SENP6

gene product
KIAA0797, SUSP1
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]). [supplied by OMIM, Jun 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
161 antibodies from 18 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Abnova Corporation
6 antibodies
Novus Biologicals
8 antibodies
antibodies-online
38 antibodies
LifeSpan BioSciences, Inc.
42 antibodies
Acris Antibodies GmbH
5 antibodies
Biorbyt
5 antibodies
Aviva Systems Biology
6 antibodies
Thermo Fisher Scientific Pierce
2 antibodies
Abgent
2 antibodies
Atlas Antibodies
1 antibody
GeneTex
3 antibodies
Everest Biotech
2 antibodies
Creative Biomart
8 antibodies
Abiocode, Inc.
1 antibody
Bioworld Technology, Inc
1 antibody
United States Biological
25 antibodies
Sigma-Aldrich
4 antibodies
Enzo Life Sciences
2 antibodies