681802

antibody from BioLegend
Targeting: MMP9 CLG4B
Provider product page for 681802

Antibody data

Product number
681802 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#681802, RRID:AB_2566497
Product name
Purified anti-MMP9
Antibody type
Monoclonal
Antigen
Human MMP-9, amino acids (Ala20-Asp707) (Accession# NP_004985.2), is expressed with a C-terminal 8His tag and a linker sequence in the 293E cell line.
Description
MMP9, or MMP-9, is a member of the matrix metalloprotease family of proteins (MMPs). Members of this family are structurally related, zinc-containing enzymes that degrade the extracellular matrix (ECM) and connective tissue proteins. Proteolytic activities of MMPs play an important role in vascular remodeling, cellular migration, and the processing of ECM proteins and adhesion molecules. MMP9 consists of a prodomain, catalytic domain, hinge region, and a hemopexin domain. It is secreted as an inactive zymogen that becomes activated extracellularly. The most relevant natural activators of proMMP9 are unknown. MMP9 activation may be mediated by removal of the prodomain by serine proteases or other MMPs, or it may be a direct response to oxidative stress that disrupts the cysteine switch. MMP9 is capable of processing cytokines and chemokines. For example, it is reported to release the biologically active form of vascular endothelial growth factor (VEGF), which indicates that MMP9 may play a crucial role in the formation of new blood vessels. Increased MMP9 expression and activity has been shown to be related to various cancers, as it may contribute to the release of metastatic cells from the bulk tumor as well as their entrance at the site of metastasis by degrading proteins in the ECM and basement membrane.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
M2101G05
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
MMP9 protein structure - 681802 shown in red.