MA1-10225
antibody from Invitrogen Antibodies
Targeting: CD44
CD44R, CSPG8, HCELL, IN, MC56, MDU2, MDU3, MIC4, Pgp1
Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations
- Western blot [1]
- Flow cytometry [1]
- Other assay [4]
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Validation data
Reference
Comment
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- Product number
- MA1-10225 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD44 Monoclonal Antibody (IM7)
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- This antibody reacts with all isoforms of mouse CD44. Western Blot: non-reducing conditions.
- Reactivity
- Human, Mouse, Canine, Feline
- Host
- Rat
- Isotype
- IgG
- Antibody clone number
- IM7
- Vial size
- 100 µg
- Concentration
- 1 mg/mL
- Storage
- 4° C, do not freeze
Submitted references Synovial membrane-derived mesenchymal progenitor cells from osteoarthritic joints in dogs possess lower chondrogenic-, and higher osteogenic capacity compared to normal joints.
SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics.
Hyaluronan content governs tissue stiffness in pancreatic islet inflammation.
xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction.
Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation.
Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14(+) Monocytes.
Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice.
ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content.
NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.
Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells.
Glibenclamide Prevents Diabetes in NOD Mice.
Collaborative Interferon-γ and Interleukin-17 Signaling Protects the Oral Mucosa from Staphylococcus aureus.
lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets.
GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal.
The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation.
Vitamin D machinery and metabolism in porcine adipose-derived mesenchymal stem cells.
Can CD44 Be a Mediator of Cell Destruction? The Challenge of Type 1 Diabetes.
ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis.
Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint.
Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.
IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells.
Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis.
CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.
c-Myb is required for pro-B cell differentiation.
Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines.
Enhanced antigen-specific primary CD4+ and CD8+ responses by codelivery of ovalbumin and toll-like receptor ligand monophosphoryl lipid A in poly(D,L-lactic-co-glycolic acid) nanoparticles.
Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.
CD8+ tumor-infiltrating lymphocytes are primed for Fas-mediated activation-induced cell death but are not apoptotic in situ.
Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody.
Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody.
Teunissen M, Ahrens NS, Snel L, Narcisi R, Kamali SA, van Osch GJVM, Meij BP, Mastbergen SC, Sivasubramaniyan K, Tryfonidou MA
Stem cell research & therapy 2022 Sep 5;13(1):457
Stem cell research & therapy 2022 Sep 5;13(1):457
SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics.
Cabello-Aguilar S, Alame M, Kon-Sun-Tack F, Fau C, Lacroix M, Colinge J
Nucleic acids research 2020 Jun 4;48(10):e55
Nucleic acids research 2020 Jun 4;48(10):e55
Hyaluronan content governs tissue stiffness in pancreatic islet inflammation.
Nagy N, de la Zerda A, Kaber G, Johnson PY, Hu KH, Kratochvil MJ, Yadava K, Zhao W, Cui Y, Navarro G, Annes JP, Wight TN, Heilshorn SC, Bollyky PL, Butte MJ
The Journal of biological chemistry 2018 Jan 12;293(2):567-578
The Journal of biological chemistry 2018 Jan 12;293(2):567-578
xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction.
Cobler L, Zhang H, Suri P, Park C, Timmerman LA
Oncotarget 2018 Aug 17;9(64):32280-32297
Oncotarget 2018 Aug 17;9(64):32280-32297
Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation.
Jacobsen EA, Ochkur SI, Doyle AD, LeSuer WE, Li W, Protheroe CA, Colbert D, Zellner KR, Shen HH, Irvin CG, Lee JJ, Lee NA
American journal of respiratory and critical care medicine 2017 May 15;195(10):1321-1332
American journal of respiratory and critical care medicine 2017 May 15;195(10):1321-1332
Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14(+) Monocytes.
Horvatinovich JM, Grogan EW, Norris M, Steinkasserer A, Lemos H, Mellor AL, Tcherepanova IY, Nicolette CA, DeBenedette MA
Journal of immunology (Baltimore, Md. : 1950) 2017 Mar 15;198(6):2286-2301
Journal of immunology (Baltimore, Md. : 1950) 2017 Mar 15;198(6):2286-2301
Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice.
van Nieuwenhuijze A, Dooley J, Humblet-Baron S, Sreenivasan J, Koenders M, Schlenner SM, Linterman M, Liston A
Cellular and molecular life sciences : CMLS 2017 Jun;74(11):2095-2106
Cellular and molecular life sciences : CMLS 2017 Jun;74(11):2095-2106
ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content.
Nowyhed HN, Chandra S, Kiosses W, Marcovecchio P, Andary F, Zhao M, Fitzgerald ML, Kronenberg M, Hedrick CC
Scientific reports 2017 Jan 16;7:40273
Scientific reports 2017 Jan 16;7:40273
NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.
Marshall NB, Vong AM, Devarajan P, Brauner MD, Kuang Y, Nayar R, Schutten EA, Castonguay CH, Berg LJ, Nutt SL, Swain SL
Journal of immunology (Baltimore, Md. : 1950) 2017 Feb 1;198(3):1142-1155
Journal of immunology (Baltimore, Md. : 1950) 2017 Feb 1;198(3):1142-1155
Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells.
Rampoldi F, Brunk F, Bonrouhi M, Federico G, Krunic D, Porubsky S, Gröne HJ, Popovic ZV
Journal of leukocyte biology 2017 Apr;101(4):1005-1014
Journal of leukocyte biology 2017 Apr;101(4):1005-1014
Glibenclamide Prevents Diabetes in NOD Mice.
Lamprianou S, Gysemans C, Bou Saab J, Pontes H, Mathieu C, Meda P
PloS one 2016;11(12):e0168839
PloS one 2016;11(12):e0168839
Collaborative Interferon-γ and Interleukin-17 Signaling Protects the Oral Mucosa from Staphylococcus aureus.
Barin JG, Talor MV, Schaub JA, Diny NL, Hou X, Hoyer M, Archer NK, Gebremariam ES, Davis MF, Miller LS, Rose NR, Čiháková D
The American journal of pathology 2016 Sep;186(9):2337-52
The American journal of pathology 2016 Sep;186(9):2337-52
lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets.
Carow B, Gao Y, Coquet J, Reilly M, Rottenberg ME
Journal of immunology (Baltimore, Md. : 1950) 2016 Sep 15;197(6):2261-8
Journal of immunology (Baltimore, Md. : 1950) 2016 Sep 15;197(6):2261-8
GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal.
Le Q, Yao W, Chen Y, Yan B, Liu C, Yuan M, Zhou Y, Ma L
Cell death & disease 2016 Nov 24;7(11):e2478
Cell death & disease 2016 Nov 24;7(11):e2478
The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation.
Kabat AM, Harrison OJ, Riffelmacher T, Moghaddam AE, Pearson CF, Laing A, Abeler-Dörner L, Forman SP, Grencis RK, Sattentau Q, Simon AK, Pott J, Maloy KJ
eLife 2016 Feb 24;5:e12444
eLife 2016 Feb 24;5:e12444
Vitamin D machinery and metabolism in porcine adipose-derived mesenchymal stem cells.
Valle YL, Almalki SG, Agrawal DK
Stem cell research & therapy 2016 Aug 17;7(1):118
Stem cell research & therapy 2016 Aug 17;7(1):118
Can CD44 Be a Mediator of Cell Destruction? The Challenge of Type 1 Diabetes.
Assayag-Asherie N, Sever D, Bogdani M, Johnson P, Weiss T, Ginzberg A, Perles S, Weiss L, Sebban LE, Turley EA, Okon E, Raz I, Naor D
PloS one 2015;10(12):e0143589
PloS one 2015;10(12):e0143589
ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis.
Moguche AO, Shafiani S, Clemons C, Larson RP, Dinh C, Higdon LE, Cambier CJ, Sissons JR, Gallegos AM, Fink PJ, Urdahl KB
The Journal of experimental medicine 2015 May 4;212(5):715-28
The Journal of experimental medicine 2015 May 4;212(5):715-28
Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint.
Fahl SP, Harris B, Coffey F, Wiest DL
Journal of immunology (Baltimore, Md. : 1950) 2015 Jan 1;194(1):200-9
Journal of immunology (Baltimore, Md. : 1950) 2015 Jan 1;194(1):200-9
Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.
Shrestha S, Yang K, Guy C, Vogel P, Neale G, Chi H
Nature immunology 2015 Feb;16(2):178-87
Nature immunology 2015 Feb;16(2):178-87
IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells.
Huang Y, Guo L, Qiu J, Chen X, Hu-Li J, Siebenlist U, Williamson PR, Urban JF Jr, Paul WE
Nature immunology 2015 Feb;16(2):161-9
Nature immunology 2015 Feb;16(2):161-9
Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis.
Thelemann C, Eren RO, Coutaz M, Brasseit J, Bouzourene H, Rosa M, Duval A, Lavanchy C, Mack V, Mueller C, Reith W, Acha-Orbea H
PloS one 2014;9(1):e86844
PloS one 2014;9(1):e86844
CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.
Wensveen FM, Unger PP, Kragten NA, Derks IA, ten Brinke A, Arens R, van Lier RA, Eldering E, van Gisbergen KP
Journal of immunology (Baltimore, Md. : 1950) 2012 May 1;188(9):4256-67
Journal of immunology (Baltimore, Md. : 1950) 2012 May 1;188(9):4256-67
c-Myb is required for pro-B cell differentiation.
Fahl SP, Crittenden RB, Allman D, Bender TP
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 1;183(9):5582-92
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 1;183(9):5582-92
Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines.
Ahonen CL, Wasiuk A, Fuse S, Turk MJ, Ernstoff MS, Suriawinata AA, Gorham JD, Kedl RM, Usherwood EJ, Noelle RJ
Blood 2008 Mar 15;111(6):3116-25
Blood 2008 Mar 15;111(6):3116-25
Enhanced antigen-specific primary CD4+ and CD8+ responses by codelivery of ovalbumin and toll-like receptor ligand monophosphoryl lipid A in poly(D,L-lactic-co-glycolic acid) nanoparticles.
Hamdy S, Elamanchili P, Alshamsan A, Molavi O, Satou T, Samuel J
Journal of biomedical materials research. Part A 2007 Jun 1;81(3):652-62
Journal of biomedical materials research. Part A 2007 Jun 1;81(3):652-62
Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.
Fisson S, Darrasse-Jèze G, Litvinova E, Septier F, Klatzmann D, Liblau R, Salomon BL
The Journal of experimental medicine 2003 Sep 1;198(5):737-46
The Journal of experimental medicine 2003 Sep 1;198(5):737-46
CD8+ tumor-infiltrating lymphocytes are primed for Fas-mediated activation-induced cell death but are not apoptotic in situ.
Radoja S, Saio M, Frey AB
Journal of immunology (Baltimore, Md. : 1950) 2001 May 15;166(10):6074-83
Journal of immunology (Baltimore, Md. : 1950) 2001 May 15;166(10):6074-83
Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody.
Lesley J, He Q, Miyake K, Hamann A, Hyman R, Kincade PW
The Journal of experimental medicine 1992 Jan 1;175(1):257-66
The Journal of experimental medicine 1992 Jan 1;175(1):257-66
Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody.
Lesley J, He Q, Miyake K, Hamann A, Hyman R, Kincade PW
The Journal of experimental medicine 1992 Jan 1;175(1):257-66
The Journal of experimental medicine 1992 Jan 1;175(1):257-66
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blotting analysis of CD44 in HeLa cells (positive; lane 2) and MOLT-4 cells (negative; lane 1) using anti-CD44 (IM7) purified Monoclonal antibody (Product # MA1-10225); non-reducing conditions.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Separation of murine splenocytes stained using anti-mouse CD44 (IM7) purified Monoclonal antibody (Product # MA1-10225) (concentration in sample 6 µg/mL, DAR APC, red) from murine splenocytes unstained by primary antibody (DAR APC, black) in flow cytometry analysis (surface staining).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig 2 CD44 expressed in the recipient's tissue rather than on the infiltrating-cells enhances the development of T1D in the cell transfer model. A) CD44-deficient non-diabetic NOD male recipients were reconstituted with inflammatory spleen cells derived from WT (CD44 +/+ -CD44 -/- ; marked #1) or CD44-deficient (CD44 -/- -CD44 -/- ; marked #2) diabetic NOD female donors. In addition, WT non-diabetic NOD male recipients were reconstituted with inflammatory spleen cells derived from WT (CD44 +/+ -CD44 +/+ ; marked #3) or CD44-deficient (CD44 -/- -CD44 +/+ ; marked #4) diabetic NOD female donors. Inflammatory cells are marked by arrows and local islet cells by arrowhead. The pancreases of all 4 combinations were removed after detection of diabetes or 200 days after cell transfer. Doing so, pancreases that were harvested approximately at the same time, were stained with anti-CD44 mAb. B) The % of diabetes-free mice (exhibiting less than 250 mg/dL urine glucose) was determined in corresponding four mouse groups, described in A . Statistical analysis by Breslow: #2 versus #3, P < 0.01; #1 versus #2 (follow up 75 to 200 days), P < 0.03; #3 versus #4 (follow up 20 to 75 days), P < 0.03.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 4. Mouse IFE. ( A ) Schematics of the IFE (arrow = axis of differentiation). ( B ) t-SNE plot of the IFE cells with the underlying black arrow representing the axis of differentiation. Some incompletely differentiated non IFE B cells lie among the IFE B subpopulation. ( C ) Cell type calling with actual subpopulations in the top color band. ( D ) Presenilin-1 (left panel) and CD44 (middle panel) immunostainings of mouse skin sections. Sections were counterstained with DAPI (epi = epidermis, * = co-localization). ( E ) Number of genes with average expression different from 0 in each IFE layer. ( F ) Number of ligands and receptors involved in LRscore > 0.5 interactions. ( G ) Flow diagram representing the number of interactions between the cell subpopulations. ( H and I ) Chord diagrams of adjacent and remote IFE K2 cell-cell interactions. ( J ) Immune marker gene expression. Il18 is expressed by macrophages, Ifi30 by antigen-presenting cells and Prdm1 by T cells (genecards.org).
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Evaluation of the CD marker location in the synovial membrane. Immunohistochemical analysis using DAB (3, 3'-diaminobenzidine, orange/brown staining) was performed to identify the location of CD90, CD44, CD73, CD271, and CD34 expression in the normal (circle) and osteoarthritic (OA, square) synovial membrane. Representative images, containing both fibrous and adipose type synovial membrane, were chosen. The scale bar is set at 50 um. Quantification of the DAB staining was performed with Image ProPlus 6.0 software (Media Cybernetics) in 3 to 6 random regions of interest (ROI) per donor, resulting in a mean percentage of DAB positive staining areas for each donor