Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Immunohistochemistry [2]
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- Product number
- NBP2-29428 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal Chromogranin A Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified. Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 0.2 mg/ml
- Storage
- Store at 4C.
Submitted references Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips.
Local Corticotropin-Releasing Factor Signaling in the Hypothalamic Paraventricular Nucleus.
Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors.
Workman MJ, Gleeson JP, Troisi EJ, Estrada HQ, Kerns SJ, Hinojosa CD, Hamilton GA, Targan SR, Svendsen CN, Barrett RJ
Cellular and molecular gastroenterology and hepatology 2018;5(4):669-677.e2
Cellular and molecular gastroenterology and hepatology 2018;5(4):669-677.e2
Local Corticotropin-Releasing Factor Signaling in the Hypothalamic Paraventricular Nucleus.
Jiang Z, Rajamanickam S, Justice NJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Feb 21;38(8):1874-1890
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Feb 21;38(8):1874-1890
Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors.
Sampedro-Núñez M, Luque RM, Ramos-Levi AM, Gahete MD, Serrano-Somavilla A, Villa-Osaba A, Adrados M, Ibáñez-Costa A, Martín-Pérez E, Culler MD, Marazuela M, Castaño JP
Oncotarget 2016 Feb 9;7(6):6593-608
Oncotarget 2016 Feb 9;7(6):6593-608
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Chromogranin A Antibody (CGA414) [NBP2-29428] - Formalin-fixed, paraffin-embedded pancreas stained with Chromogranin A Ab (CGA414).
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Chromogranin A Antibody (CGA/414) [NBP2-29428] - Formalin-fixed, paraffin-embedded human small cell Lung Carcinoma stained with Chromogranin A Monoclonal Antibody (CGA/414)