103026
antibody from BioLegend
Targeting: CD44
CD44R, CSPG8, HCELL, IN, MC56, MDU2, MDU3, MIC4, Pgp1
Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 103026 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#103026, RRID:AB_493713
- Product name
- Alexa Fluor® 700 anti-mouse/human CD44 [IM7]
- Antibody type
- Monoclonal
- Antigen
- Dexamethasone-induced myeloid leukemia M1 cells
- Description
- CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.
- Reactivity
- Human, Mouse, Bovine, Canine, Feline, Horse, Porcine, Simian
- Host
- Rat
- Conjugate
- Far-Red dye, Near infrared dye
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The CD44 antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells.
Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma.
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function.
Identification of mesenchymal stem cells in aorta-gonad-mesonephros and yolk sac of human embryos.
Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses.
The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells.
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.
The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.
Chen YW, Chen KH, Huang PI, Chen YC, Chiou GY, Lo WL, Tseng LM, Hsu HS, Chang KW, Chiou SH
Molecular cancer therapeutics 2010 Nov;9(11):2879-92
Molecular cancer therapeutics 2010 Nov;9(11):2879-92
Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma.
Yamazaki J, Mizukami T, Takizawa K, Kuramitsu M, Momose H, Masumi A, Ami Y, Hasegawa H, Hall WW, Tsujimoto H, Hamaguchi I, Yamaguchi K
Blood 2009 Sep 24;114(13):2709-20
Blood 2009 Sep 24;114(13):2709-20
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function.
Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH
Journal of translational medicine 2009 Oct 22;7:89
Journal of translational medicine 2009 Oct 22;7:89
Identification of mesenchymal stem cells in aorta-gonad-mesonephros and yolk sac of human embryos.
Wang XY, Lan Y, He WY, Zhang L, Yao HY, Hou CM, Tong Y, Liu YL, Yang G, Liu XD, Yang X, Liu B, Mao N
Blood 2008 Feb 15;111(4):2436-43
Blood 2008 Feb 15;111(4):2436-43
Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses.
Kenna TJ, Thomas R, Steptoe RJ
Blood 2008 Feb 15;111(4):2091-100
Blood 2008 Feb 15;111(4):2091-100
The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells.
Gui J, Zhu X, Dohkan J, Cheng L, Barnes PF, Su DM
International immunology 2007 Oct;19(10):1201-11
International immunology 2007 Oct;19(10):1201-11
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.
Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, Sayegh MH, Sadee W, Frank MH
Cancer research 2005 May 15;65(10):4320-33
Cancer research 2005 May 15;65(10):4320-33
The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.
Zhang N, He YW
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):6967-73
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):6967-73
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- C57BL/6 mouse splenocytes stained with IM7 Alexa Fluor® 700
- Conjugate
- Near infrared dye