FNab07177

antibody from FineTest Biotech
Targeting: RBM4 LARK, RBM4A, ZCCHC21, ZCRB3A
Provider product page for FNab07177
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
FNab07177 - Provider product page
Provider
FineTest Biotech
Product name
RBM4 antibody
Antibody type
Monoclonal
Antigen
Recombinant protein fragment
Description
RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment(IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
RNA binding motif protein 4
Epitope
IgG1
Isotype
IgG
Antibody clone number
6F6
Vial size
100¦Ìg
Concentration
Protein A+G purification
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
RBM4 protein structure - FNab07177 shown in red.