BS6889

antibody from Bioworld Technology, Inc
Targeting: IKBKB IKK-beta, IKK2, IKKB, NFKBIKB
Provider product page for BS6889
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6889 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IKKÉÇ polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human IKKÉÇ.
Description
The NF-°ÙB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory I°ÙB proteins. Most agents that activate NF-°ÙB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of I°ÙB. The key regulatory step in this pathway involves activation of a high molecular weight I°ÙB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKÏ« and IKKÉÇ serve as the catalytic subunits of the kinase and IKKÎÛ serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKÉÇ (Ser176 and Ser180 in IKKÏ«), which causes conformational changes, resulting in kinase activation.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IKBKB protein structure - BS6889 shown in red.