunology 2010 Apr;22(4):237-44
Active systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1.
Mozaffarian N, Wiedeman AE, Stevens AM
Rheumatology (Oxford, England) 2008 Sep;47(9):1335-41
Rheumatology (Oxford, England) 2008 Sep;47(9):1335-41
Upregulation of CCL20 and recruitment of CCR6+ gastric infiltrating lymphocytes in Helicobacter pylori gastritis.
Wu YY, Tsai HF, Lin WC, Hsu PI, Shun CT, Wu MS, Hsu PN
Infection and immunity 2007 Sep;75(9):4357-63
Infection and immunity 2007 Sep;75(9):4357-63
IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy.
Roque S, Nobrega C, Appelberg R, Correia-Neves M
Journal of immunology (Baltimore, Md. : 1950) 2007 Jun 15;178(12):8028-35
Journal of immunology (Baltimore, Md. : 1950) 2007 Jun 15;178(12):8028-35
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with purified UCHL1, followed by anti-mouse IgGs FITC
- Conjugate
- Unconjugated
