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antibody from BioLegend
Targeting: ITGAM
CD11B, CR3A, MAC-1
Immunocytochemistry Immunoprecipitation Immunohistochemistry
Flow cytometry Blocking/Neutralizing Other assayAntibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 101214 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#101214, RRID:AB_312797
- Product name
- LEAF™ Purified anti-mouse/human CD11b [M1/70]
- Antibody type
- Monoclonal
- Antigen
- C57BL/10 splenocytes
- Description
- CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.
- Reactivity
- Human, Mouse, Rabbit, Simian
- Host
- Rat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
Submitted references Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Peptide-MHC class II complex stability governs CD4 T cell clonal selection.
Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism.
Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding.
Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.
Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification.
Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice.
Mac-1+ cells are the predominant subset in the early hepatic lesions of mice infected with Francisella tularensis.
Charles N, Hardwick D, Daugas E, Illei GG, Rivera J
Nature medicine 2010 Jun;16(6):701-7
Nature medicine 2010 Jun;16(6):701-7
Peptide-MHC class II complex stability governs CD4 T cell clonal selection.
Baumgartner CK, Ferrante A, Nagaoka M, Gorski J, Malherbe LP
Journal of immunology (Baltimore, Md. : 1950) 2010 Jan 15;184(2):573-81
Journal of immunology (Baltimore, Md. : 1950) 2010 Jan 15;184(2):573-81
Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism.
Norian LA, Rodriguez PC, O'Mara LA, Zabaleta J, Ochoa AC, Cella M, Allen PM
Cancer research 2009 Apr 1;69(7):3086-94
Cancer research 2009 Apr 1;69(7):3086-94
Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding.
Elgazar-Carmon V, Rudich A, Hadad N, Levy R
Journal of lipid research 2008 Sep;49(9):1894-903
Journal of lipid research 2008 Sep;49(9):1894-903
Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.
Kim DD, Miwa T, Kimura Y, Schwendener RA, van Lookeren Campagne M, Song WC
Blood 2008 Aug 15;112(4):1109-19
Blood 2008 Aug 15;112(4):1109-19
Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification.
Guo Y, Maillard I, Chakraborti S, Rothenberg EV, Speck NA
Blood 2008 Aug 1;112(3):480-92
Blood 2008 Aug 1;112(3):480-92
Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice.
Tan SL, Zhao J, Bi C, Chen XC, Hepburn DL, Wang J, Sedgwick JD, Chintalacharuvu SR, Na S
Journal of immunology (Baltimore, Md. : 1950) 2006 Mar 1;176(5):2872-9
Journal of immunology (Baltimore, Md. : 1950) 2006 Mar 1;176(5):2872-9
Mac-1+ cells are the predominant subset in the early hepatic lesions of mice infected with Francisella tularensis.
Rasmussen JW, Cello J, Gil H, Forestal CA, Furie MB, Thanassi DG, Benach JL
Infection and immunity 2006 Dec;74(12):6590-8
Infection and immunity 2006 Dec;74(12):6590-8
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- C57BL/6 mouse bone marrow cells stained with LEAF™ purified M1/70, followed by anti-rat IgGs FITC
- Conjugate
- Unconjugated
