BS7760

antibody from Bioworld Technology, Inc

Targeting: PMEL D12S53E, gp100, Pmel17, SI, SIL, SILV

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS7760

Provider

Bioworld Technology, Inc

Product name

SILV polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human SILV.

Description

Cytotoxic T lymphocytes (CTL£ªs) recognize melanoma-associated antigens, which belong to three main groups. These groups include tumor-associated testis-specific antigens, melanocyte differentiation antigens and mutated or aberrantly expressed antigens, which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100, also designated ME20-M, ME20-S and PMEL 17, is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues, but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage, which results in a secreted protein. gp100 is recognized by several monoclonal antibodies, including NKI-beteb, HMB-50 and HMB-45, which are used to diagnose melanomas. Therefore, gp100 is considered a potential target for immunotherapy of malignant melanoma.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.