CILP

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]

Description

Cartilage intermediate layer protein

Tissue specificity

Low tissue specificity

Predicted location

Secreted to extracellular matrix

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

15 (65194760 - 65211473)

Ensembl ID

ENSG00000138615  (ver. 103.38)

Orthologs

Mouse Cilp: ENSMUSG00000042254

UniProt

O75339

neXtProt

NX_O75339

Human splice variants
Mouse splice variants

Protein structure