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Learnsc-7606
antibody from Santa Cruz Biotechnology
Targeting: CHUK
IkBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- sc-7606 - Provider product page
- Provider
- Santa Cruz Biotechnology
- Proper citation
- Santa Cruz Biotechnology Cat#sc-7606, RRID:AB_627784
- Product name
- Anti-CHUK
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Reactivity
- Human
- Host
- Mouse
Submitted references A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes.
Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation.
Chronic NF-kappaB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response.
The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.
Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter.
CARD11 mediates factor-specific activation of NF-κB by the T cell receptor complex
Scotto d'Abusco A, Politi L, Giordano C, Scandurra R
Arthritis research & therapy 2010;12(1):R18
Arthritis research & therapy 2010;12(1):R18
Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation.
Chun JN, Choi B, Lee KW, Lee DJ, Kang DH, Lee JY, Song IS, Kim HI, Lee SH, Kim HS, Lee NK, Lee SY, Lee KJ, Kim J, Kang SW
PloS one 2010 Mar 23;5(3):e9422
PloS one 2010 Mar 23;5(3):e9422
Chronic NF-kappaB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response.
Batsi C, Markopoulou S, Vartholomatos G, Georgiou I, Kanavaros P, Gorgoulis VG, Marcu KB, Kolettas E
Mechanisms of ageing and development 2009 Jul;130(7):409-19
Mechanisms of ageing and development 2009 Jul;130(7):409-19
The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.
McCully RR, Pomerantz JL
Molecular and cellular biology 2008 Sep;28(18):5668-86
Molecular and cellular biology 2008 Sep;28(18):5668-86
Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter.
DeMeritt IB, Milford LE, Yurochko AD
Journal of virology 2004 May;78(9):4498-507
Journal of virology 2004 May;78(9):4498-507
CARD11 mediates factor-specific activation of NF-κB by the T cell receptor complex
Joel L. Pomerantz, Elissa M. Denny, David Baltimore
The EMBO Journal 2002 Oct;21(19):5184-5194
The EMBO Journal 2002 Oct;21(19):5184-5194
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Supportive validation
- Submitted by
- per
- Main image
- Experimental details
- Western blot analysis of antibody specificity using a routine panel composed of IgG/HSA-depleted human plasma and protein lysates from selected human tissues and cell lines.
- Validation comment
- Single band corresponding to the predicted size in kDa (+/-20%).
- Primary Ab dilution
- 1:500
- Secondary Ab dilution
- 1:7000
- Lane 1
- Marker [kDa]: 230, 110, 82, 49.3, 32.2, 25.5, 17.6
- Lane 2
- RT-4
- Lane 3
- U-251MG sp
- Lane 4
- Human Plasma
- Lane 5
- Liver
- Lane 6
- Tonsil
- Theoretical target weight
- [kDa] 85
Supportive validation
- Submitted by
- per
- Main image
- Experimental details
- Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.
- Validation comment
- Staining pattern partly consistent with experimental and/or bioinformatic data.
