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LearnNBP2-27409
antibody from Novus Biologicals
Targeting: CHUK
IkBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [55]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- NBP2-27409 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal IKK alpha Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified. An 85 kDa band should be observed.
- Reactivity
- Human, Mouse, Simian
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references IKKα-mediated biogenesis of miR-196a through interaction with Drosha regulates the sensitivity of cancer cells to radiotherapy.
NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.
HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB.
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.
Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.
Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury.
A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation.
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts.
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation.
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death.
Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.
Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis.
Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines.
The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.
Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types.
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
A recessive mutant cell line with a constitutive IkappaB kinase activity.
A recessive mutant cell line with a constitutive IkappaB kinase activity.
NEMO trimerizes through its coiled-coil C-terminal domain.
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.
Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation.
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway.
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis.
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis.
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis.
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis.
Fang X, Jeong JH, Long X, Park SJ, Wang D, Shuai M, Wei R, Li C, Li S, Zhang S, Duran MB, Lo KW, Tsao SW, Glaser R, Luo Z, Feng X, Tian Y, Luo JL
Cell death and differentiation 2016 Sep 1;23(9):1471-82
Cell death and differentiation 2016 Sep 1;23(9):1471-82
NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.
Cui J, Li Y, Zhu L, Liu D, Songyang Z, Wang HY, Wang RF
Nature immunology 2012 Mar 4;13(4):387-95
Nature immunology 2012 Mar 4;13(4):387-95
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 24;109(4):E177-86
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 24;109(4):E177-86
IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.
Bakkar N, Ladner K, Canan BD, Liyanarachchi S, Bal NC, Pant M, Periasamy M, Li Q, Janssen PM, Guttridge DC
The Journal of cell biology 2012 Feb 20;196(4):497-511
The Journal of cell biology 2012 Feb 20;196(4):497-511
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Phromnoi K, Reuter S, Sung B, Prasad S, Kannappan R, Yadav VR, Chanmahasathien W, Limtrakul P, Aggarwal BB
Molecular pharmacology 2011 Feb;79(2):279-89
Molecular pharmacology 2011 Feb;79(2):279-89
Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.
Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB
Molecular pharmacology 2010 May;77(5):818-27
Molecular pharmacology 2010 May;77(5):818-27
HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB.
Huang J, Ren T, Guan H, Jiang Y, Cheng H
The Journal of biological chemistry 2009 Mar 6;284(10):6208-17
The Journal of biological chemistry 2009 Mar 6;284(10):6208-17
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.
Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun A, Snyder JP, Liotta D, Fu H
Molecular pharmacology 2008 Sep;74(3):654-61
Molecular pharmacology 2008 Sep;74(3):654-61
Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR
Proceedings of the National Academy of Sciences of the United States of America 2008 Sep 30;105(39):15058-63
Proceedings of the National Academy of Sciences of the United States of America 2008 Sep 30;105(39):15058-63
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Kunnumakkara AB, Ichikawa H, Anand P, Mohankumar CJ, Hema PS, Nair MS, Aggarwal BB
Molecular cancer therapeutics 2008 Oct;7(10):3306-17
Molecular cancer therapeutics 2008 Oct;7(10):3306-17
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Pandey MK, Sung B, Kunnumakkara AB, Sethi G, Chaturvedi MM, Aggarwal BB
Cancer research 2008 Jul 1;68(13):5370-9
Cancer research 2008 Jul 1;68(13):5370-9
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Otipoby KL, Sasaki Y, Schmidt-Supprian M, Patke A, Gareus R, Pasparakis M, Tarakhovsky A, Rajewsky K
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 26;105(34):12435-8
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 26;105(34):12435-8
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.
Jackson-Bernitsas DG, Ichikawa H, Takada Y, Myers JN, Lin XL, Darnay BG, Chaturvedi MM, Aggarwal BB
Oncogene 2007 Mar 1;26(10):1385-97
Oncogene 2007 Mar 1;26(10):1385-97
Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury.
Beraza N, Lüdde T, Assmus U, Roskams T, Vander Borght S, Trautwein C
Gastroenterology 2007 Jun;132(7):2504-17
Gastroenterology 2007 Jun;132(7):2504-17
A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
Vinolo E, Sebban H, Chaffotte A, Israël A, Courtois G, Véron M, Agou F
The Journal of biological chemistry 2006 Mar 10;281(10):6334-48
The Journal of biological chemistry 2006 Mar 10;281(10):6334-48
Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation.
Ichikawa H, Aggarwal BB
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Jan 15;12(2):662-8
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Jan 15;12(2):662-8
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.
Sethi G, Ahn KS, Sandur SK, Lin X, Chaturvedi MM, Aggarwal BB
The Journal of biological chemistry 2006 Aug 18;281(33):23425-35
The Journal of biological chemistry 2006 Aug 18;281(33):23425-35
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M
The Journal of experimental medicine 2005 May 16;201(10):1677-87
The Journal of experimental medicine 2005 May 16;201(10):1677-87
Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts.
Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S
Oncogene 2005 Jun 2;24(24):3976-86
Oncogene 2005 Jun 2;24(24):3976-86
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Ichikawa H, Takada Y, Murakami A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Ichikawa H, Takada Y, Murakami A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation.
Panopoulos A, Harraz M, Engelhardt JF, Zandi E
The Journal of biological chemistry 2005 Jan 28;280(4):2912-23
The Journal of biological chemistry 2005 Jan 28;280(4):2912-23
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Takada Y, Fang X, Jamaluddin MS, Boyd DD, Aggarwal BB
The Journal of biological chemistry 2004 Sep 17;279(38):39541-54
The Journal of biological chemistry 2004 Sep 17;279(38):39541-54
Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
Shishodia S, Aggarwal BB
The Journal of biological chemistry 2004 Nov 5;279(45):47148-58
The Journal of biological chemistry 2004 Nov 5;279(45):47148-58
Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death.
Chandrasekar B, Vemula K, Surabhi RM, Li-Weber M, Owen-Schaub LB, Jensen LE, Mummidi S
The Journal of biological chemistry 2004 May 7;279(19):20221-33
The Journal of biological chemistry 2004 May 7;279(19):20221-33
Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.
Takada Y, Aggarwal BB
The Journal of biological chemistry 2004 Feb 6;279(6):4750-9
The Journal of biological chemistry 2004 Feb 6;279(6):4750-9
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.
Shishodia S, Koul D, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2004 Aug 1;173(3):2011-22
Journal of immunology (Baltimore, Md. : 1950) 2004 Aug 1;173(3):2011-22
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.
Shishodia S, Koul D, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2004 Aug 1;173(3):2011-22
Journal of immunology (Baltimore, Md. : 1950) 2004 Aug 1;173(3):2011-22
Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis.
Takada Y, Singh S, Aggarwal BB
The Journal of biological chemistry 2004 Apr 9;279(15):15096-104
The Journal of biological chemistry 2004 Apr 9;279(15):15096-104
Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines.
Saito N, Courtois G, Chiba A, Yamamoto N, Nitta T, Hironaka N, Rowe M, Yamamoto N, Yamaoka S
The Journal of biological chemistry 2003 Nov 21;278(47):46565-75
The Journal of biological chemistry 2003 Nov 21;278(47):46565-75
The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.
Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M
Nature medicine 2003 May;9(5):575-81
Nature medicine 2003 May;9(5):575-81
Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types.
Majumdar S, Aggarwal BB
Oncogene 2003 Feb 27;22(8):1206-18
Oncogene 2003 Feb 27;22(8):1206-18
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.
Anto RJ, Mukhopadhyay A, Shishodia S, Gairola CG, Aggarwal BB
Carcinogenesis 2002 Sep;23(9):1511-8
Carcinogenesis 2002 Sep;23(9):1511-8
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.
Anto RJ, Mukhopadhyay A, Shishodia S, Gairola CG, Aggarwal BB
Carcinogenesis 2002 Sep;23(9):1511-8
Carcinogenesis 2002 Sep;23(9):1511-8
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
Makris C, Roberts JL, Karin M
Molecular and cellular biology 2002 Sep;22(18):6573-81
Molecular and cellular biology 2002 Sep;22(18):6573-81
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
Makris C, Roberts JL, Karin M
Molecular and cellular biology 2002 Sep;22(18):6573-81
Molecular and cellular biology 2002 Sep;22(18):6573-81
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR
Immunity 2002 Oct;17(4):525-35
Immunity 2002 Oct;17(4):525-35
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR
Immunity 2002 Oct;17(4):525-35
Immunity 2002 Oct;17(4):525-35
A recessive mutant cell line with a constitutive IkappaB kinase activity.
Chinanonwait N, Miura H, Yamamoto N, Yamaoka S
FEBS letters 2002 Nov 20;531(3):553-60
FEBS letters 2002 Nov 20;531(3):553-60
A recessive mutant cell line with a constitutive IkappaB kinase activity.
Chinanonwait N, Miura H, Yamamoto N, Yamaoka S
FEBS letters 2002 Nov 20;531(3):553-60
FEBS letters 2002 Nov 20;531(3):553-60
NEMO trimerizes through its coiled-coil C-terminal domain.
Agou F, Ye F, Goffinont S, Courtois G, Yamaoka S, Israël A, Véron M
The Journal of biological chemistry 2002 May 17;277(20):17464-75
The Journal of biological chemistry 2002 May 17;277(20):17464-75
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.
Majumdar S, Lamothe B, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2002 Mar 15;168(6):2644-51
Journal of immunology (Baltimore, Md. : 1950) 2002 Mar 15;168(6):2644-51
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.
Majumdar S, Lamothe B, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2002 Mar 15;168(6):2644-51
Journal of immunology (Baltimore, Md. : 1950) 2002 Mar 15;168(6):2644-51
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.
Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2002 Dec 1;169(11):6490-7
Journal of immunology (Baltimore, Md. : 1950) 2002 Dec 1;169(11):6490-7
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.
Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2002 Dec 1;169(11):6490-7
Journal of immunology (Baltimore, Md. : 1950) 2002 Dec 1;169(11):6490-7
Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation.
Miller BS, Zandi E
The Journal of biological chemistry 2001 Sep 28;276(39):36320-6
The Journal of biological chemistry 2001 Sep 28;276(39):36320-6
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
Majumdar S, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2001 Sep 1;167(5):2911-20
Journal of immunology (Baltimore, Md. : 1950) 2001 Sep 1;167(5):2911-20
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
Majumdar S, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2001 Sep 1;167(5):2911-20
Journal of immunology (Baltimore, Md. : 1950) 2001 Sep 1;167(5):2911-20
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M
Cell 2001 Dec 14;107(6):763-75
Cell 2001 Dec 14;107(6):763-75
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M
Cell 2001 Dec 14;107(6):763-75
Cell 2001 Dec 14;107(6):763-75
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway.
Koul D, Yao Y, Abbruzzese JL, Yung WK, Reddy SA
The Journal of biological chemistry 2001 Apr 6;276(14):11402-8
The Journal of biological chemistry 2001 Apr 6;276(14):11402-8
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis.
Manna SK, Mukhopadhyay A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 15;165(10):5962-9
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 15;165(10):5962-9
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis.
Manna SK, Mukhopadhyay A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 15;165(10):5962-9
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 15;165(10):5962-9
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis.
Manna SK, Mukhopadhyay A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 1;165(9):4927-34
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 1;165(9):4927-34
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis.
Manna SK, Mukhopadhyay A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 1;165(9):4927-34
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 1;165(9):4927-34
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Simple Western: IKK alpha Antibody (14A231) - Azide Free [NBP2-27409] - Analysis using Azide/BSA FREE version of NBP2-27409. Simple Western lane view shows a specific band for IKK alpha in 0.5 mg/ml of Daudi (left) and U937 (right) lysate. This exeriment was performed under reducing conditions using the 12-230 kDa separation system.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: IKK alpha Antibody (14A231) - Azide Free [NBP2-27409] - analysis of IKK in Daudi cell lysate using IKKa monoclonal antibody at 1 ug/ml.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: IKK alpha Antibody (14A231) - Azide Free [NBP2-27409] - Formalin-fixed, paraffin-embedded human kidney stained with IKKa antibody at 5 ug/ml. Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: IKK alpha Antibody (14A231) - Azide Free [NBP2-27409] - Intracellular staining of HEK293 cells using 0.5 ug of IKKa antibody (red) and isotype control (green). Intracellular flow kit was used for this test, and an anti-mouse IgG1 PE conjugated secondary antibody.
