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LearnAM20341AF-N
antibody from Acris Antibodies GmbH
Targeting: CHUK
IkBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Western blot
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [50]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- AM20341AF-N - Provider product page
- Provider
- Acris Antibodies GmbH
- Product name
- anti IKKA
- Antibody type
- Monoclonal
- Antigen
- His-tagged full-length human IKKa protein.
- Reactivity
- Human, Mouse, Simian
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 14A231
- Vial size
- 0.1 mg
- Concentration
- 0.5 mg/ml
Submitted references TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.
HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB.
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.
Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury.
Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.
Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation.
A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury.
Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation.
Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.
An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells.
Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma.
N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts.
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation.
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha.
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death.
Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis.
Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.
Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis.
IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.
Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines.
The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.
Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types.
Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
A recessive mutant cell line with a constitutive IkappaB kinase activity.
NEMO trimerizes through its coiled-coil C-terminal domain.
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.
Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation.
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway.
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis.
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis.
Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 24;109(4):E177-86
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 24;109(4):E177-86
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Phromnoi K, Reuter S, Sung B, Prasad S, Kannappan R, Yadav VR, Chanmahasathien W, Limtrakul P, Aggarwal BB
Molecular pharmacology 2011 Feb;79(2):279-89
Molecular pharmacology 2011 Feb;79(2):279-89
Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.
Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB
Molecular pharmacology 2010 May;77(5):818-27
Molecular pharmacology 2010 May;77(5):818-27
HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB.
Huang J, Ren T, Guan H, Jiang Y, Cheng H
The Journal of biological chemistry 2009 Mar 6;284(10):6208-17
The Journal of biological chemistry 2009 Mar 6;284(10):6208-17
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.
Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun A, Snyder JP, Liotta D, Fu H
Molecular pharmacology 2008 Sep;74(3):654-61
Molecular pharmacology 2008 Sep;74(3):654-61
Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR
Proceedings of the National Academy of Sciences of the United States of America 2008 Sep 30;105(39):15058-63
Proceedings of the National Academy of Sciences of the United States of America 2008 Sep 30;105(39):15058-63
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Kunnumakkara AB, Ichikawa H, Anand P, Mohankumar CJ, Hema PS, Nair MS, Aggarwal BB
Molecular cancer therapeutics 2008 Oct;7(10):3306-17
Molecular cancer therapeutics 2008 Oct;7(10):3306-17
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Pandey MK, Sung B, Kunnumakkara AB, Sethi G, Chaturvedi MM, Aggarwal BB
Cancer research 2008 Jul 1;68(13):5370-9
Cancer research 2008 Jul 1;68(13):5370-9
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Otipoby KL, Sasaki Y, Schmidt-Supprian M, Patke A, Gareus R, Pasparakis M, Tarakhovsky A, Rajewsky K
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 26;105(34):12435-8
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 26;105(34):12435-8
Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury.
Beraza N, Lüdde T, Assmus U, Roskams T, Vander Borght S, Trautwein C
Gastroenterology 2007 Jun;132(7):2504-17
Gastroenterology 2007 Jun;132(7):2504-17
Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.
Vacca A, Felli MP, Palermo R, Di Mario G, Calce A, Di Giovine M, Frati L, Gulino A, Screpanti I
The EMBO journal 2006 Mar 8;25(5):1000-8
The EMBO journal 2006 Mar 8;25(5):1000-8
Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation.
Takada Y, Gillenwater A, Ichikawa H, Aggarwal BB
The Journal of biological chemistry 2006 Mar 3;281(9):5612-22
The Journal of biological chemistry 2006 Mar 3;281(9):5612-22
A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
Vinolo E, Sebban H, Chaffotte A, Israël A, Courtois G, Véron M, Agou F
The Journal of biological chemistry 2006 Mar 10;281(10):6334-48
The Journal of biological chemistry 2006 Mar 10;281(10):6334-48
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
Sandur SK, Ichikawa H, Sethi G, Ahn KS, Aggarwal BB
The Journal of biological chemistry 2006 Jun 23;281(25):17023-33
The Journal of biological chemistry 2006 Jun 23;281(25):17023-33
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury.
Chae S, Eckmann L, Miyamoto Y, Pothoulakis C, Karin M, Kagnoff MF
Journal of immunology (Baltimore, Md. : 1950) 2006 Jul 15;177(2):1214-20
Journal of immunology (Baltimore, Md. : 1950) 2006 Jul 15;177(2):1214-20
Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation.
Ichikawa H, Aggarwal BB
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Jan 15;12(2):662-8
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Jan 15;12(2):662-8
Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.
Nenci A, Huth M, Funteh A, Schmidt-Supprian M, Bloch W, Metzger D, Chambon P, Rajewsky K, Krieg T, Haase I, Pasparakis M
Human molecular genetics 2006 Feb 15;15(4):531-42
Human molecular genetics 2006 Feb 15;15(4):531-42
An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells.
Bürckstümmer T, Bennett KL, Preradovic A, Schütze G, Hantschel O, Superti-Furga G, Bauch A
Nature methods 2006 Dec;3(12):1013-9
Nature methods 2006 Dec;3(12):1013-9
Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma.
Shishodia S, Amin HM, Lai R, Aggarwal BB
Biochemical pharmacology 2005 Sep 1;70(5):700-13
Biochemical pharmacology 2005 Sep 1;70(5):700-13
N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.
Shishodia S, Gutierrez AM, Lotan R, Aggarwal BB
Cancer research 2005 Oct 15;65(20):9555-65
Cancer research 2005 Oct 15;65(20):9555-65
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M
The Journal of experimental medicine 2005 May 16;201(10):1677-87
The Journal of experimental medicine 2005 May 16;201(10):1677-87
Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts.
Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S
Oncogene 2005 Jun 2;24(24):3976-86
Oncogene 2005 Jun 2;24(24):3976-86
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Ichikawa H, Takada Y, Murakami A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation.
Panopoulos A, Harraz M, Engelhardt JF, Zandi E
The Journal of biological chemistry 2005 Jan 28;280(4):2912-23
The Journal of biological chemistry 2005 Jan 28;280(4):2912-23
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha.
Nishio M, Endo T, Tsukada N, Ohata J, Kitada S, Reed JC, Zvaifler NJ, Kipps TJ
Blood 2005 Aug 1;106(3):1012-20
Blood 2005 Aug 1;106(3):1012-20
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Takada Y, Fang X, Jamaluddin MS, Boyd DD, Aggarwal BB
The Journal of biological chemistry 2004 Sep 17;279(38):39541-54
The Journal of biological chemistry 2004 Sep 17;279(38):39541-54
Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
Shishodia S, Aggarwal BB
The Journal of biological chemistry 2004 Nov 5;279(45):47148-58
The Journal of biological chemistry 2004 Nov 5;279(45):47148-58
Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death.
Chandrasekar B, Vemula K, Surabhi RM, Li-Weber M, Owen-Schaub LB, Jensen LE, Mummidi S
The Journal of biological chemistry 2004 May 7;279(19):20221-33
The Journal of biological chemistry 2004 May 7;279(19):20221-33
Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis.
Takada Y, Khuri FR, Aggarwal BB
The Journal of biological chemistry 2004 Jun 18;279(25):26287-99
The Journal of biological chemistry 2004 Jun 18;279(25):26287-99
Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.
Takada Y, Aggarwal BB
The Journal of biological chemistry 2004 Feb 6;279(6):4750-9
The Journal of biological chemistry 2004 Feb 6;279(6):4750-9
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.
Shishodia S, Koul D, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2004 Aug 1;173(3):2011-22
Journal of immunology (Baltimore, Md. : 1950) 2004 Aug 1;173(3):2011-22
Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis.
Takada Y, Singh S, Aggarwal BB
The Journal of biological chemistry 2004 Apr 9;279(15):15096-104
The Journal of biological chemistry 2004 Apr 9;279(15):15096-104
IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.
Sil AK, Maeda S, Sano Y, Roop DR, Karin M
Nature 2004 Apr 8;428(6983):660-4
Nature 2004 Apr 8;428(6983):660-4
Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines.
Saito N, Courtois G, Chiba A, Yamamoto N, Nitta T, Hironaka N, Rowe M, Yamamoto N, Yamaoka S
The Journal of biological chemistry 2003 Nov 21;278(47):46565-75
The Journal of biological chemistry 2003 Nov 21;278(47):46565-75
The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.
Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M
Nature medicine 2003 May;9(5):575-81
Nature medicine 2003 May;9(5):575-81
Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types.
Majumdar S, Aggarwal BB
Oncogene 2003 Feb 27;22(8):1206-18
Oncogene 2003 Feb 27;22(8):1206-18
Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.
Shishodia S, Majumdar S, Banerjee S, Aggarwal BB
Cancer research 2003 Aug 1;63(15):4375-83
Cancer research 2003 Aug 1;63(15):4375-83
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.
Anto RJ, Mukhopadhyay A, Shishodia S, Gairola CG, Aggarwal BB
Carcinogenesis 2002 Sep;23(9):1511-8
Carcinogenesis 2002 Sep;23(9):1511-8
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
Makris C, Roberts JL, Karin M
Molecular and cellular biology 2002 Sep;22(18):6573-81
Molecular and cellular biology 2002 Sep;22(18):6573-81
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR
Immunity 2002 Oct;17(4):525-35
Immunity 2002 Oct;17(4):525-35
A recessive mutant cell line with a constitutive IkappaB kinase activity.
Chinanonwait N, Miura H, Yamamoto N, Yamaoka S
FEBS letters 2002 Nov 20;531(3):553-60
FEBS letters 2002 Nov 20;531(3):553-60
NEMO trimerizes through its coiled-coil C-terminal domain.
Agou F, Ye F, Goffinont S, Courtois G, Yamaoka S, Israël A, Véron M
The Journal of biological chemistry 2002 May 17;277(20):17464-75
The Journal of biological chemistry 2002 May 17;277(20):17464-75
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.
Majumdar S, Lamothe B, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2002 Mar 15;168(6):2644-51
Journal of immunology (Baltimore, Md. : 1950) 2002 Mar 15;168(6):2644-51
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.
Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2002 Dec 1;169(11):6490-7
Journal of immunology (Baltimore, Md. : 1950) 2002 Dec 1;169(11):6490-7
Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation.
Miller BS, Zandi E
The Journal of biological chemistry 2001 Sep 28;276(39):36320-6
The Journal of biological chemistry 2001 Sep 28;276(39):36320-6
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
Majumdar S, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2001 Sep 1;167(5):2911-20
Journal of immunology (Baltimore, Md. : 1950) 2001 Sep 1;167(5):2911-20
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M
Cell 2001 Dec 14;107(6):763-75
Cell 2001 Dec 14;107(6):763-75
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway.
Koul D, Yao Y, Abbruzzese JL, Yung WK, Reddy SA
The Journal of biological chemistry 2001 Apr 6;276(14):11402-8
The Journal of biological chemistry 2001 Apr 6;276(14):11402-8
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis.
Manna SK, Mukhopadhyay A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 15;165(10):5962-9
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 15;165(10):5962-9
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis.
Manna SK, Mukhopadhyay A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 1;165(9):4927-34
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 1;165(9):4927-34
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Supportive validation
- Submitted by
- Acris Antibodies GmbH (provider)
- Main image
- Experimental details
- Western blot analysis of human Daudi lysate using IKKa antibody at 1 mg/ml.
Supportive validation
- Submitted by
- Acris Antibodies GmbH (provider)
- Main image
- Experimental details
- Formalin-fixed, paraffin-embedded human kidney stained with IKKa antibody at 5 µg/ml.Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.
Supportive validation
- Submitted by
- Acris Antibodies GmbH (provider)
- Main image
- Experimental details
- Intracellular staining of HEK293 cells using 0.5 µg of IKKa antibody (red) and isotype control (green).  Intracellular flow kit was used for this test, and an anti-mouse IgG1 PE conjugated secondary antibody.
