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LearnNB100-105
antibody from Novus Biologicals
Targeting: HIF1A
bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8
Western blot
ELISA Immunocytochemistry Immunoprecipitation Immunohistochemistry Flow cytometry Gel shift Proximity ligation assay Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [852]
- Comments [0]
- Validations
- Western blot [11]
- Immunohistochemistry [3]
- Flow cytometry [2]
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- Product number
- NB100-105 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-105, RRID:AB_10001154
- Product name
- Mouse Monoclonal HIF-1 alpha Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified.
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Feline, Porcine, Rabbit, Sheep, Simian, Xenopus
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Caspr1 Facilitates sAPPα Production by Regulating α-Secretase ADAM9 in Brain Endothelial Cells.
A Chinese Herbal Formula Suppresses Colorectal Cancer Migration and Vasculogenic Mimicry Through ROS/HIF-1α/MMP2 Pathway in Hypoxic Microenvironment.
The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma.
The secretome of human dental pulp stem cells protects myoblasts from hypoxia‑induced injury via the Wnt/β‑catenin pathway.
Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury.
Hypoxia-Inducible Factor 1α (HIF-1α) Counteracts the Acute Death of Cells Transplanted into the Injured Spinal Cord.
A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism.
Drp1-regulated PARK2-dependent mitophagy protects against renal fibrosis in unilateral ureteral obstruction.
Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages.
MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis.
Intermittent hypoxia modulates redox homeostasis, lipid metabolism associated inflammatory processes and redox post-translational modifications: Benefits at high altitude.
Increased fibrotic signaling in a murine model for intra-arterial contrast-induced acute kidney injury.
HIF-1α (Hypoxia-Inducible Factor-1α) Promotes Macrophage Necroptosis by Regulating miR-210 and miR-383.
Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1.
Mechanism of the hypoxia inducible factor 1/hypoxic response element pathway in rat myocardial ischemia/diazoxide post‑conditioning.
Effects of antibodies against human parvovirus B19 on angiogenic signaling.
Progressive hypoxia-on-a-chip: An in vitro oxygen gradient model for capturing the effects of hypoxia on primary hepatocytes in health and disease.
Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling.
MiR-375 Impairs the Invasive Capabilities of Hepatoma Cells by Targeting HIF1α Under Hypoxia.
Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis.
Histone hyperacetylation mediates enhanced IL-1β production in LPS/IFN-γ-stimulated macrophages.
Local delivery of cardiac stem cells overexpressing HIF-1α promotes angiogenesis and muscular tissue repair in a hind limb ischemia model.
REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors.
High-density lipoprotein remodelled in hypercholesterolaemic blood induce epigenetically driven down-regulation of endothelial HIF-1α expression in a preclinical animal model.
Fibroblast-specific ERK5 deficiency changes tumor vasculature and exacerbates tumor progression in a mouse model.
Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.
Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor.
Glycaemic control in diabetic rats treated with islet transplantation using plasma combined with hydroxypropylmethyl cellulose hydrogel.
Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling.
Disturbance in the regulation of miR 17-92 cluster on HIF-1-α expression contributes to clinically relevant radioresistant cells: an in vitro study.
The Expression of CNS-Specific PPARGC1A Transcripts Is Regulated by Hypoxia and a Variable GT Repeat Polymorphism.
NER-factor DDB2 regulates HIF1α and hypoxia-response genes in HNSCC.
A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells.
HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma.
Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression.
Blood Oxygen Level-Dependent Imaging and Intravoxel Incoherent Motion MRI of Early Contrast-Induced Acute Kidney Injury in a Rabbit Model.
A Three-Dimensional Culture Model of Reversibly Quiescent Myogenic Cells.
TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway.
The prognostic value of hypoxia-inducible factor-1α in advanced cancer survivors: a meta-analysis with trial sequential analysis.
AMPK Inhibition Suppresses the Malignant Phenotype of Pancreatic Cancer Cells in Part by Attenuating Aerobic Glycolysis.
Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy.
Involvement of A3 Adenosine Receptor in Neuroblastoma Progression via Modulation of the Hypoxic/Angiogenic Pathway.
Evaluation of Venous Stenosis Angioplasty in a Murine Arteriovenous Fistula Model.
Metabolic regulation of gene expression by histone lactylation.
Improved Motor Nerve Regeneration by SIRT1/Hif1a-Mediated Autophagy.
Oxidative stress-mediated TXNIP loss causes RPE dysfunction.
Evaluation of iodine contrast-induced acute kidney injury via different injection routes using BOLD-MRI.
A Hypoxia-Inducible HIF1-GAL3ST1-Sulfatide Axis Enhances ccRCC Immune Evasion via Increased Tumor Cell-Platelet Binding.
Rare variants of head and neck squamous cell carcinoma -differential immunohistochemical profiles.
A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells.
Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism.
Hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in cartilage tumors.
Hypoxia-inducible factor-1α induces CX3CR1 expression and promotes the epithelial to mesenchymal transition (EMT) in ovarian cancer cells.
Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer.
Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress.
Intra- and Postoperative Blood Flow Monitoring in a Sheep Model of Uterus Transplantation.
Caffeic Acid Phenethyl Ester Rescues Pulmonary Arterial Hypertension through the Inhibition of AKT/ERK-Dependent PDGF/HIF-1α In Vitro and In Vivo.
Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses.
IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function.
HIF-1α protects against oxidative stress by directly targeting mitochondria.
Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment.
Protein kinase C binding protein 1 inhibits hypoxia-inducible factor-1 in the heart.
Vascularized 3D printed scaffolds for promoting bone regeneration.
Expression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia-inducible factor-1.
Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma.
Effects of empagliflozin on nondiabetic salt-sensitive hypertension in uninephrectomized rats.
A close relationship between HIF-1α expression and bone metastases in advanced NSCLC, a retrospective analysis.
Exenatide mitigates inflammation and hypoxia along with improved angiogenesis in obese fat tissue.
Periprosthetic hypoxia as consequence of TRPM7 mediated cobalt influx in osteoblasts.
RANKL blockade suppresses pathological angiogenesis and vascular leakage in ischemic retinopathy.
H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer.
Blood-Stage Plasmodium Berghei ANKA Infection Promotes Hepatic Fibrosis by Enhancing Hedgehog Signaling in Mice.
Heme Oxygenase-2 Localizes to Mitochondria and Regulates Hypoxic Responses in Hepatocytes.
Hypoxia-Induced Reporter Genes with Different Half-Lives.
Induction and Assessment of Hypoxia in Glioblastoma Cells In Vitro.
Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression.
CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration.
Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APPswe/PS1dE9 Mice and Their Wild Type Littermates.
Upregulation of the alternative splicing factor NOVA2 in colorectal cancer vasculature.
Aerosolized deferoxamine administration in mouse model of bronchopulmonary dysplasia improve pulmonary development.
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
The family of 14-3-3 proteins and specifically 14-3-3σ are up-regulated during the development of renal pathologies.
Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3.
Intrauterine Exposure to Cadmium Reduces HIF-1 DNA-Binding Ability in Rat Fetal Kidneys.
Effect of hypoxia on caveolae-related protein expression and insulin signaling in adipocytes.
GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation.
Combined use of external therapeutic ultrasound and tirofiban has synergistic therapeutic effects on no-reflow after myocardial reperfusion.
Vascular Permeability Assay in Human Coronary and Mouse Brachiocephalic Arteries.
Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
Dysregulated cancer cell transdifferentiation into erythrocytes is an additional metabolic stress in hepatocellular carcinoma.
Increased expression of hypoxia-inducible factor-1 alpha and its impact on transcriptional changes and prognosis in malignant tumours of the ocular adnexa.
Knockdown of HIF-1α impairs post-ischemic vascular reconstruction in the brain via deficient homing and sprouting bmEPCs.
Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia.
Dehydrocostus Lactone Enhances Chemotherapeutic Potential of Doxorubicin in Lung Cancer by Inducing Cell Death and Limiting Metastasis.
High mobility group protein B1 controls liver cancer initiation through yes-associated protein -dependent aerobic glycolysis.
HIF-1α stabilization reduces retinal degeneration in a mouse model of retinitis pigmentosa.
Postconditioning with repeated mild hypoxia protects neonatal hypoxia-ischemic rats against brain damage and promotes rehabilitation of brain function.
WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.
Highly efficient local delivery of endothelial progenitor cells significantly potentiates angiogenesis and full-thickness wound healing.
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia.
A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro.
Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma.
Histone deacetylase 8 protects human proximal tubular epithelial cells from hypoxia-mimetic cobalt- and hypoxia/reoxygenation-induced mitochondrial fission and cytotoxicity.
Inflammation stimulates hypoxia-inducible factor-1α regulatory activity in 3T3-L1 adipocytes with conditioned medium from lipopolysaccharide-activated RAW 264.7 macrophages.
Retinoic acid receptor-related orphan receptor RORα regulates differentiation and survival of keratinocytes during hypoxia.
Hepatic dysfunction and thrombocytopenia induced by excess sFlt1 in mice lacking endothelial nitric oxide synthase.
Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma.
Chemotherapeutic Drug Based Metal-Organic Particles for Microvesicle-Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy.
Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury.
Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C.
Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase.
Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region.
Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1α and Slug signaling pathways.
Acute hypoxic exposure and prolyl-hydroxylase inhibition improves synaptic transmission recovery time from a subsequent hypoxic insult in rat hippocampus.
Prognostic significance of the programmed death ligand 1 expression in clear cell renal cell carcinoma and correlation with the tumor microenvironment and hypoxia-inducible factor expression.
Post-translational modifications of eNOS augment nitric oxide availability and facilitates hypoxia adaptation in Ladakhi women.
Innate immune memory in the brain shapes neurological disease hallmarks.
Intermittent hypoxia induces beneficial cardiovascular remodeling in left ventricular function of type 1 diabetic rat.
High-intensity interval training in hypoxia does not affect muscle HIF responses to acute hypoxia in humans.
WITHDRAWN:Mitochondrial targeting of HIF-1α inhibits hypoxia-induced apoptosis independently of its transcriptional activity.
Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway.
Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice.
Orai1, 2, 3 and STIM1 promote store-operated calcium entry in pulmonary arterial smooth muscle cells.
miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells.
Correlation of hypoxia inducible transcription factor in breast cancer and SUVmax of F-18 FDG PET/CT.
Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor.
Inflammation-induced fetal growth restriction in rats is associated with increased placental HIF-1α accumulation.
Markers of oxidative/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds.
Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death.
Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor.
NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy.
A novel iron (II) preferring dopamine agonist chelator D-607 significantly suppresses α-syn- and MPTP-induced toxicities in vivo.
Nicotine promotes blood retinal barrier damage in a model of human diabetic macular edema.
Evaluation of xenogeneic extracellular matrix fabricated from CuCl2-conditioned mesenchymal stem cell sheets as a bioactive wound dressing material.
BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells.
Bi-directionally protective communication between neurons and astrocytes under ischemia.
Janus kinase 3 regulates adherens junctions and epithelial mesenchymal transition through β-catenin.
Daam2 driven degradation of VHL promotes gliomagenesis.
Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/IP-10 and abrogation of HIF activity in soft tissue sarcomas.
Oligomer procyanidins (F2) repress HIF-1α expression in human U87 glioma cells by inhibiting the EGFR/ AKT/mTOR and MAPK/ERK1/2 signaling pathways in vitro and in vivo.
Targeting MTA1/HIF-1α signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression.
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.
HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma.
Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells.
Caffeic acid phenethyl ester promotes haematopoietic stem/progenitor cell homing and engraftment.
Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells.
Low Dose Radiation Causes Skin Cancer in Mice and Has a Differential Effect on Distinct Epidermal Stem Cells.
PACAP and VIP Inhibit HIF-1α-Mediated VEGF Expression in a Model of Diabetic Macular Edema.
Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways.
Acute intermittent hypoxia in rats activates muscle proteolytic pathways through a gluccorticoid-dependent mechanism.
Implication of VHL, ERK5, and HIF-1alpha in clear cell renal cell carcinoma: Molecular basis.
CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis.
Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis.
Brain-Derived Neurotrophic Factor Loaded PS80 PBCA Nanocarrier for In Vitro Neural Differentiation of Mouse Induced Pluripotent Stem Cells.
Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma.
Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression.
Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells.
Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.
The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis.
Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations.
ASK1 regulates the survival of neuroblastoma cells by interacting with TLX and stabilizing HIF-1α.
Expression of hypoxia-inducible factor-1α in synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis.
Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer.
Broad-Spectrum Inhibition of the CC-Chemokine Class Improves Wound Healing and Wound Angiogenesis.
PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes.
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis.
Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.
Photoacoustic imaging for in vivo quantification of placental oxygenation in mice.
Bisphenol A induces proliferative effects on both breast cancer cells and vascular endothelial cells through a shared GPER-dependent pathway in hypoxia.
Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways.
Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.
Antifibrotic effects of cyclosporine A on TGF-β1-treated lung fibroblasts and lungs from bleomycin-treated mice: role of hypoxia-inducible factor-1α.
Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer.
TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.
The hypoxia-inducible factors HIF1α and HIF2α are dispensable for embryonic muscle development but essential for postnatal muscle regeneration.
Deletion of hypoxia-inducible factor-1α in myeloid lineage exaggerates angiotensin II-induced formation of abdominal aortic aneurysm.
Enhancement of early cardiac differentiation of dedifferentiated fat cells by dimethyloxalylglycine via notch signaling pathway.
PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression.
MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma.
The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia.
Erythropoietin and a nonerythropoietic peptide analog promote aortic endothelial cell repair under hypoxic conditions: role of nitric oxide.
Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α Pathway.
Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats.
Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy.
Immunomodulatory effect of captopril and local irradiation on myeloid-derived suppressor cells.
Differential KrasV12 protein levels control a switch regulating lung cancer cell morphology and motility.
Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2.
Analysis of a Nitroreductase-Based Hypoxia Sensor in Primary Neuronal Cultures.
Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS.
High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I.
MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer.
Zinc Attenuates Tubulointerstitial Fibrosis in Diabetic Nephropathy Via Inhibition of HIF Through PI-3K Signaling.
Impact of macrophages on tumor growth characteristics in a murine ocular tumor model.
24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development.
Transcription Factor HIF-1α Controls Expression of the Cytokine IL-22 in CD4 T Cells.
Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.
Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury.
Expression of glucose transporter-1 is correlated with hypoxia-inducible factor 1α and malignant potential in pancreatic neuroendocrine tumors.
Targeting renal cell carcinoma with a HIF-2 antagonist.
Relevance of microRNA-18a and microRNA-199a-5p to hepatocellular carcinoma recurrence after living donor liver transplantation.
c-MYC inhibition impairs hypoxia response in glioblastoma multiforme.
Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis.
Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons.
Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression.
Estradiol, TGF-β1 and hypoxia promote breast cancer stemness and EMT-mediated breast cancer migration.
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.
Parkin modulates expression of HIF-1α and HIF-3α during hypoxia in gliobastoma-derived cell lines in vitro.
CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma.
Hypoxia Potentiates Anabolic Effects of Exogenous Hyaluronic Acid in Rat Articular Cartilage.
Oxygen as a chemoattractant: confirming cellular hypoxia in paper-based invasion assays.
Zinc finger protein 91 (ZFP91) activates HIF-1α via NF-κB/p65 to promote proliferation and tumorigenesis of colon cancer.
Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity.
Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts.
Propofol but not sevoflurane prevents mitochondrial dysfunction and oxidative stress by limiting HIF-1α activation in hepatic ischemia/reperfusion injury.
Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions.
Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia-Inducible Factor 1-α (HIF1-α) in an Ovine Model of Acute Myocardial Infarction.
Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected with Histoplasma capsulatum.
Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy.
Apelin as a marker for monitoring the tumor vessel normalization window during antiangiogenic therapy.
Monoamine oxidase B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1α and with transcription factors Sp1 and Sp3.
MicroRNA 211 Functions as a Metabolic Switch in Human Melanoma Cells.
An ID2-dependent mechanism for VHL inactivation in cancer.
Hypoxia inducible factor-1 mediates upregulation of urokinase-type plasminogen activator receptor gene transcription during hypoxia in cervical cancer cells.
Detection and identification of protein citrullination in complex biological systems.
Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer.
Role of deltaNp63(pos)CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas.
Regulation of glucose metabolism by p62/SQSTM1 through HIF1α.
Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion.
A Chemokine Receptor, CXCR4, Which Is Regulated by Hypoxia-Inducible Factor 2α, Is Crucial for Functional Endothelial Progenitor Cells Migration to Ischemic Tissue and Wound Repair.
Inhibition of Prolyl Hydroxylase Attenuates Fas Ligand-Induced Apoptosis and Lung Injury in Mice.
(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells.
Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia.
Expression of hypoxia-inducible factor-1α affects tumor proliferation and antiapoptosis in surgically resected lung cancer.
Sphingosine 1‑phosphate induced by hypoxia increases the expression of PAI‑1 in HepG2 cells via HIF‑1α.
Sprouty2 Protein Regulates Hypoxia-inducible Factor-α (HIFα) Protein Levels and Transcription of HIFα-responsive Genes.
GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis.
PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis.
Upregulating Hif-1α by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound.
Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers.
Bortezomib enhances the radiosensitivity of hypoxic cervical cancer cells by inhibiting HIF-1α expression.
Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells.
Danshen improves damaged cardiac angiogenesis and cardiac function induced by myocardial infarction by modulating HIF1α/VEGFA signaling pathway.
Nek6 and Hif-1α cooperate with the cytoskeletal gateway of drug resistance to drive outcome in serous ovarian cancer.
A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway.
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
Attenuation of choroidal neovascularization by histone deacetylase inhibitor.
Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival.
Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to ¹⁸F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors.
Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice.
HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression.
Overexpression of hypoxia-inducible factor prolyl hydoxylase-2 attenuates hypoxia-induced vascular endothelial growth factor expression in luteal cells.
MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury.
Reactive oxygen species production has a critical role in hypoxia-induced Stat3 activation and angiogenesis in human glioblastoma.
Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1α in cancer cells.
Gene expression profiling of changes induced by maternal diabetes in the embryonic heart.
Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation.
Loss of Siah2 does not impact angiogenic potential of murine endothelial cells.
Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma.
Caffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1α signaling pathways in human retinal pigment epithelial cells under hypoxic conditions.
Hypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia.
Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes.
Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation.
FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation.
HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells.
High nuclear hypoxia-inducible factor 1 alpha expression is a predictor of distant recurrence in patients with resected pancreatic adenocarcinoma.
Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1α.
IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection.
A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules.
E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity.
3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1α and NF-κB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions.
SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia.
Oxygen-regulated gene expression in murine cumulus cells.
Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity.
Only very early oxygen therapy attenuates posthemorrhagic edema formation and blood-brain barrier disruption in murine intracerebral hemorrhage.
RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model.
Priming Wharton's jelly-derived mesenchymal stromal/stem cells with ROCK inhibitor improves recovery in an intracerebral hemorrhage model.
Enhanced hypoxia-inducible factor (HIF)-1α stability induced by 5-hydroxymethyl-2-furfural (5-HMF) contributes to protection against hypoxia.
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model.
3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma.
Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors.
High-intensity interval training-induced metabolic adaptation coupled with an increase in Hif-1α and glycolytic protein expression.
Hypoxia inducible factor 1α down regulates cell surface expression of α1,2-fucosylated glycans in human pancreatic adenocarcinoma cells.
An innovative three-dimensional gelatin foam culture system for improved study of glioblastoma stem cell behavior.
The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe.
A PKM2 signature in the failing heart.
BRCA1 induces major energetic metabolism reprogramming in breast cancer cells.
Important role of autophagy in endothelial cell response to ionizing radiation.
HIF1α and HIF2α exert distinct nutrient preferences in renal cells.
Clinical and prognostic significance of HIF-1α, PTEN, CD44v6, and survivin for gastric cancer: a meta-analysis.
Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm.
Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction.
The prolyl hydroxylase inhibitor dimethyloxalylglycine enhances dentin sialophoshoprotein expression through VEGF-induced Runx2 stabilization.
The vitamin D analogue ED71 but Not 1,25(OH)2D3 targets HIF1α protein in osteoclasts.
Severe blunt muscle trauma in rats: only marginal hypoxia in the injured area.
The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme.
High glucose activates ChREBP-mediated HIF-1α and VEGF expression in human RPE cells under normoxia.
Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment.
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments.
Stem cell niches in glioblastoma: a neuropathological view.
Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).
Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone.
Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1α/OATPs signaling axis.
Influence of preoperative transcatheter arterial chemoembolization on gene expression in the HIF-1α pathway in patients with hepatocellular carcinoma.
HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth.
Hypoxia-induced miR-210 modulates tissue response to acute peripheral ischemia.
PCB 126 perturbs hypoxia-induced HIF-1α activity and glucose consumption in human HepG2 cells.
Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression.
Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α.
HIF-1 alpha-induced up-regulation of miR-9 contributes to phenotypic modulation in pulmonary artery smooth muscle cells during hypoxia.
Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice.
Hypoxia-inducible factor-1α upregulation in microglia following hypoxia protects against ischemia-induced cerebral infarction.
SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1α-dependent pathway.
Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation.
Augmentation of LPS-induced vascular endothelial cell growth factor production in macrophages by transforming growth factor-β1.
Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion.
Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1.
Prolyl hydroxylase inhibitors protect from the bone loss in ovariectomy rats by increasing bone vascularity.
Dynamic hypoxia in scar tissue during human hypertrophic scar progression.
Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response.
Noninvasive assessment of hypoxia in rabbit advanced atherosclerosis using ¹⁸F-fluoromisonidazole positron emission tomographic imaging.
Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation.
EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300.
Epidermal deletion of HIF-2α stimulates wound closure.
Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axis.
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.
Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease.
Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression.
Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight.
Elevated protein carbonyl and HIF-1α levels in eyes with proliferative diabetic retinopathy.
HIF-2α/ARNT complex regulates hair development via induction of p21(Waf1/Cip1) and p27(Kip1).
β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α.
Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells.
Disruption of chaperone-mediated autophagy-dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization.
Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia.
Sox9 and Hif-2α regulate TUBB3 gene expression and affect ovarian cancer aggressiveness.
Overexpression of hypoxia-inducible factor-1α is a predictor of poor prognosis in cervical cancer: a clinicopathologic study and a meta-analysis.
HIF-1α, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia.
Hypoxia-inducible factor-1α and its role in the proliferation of retinoblastoma cells.
The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP-protein kinase A signalling pathway in white adipose tissue.
Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts.
Expression of hypoxia-inducible factor-1α, vascular endothelial growth factor and prolyl hydroxylase domain protein 2 in cutaneous squamous cell carcinoma and precursor lesions and their relationship with histological stages and clinical features.
DMOG ameliorates IFN-γ-induced intestinal barrier dysfunction by suppressing PHD2-dependent HIF-1α degradation.
High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α.
Preoperative dynamic contrast-enhanced MRI correlates with molecular markers of hypoxia and vascularity in specific areas of intratumoral microenvironment and is predictive of patient outcome.
The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells.
Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation.
Hyperoxia inhibits glucose-induced insulin secretion and mitochondrial metabolism in rat pancreatic islets.
Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus.
Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke.
Molecular changes in bone marrow, tumor and serum after conductive ablation of murine 4T1 breast carcinoma.
GDNF increases cell motility in human colon cancer through VEGF-VEGFR1 interaction.
Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression.
Partial deficiency of HIF-1α stimulates pathological cardiac changes in streptozotocin-induced diabetic mice.
MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells.
A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection.
Anthrax lethal toxin inhibits translation of hypoxia-inducible factor 1α and causes decreased tolerance to hypoxic stress.
Upregulation of HIF-1α via activation of ERK and PI3K pathway mediated protective response to microwave-induced mitochondrial injury in neuron-like cells.
Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells.
Connexin 43 suppresses tumor angiogenesis by down-regulation of vascular endothelial growth factor via hypoxic-induced factor-1α.
Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells.
Expression of HIF-1α and MDR1/P-glycoprotein in refractory mesial temporal lobe epilepsy patients and pharmacoresistant temporal lobe epilepsy rat model kindled by coriaria lactone.
Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1) dependent mechanism.
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α.
Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency.
Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 α in lung tumor.
Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling.
Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α.
Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype.
Proteomic screening of human targets of viral microRNAs reveals functions associated with immune evasion and angiogenesis.
Convergent RANK- and c-Met-mediated signaling components predict survival of patients with prostate cancer: an interracial comparative study.
Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort.
STAT3 or USF2 contributes to HIF target gene specificity.
Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis.
Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma.
Melittin suppresses HIF-1α/VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical carcinoma cells.
Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.
Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells.
Hypoxia and hypoxia mimetics decrease aquaporin 5 (AQP5) expression through both hypoxia inducible factor-1α and proteasome-mediated pathways.
Metformin as an adjuvant drug against pediatric sarcomas: hypoxia limits therapeutic effects of the drug.
Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1α.
Hyperoxia exposure impairs nephrogenesis in the neonatal rat: role of HIF-1α.
Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis.
Mitochondrial respiration regulates adipogenic differentiation of human mesenchymal stem cells.
Clinicopathological implications of the expression of hypoxia-related proteins in gastric cancer.
Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation.
Impaired cytoplasmic-nuclear transport of hypoxia-inducible factor-1α in amyotrophic lateral sclerosis.
HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
Measurement of cell respiration and oxygenation in standard multichannel biochips using phosphorescent O2-sensitive probes.
Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells.
MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors.
Role of hepatic resident and infiltrating macrophages in liver repair after acute injury.
Correlation between ¹⁸F-FDG uptake and the expression of glucose transporter-1 and hypoxia-inducible factor-1α in transplanted VX2 tumors.
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis.
Expression of hypoxia-inducible factor-1α and vascular density in mammary adenomas and adenocarcinomas in bitches.
Tumor cells upregulate normoxic HIF-1α in response to doxorubicin.
Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells.
Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics.
Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics.
Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo.
Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype.
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function.
EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate.
Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma.
Effect of advanced glycation end products on the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor proteins in RF/6A cells.
Siah2-deficient mice show impaired skin wound repair.
Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression.
The histone demethylase JMJD1A regulates adrenomedullin-mediated cell proliferation in hepatocellular carcinoma under hypoxia.
Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex.
Glucose transporter 1 (GLUT1) of anaerobic glycolysis as predictive and prognostic values in neoadjuvant chemoradiotherapy and laparoscopic surgery for locally advanced rectal cancer.
Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007.
Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice.
Protective role of growth hormone against hyperhomocysteinemia-induced glomerular injury.
Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes.
Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer.
Hypoxia-induced regulation of the very low density lipoprotein receptor.
Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues.
Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.
Effects of oxygen tension and IGF-I on HIF-1α protein expression in mouse blastocysts.
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.
Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1α-related defense mechanisms.
The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb.
Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α.
Hypoxia inducible factor-1α-mediated activation of survivin in cervical cancer cells.
Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells.
MicroRNA-183 upregulates HIF-1α by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells.
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients.
HNF4α contributes to glucose formation in aged rat hepatocytes.
MiR-199a suppresses the hypoxia-induced proliferation of non-small cell lung cancer cells through targeting HIF1α.
Overexpression of hypoxia inducible factor-1 alpha is an independent risk factor for recurrence after curative resection of colorectal liver metastases.
Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas.
The presence of adenosine A2a receptor in thyrocytes and its involvement in Graves' IgG-induced VEGF expression.
Simvastatin reduces venous stenosis formation in a murine hemodialysis vascular access model.
Macrophages transmit potent proangiogenic effects of oxLDL in vitro and in vivo involving HIF-1α activation: a novel aspect of angiogenesis in atherosclerosis.
Integrated molecular analysis of clear-cell renal cell carcinoma.
Characterization of biological features of a rat F98 GBM model: a PET-MRI study with [18F]FAZA and [18F]FDG.
Phospho-Rb (Ser780) as a biomarker in patients with cervical lymph node metastases from an unknown primary tumour: a retrospective cohort study.
miR-210 regulates the interaction between pancreatic cancer cells and stellate cells.
Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia.
MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α.
Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model.
Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis.
Echinomycin in the prevention of heterotopic ossification - an experimental antibiotic agent shows promising results in a murine model.
In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli.
DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.
Hyperglycaemia is associated with impaired vasa vasorum neovascularization and accelerated atherosclerosis in apolipoprotein-E deficient mice.
C/EBP homologous binding protein (CHOP) underlies neural injury in sleep apnea model.
Epo deficiency alters cardiac adaptation to chronic hypoxia.
Expression of MUC17 is regulated by HIF1α-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer.
Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.
The importance of GLUT3 for de novo lipogenesis in hypoxia-induced lipid loading of human macrophages.
Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage.
Soluble epoxide hydrolase activity determines the severity of ischemia-reperfusion injury in kidney.
Suppression of experimental choroidal neovascularization by curcumin in mice.
A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer.
HIF-1α inhibition reduces nasal inflammation in a murine allergic rhinitis model.
Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process.
The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells.
Dry needling at myofascial trigger spots of rabbit skeletal muscles modulates the biochemicals associated with pain, inflammation, and hypoxia.
Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors.
The role of androgens on hypoxia-inducible factor (HIF)-1α-induced angiogenesis and on the survival of ischemically challenged skin flaps in a rat model.
Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG.
Impaired response of hypoxic sensor protein HIF-1α and its downstream proteins in the spinal motor neurons of ALS model mice.
Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury: possible involvements in hypoxia-inducible factor 1α (HIF-1α).
Glucotoxicity induces glucose-6-phosphatase catalytic unit expression by acting on the interaction of HIF-1α with CREB-binding protein.
Role of FDG-PET as a biological marker for predicting the hypoxic status of tongue cancer.
Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1.
IL-1β-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway.
The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1α mRNA stability.
Effect of trifluoperazine on toxicity, HIF-1α induction and hepatocyte regeneration in acetaminophen toxicity in mice.
A validated regulatory network for Th17 cell specification.
N-acetylcysteine protects against hypoxia mimetic-induced autophagy by targeting the HIF-1α pathway in retinal ganglion cells.
Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.
Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle.
Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension.
Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy.
Increased activation of the hypoxia-inducible factor pathway in varicose veins.
Effects of oxygen on zonal marker expression in human articular chondrocytes.
Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis.
Effects of hypoxic preconditioning on the expression of iron influx and efflux proteins in primary neuron culture.
Role of histone deacetylase expression in intrahepatic cholangiocarcinoma.
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.
Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through HIF-1α pathway.
Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis.
HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function.
Expression of cardiac GATA4 and downstream genes after exercise training in the db/db mouse.
Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma.
Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma.
Angiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats.
Predicting outcomes of patients with intracranial meningiomas using molecular markers of hypoxia, vascularity, and proliferation.
Hypoxia-inducible factor-1-regulated protein expression and oligodendroglioma patient outcome: comparison with established biomarkers and preoperative UCSF low-grade scoring system.
Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α.
Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung.
Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury.
Rapamycin decreases survivin expression to induce NSCLC cell apoptosis under hypoxia through inhibiting HIF-1α induction.
Uremia induces functional incompetence of bone marrow-derived stromal cells.
Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury.
A myeloid hypoxia-inducible factor 1α-Krüppel-like factor 2 pathway regulates gram-positive endotoxin-mediated sepsis.
Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.
Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism.
Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis.
Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells.
Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21.
Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling.
Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1α via activation of PGE(2)-cAMP signaling.
Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts.
Hypoxia-inducible factor 1-α induces miR-210 in normoxic differentiating myoblasts.
Hypoxia and HIF-1 increase S100A8 and S100A9 expression in prostate cancer.
Nicotinic modulation of therapeutic response in vitro and in vivo.
Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensing.
Correlation of a priori DCE-MRI and (1)H-MRS data with molecular markers in neck nodal metastases: Initial analysis.
Liposome-encapsulated hemoglobin attenuates cardiac dysfunction and sympathetic activity during hypohemoglobinemic shock.
Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors.
Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging.
Low density lipoprotein receptor-related protein 1 expression correlates with cholesteryl ester accumulation in the myocardium of ischemic cardiomyopathy patients.
NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme.
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.
A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration.
Assessment of stanniocalcin-1 as a prognostic marker in human esophageal squamous cell carcinoma.
Hypoxic preconditioning increases iron transport rate in astrocytes.
Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas.
Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice.
Iron facilitator LS081 reduces hypoxia-inducible factor-1α protein and functions as anticancer agent in hepatocellular carcinoma.
Differential impact of EGFR-targeted therapies on hypoxia responses: implications for treatment sensitivity in triple-negative metastatic breast cancer.
NADPH oxidase subunit 4-mediated reactive oxygen species contribute to cycling hypoxia-promoted tumor progression in glioblastoma multiforme.
Intermittent hypoxia after transient focal ischemia induces hippocampal neurogenesis and c-Fos expression and reverses spatial memory deficits in rats.
Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis.
Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation.
EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate.
Hypoxia inducible factor expression in intrahepatic cholangiocarcinoma.
Trichinella spiralis infection induces angiogenic factor thymosin β4 expression.
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis.
Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds.
The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: pathological consideration of their potential roles.
Crohn disease-associated Escherichia coli promote gastrointestinal inflammatory disorders by activation of HIF-dependent responses.
Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD).
Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia.
Role of hypoxia-inducible factors in the dexrazoxane-mediated protection of cardiomyocytes from doxorubicin-induced toxicity.
Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells.
Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.
NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.
Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition.
Hypoxia-inducible factor 1α expression is a prognostic biomarker in patients with astrocytic tumors associated with necrosis on MR image.
Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats.
Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells.
Shedding of Epstein-Barr virus and cytomegalovirus from the genital tract of women in a periurban community in Andhra Pradesh, India.
Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats.
Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?
NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α.
Identification of a mechanism underlying regulation of the anti-angiogenic forkhead transcription factor FoxO1 in cultured endothelial cells and ischemic muscle.
Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase.
Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression.
Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss.
Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse.
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.
Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1α in mouse hepatocytes.
Wnt-β-catenin signaling protects against hepatic ischemia and reperfusion injury in mice.
Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors.
Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94.
Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro.
Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer.
Hypoxia-inducible factors: post-translational crosstalk of signaling pathways.
Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2α.
HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy.
Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role.
Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis.
Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression.
PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2.
Suppression of cyclin D1 by hypoxia-inducible factor-1 via direct mechanism inhibits the proliferation and 5-fluorouracil-induced apoptosis of A549 cells.
Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study.
Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization.
Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia.
p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast cancer cells.
Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay.
Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay.
Double immunohistochemical staining method for HIF-1alpha and its regulators PHD2 and PHD3 in formalin-fixed paraffin-embedded tissues.
Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury.
Hypoxia-inducible factor-1alpha regulates the expression of nucleotide excision repair proteins in keratinocytes.
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
HIF-1α Promotes A Hypoxia-Independent Cell Migration.
Hypoxia is important for establishing vascularization during corpus luteum formation in cattle.
Hypoxia is important for establishing vascularization during corpus luteum formation in cattle.
Human nephrosclerosis triggers a hypoxia-related glomerulopathy.
Clinicopathological implications of expressions of hypoxia-related molecules in esophageal superficial squamous cell carcinoma.
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.
Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP.
Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes.
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells.
Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade.
Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage.
mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition.
Pharmacological stimulation of soluble guanylate cyclase modulates hypoxia-inducible factor-1alpha in rat heart.
Hypoxia-inducible factor-1alpha expression predicts the response to 5-fluorouracil-based adjuvant chemotherapy in advanced gastric cancer.
Hypoxia-inducible factor-1alpha expression predicts the response to 5-fluorouracil-based adjuvant chemotherapy in advanced gastric cancer.
TSC2 deficiency increases PTEN via HIF1alpha.
Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response.
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization.
Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation.
Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury.
Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance.
Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons.
Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing.
The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity.
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells.
Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression.
Regulation of thioredoxin by ceramide in retinal pigment epithelial cells.
Hypoxia-regulated activity of PKCepsilon in the lens.
Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia.
Molecular signatures of localized clear cell renal cell carcinoma to predict disease-free survival after nephrectomy.
Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity.
Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression.
Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible factor pathway.
Hyperglycemia-enhanced ischemic brain damage in mutant manganese SOD mice is associated with suppression of HIF-1alpha.
Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition.
Signaling by hypoxia-inducible factors is critical for ovulation in mice.
Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.
mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.
Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium.
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.
MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression.
Magnesium deficiency causes loss of response to intermittent hypoxia in paraganglion cells.
A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak.
Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma.
Hypoxia decreases insulin signaling pathways in adipocytes.
The prognostic value of hypoxia markers in T2-staged oral tongue cancer.
Increased renal adrenomedullin expression in rats with ureteral obstruction.
IFATS collection: Adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia.
Adventitial transplantation of blood outgrowth endothelial cells in porcine haemodialysis grafts alleviates hypoxia and decreases neointimal proliferation through a matrix metalloproteinase-9-mediated pathway--a pilot study.
Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.
Effect of hypoxia on the expression of phosphoglycerate kinase and antitumor activity of troxacitabine and gemcitabine in non-small cell lung carcinoma.
Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression.
Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone.
HIF-1alpha-dependent gene expression program during the nucleic acid-triggered antiviral innate immune responses.
IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain.
A HIF-1alpha-dependent autocrine feedback loop promotes survival of serum-deprived prostate cancer cells.
Cytogenetic and molecular tumor profiling for type 1 and type 2 papillary renal cell carcinoma.
Construction of mutant TKGFP for real-time imaging of temporal dynamics of HIF-1 signal transduction activity mediated by hypoxia and reoxygenation in tumors in living mice.
Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia.
Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan.
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.
Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.
Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3.
Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity.
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy.
GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis.
Hypoxia stimulates via separate pathways ERK phosphorylation and NF-kappaB activation in skeletal muscle cells in primary culture.
Protection of retinal cells from ischemia by a novel gap junction inhibitor.
Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.
Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation.
Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney.
The C1772T genetic polymorphism in human HIF-1alpha gene associates with expression of HIF-1alpha protein in breast cancer.
PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress.
Molecular angiogenic signaling in angiofibromas after embolization: implications for therapy.
Divergent effects of hypoxia on dendritic cell functions.
HIV-1 upregulates VEGF in podocytes.
Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family.
Hypoxia-stimulated vascular endothelial growth factor production in human nasal polyp fibroblasts: effect of epigallocatechin-3-gallate on hypoxia-inducible factor-1 alpha synthesis.
Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1alpha in the renal medulla.
AMP-activated protein kinase is essential for survival in chronic hypoxia.
Clinicopathologic significance of HIF-1alpha, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer.
Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia.
Metallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1alpha.
Spironolactone suppresses peritubular capillary loss and prevents deoxycorticosterone acetate/salt-induced tubulointerstitial fibrosis.
Inhibition of bFGF-receptor type 2 increases kidney damage and suppresses nephrogenic protein expression after ischemic acute renal failure.
HIF activation protects from acute kidney injury.
Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection.
A possible role for hypoxia-induced apelin expression in enteric cell proliferation.
Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor.
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling.
Prognostic values of pathologic findings and hypoxia markers in 21 patients with salivary duct carcinoma.
Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia.
Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia.
Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals.
ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo.
The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma.
Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation.
Placental HIFs as markers of cerebral hypoxic distress in fetal mice.
Hypoxia-inducible factor-1alpha protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression.
mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha.
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.
The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells.
Glomerular endothelium in kidneys with congenital nephrotic syndrome of the Finnish type (NPHS1).
Evidence for sustained renal hypoxia and transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury.
HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus.
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
High-fat, high-sucrose, and high-cholesterol diets accelerate tumor growth and metastasis in tumor-bearing mice.
Improved nuclear localization of DNA-binding polyamides.
Acute hypobaric hypoxia (5486 m) induces greater pulmonary HIF-1 activation in hilltop compared to madison rats.
The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine.
The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling.
Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair.
Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells.
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.
Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway.
Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo.
Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model.
Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency.
Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1alpha, and C/EBPalpha.
Involvement of hypoxia-inducible transcription factors in polycystic kidney disease.
Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning.
Hypoxia-inducible transcription factor-1 alpha determines sensitivity of endothelial cells to the proteosome inhibitor bortezomib.
Hypoxia inducible factor regulates the cardiac expression and secretion of apelin.
The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.
Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy.
Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia.
Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats.
Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells.
Immunohistochemical detection of hypoxia-inducible factor-1alpha in human renal allograft biopsies.
Hypoxic regulation of Id-1 and activation of the unfolded protein response are aberrant in neuroblastoma.
Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2.
Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization.
Insulin-induced activation of hypoxia-inducible factor-1 requires generation of reactive oxygen species by NADPH oxidase.
Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221.
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.
Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization.
Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms.
Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.
Hypoxia-inducible factors in the first trimester human lung.
Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney.
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer.
Pressure gradients and transport in the murine femur upon hindlimb suspension.
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Oxygen concentration is an important factor for modulating progesterone synthesis in bovine corpus luteum.
Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy.
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells.
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.
Overexpression of hypoxia-inducible factor 1alpha and p53 is a marker for an unfavorable prognosis in gastric cancer.
Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone.
Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice.
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes.
Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes.
Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response.
HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells.
Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.
Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures.
Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha.
Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis.
Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis.
Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension.
Calcium signaling stimulates translation of HIF-alpha during hypoxia.
EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms.
Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1.
A constitutively active hypoxia-inducible factor-1alpha/VP16 hybrid factor activates expression of the human B-type natriuretic peptide gene.
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation.
White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.
Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia.
Activation of hypoxia-inducible factor 1 during macrophage differentiation.
Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure.
Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
Synergistic effects of CoCl(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells.
Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice.
Essential role of B-Raf in ERK activation during extraembryonic development.
Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation.
Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia.
Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.
Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1alpha variant for local induction of angiogenesis.
Expression of hypoxia-inducible factor (HIF)-1alpha as a biomarker of outcome in soft-tissue sarcomas.
bFGF induces an earlier expression of nephrogenic proteins after ischemic acute renal failure.
Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.
Relationship of hypoxia-inducible factor 1alpha and p21WAF1/CIP1 expression to cell apoptosis and clinical outcome in patients with gastric cancer.
Hypoxia and expression of hypoxia-inducible factor in the aging kidney.
Hypoxia and expression of hypoxia-inducible factor in the aging kidney.
Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia.
Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic renal ischemia.
Estrogen induces angiogenesis of the female rabbit bladder.
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels.
Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.
Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.
Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins.
Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility.
Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia.
Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer.
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity.
Up-regulation of c-met protooncogene product expression through hypoxia-inducible factor-1alpha is involved in trophoblast invasion under low-oxygen tension.
Expression of hypoxia-inducible factor-1alpha in esophageal squamous cell carcinoma.
Adaptive responses to mitochondrial dysfunction in the rho degrees Namalwa cell.
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor.
Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line.
Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo: estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter.
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.
Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells.
Genistein inhibited retinal neovascularization and expression of vascular endothelial growth factor and hypoxia inducible factor 1alpha in a mouse model of oxygen-induced retinopathy.
A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells.
Determination of the role of hypoxia-inducible factor 1 in wound healing.
Carotid chemodenervation approach to study oxygen sensing in brain stem catecholaminergic cells.
Protocol of radiotherapy for glioblastoma according to the expression of HIF-1.
Protocol of radiotherapy for glioblastoma according to the expression of HIF-1.
Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia.
Hypoxia-inducible factor-1 transactivates transforming growth factor-beta3 in trophoblast.
Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head.
c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism.
Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species.
Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene.
Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways.
Expression and localization of hypoxia-inducible factor-1 subunits in the adult rat epididymis.
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.
HIF-1-mediated activation of telomerase in cervical cancer cells.
Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.
Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells.
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression.
Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression.
Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium.
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer.
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis.
Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis.
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.
Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription.
Hypoxia reduces hormone responsiveness of human breast cancer cells.
Hypoxia reduces hormone responsiveness of human breast cancer cells.
DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance.
DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance.
Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy.
Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis.
Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis.
HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha.
Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem.
Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem.
Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite.
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer.
Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells.
Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells.
Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha.
Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha.
Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
Aging persons' estimates of vehicular motion.
Aging persons' estimates of vehicular motion.
Tang SY, Liu DX, Li Y, Wang KJ, Wang XF, Su ZK, Fang WG, Qin XX, Wei JY, Zhao WD, Chen YH
Frontiers in molecular neuroscience 2020;13:23
Frontiers in molecular neuroscience 2020;13:23
A Chinese Herbal Formula Suppresses Colorectal Cancer Migration and Vasculogenic Mimicry Through ROS/HIF-1α/MMP2 Pathway in Hypoxic Microenvironment.
Zong S, Tang Y, Li W, Han S, Shi Q, Ruan X, Hou F
Frontiers in pharmacology 2020;11:705
Frontiers in pharmacology 2020;11:705
The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma.
Chen L, Wang Z, Xu Q, Liu Y, Chen L, Guo S, Wang H, Zeng K, Liu J, Zeng S, Yu L
Theranostics 2020;10(8):3562-3578
Theranostics 2020;10(8):3562-3578
The secretome of human dental pulp stem cells protects myoblasts from hypoxia‑induced injury via the Wnt/β‑catenin pathway.
Zhang W, Yu L, Han X, Pan J, Deng J, Zhu L, Lu Y, Huang W, Liu S, Li Q, Liu Y
International journal of molecular medicine 2020 May;45(5):1501-1513
International journal of molecular medicine 2020 May;45(5):1501-1513
Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury.
Torigoe K, Obata Y, Torigoe M, Oka S, Yamamoto K, Koji T, Ueda H, Mukae H, Nishino T
Clinical and experimental nephrology 2020 May;24(5):411-419
Clinical and experimental nephrology 2020 May;24(5):411-419
Hypoxia-Inducible Factor 1α (HIF-1α) Counteracts the Acute Death of Cells Transplanted into the Injured Spinal Cord.
David BT, Curtin JJ, Goldberg DC, Scorpio K, Kandaswamy V, Hill CE
eNeuro 2020 May Jun;7(3)
eNeuro 2020 May Jun;7(3)
A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism.
Ho JJD, Balukoff NC, Theodoridis PR, Wang M, Krieger JR, Schatz JH, Lee S
Nature communications 2020 May 29;11(1):2677
Nature communications 2020 May 29;11(1):2677
Drp1-regulated PARK2-dependent mitophagy protects against renal fibrosis in unilateral ureteral obstruction.
Li S, Lin Q, Shao X, Zhu X, Wu J, Wu B, Zhang M, Zhou W, Zhou Y, Jin H, Zhang Z, Qi C, Shen J, Mou S, Gu L, Ni Z
Free radical biology & medicine 2020 May 20;152:632-649
Free radical biology & medicine 2020 May 20;152:632-649
Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages.
Ménégaut L, Thomas C, Jalil A, Julla JB, Magnani C, Ceroi A, Basmaciyan L, Dumont A, Le Goff W, Mathew MJ, Rébé C, Dérangère V, Laubriet A, Crespy V, Pais de Barros JP, Steinmetz E, Venteclef N, Saas P, Lagrost L, Masson D
Cell reports 2020 May 19;31(7):107665
Cell reports 2020 May 19;31(7):107665
MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis.
Chen YL, Sheu JJ, Sun CK, Huang TH, Lin YP, Yip HK
Molecular medicine (Cambridge, Mass.) 2020 May 14;26(1):46
Molecular medicine (Cambridge, Mass.) 2020 May 14;26(1):46
Intermittent hypoxia modulates redox homeostasis, lipid metabolism associated inflammatory processes and redox post-translational modifications: Benefits at high altitude.
Gangwar A, Paul S, Ahmad Y, Bhargava K
Scientific reports 2020 May 13;10(1):7899
Scientific reports 2020 May 13;10(1):7899
Increased fibrotic signaling in a murine model for intra-arterial contrast-induced acute kidney injury.
Sharma A, Kilari S, Cai C, Simeon ML, Misra S
American journal of physiology. Renal physiology 2020 May 1;318(5):F1210-F1219
American journal of physiology. Renal physiology 2020 May 1;318(5):F1210-F1219
HIF-1α (Hypoxia-Inducible Factor-1α) Promotes Macrophage Necroptosis by Regulating miR-210 and miR-383.
Karshovska E, Wei Y, Subramanian P, Mohibullah R, Geißler C, Baatsch I, Popal A, Corbalán Campos J, Exner N, Schober A
Arteriosclerosis, thrombosis, and vascular biology 2020 Mar;40(3):583-596
Arteriosclerosis, thrombosis, and vascular biology 2020 Mar;40(3):583-596
Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1.
Rajendran G, Schonfeld MP, Tiwari R, Huang S, Torosyan R, Fields T, Park J, Susztak K, Kapitsinou PP
Journal of the American Society of Nephrology : JASN 2020 Mar;31(3):501-516
Journal of the American Society of Nephrology : JASN 2020 Mar;31(3):501-516
Mechanism of the hypoxia inducible factor 1/hypoxic response element pathway in rat myocardial ischemia/diazoxide post‑conditioning.
Li J, Zhou W, Chen W, Wang H, Zhang Y, Yu T
Molecular medicine reports 2020 Mar;21(3):1527-1536
Molecular medicine reports 2020 Mar;21(3):1527-1536
Effects of antibodies against human parvovirus B19 on angiogenic signaling.
Su CC, Hsu TC, Hsiao CH, Chiu CC, Tzang BS
Molecular medicine reports 2020 Mar;21(3):1320-1327
Molecular medicine reports 2020 Mar;21(3):1320-1327
Progressive hypoxia-on-a-chip: An in vitro oxygen gradient model for capturing the effects of hypoxia on primary hepatocytes in health and disease.
Kang YBA, Eo J, Bulutoglu B, Yarmush ML, Usta OB
Biotechnology and bioengineering 2020 Mar;117(3):763-775
Biotechnology and bioengineering 2020 Mar;117(3):763-775
Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling.
Okada K, Mori D, Makii Y, Nakamoto H, Murahashi Y, Yano F, Chang SH, Taniguchi Y, Kobayashi H, Semba H, Takeda N, Piao W, Hanaoka K, Nagano T, Tanaka S, Saito T
Scientific reports 2020 Mar 25;10(1):5425
Scientific reports 2020 Mar 25;10(1):5425
MiR-375 Impairs the Invasive Capabilities of Hepatoma Cells by Targeting HIF1α Under Hypoxia.
Wang C, Luo J, Chen Z, Ye M, Hong Y, Liu J, Nie J, Zhao Q, Chang Y
Digestive diseases and sciences 2020 Mar 25;
Digestive diseases and sciences 2020 Mar 25;
Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis.
Barbosa DM, Fahlbusch P, Herzfeld de Wiza D, Jacob S, Kettel U, Al-Hasani H, Krüger M, Ouwens DM, Hartwig S, Lehr S, Kotzka J, Knebel B
Scientific reports 2020 Mar 17;10(1):4888
Scientific reports 2020 Mar 17;10(1):4888
Histone hyperacetylation mediates enhanced IL-1β production in LPS/IFN-γ-stimulated macrophages.
Dong Z, Li R, Xu L, Xin K, Xu Y, Shi H, Sun A, Ge J
Immunology 2020 Jun;160(2):183-197
Immunology 2020 Jun;160(2):183-197
Local delivery of cardiac stem cells overexpressing HIF-1α promotes angiogenesis and muscular tissue repair in a hind limb ischemia model.
Pei X, Kim H, Lee M, Wang N, Shin J, Lee S, Yoon M, Yang VC, He H
Journal of controlled release : official journal of the Controlled Release Society 2020 Jun 10;322:610-621
Journal of controlled release : official journal of the Controlled Release Society 2020 Jun 10;322:610-621
REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors.
Qiao S, Koh SB, Vivekanandan V, Salunke D, Patra KC, Zaganjor E, Ross K, Mizukami Y, Jeanfavre S, Chen A, Mino-Kenudson M, Ramaswamy S, Clish C, Haigis M, Bardeesy N, Ellisen LW
Genes & development 2020 Jun 1;34(11-12):751-766
Genes & development 2020 Jun 1;34(11-12):751-766
High-density lipoprotein remodelled in hypercholesterolaemic blood induce epigenetically driven down-regulation of endothelial HIF-1α expression in a preclinical animal model.
Ben-Aicha S, Escate R, Casaní L, Padró T, Peña E, Arderiu G, Mendieta G, Badimón L, Vilahur G
Cardiovascular research 2020 Jun 1;116(7):1288-1299
Cardiovascular research 2020 Jun 1;116(7):1288-1299
Fibroblast-specific ERK5 deficiency changes tumor vasculature and exacerbates tumor progression in a mouse model.
Imanishi M, Yamakawa Y, Fukushima K, Ikuto R, Maegawa A, Izawa-Ishizawa Y, Horinouchi Y, Kondo M, Kishuku M, Goda M, Zamami Y, Takechi K, Chuma M, Ikeda Y, Tsuchiya K, Fujino H, Tsuneyama K, Ishizawa K
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jul;393(7):1239-1250
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jul;393(7):1239-1250
Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.
Singh A, Wilson JW, Schofield CJ, Chen R
Scientific reports 2020 Jan 31;10(1):1597
Scientific reports 2020 Jan 31;10(1):1597
Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor.
Wu JY, Huang TW, Hsieh YT, Wang YF, Yen CC, Lee GL, Yeh CC, Peng YJ, Kuo YY, Wen HT, Lin HC, Hsiao CW, Wu KK, Kung HJ, Hsu YJ, Kuo CC
Molecular cell 2020 Jan 16;77(2):213-227.e5
Molecular cell 2020 Jan 16;77(2):213-227.e5
Glycaemic control in diabetic rats treated with islet transplantation using plasma combined with hydroxypropylmethyl cellulose hydrogel.
Schaschkow A, Sigrist S, Mura C, Barthes J, Vrana NE, Czuba E, Lemaire F, Neidl R, Dissaux C, Lejay A, Lavalle P, Bruant-Rodier C, Bouzakri K, Pinget M, Maillard E
Acta biomaterialia 2020 Jan 15;102:259-272
Acta biomaterialia 2020 Jan 15;102:259-272
Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling.
Madsen PM, Desu HL, de Rivero Vaccari JP, Florimon Y, Ellman DG, Keane RW, Clausen BH, Lambertsen KL, Brambilla R
Brain, behavior, and immunity 2020 Feb;84:132-146
Brain, behavior, and immunity 2020 Feb;84:132-146
Disturbance in the regulation of miR 17-92 cluster on HIF-1-α expression contributes to clinically relevant radioresistant cells: an in vitro study.
Roudkenar MH, Fukumoto M, Roushandeh AM, Kuwahra Y, Uroshihara Y, Harada H, Fukumoto M
Cytotechnology 2020 Feb;72(1):141-153
Cytotechnology 2020 Feb;72(1):141-153
The Expression of CNS-Specific PPARGC1A Transcripts Is Regulated by Hypoxia and a Variable GT Repeat Polymorphism.
Soyal SM, Bonova P, Kwik M, Zara G, Auer S, Scharler C, Strunk D, Nofziger C, Paulmichl M, Patsch W
Molecular neurobiology 2020 Feb;57(2):752-764
Molecular neurobiology 2020 Feb;57(2):752-764
NER-factor DDB2 regulates HIF1α and hypoxia-response genes in HNSCC.
Bommi PV, Chand V, Mukhopadhyay NK, Raychaudhuri P, Bagchi S
Oncogene 2020 Feb;39(8):1784-1796
Oncogene 2020 Feb;39(8):1784-1796
A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells.
Yoo HC, Park SJ, Nam M, Kang J, Kim K, Yeo JH, Kim JK, Heo Y, Lee HS, Lee MY, Lee CW, Kang JS, Kim YH, Lee J, Choi J, Hwang GS, Bang S, Han JM
Cell metabolism 2020 Feb 4;31(2):267-283.e12
Cell metabolism 2020 Feb 4;31(2):267-283.e12
HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma.
Courtney KD, Ma Y, Diaz de Leon A, Christie A, Xie Z, Woolford L, Singla N, Joyce A, Hill H, Madhuranthakam AJ, Yuan Q, Xi Y, Zhang Y, Chang J, Fatunde O, Arriaga Y, Frankel AE, Kalva S, Zhang S, McKenzie T, Reig Torras O, Figlin RA, Rini BI, McKay RM, Kapur P, Wang T, Pedrosa I, Brugarolas J
Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Feb 15;26(4):793-803
Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Feb 15;26(4):793-803
Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression.
Weng ML, Chen WK, Chen XY, Lu H, Sun ZR, Yu Q, Sun PF, Xu YJ, Zhu MM, Jiang N, Zhang J, Zhang JP, Song YL, Ma D, Zhang XP, Miao CH
Nature communications 2020 Apr 20;11(1):1869
Nature communications 2020 Apr 20;11(1):1869
Blood Oxygen Level-Dependent Imaging and Intravoxel Incoherent Motion MRI of Early Contrast-Induced Acute Kidney Injury in a Rabbit Model.
Wang Y, Zhang X, Hua Z, Xie L, Jiang X, Wang R, Gao P, Ren K
Kidney & blood pressure research 2019;44(4):496-512
Kidney & blood pressure research 2019;44(4):496-512
A Three-Dimensional Culture Model of Reversibly Quiescent Myogenic Cells.
Aguanno S, Petrelli C, Di Siena S, De Angelis L, Pellegrini M, Naro F
Stem cells international 2019;2019:7548160
Stem cells international 2019;2019:7548160
TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway.
Hong B, Zhou J, Ma K, Zhang J, Xie H, Zhang K, Li L, Cai L, Zhang N, Zhang Z, Gong K
International journal of biological sciences 2019;15(3):587-597
International journal of biological sciences 2019;15(3):587-597
The prognostic value of hypoxia-inducible factor-1α in advanced cancer survivors: a meta-analysis with trial sequential analysis.
Han S, Huang T, Hou F, Yao L, Wang X, Wu X
Therapeutic advances in medical oncology 2019;11:1758835919875851
Therapeutic advances in medical oncology 2019;11:1758835919875851
AMPK Inhibition Suppresses the Malignant Phenotype of Pancreatic Cancer Cells in Part by Attenuating Aerobic Glycolysis.
Hu M, Chen X, Ma L, Ma Y, Li Y, Song H, Xu J, Zhou L, Li X, Jiang Y, Kong B, Huang P
Journal of Cancer 2019;10(8):1870-1878
Journal of Cancer 2019;10(8):1870-1878
Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy.
Wang Y, Wang B, Qi X, Zhang X, Ren K
Frontiers in pharmacology 2019;10:833
Frontiers in pharmacology 2019;10:833
Involvement of A3 Adenosine Receptor in Neuroblastoma Progression via Modulation of the Hypoxic/Angiogenic Pathway.
Maugeri G, D'Amico AG, Federico C, Saccone S, Giunta S, Cavallaro S, D'Agata V
Journal of molecular neuroscience : MN 2019 Sep;69(1):166-176
Journal of molecular neuroscience : MN 2019 Sep;69(1):166-176
Evaluation of Venous Stenosis Angioplasty in a Murine Arteriovenous Fistula Model.
Cai C, Yang B, Kilari S, Li Y, Zhao C, Sharma A, Misra S
Journal of vascular and interventional radiology : JVIR 2019 Sep;30(9):1512-1521.e3
Journal of vascular and interventional radiology : JVIR 2019 Sep;30(9):1512-1521.e3
Metabolic regulation of gene expression by histone lactylation.
Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Ding J, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman HA, Dai L, Ren B, Roeder RG, Becker L, Zhao Y
Nature 2019 Oct;574(7779):575-580
Nature 2019 Oct;574(7779):575-580
Improved Motor Nerve Regeneration by SIRT1/Hif1a-Mediated Autophagy.
Romeo-Guitart D, Leiva-Rodriguez T, Forés J, Casas C
Cells 2019 Oct 30;8(11)
Cells 2019 Oct 30;8(11)
Oxidative stress-mediated TXNIP loss causes RPE dysfunction.
Ji Cho M, Yoon SJ, Kim W, Park J, Lee J, Park JG, Cho YL, Hun Kim J, Jang H, Park YJ, Lee SH, Min JK
Experimental & molecular medicine 2019 Oct 15;51(10):1-13
Experimental & molecular medicine 2019 Oct 15;51(10):1-13
Evaluation of iodine contrast-induced acute kidney injury via different injection routes using BOLD-MRI.
Wang Z, Ren K
Renal failure 2019 Nov;41(1):341-353
Renal failure 2019 Nov;41(1):341-353
A Hypoxia-Inducible HIF1-GAL3ST1-Sulfatide Axis Enhances ccRCC Immune Evasion via Increased Tumor Cell-Platelet Binding.
Robinson CM, Poon BPK, Kano Y, Pluthero FG, Kahr WHA, Ohh M
Molecular cancer research : MCR 2019 Nov;17(11):2306-2317
Molecular cancer research : MCR 2019 Nov;17(11):2306-2317
Rare variants of head and neck squamous cell carcinoma -differential immunohistochemical profiles.
Allon I, Vered M, Kaplan I, Nahlieli O, Yahalom R, Shalmon B, Srouji S, Livoff A
Acta histochemica 2019 Nov;121(8):151444
Acta histochemica 2019 Nov;121(8):151444
A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells.
Ghezzi C, Wong A, Chen BY, Ribalet B, Damoiseaux R, Clark PM
Nature communications 2019 Nov 29;10(1):5444
Nature communications 2019 Nov 29;10(1):5444
Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism.
Terabe K, Ohashi Y, Tsuchiya S, Ishizuka S, Knudson CB, Knudson W
The Journal of biological chemistry 2019 Nov 22;294(47):17799-17817
The Journal of biological chemistry 2019 Nov 22;294(47):17799-17817
Hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in cartilage tumors.
Kouvaras E, Christoni Z, Siasios I, Malizos K, Koukoulis GK, Ioannou M
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2019 May;94(4):283-289
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2019 May;94(4):283-289
Hypoxia-inducible factor-1α induces CX3CR1 expression and promotes the epithelial to mesenchymal transition (EMT) in ovarian cancer cells.
Singh SK, Mishra MK, Singh R
Journal of ovarian research 2019 May 10;12(1):42
Journal of ovarian research 2019 May 10;12(1):42
Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer.
Fujimoto TN, Colbert LE, Huang Y, Molkentine JM, Deorukhkar A, Baseler L, de la Cruz Bonilla M, Yu M, Lin D, Gupta S, Cabeceiras PK, Kingsley CV, Tailor RC, Sawakuchi GO, Koay EJ, Piwnica-Worms H, Maitra A, Taniguchi CM
Cancer research 2019 May 1;79(9):2327-2338
Cancer research 2019 May 1;79(9):2327-2338
Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress.
Laurent V, Toulet A, Attané C, Milhas D, Dauvillier S, Zaidi F, Clement E, Cinato M, Le Gonidec S, Guérard A, Lehuédé C, Garandeau D, Nieto L, Renaud-Gabardos E, Prats AC, Valet P, Malavaud B, Muller C
Molecular cancer research : MCR 2019 Mar;17(3):821-835
Molecular cancer research : MCR 2019 Mar;17(3):821-835
Intra- and Postoperative Blood Flow Monitoring in a Sheep Model of Uterus Transplantation.
Kengelbach-Weigand A, Lotz L, Schmid R, Lang W, Beckmann MW, Hoffmann I, Horch RE, Renner SP, Dittrich R, Boos AM, Hildebrandt T
In vivo (Athens, Greece) 2019 Mar-Apr;33(2):325-336
In vivo (Athens, Greece) 2019 Mar-Apr;33(2):325-336
Caffeic Acid Phenethyl Ester Rescues Pulmonary Arterial Hypertension through the Inhibition of AKT/ERK-Dependent PDGF/HIF-1α In Vitro and In Vivo.
Cheng CC, Chi PL, Shen MC, Shu CW, Wann SR, Liu CP, Tseng CJ, Huang WC
International journal of molecular sciences 2019 Mar 22;20(6)
International journal of molecular sciences 2019 Mar 22;20(6)
Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses.
Zhang F, Li R, Yang Y, Shi C, Shen Y, Lu C, Chen Y, Zhou W, Lin A, Yu L, Zhang W, Xue Z, Wang J, Cai Z
Immunity 2019 Mar 19;50(3):738-750.e7
Immunity 2019 Mar 19;50(3):738-750.e7
IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function.
Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S
Nature communications 2019 Jun 18;10(1):2679
Nature communications 2019 Jun 18;10(1):2679
HIF-1α protects against oxidative stress by directly targeting mitochondria.
Li HS, Zhou YN, Li L, Li SF, Long D, Chen XL, Zhang JB, Feng L, Li YP
Redox biology 2019 Jul;25:101109
Redox biology 2019 Jul;25:101109
Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment.
Qi D, Wei M, Jiao S, Song Y, Wang X, Xie G, Taranto J, Liu Y, Duan Y, Yu B, Li H, Shah YM, Xu Q, Du J, Gonzalez FJ, Qu A
Cell death & disease 2019 Jul 18;10(8):544
Cell death & disease 2019 Jul 18;10(8):544
Protein kinase C binding protein 1 inhibits hypoxia-inducible factor-1 in the heart.
Schunke KJ, Walton CB, Veal DR, Mafnas CT, Anderson CD, Williams AL, Shohet RV
Cardiovascular research 2019 Jul 1;115(8):1332-1342
Cardiovascular research 2019 Jul 1;115(8):1332-1342
Vascularized 3D printed scaffolds for promoting bone regeneration.
Yan Y, Chen H, Zhang H, Guo C, Yang K, Chen K, Cheng R, Qian N, Sandler N, Zhang YS, Shen H, Qi J, Cui W, Deng L
Biomaterials 2019 Jan;190-191:97-110
Biomaterials 2019 Jan;190-191:97-110
Expression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia-inducible factor-1.
Lee M, Wang C, Jin SW, Labrecque MP, Beischlag TV, Brockman MA, Choy JC
Free radical biology & medicine 2019 Jan;130:278-287
Free radical biology & medicine 2019 Jan;130:278-287
Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma.
Williams PA, Braine CE, Kizhatil K, Foxworth NE, Tolman NG, Harder JM, Scott RA, Sousa GL, Panitch A, Howell GR, John SWM
Molecular neurodegeneration 2019 Jan 22;14(1):6
Molecular neurodegeneration 2019 Jan 22;14(1):6
Effects of empagliflozin on nondiabetic salt-sensitive hypertension in uninephrectomized rats.
Kim S, Jo CH, Kim GH
Hypertension research : official journal of the Japanese Society of Hypertension 2019 Dec;42(12):1905-1915
Hypertension research : official journal of the Japanese Society of Hypertension 2019 Dec;42(12):1905-1915
A close relationship between HIF-1α expression and bone metastases in advanced NSCLC, a retrospective analysis.
Pezzuto A, Perrone G, Orlando N, Citarella F, Ciccozzi M, Scarlata S, Tonini G
Oncotarget 2019 Dec 17;10(66):7071-7079
Oncotarget 2019 Dec 17;10(66):7071-7079
Exenatide mitigates inflammation and hypoxia along with improved angiogenesis in obese fat tissue.
Xian Y, Chen Z, Deng H, Cai M, Liang H, Xu W, Weng J, Xu F
The Journal of endocrinology 2019 Aug;242(2):79-89
The Journal of endocrinology 2019 Aug;242(2):79-89
Periprosthetic hypoxia as consequence of TRPM7 mediated cobalt influx in osteoblasts.
Römmelt C, Munsch T, Drynda A, Lessmann V, Lohmann CH, Bertrand J
Journal of biomedical materials research. Part B, Applied biomaterials 2019 Aug;107(6):1806-1813
Journal of biomedical materials research. Part B, Applied biomaterials 2019 Aug;107(6):1806-1813
RANKL blockade suppresses pathological angiogenesis and vascular leakage in ischemic retinopathy.
Ock S, Park S, Lee J, Kim J
Biochemical and biophysical research communications 2019 Aug 20;516(2):350-356
Biochemical and biophysical research communications 2019 Aug 20;516(2):350-356
H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer.
Bacci L, Aiello A, Ripoli C, Loria R, Pugliese D, Pierconti F, Rotili D, Strigari L, Pinto F, Bassi PF, Mai A, Grassi C, Pontecorvi A, Falcioni R, Farsetti A, Nanni S
International journal of molecular sciences 2019 Aug 17;20(16)
International journal of molecular sciences 2019 Aug 17;20(16)
Blood-Stage Plasmodium Berghei ANKA Infection Promotes Hepatic Fibrosis by Enhancing Hedgehog Signaling in Mice.
Kim J, Wang S, Lee C, Sung S, Shin Y, Song KS, Cha HJ, Ock M, Jung Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(4):1414-1428
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(4):1414-1428
Heme Oxygenase-2 Localizes to Mitochondria and Regulates Hypoxic Responses in Hepatocytes.
Waltz PK, Kautza B, Luciano J, Dyer M, Stolz DB, Loughran P, Neal MD, Sperry JL, Rosengart MR, Zuckerbraun BS
Oxidative medicine and cellular longevity 2018;2018:2021645
Oxidative medicine and cellular longevity 2018;2018:2021645
Hypoxia-Induced Reporter Genes with Different Half-Lives.
Krishnamachary B, Danhier P, Kakkad S, Bharti SK, Bhujwalla ZM
Methods in molecular biology (Clifton, N.J.) 2018;1790:113-125
Methods in molecular biology (Clifton, N.J.) 2018;1790:113-125
Induction and Assessment of Hypoxia in Glioblastoma Cells In Vitro.
Gagner JP, Lechpammer M, Zagzag D
Methods in molecular biology (Clifton, N.J.) 2018;1741:111-123
Methods in molecular biology (Clifton, N.J.) 2018;1741:111-123
Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression.
Hassan A, Arnold BM, Caine S, Toosi BM, Verge VMK, Muir GD
PloS one 2018;13(5):e0197486
PloS one 2018;13(5):e0197486
CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration.
Liu Z, Zheng Z, Qi J, Wang J, Zhou Q, Hu F, Liang J, Li C, Zhang W, Zhang X
Journal of biological engineering 2018;12:35
Journal of biological engineering 2018;12:35
Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APPswe/PS1dE9 Mice and Their Wild Type Littermates.
Zhang F, Zhong R, Qi H, Li S, Cheng C, Liu X, Liu Y, Le W
Frontiers in neuroscience 2018;12:314
Frontiers in neuroscience 2018;12:314
Upregulation of the alternative splicing factor NOVA2 in colorectal cancer vasculature.
Gallo S, Arcidiacono MV, Tisato V, Piva R, Penolazzi L, Bosi C, Feo CV, Gafà R, Secchiero P
OncoTargets and therapy 2018;11:6049-6056
OncoTargets and therapy 2018;11:6049-6056
Aerosolized deferoxamine administration in mouse model of bronchopulmonary dysplasia improve pulmonary development.
Chen Y, Gao S, Yan Y, Qian J, Chen H
American journal of translational research 2018;10(1):325-332
American journal of translational research 2018;10(1):325-332
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
Li X, Cui XX, Chen YJ, Wu TT, Xu H, Yin H, Wu YC
Frontiers in aging neuroscience 2018;10:121
Frontiers in aging neuroscience 2018;10:121
The family of 14-3-3 proteins and specifically 14-3-3σ are up-regulated during the development of renal pathologies.
Rizou M, Frangou EA, Marineli F, Prakoura N, Zoidakis J, Gakiopoulou H, Liapis G, Kavvadas P, Chatziantoniou C, Makridakis M, Vlahou A, Boletis J, Vlahakos D, Goumenos D, Daphnis E, Iatrou C, Charonis AS
Journal of cellular and molecular medicine 2018 Sep;22(9):4139-4149
Journal of cellular and molecular medicine 2018 Sep;22(9):4139-4149
Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3.
Xing Y, Mi C, Wang Z, Zhang ZH, Li MY, Zuo HX, Wang JY, Jin X, Ma J
Pharmacological research 2018 Sep;135:166-180
Pharmacological research 2018 Sep;135:166-180
Intrauterine Exposure to Cadmium Reduces HIF-1 DNA-Binding Ability in Rat Fetal Kidneys.
Jacobo-Estrada T, Cardenas-Gonzalez M, Santoyo-Sánchez MP, Thevenod F, Barbier O
Toxics 2018 Sep 3;6(3)
Toxics 2018 Sep 3;6(3)
Effect of hypoxia on caveolae-related protein expression and insulin signaling in adipocytes.
Varela-Guruceaga M, Milagro FI, Martínez JA, de Miguel C
Molecular and cellular endocrinology 2018 Sep 15;473:257-267
Molecular and cellular endocrinology 2018 Sep 15;473:257-267
GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation.
Drareni K, Ballaire R, Barilla S, Mathew MJ, Toubal A, Fan R, Liang N, Chollet C, Huang Z, Kondili M, Foufelle F, Soprani A, Roussel R, Gautier JF, Alzaid F, Treuter E, Venteclef N
Cell reports 2018 Sep 11;24(11):2957-2971.e6
Cell reports 2018 Sep 11;24(11):2957-2971.e6
Combined use of external therapeutic ultrasound and tirofiban has synergistic therapeutic effects on no-reflow after myocardial reperfusion.
Xu TY, Zhao H, Qiao ZQ, He B, Shen XD
Echocardiography (Mount Kisco, N.Y.) 2018 Oct;35(10):1671-1679
Echocardiography (Mount Kisco, N.Y.) 2018 Oct;35(10):1671-1679
Vascular Permeability Assay in Human Coronary and Mouse Brachiocephalic Arteries.
Guo L, Fernandez R, Sakamoto A, Cornelissen A, Paek KH, Lee PJ, Weinstein LM, Collado-Rivera CJ, Harari E, Kutys R, Samuda TS, Singer NA, Kutyna MD, Kolodgie FD, Virmani R, Finn AV
Bio-protocol 2018 Oct 20;8(20)
Bio-protocol 2018 Oct 20;8(20)
Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G
Cancer discovery 2018 Nov;8(11):1438-1457
Cancer discovery 2018 Nov;8(11):1438-1457
Dysregulated cancer cell transdifferentiation into erythrocytes is an additional metabolic stress in hepatocellular carcinoma.
Hughes A, Dhoot GK
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2018 Nov;40(11):1010428318811467
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2018 Nov;40(11):1010428318811467
Increased expression of hypoxia-inducible factor-1 alpha and its impact on transcriptional changes and prognosis in malignant tumours of the ocular adnexa.
Lange CAK, Lehnert P, Boneva SK, Zhang P, Ludwig F, Boeker M, Hoffmeier K, Horres R, Schlunck G, Reinhard T, Böhringer D, Auw-Haedrich C
Eye (London, England) 2018 Nov;32(11):1772-1782
Eye (London, England) 2018 Nov;32(11):1772-1782
Knockdown of HIF-1α impairs post-ischemic vascular reconstruction in the brain via deficient homing and sprouting bmEPCs.
Liu Y, Ran H, Xiao Y, Wang H, Chen Y, Chen W, Xu X
Brain pathology (Zurich, Switzerland) 2018 Nov;28(6):860-874
Brain pathology (Zurich, Switzerland) 2018 Nov;28(6):860-874
Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia.
Leppänen J, Helminen O, Huhta H, Kauppila JH, Isohookana J, Haapasaari KM, Karihtala P, Parkkila S, Saarnio J, Lehenkari PP, Karttunen TJ
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2018 Nov;126(11):852-863
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2018 Nov;126(11):852-863
Dehydrocostus Lactone Enhances Chemotherapeutic Potential of Doxorubicin in Lung Cancer by Inducing Cell Death and Limiting Metastasis.
Sheng W, Mao H, Wang C, Yang N, Zhang Z, Han J
Medical science monitor : international medical journal of experimental and clinical research 2018 Nov 2;24:7850-7861
Medical science monitor : international medical journal of experimental and clinical research 2018 Nov 2;24:7850-7861
High mobility group protein B1 controls liver cancer initiation through yes-associated protein -dependent aerobic glycolysis.
Chen R, Zhu S, Fan XG, Wang H, Lotze MT, Zeh HJ 3rd, Billiar TR, Kang R, Tang D
Hepatology (Baltimore, Md.) 2018 May;67(5):1823-1841
Hepatology (Baltimore, Md.) 2018 May;67(5):1823-1841
HIF-1α stabilization reduces retinal degeneration in a mouse model of retinitis pigmentosa.
Olivares-González L, Martínez-Fernández de la Cámara C, Hervás D, Millán JM, Rodrigo R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2438-2451
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2438-2451
Postconditioning with repeated mild hypoxia protects neonatal hypoxia-ischemic rats against brain damage and promotes rehabilitation of brain function.
Deng Q, Chang Y, Cheng X, Luo X, Zhang J, Tang X
Brain research bulletin 2018 May;139:31-37
Brain research bulletin 2018 May;139:31-37
WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.
Abu-Remaileh M, Khalaileh A, Pikarsky E, Aqeilan RI
Cell death & disease 2018 May 1;9(5):511
Cell death & disease 2018 May 1;9(5):511
Highly efficient local delivery of endothelial progenitor cells significantly potentiates angiogenesis and full-thickness wound healing.
Wang C, Wang Q, Gao W, Zhang Z, Lou Y, Jin H, Chen X, Lei B, Xu H, Mao C
Acta biomaterialia 2018 Mar 15;69:156-169
Acta biomaterialia 2018 Mar 15;69:156-169
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, Li Y, You W, Dong Q, Hong T, Yan Z, Jin S, Wang T, Zhao W, Mai H, Huang J, Han X, Ji Q, Song Q, Yang C, Zhao S, Xu X, Ye Q
Cancer cell 2018 Mar 12;33(3):368-385.e7
Cancer cell 2018 Mar 12;33(3):368-385.e7
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove ML, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV
The Journal of clinical investigation 2018 Mar 1;128(3):1106-1124
The Journal of clinical investigation 2018 Mar 1;128(3):1106-1124
PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia.
Maugeri G, D'Amico AG, Rasà DM, Saccone S, Federico C, Cavallaro S, D'Agata V
Neuropeptides 2018 Jun;69:84-91
Neuropeptides 2018 Jun;69:84-91
A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro.
Lee DE, Alhallak K, Jenkins SV, Vargas I, Greene NP, Quinn KP, Griffin RJ, Dings RPM, Rajaram N
Scientific reports 2018 Jun 11;8(1):8815
Scientific reports 2018 Jun 11;8(1):8815
Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma.
Leppänen J, Helminen O, Huhta H, Kauppila JH, Isohookana J, Haapasaari KM, Parkkila S, Saarnio J, Lehenkari PP, Karttunen TJ
World journal of surgical oncology 2018 Jul 4;16(1):127
World journal of surgical oncology 2018 Jul 4;16(1):127
Histone deacetylase 8 protects human proximal tubular epithelial cells from hypoxia-mimetic cobalt- and hypoxia/reoxygenation-induced mitochondrial fission and cytotoxicity.
Ha SD, Solomon O, Akbari M, Sener A, Kim SO
Scientific reports 2018 Jul 27;8(1):11332
Scientific reports 2018 Jul 27;8(1):11332
Inflammation stimulates hypoxia-inducible factor-1α regulatory activity in 3T3-L1 adipocytes with conditioned medium from lipopolysaccharide-activated RAW 264.7 macrophages.
Lopez-Pascual A, Lorente-Cebrián S, Moreno-Aliaga MJ, Martinez JA, González-Muniesa P
Journal of cellular physiology 2018 Jan;234(1):550-560
Journal of cellular physiology 2018 Jan;234(1):550-560
Retinoic acid receptor-related orphan receptor RORα regulates differentiation and survival of keratinocytes during hypoxia.
Li H, Zhou L, Dai J
Journal of cellular physiology 2018 Jan;233(1):641-650
Journal of cellular physiology 2018 Jan;233(1):641-650
Hepatic dysfunction and thrombocytopenia induced by excess sFlt1 in mice lacking endothelial nitric oxide synthase.
Oe Y, Ko M, Fushima T, Sato E, Karumanchi SA, Sato H, Sugawara J, Ito S, Takahashi N
Scientific reports 2018 Jan 8;8(1):102
Scientific reports 2018 Jan 8;8(1):102
Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma.
Liu Y, Tan X, Liu W, Chen X, Hou X, Shen D, Ding Y, Yin J, Wang L, Zhang H, Yu Y, Hou J, Thompson TC, Cao G
Chinese journal of cancer 2018 Jan 22;37(1):2
Chinese journal of cancer 2018 Jan 22;37(1):2
Chemotherapeutic Drug Based Metal-Organic Particles for Microvesicle-Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy.
Zhang D, Wu M, Cai Z, Liao N, Ke K, Liu H, Li M, Liu G, Yang H, Liu X, Liu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2018 Feb;5(2):1700648
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2018 Feb;5(2):1700648
Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury.
Koeppen M, Lee JW, Seo SW, Brodsky KS, Kreth S, Yang IV, Buttrick PM, Eckle T, Eltzschig HK
Nature communications 2018 Feb 26;9(1):816
Nature communications 2018 Feb 26;9(1):816
Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C.
Lin Z, Liu F, Shi P, Song A, Huang Z, Zou D, Chen Q, Li J, Gao X
Stem cell research & therapy 2018 Feb 26;9(1):47
Stem cell research & therapy 2018 Feb 26;9(1):47
Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase.
Li Z, Ding Q, Ling LP, Wu Y, Meng DX, Li X, Zhang CQ
World journal of gastroenterology 2018 Feb 21;24(7):819-832
World journal of gastroenterology 2018 Feb 21;24(7):819-832
Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region.
Seira N, Yamagata K, Fukushima K, Araki Y, Kurata N, Yanagisawa N, Mashimo M, Nakamura H, Regan JW, Murayama T, Fujino H
Pharmacology research & perspectives 2018 Dec;6(6):e00441
Pharmacology research & perspectives 2018 Dec;6(6):e00441
Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1α and Slug signaling pathways.
Wang JY, Wang Z, Li MY, Zhang Z, Mi C, Zuo HX, Xing Y, Wu YL, Lian LH, Xu GH, Piao LX, Ma J, Jin X
Chemico-biological interactions 2018 Dec 25;296:134-144
Chemico-biological interactions 2018 Dec 25;296:134-144
Acute hypoxic exposure and prolyl-hydroxylase inhibition improves synaptic transmission recovery time from a subsequent hypoxic insult in rat hippocampus.
Lanigan S, Corcoran AE, Wall A, Mukandala G, O'Connor JJ
Brain research 2018 Dec 15;1701:212-218
Brain research 2018 Dec 15;1701:212-218
Prognostic significance of the programmed death ligand 1 expression in clear cell renal cell carcinoma and correlation with the tumor microenvironment and hypoxia-inducible factor expression.
Tatli Dogan H, Kiran M, Bilgin B, Kiliçarslan A, Sendur MAN, Yalçin B, Ardiçoglu A, Atmaca AF, Gumuskaya B
Diagnostic pathology 2018 Aug 25;13(1):60
Diagnostic pathology 2018 Aug 25;13(1):60
Post-translational modifications of eNOS augment nitric oxide availability and facilitates hypoxia adaptation in Ladakhi women.
Pooja, Ghosh D, Bhargava K, Sethy NK
Nitric oxide : biology and chemistry 2018 Aug 1;78:103-112
Nitric oxide : biology and chemistry 2018 Aug 1;78:103-112
Innate immune memory in the brain shapes neurological disease hallmarks.
Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, Skodras A, Blank T, Staszewski O, Datta M, Centeno TP, Capece V, Islam MR, Kerimoglu C, Staufenbiel M, Schultze JL, Beyer M, Prinz M, Jucker M, Fischer A, Neher JJ
Nature 2018 Apr;556(7701):332-338
Nature 2018 Apr;556(7701):332-338
Intermittent hypoxia induces beneficial cardiovascular remodeling in left ventricular function of type 1 diabetic rat.
Akat F, Fıçıcılar H, Durak A, Tuncay E, Dursun AD, Topal Çelikkan F, Sabuncuoğlu B, Turan B, Baştuğ M
Anatolian journal of cardiology 2018 Apr;19(4):259-266
Anatolian journal of cardiology 2018 Apr;19(4):259-266
High-intensity interval training in hypoxia does not affect muscle HIF responses to acute hypoxia in humans.
De Smet S, D'Hulst G, Poffé C, Van Thienen R, Berardi E, Hespel P
European journal of applied physiology 2018 Apr;118(4):847-862
European journal of applied physiology 2018 Apr;118(4):847-862
WITHDRAWN:Mitochondrial targeting of HIF-1α inhibits hypoxia-induced apoptosis independently of its transcriptional activity.
Li HS, Zhou YN, Li L, Li SF, Long D, Chen XL, Zhang JB, Li YP, Feng L
Free radical biology & medicine 2018 Apr 26;
Free radical biology & medicine 2018 Apr 26;
Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway.
Kang H, Yang K, Xiao L, Guo L, Guo C, Yan Y, Qi J, Wang F, Ryffel B, Li C, Deng L
Frontiers in immunology 2017;8:1312
Frontiers in immunology 2017;8:1312
Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice.
Masuelli L, Granato M, Benvenuto M, Mattera R, Bernardini R, Mattei M, d'Amati G, D'Orazi G, Faggioni A, Bei R, Cirone M
Oncoimmunology 2017;6(11):e1356151
Oncoimmunology 2017;6(11):e1356151
Orai1, 2, 3 and STIM1 promote store-operated calcium entry in pulmonary arterial smooth muscle cells.
Wang J, Xu C, Zheng Q, Yang K, Lai N, Wang T, Tang H, Lu W
Cell death discovery 2017;3:17074
Cell death discovery 2017;3:17074
miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells.
Caggiano R, Cattaneo F, Moltedo O, Esposito G, Perrino C, Trimarco B, Ammendola R, Faraonio R
Oxidative medicine and cellular longevity 2017;2017:9308310
Oxidative medicine and cellular longevity 2017;2017:9308310
Correlation of hypoxia inducible transcription factor in breast cancer and SUVmax of F-18 FDG PET/CT.
Jeong YJ, Jung JW, Cho YY, Park SH, Oh HK, Kang S
Nuclear medicine review. Central & Eastern Europe 2017;20(1):32-38
Nuclear medicine review. Central & Eastern Europe 2017;20(1):32-38
Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor.
Fukushima S, Endo M, Matsumoto Y, Fukushi JI, Matsunobu T, Kawaguchi KI, Setsu N, IIda K, Yokoyama N, Nakagawa M, Yahiro K, Oda Y, Iwamoto Y, Nakashima Y
PloS one 2017;12(5):e0178064
PloS one 2017;12(5):e0178064
Inflammation-induced fetal growth restriction in rats is associated with increased placental HIF-1α accumulation.
Robb KP, Cotechini T, Allaire C, Sperou A, Graham CH
PloS one 2017;12(4):e0175805
PloS one 2017;12(4):e0175805
Markers of oxidative/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds.
Toblli JE, Cao G, Giani JF, Dominici FP, Angerosa M
Drug design, development and therapy 2017;11:2251-2263
Drug design, development and therapy 2017;11:2251-2263
Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death.
Lee KH, Lee SJ, Lee HJ, Choi GE, Jung YH, Kim DI, Gabr AA, Ryu JM, Han HJ
Frontiers in molecular neuroscience 2017;10:229
Frontiers in molecular neuroscience 2017;10:229
Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor.
Fujii T, Nagamatsu T, Morita K, Schust DJ, Iriyama T, Komatsu A, Osuga Y, Fujii T
Scientific reports 2017 Sep 29;7(1):12455
Scientific reports 2017 Sep 29;7(1):12455
NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy.
Wang H, Li W, Xu J, Zhang T, Zuo D, Zhou Z, Lin B, Wang G, Wang Z, Sun W, Sun M, Chang S, Cai Z, Hua Y
Cell death & disease 2017 Sep 14;8(9):e3048
Cell death & disease 2017 Sep 14;8(9):e3048
A novel iron (II) preferring dopamine agonist chelator D-607 significantly suppresses α-syn- and MPTP-induced toxicities in vivo.
Das B, Rajagopalan S, Joshi GS, Xu L, Luo D, Andersen JK, Todi SV, Dutta AK
Neuropharmacology 2017 Sep 1;123:88-99
Neuropharmacology 2017 Sep 1;123:88-99
Nicotine promotes blood retinal barrier damage in a model of human diabetic macular edema.
Maugeri G, D'Amico AG, Rasà DM, La Cognata V, Saccone S, Federico C, Cavallaro S, D'Agata V
Toxicology in vitro : an international journal published in association with BIBRA 2017 Oct;44:182-189
Toxicology in vitro : an international journal published in association with BIBRA 2017 Oct;44:182-189
Evaluation of xenogeneic extracellular matrix fabricated from CuCl2-conditioned mesenchymal stem cell sheets as a bioactive wound dressing material.
Du HC, Jiang L, Geng WX, Li J, Zhang R, Dang JG, Shu MG, Li LW
Journal of biomaterials applications 2017 Oct;32(4):472-483
Journal of biomaterials applications 2017 Oct;32(4):472-483
BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells.
Lee HJ, Jung YH, Choi GE, Ko SH, Lee SJ, Lee SH, Han HJ
Redox biology 2017 Oct;13:426-443
Redox biology 2017 Oct;13:426-443
Bi-directionally protective communication between neurons and astrocytes under ischemia.
Wu XM, Qian C, Zhou YF, Yan YC, Luo QQ, Yung WH, Zhang FL, Jiang LR, Qian ZM, Ke Y
Redox biology 2017 Oct;13:20-31
Redox biology 2017 Oct;13:20-31
Janus kinase 3 regulates adherens junctions and epithelial mesenchymal transition through β-catenin.
Mishra J, Das JK, Kumar N
The Journal of biological chemistry 2017 Oct 6;292(40):16406-16419
The Journal of biological chemistry 2017 Oct 6;292(40):16406-16419
Daam2 driven degradation of VHL promotes gliomagenesis.
Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen B
eLife 2017 Oct 20;6
eLife 2017 Oct 20;6
Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/IP-10 and abrogation of HIF activity in soft tissue sarcomas.
Carew JS, Espitia CM, Zhao W, Mita MM, Mita AC, Nawrocki ST
Oncotarget 2017 Oct 17;8(49):86769-86783
Oncotarget 2017 Oct 17;8(49):86769-86783
Oligomer procyanidins (F2) repress HIF-1α expression in human U87 glioma cells by inhibiting the EGFR/ AKT/mTOR and MAPK/ERK1/2 signaling pathways in vitro and in vivo.
Zheng HL, Wang LH, Sun BS, Li Y, Yang JY, Wu CF
Oncotarget 2017 Oct 17;8(49):85252-85262
Oncotarget 2017 Oct 17;8(49):85252-85262
Targeting MTA1/HIF-1α signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression.
Butt NA, Kumar A, Dhar S, Rimando AM, Akhtar I, Hancock JC, Lage JM, Pound CR, Lewin JR, Gomez CR, Levenson AS
Cancer medicine 2017 Nov;6(11):2673-2685
Cancer medicine 2017 Nov;6(11):2673-2685
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.
Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ
Nature medicine 2017 Nov;23(11):1298-1308
Nature medicine 2017 Nov;23(11):1298-1308
HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma.
Li W, Chen C, Zhao X, Ye H, Zhao Y, Fu Z, Pan W, Zheng S, Wei L, Nong T, Li Z, Chen R
Journal of cellular and molecular medicine 2017 Nov;21(11):2896-2908
Journal of cellular and molecular medicine 2017 Nov;21(11):2896-2908
Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells.
Parra V, Bravo-Sagua R, Norambuena-Soto I, Hernández-Fuentes CP, Gómez-Contreras AG, Verdejo HE, Mellado R, Chiong M, Lavandero S, Castro PF
Biochimica et biophysica acta. Molecular basis of disease 2017 Nov;1863(11):2891-2903
Biochimica et biophysica acta. Molecular basis of disease 2017 Nov;1863(11):2891-2903
Caffeic acid phenethyl ester promotes haematopoietic stem/progenitor cell homing and engraftment.
Chen X, Han Y, Zhang B, Liu Y, Wang S, Liao T, Deng Z, Fan Z, Zhang J, He L, Yue W, Li Y, Pei X
Stem cell research & therapy 2017 Nov 7;8(1):255
Stem cell research & therapy 2017 Nov 7;8(1):255
Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells.
Gonçalves AF, Adlesic M, Brandt S, Hejhal T, Harlander S, Sommer L, Shakhova O, Wild PJ, Frew IJ
Nature communications 2017 Nov 13;8(1):1466
Nature communications 2017 Nov 13;8(1):1466
Low Dose Radiation Causes Skin Cancer in Mice and Has a Differential Effect on Distinct Epidermal Stem Cells.
Revenco T, Lapouge G, Moers V, Brohée S, Sotiropoulou PA
Stem cells (Dayton, Ohio) 2017 May;35(5):1355-1364
Stem cells (Dayton, Ohio) 2017 May;35(5):1355-1364
PACAP and VIP Inhibit HIF-1α-Mediated VEGF Expression in a Model of Diabetic Macular Edema.
Maugeri G, D'Amico AG, Saccone S, Federico C, Cavallaro S, D'Agata V
Journal of cellular physiology 2017 May;232(5):1209-1215
Journal of cellular physiology 2017 May;232(5):1209-1215
Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways.
Mi C, Ma J, Wang KS, Zuo HX, Wang Z, Li MY, Piao LX, Xu GH, Li X, Quan ZS, Jin X
Journal of ethnopharmacology 2017 May 5;203:27-38
Journal of ethnopharmacology 2017 May 5;203:27-38
Acute intermittent hypoxia in rats activates muscle proteolytic pathways through a gluccorticoid-dependent mechanism.
Przygodda F, Manfredi LH, Machado J, Gonçalves DAP, Zanon NM, Bonagamba LGH, Machado BH, Kettelhut ÍC, Navegantes LCC
Journal of applied physiology (Bethesda, Md. : 1985) 2017 May 1;122(5):1114-1124
Journal of applied physiology (Bethesda, Md. : 1985) 2017 May 1;122(5):1114-1124
Implication of VHL, ERK5, and HIF-1alpha in clear cell renal cell carcinoma: Molecular basis.
Serrano-Oviedo L, Giménez-Bachs JM, Nam-Cha SY, Cimas FJ, García-Cano J, Sánchez-Prieto R, Salinas-Sánchez AS
Urologic oncology 2017 Mar;35(3):114.e15-114.e22
Urologic oncology 2017 Mar;35(3):114.e15-114.e22
CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis.
Ridiandries A, Tan JT, Ravindran D, Williams H, Medbury HJ, Lindsay L, Hawkins C, Prosser HC, Bursill CA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Mar;31(3):1179-1192
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Mar;31(3):1179-1192
Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis.
An YA, Sun K, Joffin N, Zhang F, Deng Y, Donzé O, Kusminski CM, Scherer PE
eLife 2017 Mar 29;6
eLife 2017 Mar 29;6
Brain-Derived Neurotrophic Factor Loaded PS80 PBCA Nanocarrier for In Vitro Neural Differentiation of Mouse Induced Pluripotent Stem Cells.
Chung CY, Lin MH, Lee IN, Lee TH, Lee MH, Yang JT
International journal of molecular sciences 2017 Mar 19;18(3)
International journal of molecular sciences 2017 Mar 19;18(3)
Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma.
Song Y, Zheng S, Wang J, Long H, Fang L, Wang G, Li Z, Que T, Liu Y, Li Y, Zhang X, Fang W, Qi S
Oncotarget 2017 Jun 27;8(26):41947-41962
Oncotarget 2017 Jun 27;8(26):41947-41962
Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression.
Shih JW, Chiang WF, Wu ATH, Wu MH, Wang LY, Yu YL, Hung YW, Wang WC, Chu CY, Hung CL, Changou CA, Yen Y, Kung HJ
Nature communications 2017 Jun 22;8:15874
Nature communications 2017 Jun 22;8:15874
Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells.
Alhallak K, Jenkins SV, Lee DE, Greene NP, Quinn KP, Griffin RJ, Dings RPM, Rajaram N
Journal of biomedical optics 2017 Jun 1;22(6):60502
Journal of biomedical optics 2017 Jun 1;22(6):60502
Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.
Harlander S, Schönenberger D, Toussaint NC, Prummer M, Catalano A, Brandt L, Moch H, Wild PJ, Frew IJ
Nature medicine 2017 Jul;23(7):869-877
Nature medicine 2017 Jul;23(7):869-877
The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis.
Judge JL, Lacy SH, Ku WY, Owens KM, Hernady E, Thatcher TH, Williams JP, Phipps RP, Sime PJ, Kottmann RM
Radiation research 2017 Jul;188(1):35-43
Radiation research 2017 Jul;188(1):35-43
Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations.
Ke S, Chen S, Dong Z, Hong CS, Zhang Q, Tang L, Yang P, Zhai J, Yan H, Shen F, Zhuang Z, Wen W, Wang H
Hepatology (Baltimore, Md.) 2017 Jan;65(1):134-151
Hepatology (Baltimore, Md.) 2017 Jan;65(1):134-151
ASK1 regulates the survival of neuroblastoma cells by interacting with TLX and stabilizing HIF-1α.
Sobhan PK, Zhai Q, Green LC, Hansford LM, Funa K
Cellular signalling 2017 Jan;30:104-117
Cellular signalling 2017 Jan;30:104-117
Expression of hypoxia-inducible factor-1α in synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis.
Qing L, Lei P, Liu H, Xie J, Wang L, Wen T, Hu Y
Experimental and therapeutic medicine 2017 Jan;13(1):63-68
Experimental and therapeutic medicine 2017 Jan;13(1):63-68
Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer.
Fraga A, Ribeiro R, Coelho A, Vizcaíno JR, Coutinho H, Lopes JM, Príncipe P, Lobato C, Lopes C, Medeiros R
BMC urology 2017 Jan 31;17(1):12
BMC urology 2017 Jan 31;17(1):12
Broad-Spectrum Inhibition of the CC-Chemokine Class Improves Wound Healing and Wound Angiogenesis.
Ridiandries A, Bursill C, Tan J
International journal of molecular sciences 2017 Jan 13;18(1)
International journal of molecular sciences 2017 Jan 13;18(1)
PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes.
Ponente M, Campanini L, Cuttano R, Piunti A, Delledonne GA, Coltella N, Valsecchi R, Villa A, Cavallaro U, Pattini L, Doglioni C, Bernardi R
JCI insight 2017 Feb 23;2(4):e87380
JCI insight 2017 Feb 23;2(4):e87380
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis.
Feng Q, Zhang C, Lum D, Druso JE, Blank B, Wilson KF, Welm A, Antonyak MA, Cerione RA
Nature communications 2017 Feb 16;8:14450
Nature communications 2017 Feb 16;8:14450
Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.
Ariazi JL, Duffy KJ, Adams DF, Fitch DM, Luo L, Pappalardi M, Biju M, DiFilippo EH, Shaw T, Wiggall K, Erickson-Miller C
The Journal of pharmacology and experimental therapeutics 2017 Dec;363(3):336-347
The Journal of pharmacology and experimental therapeutics 2017 Dec;363(3):336-347
Photoacoustic imaging for in vivo quantification of placental oxygenation in mice.
Yamaleyeva LM, Sun Y, Bledsoe T, Hoke A, Gurley SB, Brosnihan KB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Dec;31(12):5520-5529
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Dec;31(12):5520-5529
Bisphenol A induces proliferative effects on both breast cancer cells and vascular endothelial cells through a shared GPER-dependent pathway in hypoxia.
Xu F, Wang X, Wu N, He S, Yi W, Xiang S, Zhang P, Xie X, Ying C
Environmental pollution (Barking, Essex : 1987) 2017 Dec;231(Pt 2):1609-1620
Environmental pollution (Barking, Essex : 1987) 2017 Dec;231(Pt 2):1609-1620
Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways.
Ullah K, Rosendahl AH, Izzi V, Bergmann U, Pihlajaniemi T, Mäki JM, Myllyharju J
Scientific reports 2017 Dec 8;7(1):17220
Scientific reports 2017 Dec 8;7(1):17220
Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.
Suh JH, Lai L, Nam D, Kim J, Jo J, Taffet GE, Kim E, Kaelber JT, Lee HK, Entman ML, Cooke JP, Reineke EL
The Journal of biological chemistry 2017 Dec 29;292(52):21643-21652
The Journal of biological chemistry 2017 Dec 29;292(52):21643-21652
Antifibrotic effects of cyclosporine A on TGF-β1-treated lung fibroblasts and lungs from bleomycin-treated mice: role of hypoxia-inducible factor-1α.
Yamazaki R, Kasuya Y, Fujita T, Umezawa H, Yanagihara M, Nakamura H, Yoshino I, Tatsumi K, Murayama T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Aug;31(8):3359-3371
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Aug;31(8):3359-3371
Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer.
Gu J, Li Y, Zeng J, Wang B, Ji K, Tang Y, Sun Q
Scientific reports 2017 Aug 8;7(1):7546
Scientific reports 2017 Aug 8;7(1):7546
TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.
Shimauchi T, Numaga-Tomita T, Ito T, Nishimura A, Matsukane R, Oda S, Hoka S, Ide T, Koitabashi N, Uchida K, Sumimoto H, Mori Y, Nishida M
JCI insight 2017 Aug 3;2(15)
JCI insight 2017 Aug 3;2(15)
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.
Xu T, Stewart KM, Wang X, Liu K, Xie M, Ryu JK, Li K, Ma T, Wang H, Ni L, Zhu S, Cao N, Zhu D, Zhang Y, Akassoglou K, Dong C, Driggers EM, Ding S
Nature 2017 Aug 10;548(7666):228-233
Nature 2017 Aug 10;548(7666):228-233
The hypoxia-inducible factors HIF1α and HIF2α are dispensable for embryonic muscle development but essential for postnatal muscle regeneration.
Yang X, Yang S, Wang C, Kuang S
The Journal of biological chemistry 2017 Apr 7;292(14):5981-5991
The Journal of biological chemistry 2017 Apr 7;292(14):5981-5991
Deletion of hypoxia-inducible factor-1α in myeloid lineage exaggerates angiotensin II-induced formation of abdominal aortic aneurysm.
Takahara Y, Tokunou T, Kojima H, Hirooka Y, Ichiki T
Clinical science (London, England : 1979) 2017 Apr 1;131(7):609-620
Clinical science (London, England : 1979) 2017 Apr 1;131(7):609-620
Enhancement of early cardiac differentiation of dedifferentiated fat cells by dimethyloxalylglycine via notch signaling pathway.
Li F, Li Z, Jiang Z, Tian Y, Wang Z, Yi W, Zhang C
American journal of translational research 2016;8(11):4791-4801
American journal of translational research 2016;8(11):4791-4801
PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression.
Maugeri G, D'Amico AG, Reitano R, Magro G, Cavallaro S, Salomone S, D'Agata V
Frontiers in pharmacology 2016;7:139
Frontiers in pharmacology 2016;7:139
MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma.
Lo Dico A, Costa V, Martelli C, Diceglie C, Rajata F, Rizzo A, Mancone C, Tripodi M, Ottobrini L, Alessandro R, Conigliaro A
Theranostics 2016;6(8):1105-18
Theranostics 2016;6(8):1105-18
The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia.
Zhang Q, Doucet M, Tomlinson RE, Han X, Quarles LD, Collins MT, Clemens TL
Bone research 2016;4:16011
Bone research 2016;4:16011
Erythropoietin and a nonerythropoietic peptide analog promote aortic endothelial cell repair under hypoxic conditions: role of nitric oxide.
Heikal L, Ghezzi P, Mengozzi M, Stelmaszczuk B, Feelisch M, Ferns GA
Hypoxia (Auckland, N.Z.) 2016;4:121-133
Hypoxia (Auckland, N.Z.) 2016;4:121-133
Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α Pathway.
Huang X, He Z, Jiang X, Hou M, Tang Z, Zhen X, Liang Y, Ma J
PloS one 2016;11(3):e0151553
PloS one 2016;11(3):e0151553
Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats.
Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, Akaike T, Kusakari Y, Fujiwara M, Ogawa K, Goda N, Ida H, Minamisawa S
PloS one 2016;11(2):e0148666
PloS one 2016;11(2):e0148666
Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy.
Wert KJ, Mahajan VB, Zhang L, Yan Y, Li Y, Tosi J, Hsu CW, Nagasaki T, Janisch KM, Grant MB, Mahajan M, Bassuk AG, Tsang SH
Signal transduction and targeted therapy 2016;1
Signal transduction and targeted therapy 2016;1
Immunomodulatory effect of captopril and local irradiation on myeloid-derived suppressor cells.
Cho WK, Shin SW, Kim SY, Hong CW, Choi C, Park W, Noh JM
Radiation oncology journal 2016 Sep;34(3):223-229
Radiation oncology journal 2016 Sep;34(3):223-229
Differential KrasV12 protein levels control a switch regulating lung cancer cell morphology and motility.
Schäfer C, Mohan A, Burford W, Driscoll MK, Ludlow AT, Wright WE, Shay JW, Danuser G
Convergent science physical oncology 2016 Sep;2(3):035004
Convergent science physical oncology 2016 Sep;2(3):035004
Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2.
Yaghi L, Poras I, Simoes RT, Donadi EA, Tost J, Daunay A, de Almeida BS, Carosella ED, Moreau P
Oncotarget 2016 Sep 27;7(39):63690-63707
Oncotarget 2016 Sep 27;7(39):63690-63707
Analysis of a Nitroreductase-Based Hypoxia Sensor in Primary Neuronal Cultures.
Lizama-Manibusan BN, Klein S, McKenzie JR, Cliffel DE, McLaughlin B
ACS chemical neuroscience 2016 Sep 21;7(9):1188-91
ACS chemical neuroscience 2016 Sep 21;7(9):1188-91
Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS.
Miyake T, Nakamura S, Zhao M, So K, Inoue K, Numata T, Takahashi N, Shirakawa H, Mori Y, Nakagawa T, Kaneko S
Nature communications 2016 Sep 15;7:12840
Nature communications 2016 Sep 15;7:12840
High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I.
Tan JT, Prosser HC, Dunn LL, Vanags LZ, Ridiandries A, Tsatralis T, Lecce L, Clayton ZE, Yuen SC, Robertson S, Lam YT, Celermajer DS, Ng MK, Bursill CA
Diabetes 2016 Oct;65(10):3091-103
Diabetes 2016 Oct;65(10):3091-103
MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer.
Cui J, Duan B, Zhao X, Chen Y, Sun S, Deng W, Zhang Y, Du J, Chen Y, Gu L
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13455-13467
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13455-13467
Zinc Attenuates Tubulointerstitial Fibrosis in Diabetic Nephropathy Via Inhibition of HIF Through PI-3K Signaling.
Zhang X, Liang D, Fan J, Lian X, Zhao Y, Wang X, Chi ZH, Zhang P
Biological trace element research 2016 Oct;173(2):372-83
Biological trace element research 2016 Oct;173(2):372-83
Impact of macrophages on tumor growth characteristics in a murine ocular tumor model.
Stei MM, Loeffler KU, Kurts C, Hoeller T, Pfarrer C, Holz FG, Herwig-Carl MC
Experimental eye research 2016 Oct;151:9-18
Experimental eye research 2016 Oct;151:9-18
24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development.
Soncini M, Corna G, Moresco M, Coltella N, Restuccia U, Maggioni D, Raccosta L, Lin CY, Invernizzi F, Crocchiolo R, Doglioni C, Traversari C, Bachi A, Bernardi R, Bordignon C, Gustafsson JÅ, Russo V
Proceedings of the National Academy of Sciences of the United States of America 2016 Oct 11;113(41):E6219-E6227
Proceedings of the National Academy of Sciences of the United States of America 2016 Oct 11;113(41):E6219-E6227
Transcription Factor HIF-1α Controls Expression of the Cytokine IL-22 in CD4 T Cells.
Budda SA, Girton A, Henderson JG, Zenewicz LA
Journal of immunology (Baltimore, Md. : 1950) 2016 Oct 1;197(7):2646-52
Journal of immunology (Baltimore, Md. : 1950) 2016 Oct 1;197(7):2646-52
Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.
Wang X, Yang H, Yanagisawa D, Bellier JP, Morino K, Zhao S, Liu P, Vigers P, Tooyama I
Neurobiology of aging 2016 Nov;47:168-179
Neurobiology of aging 2016 Nov;47:168-179
Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury.
Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH
Nature medicine 2016 Nov;22(11):1335-1341
Nature medicine 2016 Nov;22(11):1335-1341
Expression of glucose transporter-1 is correlated with hypoxia-inducible factor 1α and malignant potential in pancreatic neuroendocrine tumors.
Fujino M, Aishima S, Shindo K, Oda Y, Morimatsu K, Tsutsumi K, Otsuka T, Tanaka M, Oda Y
Oncology letters 2016 Nov;12(5):3337-3343
Oncology letters 2016 Nov;12(5):3337-3343
Targeting renal cell carcinoma with a HIF-2 antagonist.
Chen W, Hill H, Christie A, Kim MS, Holloman E, Pavia-Jimenez A, Homayoun F, Ma Y, Patel N, Yell P, Hao G, Yousuf Q, Joyce A, Pedrosa I, Geiger H, Zhang H, Chang J, Gardner KH, Bruick RK, Reeves C, Hwang TH, Courtney K, Frenkel E, Sun X, Zojwalla N, Wong T, Rizzi JP, Wallace EM, Josey JA, Xie Y, Xie XJ, Kapur P, McKay RM, Brugarolas J
Nature 2016 Nov 3;539(7627):112-117
Nature 2016 Nov 3;539(7627):112-117
Relevance of microRNA-18a and microRNA-199a-5p to hepatocellular carcinoma recurrence after living donor liver transplantation.
Morita K, Shirabe K, Taketomi A, Soejima Y, Yoshizumi T, Uchiyama H, Ikegami T, Yamashita Y, Sugimachi K, Harimoto N, Itoh S, Ikeda T, Maehara Y
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2016 May;22(5):665-76
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2016 May;22(5):665-76
c-MYC inhibition impairs hypoxia response in glioblastoma multiforme.
Mongiardi MP, Savino M, Falchetti ML, Illi B, Bozzo F, Valle C, Helmer-Citterich M, Ferrè F, Nasi S, Levi A
Oncotarget 2016 May 31;7(22):33257-71
Oncotarget 2016 May 31;7(22):33257-71
Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis.
Kowalik MA, Guzzo G, Morandi A, Perra A, Menegon S, Masgras I, Trevisan E, Angioni MM, Fornari F, Quagliata L, Ledda-Columbano GM, Gramantieri L, Terracciano L, Giordano S, Chiarugi P, Rasola A, Columbano A
Oncotarget 2016 May 31;7(22):32375-93
Oncotarget 2016 May 31;7(22):32375-93
Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons.
Hung YH, Chang SH, Huang CT, Yin JH, Hwang CS, Yang LY, Yang DI
Molecular neurobiology 2016 Mar;53(2):793-809
Molecular neurobiology 2016 Mar;53(2):793-809
Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression.
Aiken J, Roudier E, Ciccone J, Drouin G, Stromberg A, Vojnovic J, Olfert IM, Haas T, Gustafsson T, Grenier G, Birot O
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Mar;30(3):1120-34
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Mar;30(3):1120-34
Estradiol, TGF-β1 and hypoxia promote breast cancer stemness and EMT-mediated breast cancer migration.
Park SJ, Kim JG, Kim ND, Yang K, Shim JW, Heo K
Oncology letters 2016 Mar;11(3):1895-1902
Oncology letters 2016 Mar;11(3):1895-1902
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.
Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR
Science translational medicine 2016 Mar 2;8(328):328ra29
Science translational medicine 2016 Mar 2;8(328):328ra29
Parkin modulates expression of HIF-1α and HIF-3α during hypoxia in gliobastoma-derived cell lines in vitro.
Maugeri G, D'Amico AG, Reitano R, Saccone S, Federico C, Cavallaro S, D'Agata V
Cell and tissue research 2016 Jun;364(3):465-474
Cell and tissue research 2016 Jun;364(3):465-474
CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma.
Schokrpur S, Hu J, Moughon DL, Liu P, Lin LC, Hermann K, Mangul S, Guan W, Pellegrini M, Xu H, Wu L
Scientific reports 2016 Jun 30;6:29032
Scientific reports 2016 Jun 30;6:29032
Hypoxia Potentiates Anabolic Effects of Exogenous Hyaluronic Acid in Rat Articular Cartilage.
Ichimaru S, Nakagawa S, Arai Y, Kishida T, Shin-Ya M, Honjo K, Tsuchida S, Inoue H, Fujiwara H, Shimomura S, Mazda O, Kubo T
International journal of molecular sciences 2016 Jun 25;17(7)
International journal of molecular sciences 2016 Jun 25;17(7)
Oxygen as a chemoattractant: confirming cellular hypoxia in paper-based invasion assays.
Truong AS, Lockett MR
The Analyst 2016 Jun 21;141(12):3874-82
The Analyst 2016 Jun 21;141(12):3874-82
Zinc finger protein 91 (ZFP91) activates HIF-1α via NF-κB/p65 to promote proliferation and tumorigenesis of colon cancer.
Ma J, Mi C, Wang KS, Lee JJ, Jin X
Oncotarget 2016 Jun 14;7(24):36551-36562
Oncotarget 2016 Jun 14;7(24):36551-36562
Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity.
Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, Chen X, Hofer L, Macher-Goeppinger S, Tolstov Y, Korzeniewski N, Duensing A, Grüllich C, Jäger D, Perner S, Schönberg G, Nyarangi-Dix J, Isaac S, Hatiboglu G, Teber D, Hadaschik B, Pahernik S, Roth W, Eils R, Schlesner M, Sültmann H, Hohenfellner M, Grabe N, Duensing S
Nature communications 2016 Jun 13;7:ncomms11845
Nature communications 2016 Jun 13;7:ncomms11845
Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts.
Mousavizadeh R, Scott A, Lu A, Ardekani GS, Behzad H, Lundgreen K, Ghaffari M, McCormack RG, Duronio V
The Journal of physiology 2016 Jun 1;594(11):2971-83
The Journal of physiology 2016 Jun 1;594(11):2971-83
Propofol but not sevoflurane prevents mitochondrial dysfunction and oxidative stress by limiting HIF-1α activation in hepatic ischemia/reperfusion injury.
Bellanti F, Mirabella L, Mitarotonda D, Blonda M, Tamborra R, Cinnella G, Fersini A, Ambrosi A, Dambrosio M, Vendemiale G, Serviddio G
Free radical biology & medicine 2016 Jul;96:323-33
Free radical biology & medicine 2016 Jul;96:323-33
Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions.
Guinot A, Lehmann H, Wild PJ, Frew IJ
The Journal of pathology 2016 Jul;239(3):365-73
The Journal of pathology 2016 Jul;239(3):365-73
Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia-Inducible Factor 1-α (HIF1-α) in an Ovine Model of Acute Myocardial Infarction.
Hnatiuk AP, Ong SG, Olea FD, Locatelli P, Riegler J, Lee WH, Jen CH, De Lorenzi A, Giménez CS, Laguens R, Wu JC, Crottogini A
Journal of the American Heart Association 2016 Jul 6;5(7)
Journal of the American Heart Association 2016 Jul 6;5(7)
Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected with Histoplasma capsulatum.
Fecher RA, Horwath MC, Friedrich D, Rupp J, Deepe GS Jr
Journal of immunology (Baltimore, Md. : 1950) 2016 Jul 15;197(2):565-79
Journal of immunology (Baltimore, Md. : 1950) 2016 Jul 15;197(2):565-79
Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy.
Yoon C, Chang KK, Lee JH, Tap WD, Hart CP, Simon MC, Yoon SS
Oncotarget 2016 Jul 12;7(28):42844-42858
Oncotarget 2016 Jul 12;7(28):42844-42858
Apelin as a marker for monitoring the tumor vessel normalization window during antiangiogenic therapy.
Zhang L, Takara K, Yamakawa D, Kidoya H, Takakura N
Cancer science 2016 Jan;107(1):36-44
Cancer science 2016 Jan;107(1):36-44
Monoamine oxidase B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1α and with transcription factors Sp1 and Sp3.
Sharpe MA, Baskin DS
Oncotarget 2016 Jan 19;7(3):3379-93
Oncotarget 2016 Jan 19;7(3):3379-93
MicroRNA 211 Functions as a Metabolic Switch in Human Melanoma Cells.
Mazar J, Qi F, Lee B, Marchica J, Govindarajan S, Shelley J, Li JL, Ray A, Perera RJ
Molecular and cellular biology 2016 Jan 19;36(7):1090-108
Molecular and cellular biology 2016 Jan 19;36(7):1090-108
An ID2-dependent mechanism for VHL inactivation in cancer.
Lee SB, Frattini V, Bansal M, Castano AM, Sherman D, Hutchinson K, Bruce JN, Califano A, Liu G, Cardozo T, Iavarone A, Lasorella A
Nature 2016 Jan 14;529(7585):172-7
Nature 2016 Jan 14;529(7585):172-7
Hypoxia inducible factor-1 mediates upregulation of urokinase-type plasminogen activator receptor gene transcription during hypoxia in cervical cancer cells.
Nishi H, Sasaki T, Nagamitsu Y, Terauchi F, Nagai T, Nagao T, Isaka K
Oncology reports 2016 Feb;35(2):992-8
Oncology reports 2016 Feb;35(2):992-8
Detection and identification of protein citrullination in complex biological systems.
Clancy KW, Weerapana E, Thompson PR
Current opinion in chemical biology 2016 Feb;30:1-6
Current opinion in chemical biology 2016 Feb;30:1-6
Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer.
Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H
Oncology letters 2016 Feb;11(2):1026-1034
Oncology letters 2016 Feb;11(2):1026-1034
Role of deltaNp63(pos)CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas.
Yamano S, Gi M, Tago Y, Doi K, Okada S, Hirayama Y, Tachibana H, Ishii N, Fujioka M, Tatsumi K, Wanibuchi H
Cancer science 2016 Feb;107(2):123-32
Cancer science 2016 Feb;107(2):123-32
Regulation of glucose metabolism by p62/SQSTM1 through HIF1α.
Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, Yu G, Xiao W, Xu H, Ye Z
Journal of cell science 2016 Feb 15;129(4):817-30
Journal of cell science 2016 Feb 15;129(4):817-30
Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion.
Mori H, Yao Y, Learman BS, Kurozumi K, Ishida J, Ramakrishnan SK, Overmyer KA, Xue X, Cawthorn WP, Reid MA, Taylor M, Ning X, Shah YM, MacDougald OA
Scientific reports 2016 Feb 10;6:21520
Scientific reports 2016 Feb 10;6:21520
A Chemokine Receptor, CXCR4, Which Is Regulated by Hypoxia-Inducible Factor 2α, Is Crucial for Functional Endothelial Progenitor Cells Migration to Ischemic Tissue and Wound Repair.
Tu TC, Nagano M, Yamashita T, Hamada H, Ohneda K, Kimura K, Ohneda O
Stem cells and development 2016 Feb 1;25(3):266-76
Stem cells and development 2016 Feb 1;25(3):266-76
Inhibition of Prolyl Hydroxylase Attenuates Fas Ligand-Induced Apoptosis and Lung Injury in Mice.
Nagamine Y, Tojo K, Yazawa T, Takaki S, Baba Y, Goto T, Kurahashi K
American journal of respiratory cell and molecular biology 2016 Dec;55(6):878-888
American journal of respiratory cell and molecular biology 2016 Dec;55(6):878-888
(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells.
Zhang YT, Li FM, Guo YZ, Jiang LR, Ma J, Ke Y, Qian ZM
European journal of pharmacology 2016 Dec 5;792:48-53
European journal of pharmacology 2016 Dec 5;792:48-53
Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia.
Badar T, Handisides DR, Benito JM, Richie MA, Borthakur G, Jabbour E, Harutyunyan K, Konoplev S, Faderl S, Kroll S, Andreeff M, Pearce T, Kantarjian HM, Cortes JE, Thomas DA, Konopleva M
American journal of hematology 2016 Aug;91(8):800-5
American journal of hematology 2016 Aug;91(8):800-5
Expression of hypoxia-inducible factor-1α affects tumor proliferation and antiapoptosis in surgically resected lung cancer.
Takasaki C, Kobayashi M, Ishibashi H, Akashi T, Okubo K
Molecular and clinical oncology 2016 Aug;5(2):295-300
Molecular and clinical oncology 2016 Aug;5(2):295-300
Sphingosine 1‑phosphate induced by hypoxia increases the expression of PAI‑1 in HepG2 cells via HIF‑1α.
Sanagawa A, Iwaki S, Asai M, Sakakibara D, Norimoto H, Sobel BE, Fujii S
Molecular medicine reports 2016 Aug;14(2):1841-8
Molecular medicine reports 2016 Aug;14(2):1841-8
Sprouty2 Protein Regulates Hypoxia-inducible Factor-α (HIFα) Protein Levels and Transcription of HIFα-responsive Genes.
Hicks KC, Patel TB
The Journal of biological chemistry 2016 Aug 5;291(32):16787-801
The Journal of biological chemistry 2016 Aug 5;291(32):16787-801
GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis.
Littlewood-Evans A, Sarret S, Apfel V, Loesle P, Dawson J, Zhang J, Muller A, Tigani B, Kneuer R, Patel S, Valeaux S, Gommermann N, Rubic-Schneider T, Junt T, Carballido JM
The Journal of experimental medicine 2016 Aug 22;213(9):1655-62
The Journal of experimental medicine 2016 Aug 22;213(9):1655-62
PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.
Samanta D, Park Y, Andrabi SA, Shelton LM, Gilkes DM, Semenza GL
Cancer research 2016 Aug 1;76(15):4430-42
Cancer research 2016 Aug 1;76(15):4430-42
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis.
Luo B, Wang M, Hou N, Hu X, Jia G, Qin X, Zuo X, Liu Y, Luo K, Song W, Wang K, Pang M
Neoplasia (New York, N.Y.) 2016 Apr;18(4):242-52
Neoplasia (New York, N.Y.) 2016 Apr;18(4):242-52
Upregulating Hif-1α by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound.
Chen H, Jia P, Kang H, Zhang H, Liu Y, Yang P, Yan Y, Zuo G, Guo L, Jiang M, Qi J, Liu Y, Cui W, Santos HA, Deng L
Advanced healthcare materials 2016 Apr 20;5(8):907-18
Advanced healthcare materials 2016 Apr 20;5(8):907-18
Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers.
Ananthula S, Sinha A, El Gassim M, Batth S, Marshall GD Jr, Gardner LH, Shimizu Y, ElShamy WM
Oncotarget 2016 Apr 12;7(15):20869-89
Oncotarget 2016 Apr 12;7(15):20869-89
Bortezomib enhances the radiosensitivity of hypoxic cervical cancer cells by inhibiting HIF-1α expression.
Cui H, Qin Q, Yang M, Zhang H, Liu Z, Yang Y, Chen X, Zhu H, Wang D, Meng C, Song H, Ma J, Huang G, Cai J, Sun X, Wang Z
International journal of clinical and experimental pathology 2015;8(8):9032-41
International journal of clinical and experimental pathology 2015;8(8):9032-41
Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells.
Fan Y, Wang L, Liu C, Zhu H, Zhou L, Wang Y, Wu X, Li Q
International journal of clinical and experimental pathology 2015;8(3):2505-14
International journal of clinical and experimental pathology 2015;8(3):2505-14
Danshen improves damaged cardiac angiogenesis and cardiac function induced by myocardial infarction by modulating HIF1α/VEGFA signaling pathway.
Ai F, Chen M, Li W, Yang Y, Xu G, Gui F, Liu Z, Bai X, Chen Z
International journal of clinical and experimental medicine 2015;8(10):18311-8
International journal of clinical and experimental medicine 2015;8(10):18311-8
Nek6 and Hif-1α cooperate with the cytoskeletal gateway of drug resistance to drive outcome in serous ovarian cancer.
Donato MD, Fanelli M, Mariani M, Raspaglio G, Pandya D, He S, Fiedler P, Petrillo M, Scambia G, Ferlini C
American journal of cancer research 2015;5(6):1862-77
American journal of cancer research 2015;5(6):1862-77
A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway.
Sun L, Xu C, Chen G, Yu M, Yang S, Qiu Y, Peng K, Wang W, Xiao W, Yang H
International journal of biological sciences 2015;11(6):664-71
International journal of biological sciences 2015;11(6):664-71
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura A, Pugh CW, Ratcliffe PJ, Schofield CJ
PloS one 2015;10(7):e0132004
PloS one 2015;10(7):e0132004
Attenuation of choroidal neovascularization by histone deacetylase inhibitor.
Chan N, He S, Spee CK, Ishikawa K, Hinton DR
PloS one 2015;10(3):e0120587
PloS one 2015;10(3):e0120587
Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival.
Fillmore N, Huqi A, Jaswal JS, Mori J, Paulin R, Haromy A, Onay-Besikci A, Ionescu L, Thébaud B, Michelakis E, Lopaschuk GD
PloS one 2015;10(3):e0120257
PloS one 2015;10(3):e0120257
Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to ¹⁸F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors.
Cho MH, Park CK, Park M, Kim WK, Cho A, Kim H
PloS one 2015;10(10):e0141413
PloS one 2015;10(10):e0141413
Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice.
Nakatani K, Watabe T, Masuda D, Imaizumi M, Shimosegawa E, Kobayashi T, Sairyo M, Zhu Y, Okada T, Kawase R, Nakaoka H, Naito A, Ohama T, Koseki M, Oka T, Akazawa H, Nishida M, Komuro I, Sakata Y, Hatazawa J, Yamashita S
Metabolism: clinical and experimental 2015 Sep;64(9):1165-74
Metabolism: clinical and experimental 2015 Sep;64(9):1165-74
HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression.
Shao J, Zhang Y, Yang T, Qi J, Zhang L, Deng L
In vitro cellular & developmental biology. Animal 2015 Sep;51(8):808-14
In vitro cellular & developmental biology. Animal 2015 Sep;51(8):808-14
Overexpression of hypoxia-inducible factor prolyl hydoxylase-2 attenuates hypoxia-induced vascular endothelial growth factor expression in luteal cells.
Zhang Z, Pang X, Tang Z, Yin D, Wang Z
Molecular medicine reports 2015 Sep;12(3):3809-3814
Molecular medicine reports 2015 Sep;12(3):3809-3814
MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury.
Wang IK, Sun KT, Tsai TH, Chen CW, Chang SS, Yu TM, Yen TH, Lin FY, Huang CC, Li CY
Life sciences 2015 Sep 1;136:133-41
Life sciences 2015 Sep 1;136:133-41
Reactive oxygen species production has a critical role in hypoxia-induced Stat3 activation and angiogenesis in human glioblastoma.
Yu MO, Park KJ, Park DH, Chung YG, Chi SG, Kang SH
Journal of neuro-oncology 2015 Oct;125(1):55-63
Journal of neuro-oncology 2015 Oct;125(1):55-63
Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1α in cancer cells.
Kim KK, Abelman S, Yano N, Ribeiro JR, Singh RK, Tipping M, Moore RG
Scientific reports 2015 Oct 15;5:14296
Scientific reports 2015 Oct 15;5:14296
Gene expression profiling of changes induced by maternal diabetes in the embryonic heart.
Bohuslavova R, Skvorova L, Cerychova R, Pavlinkova G
Reproductive toxicology (Elmsford, N.Y.) 2015 Nov;57:147-56
Reproductive toxicology (Elmsford, N.Y.) 2015 Nov;57:147-56
Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation.
Lehmann H, Vicari D, Wild PJ, Frew IJ
Journal of the American Society of Nephrology : JASN 2015 Nov;26(11):2778-88
Journal of the American Society of Nephrology : JASN 2015 Nov;26(11):2778-88
Loss of Siah2 does not impact angiogenic potential of murine endothelial cells.
Wong CS, Chen A, Liu MC, Parker BS, Möller A
Microvascular research 2015 Nov;102:38-45
Microvascular research 2015 Nov;102:38-45
Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma.
Srivastava S, Thakkar B, Yeoh KG, Ho KY, Teh M, Soong R, Salto-Tellez M
Virchows Archiv : an international journal of pathology 2015 May;466(5):541-8
Virchows Archiv : an international journal of pathology 2015 May;466(5):541-8
Caffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1α signaling pathways in human retinal pigment epithelial cells under hypoxic conditions.
Paeng SH, Jung WK, Park WS, Lee DS, Kim GY, Choi YH, Seo SK, Jang WH, Choi JS, Lee YM, Park S, Choi IW
International journal of molecular medicine 2015 May;35(5):1419-26
International journal of molecular medicine 2015 May;35(5):1419-26
Hypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia.
Li R, Wang Y, Yang Z, He Y, Zhao T, Fan M, Wang X, Zhu L, Wang X
Cell stress & chaperones 2015 May;20(3):507-16
Cell stress & chaperones 2015 May;20(3):507-16
Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes.
Hasan AU, Ohmori K, Konishi K, Igarashi J, Hashimoto T, Kamitori K, Yamaguchi F, Tsukamoto I, Uyama T, Ishihara Y, Noma T, Tokuda M, Kohno M
Molecular and cellular endocrinology 2015 May 5;406:10-8
Molecular and cellular endocrinology 2015 May 5;406:10-8
Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation.
Liu X, Chen Z, Xu C, Leng X, Cao H, Ouyang G, Xiao W
Nucleic acids research 2015 May 26;43(10):5081-98
Nucleic acids research 2015 May 26;43(10):5081-98
FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation.
El Assar M, Sánchez-Puelles JM, Royo I, López-Hernández E, Sánchez-Ferrer A, Aceña JL, Rodríguez-Mañas L, Angulo J
British journal of pharmacology 2015 Mar;172(5):1277-91
British journal of pharmacology 2015 Mar;172(5):1277-91
HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells.
Marhold M, Tomasich E, El-Gazzar A, Heller G, Spittler A, Horvat R, Krainer M, Horak P
Molecular cancer research : MCR 2015 Mar;13(3):556-64
Molecular cancer research : MCR 2015 Mar;13(3):556-64
High nuclear hypoxia-inducible factor 1 alpha expression is a predictor of distant recurrence in patients with resected pancreatic adenocarcinoma.
Colbert LE, Fisher SB, Balci S, Saka B, Chen Z, Kim S, El-Rayes BF, Adsay NV, Maithel SK, Landry JC, Curran WJ Jr
International journal of radiation oncology, biology, physics 2015 Mar 1;91(3):631-9
International journal of radiation oncology, biology, physics 2015 Mar 1;91(3):631-9
Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1α.
Wang F, Zhang G, Xing T, Lu Z, Li J, Peng C, Liu G, Wang N
Journal of cellular and molecular medicine 2015 Jun;19(6):1400-9
Journal of cellular and molecular medicine 2015 Jun;19(6):1400-9
IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection.
Hammami A, Charpentier T, Smans M, Stäger S
PLoS pathogens 2015 Jun;11(6):e1004938
PLoS pathogens 2015 Jun;11(6):e1004938
A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules.
Espana-Agusti J, Tuveson DA, Adams DJ, Matakidou A
Scientific reports 2015 Jun 5;5:11061
Scientific reports 2015 Jun 5;5:11061
E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity.
Lee JH, Elly C, Park Y, Liu YC
Immunity 2015 Jun 16;42(6):1062-74
Immunity 2015 Jun 16;42(6):1062-74
3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1α and NF-κB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions.
Park H, Lee DS, Yim MJ, Choi YH, Park S, Seo SK, Choi JS, Jang WH, Yea SS, Park WS, Lee CM, Jung WK, Choi IW
International journal of molecular medicine 2015 Jul;36(1):301-8
International journal of molecular medicine 2015 Jul;36(1):301-8
SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia.
Joo HY, Yun M, Jeong J, Park ER, Shin HJ, Woo SR, Jung JK, Kim YM, Park JJ, Kim J, Lee KH
Biochemical and biophysical research communications 2015 Jul 10;462(4):294-300
Biochemical and biophysical research communications 2015 Jul 10;462(4):294-300
Oxygen-regulated gene expression in murine cumulus cells.
Kind KL, Tam KK, Banwell KM, Gauld AD, Russell DL, Macpherson AM, Brown HM, Frank LA, Peet DJ, Thompson JG
Reproduction, fertility, and development 2015 Jan;27(2):407-18
Reproduction, fertility, and development 2015 Jan;27(2):407-18
Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity.
Jeong S, Park H, Hong S, Yum S, Kim W, Jung Y
European journal of pharmacology 2015 Jan 15;747:114-22
European journal of pharmacology 2015 Jan 15;747:114-22
Only very early oxygen therapy attenuates posthemorrhagic edema formation and blood-brain barrier disruption in murine intracerebral hemorrhage.
Zhou W, Marinescu M, Veltkamp R
Neurocritical care 2015 Feb;22(1):121-32
Neurocritical care 2015 Feb;22(1):121-32
RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model.
Gillespie DL, Aguirre MT, Ravichandran S, Leishman LL, Berrondo C, Gamboa JT, Wang L, King R, Wang X, Tan M, Malamas A, Lu ZR, Jensen RL
Journal of neurosurgery 2015 Feb;122(2):331-41
Journal of neurosurgery 2015 Feb;122(2):331-41
Priming Wharton's jelly-derived mesenchymal stromal/stem cells with ROCK inhibitor improves recovery in an intracerebral hemorrhage model.
Lee HS, Kim KS, Lim HS, Choi M, Kim HK, Ahn HY, Shin JC, Joe YA
Journal of cellular biochemistry 2015 Feb;116(2):310-9
Journal of cellular biochemistry 2015 Feb;116(2):310-9
Enhanced hypoxia-inducible factor (HIF)-1α stability induced by 5-hydroxymethyl-2-furfural (5-HMF) contributes to protection against hypoxia.
He YL, Li MM, Wu LY, Zhao T, Di Y, Huang X, Ding XF, Wu KW, Fan M, Zhu LL
Molecular medicine (Cambridge, Mass.) 2015 Feb 23;20:590-600
Molecular medicine (Cambridge, Mass.) 2015 Feb 23;20:590-600
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Rutz S, Kayagaki N, Phung QT, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang OW, Cochran AG, Vasser M, Fauber BP, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick DS, Lill JR, Ouyang W, Dixit VM
Nature 2015 Feb 19;518(7539):417-21
Nature 2015 Feb 19;518(7539):417-21
Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model.
Brandes F, Schmidt K, Wagner C, Redekopf J, Schlitt HJ, Geissler EK, Lang SA
BMC cancer 2015 Feb 19;15:71
BMC cancer 2015 Feb 19;15:71
3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma.
de la Puente P, Muz B, Gilson RC, Azab F, Luderer M, King J, Achilefu S, Vij R, Azab AK
Biomaterials 2015 Dec;73:70-84
Biomaterials 2015 Dec;73:70-84
Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors.
Danhier P, Krishnamachary B, Bharti S, Kakkad S, Mironchik Y, Bhujwalla ZM
Neoplasia (New York, N.Y.) 2015 Dec;17(12):871-881
Neoplasia (New York, N.Y.) 2015 Dec;17(12):871-881
High-intensity interval training-induced metabolic adaptation coupled with an increase in Hif-1α and glycolytic protein expression.
Abe T, Kitaoka Y, Kikuchi DM, Takeda K, Numata O, Takemasa T
Journal of applied physiology (Bethesda, Md. : 1985) 2015 Dec 1;119(11):1297-302
Journal of applied physiology (Bethesda, Md. : 1985) 2015 Dec 1;119(11):1297-302
Hypoxia inducible factor 1α down regulates cell surface expression of α1,2-fucosylated glycans in human pancreatic adenocarcinoma cells.
Belo AI, van Vliet SJ, Maus A, Laan LC, Nauta TD, Koolwijk P, Tefsen B, van Die I
FEBS letters 2015 Aug 19;589(18):2359-66
FEBS letters 2015 Aug 19;589(18):2359-66
An innovative three-dimensional gelatin foam culture system for improved study of glioblastoma stem cell behavior.
Yang MY, Chiao MT, Lee HT, Chen CM, Yang YC, Shen CC, Ma HI
Journal of biomedical materials research. Part B, Applied biomaterials 2015 Apr;103(3):618-28
Journal of biomedical materials research. Part B, Applied biomaterials 2015 Apr;103(3):618-28
The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe.
Takata S, Masuda T, Nakamura S, Kuchimaru T, Tsuruma K, Shimazawa M, Nagasawa H, Kizaka-Kondoh S, Hara H
Scientific reports 2015 Apr 30;5:9898
Scientific reports 2015 Apr 30;5:9898
A PKM2 signature in the failing heart.
Rees ML, Subramaniam J, Li Y, Hamilton DJ, Frazier OH, Taegtmeyer H
Biochemical and biophysical research communications 2015 Apr 10;459(3):430-6
Biochemical and biophysical research communications 2015 Apr 10;459(3):430-6
BRCA1 induces major energetic metabolism reprogramming in breast cancer cells.
Privat M, Radosevic-Robin N, Aubel C, Cayre A, Penault-Llorca F, Marceau G, Sapin V, Bignon YJ, Morvan D
PloS one 2014;9(7):e102438
PloS one 2014;9(7):e102438
Important role of autophagy in endothelial cell response to ionizing radiation.
Kalamida D, Karagounis IV, Giatromanolaki A, Koukourakis MI
PloS one 2014;9(7):e102408
PloS one 2014;9(7):e102408
HIF1α and HIF2α exert distinct nutrient preferences in renal cells.
Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK
PloS one 2014;9(5):e98705
PloS one 2014;9(5):e98705
Clinical and prognostic significance of HIF-1α, PTEN, CD44v6, and survivin for gastric cancer: a meta-analysis.
Chen J, Li T, Liu Q, Jiao H, Yang W, Liu X, Huo Z
PloS one 2014;9(3):e91842
PloS one 2014;9(3):e91842
Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm.
Sano M, Sasaki T, Hirakawa S, Sakabe J, Ogawa M, Baba S, Zaima N, Tanaka H, Inuzuka K, Yamamoto N, Setou M, Sato K, Konno H, Unno N
PloS one 2014;9(3):e89830
PloS one 2014;9(3):e89830
Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction.
Wu X, He L, Chen F, He X, Cai Y, Zhang G, Yi Q, He M, Luo J
PloS one 2014;9(11):e112891
PloS one 2014;9(11):e112891
The prolyl hydroxylase inhibitor dimethyloxalylglycine enhances dentin sialophoshoprotein expression through VEGF-induced Runx2 stabilization.
Rahman SU, Lee MS, Baek JH, Ryoo HM, Woo KM
PloS one 2014;9(11):e112078
PloS one 2014;9(11):e112078
The vitamin D analogue ED71 but Not 1,25(OH)2D3 targets HIF1α protein in osteoclasts.
Sato Y, Miyauchi Y, Yoshida S, Morita M, Kobayashi T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Watanabe R, Miyamoto K, Morioka H, Matsumoto M, Toyama Y, Miyamoto T
PloS one 2014;9(11):e111845
PloS one 2014;9(11):e111845
Severe blunt muscle trauma in rats: only marginal hypoxia in the injured area.
Funk K, Scheerer N, Verhaegh R, Pütter C, Fandrey J, de Groot H
PloS one 2014;9(10):e111151
PloS one 2014;9(10):e111151
The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme.
Wang E, Zhang C, Polavaram N, Liu F, Wu G, Schroeder MA, Lau JS, Mukhopadhyay D, Jiang SW, O'Neill BP, Datta K, Li J
PloS one 2014;9(1):e86102
PloS one 2014;9(1):e86102
High glucose activates ChREBP-mediated HIF-1α and VEGF expression in human RPE cells under normoxia.
Chang ML, Chiu CJ, Shang F, Taylor A
Advances in experimental medicine and biology 2014;801:609-21
Advances in experimental medicine and biology 2014;801:609-21
Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment.
Narise K, Okuda K, Enomoto Y, Hirayama T, Nagasawa H
Drug design, development and therapy 2014;8:701-17
Drug design, development and therapy 2014;8:701-17
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments.
Zhang X, Fryknäs M, Hernlund E, Fayad W, De Milito A, Olofsson MH, Gogvadze V, Dang L, Påhlman S, Schughart LA, Rickardson L, D'Arcy P, Gullbo J, Nygren P, Larsson R, Linder S
Nature communications 2014;5:3295
Nature communications 2014;5:3295
Stem cell niches in glioblastoma: a neuropathological view.
Schiffer D, Mellai M, Annovazzi L, Caldera V, Piazzi A, Denysenko T, Melcarne A
BioMed research international 2014;2014:725921
BioMed research international 2014;2014:725921
Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).
Gauter-Fleckenstein B, Reboucas JS, Fleckenstein K, Tovmasyan A, Owzar K, Jiang C, Batinic-Haberle I, Vujaskovic Z
Redox biology 2014;2:400-10
Redox biology 2014;2:400-10
Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone.
Frey JL, Stonko DP, Faugere MC, Riddle RC
Bone research 2014;2:14005
Bone research 2014;2:14005
Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1α/OATPs signaling axis.
Wu JB, Shao C, Li X, Shi C, Li Q, Hu P, Chen YT, Dou X, Sahu D, Li W, Harada H, Zhang Y, Wang R, Zhau HE, Chung LW
Biomaterials 2014 Sep;35(28):8175-85
Biomaterials 2014 Sep;35(28):8175-85
Influence of preoperative transcatheter arterial chemoembolization on gene expression in the HIF-1α pathway in patients with hepatocellular carcinoma.
Xu W, Kwon JH, Moon YH, Kim YB, Yu YS, Lee N, Choi KY, Kim YS, Park YK, Kim BW, Wang HJ
Journal of cancer research and clinical oncology 2014 Sep;140(9):1507-15
Journal of cancer research and clinical oncology 2014 Sep;140(9):1507-15
HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth.
Queisser MA, Dada LA, Deiss-Yehiely N, Angulo M, Zhou G, Kouri FM, Knab LM, Liu J, Stegh AH, DeCamp MM, Budinger GR, Chandel NS, Ciechanover A, Iwai K, Sznajder JI
American journal of respiratory and critical care medicine 2014 Sep 15;190(6):688-98
American journal of respiratory and critical care medicine 2014 Sep 15;190(6):688-98
Hypoxia-induced miR-210 modulates tissue response to acute peripheral ischemia.
Zaccagnini G, Maimone B, Di Stefano V, Fasanaro P, Greco S, Perfetti A, Capogrossi MC, Gaetano C, Martelli F
Antioxidants & redox signaling 2014 Sep 10;21(8):1177-88
Antioxidants & redox signaling 2014 Sep 10;21(8):1177-88
PCB 126 perturbs hypoxia-induced HIF-1α activity and glucose consumption in human HepG2 cells.
Vorrink SU, Sarsour EH, Olivier AK, Robertson LW, Goswami PC, Domann FE
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2014 Oct;66(8):377-82
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2014 Oct;66(8):377-82
Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression.
Kasper LH, Qu C, Obenauer JC, McGoldrick DJ, Brindle PK
Nucleic acids research 2014 Oct;42(18):11363-82
Nucleic acids research 2014 Oct;42(18):11363-82
Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α.
Yang X, Zhu H, Ge Y, Liu J, Cai J, Qin Q, Zhan L, Zhang C, Xu L, Liu Z, Yang Y, Yang Y, Ma J, Cheng H, Sun X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Oct;35(10):10443-8
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Oct;35(10):10443-8
HIF-1 alpha-induced up-regulation of miR-9 contributes to phenotypic modulation in pulmonary artery smooth muscle cells during hypoxia.
Shan F, Li J, Huang QY
Journal of cellular physiology 2014 Oct;229(10):1511-20
Journal of cellular physiology 2014 Oct;229(10):1511-20
Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice.
Yoshikawa N, Shimizu N, Ojima H, Kobayashi H, Hosono O, Tanaka H
Biochemical and biophysical research communications 2014 Oct 24;453(3):600-5
Biochemical and biophysical research communications 2014 Oct 24;453(3):600-5
Hypoxia-inducible factor-1α upregulation in microglia following hypoxia protects against ischemia-induced cerebral infarction.
Huang T, Huang W, Zhang Z, Yu L, Xie C, Zhu D, Peng Z, Chen J
Neuroreport 2014 Oct 1;25(14):1122-8
Neuroreport 2014 Oct 1;25(14):1122-8
SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1α-dependent pathway.
Gu J, Fan Y, Liu X, Zhou L, Cheng J, Cai R, Xue S
Cardiovascular research 2014 Oct 1;104(1):83-92
Cardiovascular research 2014 Oct 1;104(1):83-92
Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation.
Abu-Remaileh M, Aqeilan RI
Cell death and differentiation 2014 Nov;21(11):1805-14
Cell death and differentiation 2014 Nov;21(11):1805-14
Augmentation of LPS-induced vascular endothelial cell growth factor production in macrophages by transforming growth factor-β1.
Koide N, Odkhuu E, Naiki Y, Tsolmongyn B, Ito K, Komatsu T, Yoshida T, Yokochi T
Innate immunity 2014 Nov;20(8):816-25
Innate immunity 2014 Nov;20(8):816-25
Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion.
Fujikuni N, Yamamoto H, Tanabe K, Naito Y, Sakamoto N, Tanaka Y, Yanagihara K, Oue N, Yasui W, Ohdan H
Cancer science 2014 Nov;105(11):1411-20
Cancer science 2014 Nov;105(11):1411-20
Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1.
Shinohara M, Kibi M, Riley IR, Chiang N, Dalli J, Kraft BD, Piantadosi CA, Choi AM, Serhan CN
American journal of physiology. Lung cellular and molecular physiology 2014 Nov 15;307(10):L746-57
American journal of physiology. Lung cellular and molecular physiology 2014 Nov 15;307(10):L746-57
Prolyl hydroxylase inhibitors protect from the bone loss in ovariectomy rats by increasing bone vascularity.
Liu X, Tu Y, Zhang L, Qi J, Ma T, Deng L
Cell biochemistry and biophysics 2014 May;69(1):141-9
Cell biochemistry and biophysics 2014 May;69(1):141-9
Dynamic hypoxia in scar tissue during human hypertrophic scar progression.
Zheng J, Song F, Lu SL, Wang XQ
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2014 May;40(5):511-8
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2014 May;40(5):511-8
Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response.
Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, Shadfan M, Asara JM, Ha CS, Ben-Sahra I, Manning BD, Little JB, Yuan ZM
Cell death and differentiation 2014 May;21(5):836-44
Cell death and differentiation 2014 May;21(5):836-44
Noninvasive assessment of hypoxia in rabbit advanced atherosclerosis using ¹⁸F-fluoromisonidazole positron emission tomographic imaging.
Mateo J, Izquierdo-Garcia D, Badimon JJ, Fayad ZA, Fuster V
Circulation. Cardiovascular imaging 2014 Mar;7(2):312-20
Circulation. Cardiovascular imaging 2014 Mar;7(2):312-20
Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation.
Chen TM, Shih YH, Tseng JT, Lai MC, Wu CH, Li YH, Tsai SJ, Sun HS
Nucleic acids research 2014 Mar;42(5):2932-44
Nucleic acids research 2014 Mar;42(5):2932-44
EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300.
Chen Z, Liu X, Mei Z, Wang Z, Xiao W
Molecular and cellular biology 2014 Mar;34(6):1085-99
Molecular and cellular biology 2014 Mar;34(6):1085-99
Epidermal deletion of HIF-2α stimulates wound closure.
Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson RS
The Journal of investigative dermatology 2014 Mar;134(3):801-808
The Journal of investigative dermatology 2014 Mar;134(3):801-808
Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axis.
White NM, Masui O, Newsted D, Scorilas A, Romaschin AD, Bjarnason GA, Siu KW, Yousef GM
British journal of cancer 2014 Mar 4;110(5):1250-9
British journal of cancer 2014 Mar 4;110(5):1250-9
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.
Pawlus MR, Wang L, Hu CJ
Oncogene 2014 Mar 27;33(13):1670-9
Oncogene 2014 Mar 27;33(13):1670-9
Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease.
Zhang WG, He L, Shi XM, Wu SS, Zhang B, Mei L, Xu YJ, Zhang ZX, Zhao JP, Zhang HL
Respiratory research 2014 Mar 25;15:33
Respiratory research 2014 Mar 25;15:33
Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression.
Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GL
The Biochemical journal 2014 Mar 1;458(2):203-11
The Biochemical journal 2014 Mar 1;458(2):203-11
Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight.
Kawakami T, Yoshimi M, Kadota Y, Inoue M, Sato M, Suzuki S
Toxicology and applied pharmacology 2014 Mar 1;275(2):134-44
Toxicology and applied pharmacology 2014 Mar 1;275(2):134-44
Elevated protein carbonyl and HIF-1α levels in eyes with proliferative diabetic retinopathy.
Loukovaara S, Koivunen P, Inglés M, Escobar J, Vento M, Andersson S
Acta ophthalmologica 2014 Jun;92(4):323-7
Acta ophthalmologica 2014 Jun;92(4):323-7
HIF-2α/ARNT complex regulates hair development via induction of p21(Waf1/Cip1) and p27(Kip1).
Imamura Y, Tomita S, Imanishi M, Kihira Y, Ikeda Y, Ishizawa K, Tsuchiya K, Tamaki T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jun;28(6):2517-24
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jun;28(6):2517-24
β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α.
Kim YS, Lee HA, Lim JY, Kim Y, Jung CH, Yoo SH, Kim Y
The Journal of nutritional biochemistry 2014 Jun;25(6):655-64
The Journal of nutritional biochemistry 2014 Jun;25(6):655-64
Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells.
Huang YH, Lin MH, Wang PC, Wu YC, Chiang HL, Wang YL, Chang JH, Huang YK, Gu SY, Ho HN, Ling TY
Molecular human reproduction 2014 Jun;20(6):526-37
Molecular human reproduction 2014 Jun;20(6):526-37
Disruption of chaperone-mediated autophagy-dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization.
Zhang L, Sun Y, Fei M, Tan C, Wu J, Zheng J, Tang J, Sun W, Lv Z, Bao J, Xu Q, Yu H
Autophagy 2014 Jun;10(6):1015-35
Autophagy 2014 Jun;10(6):1015-35
Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia.
Pan WL, Wong JH, Fang EF, Chan YS, Ng TB, Cheung RC
Biochemical pharmacology 2014 Jun 1;89(3):329-39
Biochemical pharmacology 2014 Jun 1;89(3):329-39
Sox9 and Hif-2α regulate TUBB3 gene expression and affect ovarian cancer aggressiveness.
Raspaglio G, Petrillo M, Martinelli E, Li Puma DD, Mariani M, De Donato M, Filippetti F, Mozzetti S, Prislei S, Zannoni GF, Scambia G, Ferlini C
Gene 2014 Jun 1;542(2):173-81
Gene 2014 Jun 1;542(2):173-81
Overexpression of hypoxia-inducible factor-1α is a predictor of poor prognosis in cervical cancer: a clinicopathologic study and a meta-analysis.
Huang M, Chen Q, Xiao J, Yao T, Bian L, Liu C, Lin Z
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2014 Jul;24(6):1054-64
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2014 Jul;24(6):1054-64
HIF-1α, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia.
Allon I, Kaplan I, Allon DM, Vered H, Shlomi B, Hirshberg A
Oral diseases 2014 Jul;20(5):440-5
Oral diseases 2014 Jul;20(5):440-5
Hypoxia-inducible factor-1α and its role in the proliferation of retinoblastoma cells.
Fernandes BF, Coates J, Odashiro AN, Quezada C, Huynh A, Odashiro PR, Odashiro M, Burnier MN Jr
Pathology oncology research : POR 2014 Jul;20(3):557-63
Pathology oncology research : POR 2014 Jul;20(3):557-63
The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP-protein kinase A signalling pathway in white adipose tissue.
Xiong Y, Qu Z, Chen N, Gong H, Song M, Chen X, Du J, Xu C
Molecular and cellular endocrinology 2014 Jul 5;392(1-2):106-14
Molecular and cellular endocrinology 2014 Jul 5;392(1-2):106-14
Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts.
Miyazaki S, Kikuchi H, Iino I, Uehara T, Setoguchi T, Fujita T, Hiramatsu Y, Ohta M, Kamiya K, Kitagawa K, Kitagawa M, Baba S, Konno H
International journal of cancer 2014 Jul 15;135(2):295-307
International journal of cancer 2014 Jul 15;135(2):295-307
Expression of hypoxia-inducible factor-1α, vascular endothelial growth factor and prolyl hydroxylase domain protein 2 in cutaneous squamous cell carcinoma and precursor lesions and their relationship with histological stages and clinical features.
An X, Xu G, Yang L, Wang Y, Li Y, McHepange UO, Shen G, Tu Y, Tao J
The Journal of dermatology 2014 Jan;41(1):76-83
The Journal of dermatology 2014 Jan;41(1):76-83
DMOG ameliorates IFN-γ-induced intestinal barrier dysfunction by suppressing PHD2-dependent HIF-1α degradation.
Wang WS, Liang HY, Cai YJ, Yang H
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2014 Jan;34(1):60-9
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2014 Jan;34(1):60-9
High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α.
Tan JT, Prosser HC, Vanags LZ, Monger SA, Ng MK, Bursill CA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jan;28(1):206-17
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jan;28(1):206-17
Preoperative dynamic contrast-enhanced MRI correlates with molecular markers of hypoxia and vascularity in specific areas of intratumoral microenvironment and is predictive of patient outcome.
Jensen RL, Mumert ML, Gillespie DL, Kinney AY, Schabel MC, Salzman KL
Neuro-oncology 2014 Jan;16(2):280-91
Neuro-oncology 2014 Jan;16(2):280-91
The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells.
Bertozzi D, Marinello J, Manzo SG, Fornari F, Gramantieri L, Capranico G
Molecular cancer therapeutics 2014 Jan;13(1):239-48
Molecular cancer therapeutics 2014 Jan;13(1):239-48
Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation.
Pantel A, Teixeira A, Haddad E, Wood EG, Steinman RM, Longhi MP
PLoS biology 2014 Jan;12(1):e1001759
PLoS biology 2014 Jan;12(1):e1001759
Hyperoxia inhibits glucose-induced insulin secretion and mitochondrial metabolism in rat pancreatic islets.
Ma Z, Moruzzi N, Catrina SB, Grill V, Björklund A
Biochemical and biophysical research communications 2014 Jan 3;443(1):223-8
Biochemical and biophysical research communications 2014 Jan 3;443(1):223-8
Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus.
Wall AM, Corcoran AE, O'Halloran KD, O'Connor JJ
Neurobiology of disease 2014 Feb;62:8-17
Neurobiology of disease 2014 Feb;62:8-17
Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke.
Cheng YL, Park JS, Manzanero S, Choi Y, Baik SH, Okun E, Gelderblom M, Fann DY, Magnus T, Launikonis BS, Mattson MP, Sobey CG, Jo DG, Arumugam TV
Neurobiology of disease 2014 Feb;62:286-95
Neurobiology of disease 2014 Feb;62:286-95
Molecular changes in bone marrow, tumor and serum after conductive ablation of murine 4T1 breast carcinoma.
Przybyla BD, Shafirstein G, Vishal SJ, Dennis RA, Griffin RJ
International journal of oncology 2014 Feb;44(2):600-8
International journal of oncology 2014 Feb;44(2):600-8
GDNF increases cell motility in human colon cancer through VEGF-VEGFR1 interaction.
Huang SM, Chen TS, Chiu CM, Chang LK, Liao KF, Tan HM, Yeh WL, Chang GR, Wang MY, Lu DY
Endocrine-related cancer 2014 Feb;21(1):73-84
Endocrine-related cancer 2014 Feb;21(1):73-84
Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression.
Zhang C, Yang X, Zhang Q, Yang B, Xu L, Qin Q, Zhu H, Liu J, Cai J, Tao G, Ma J, Ge X, Zhang S, Cheng H, Sun X
Acta oto-laryngologica 2014 Feb;134(2):185-92
Acta oto-laryngologica 2014 Feb;134(2):185-92
Partial deficiency of HIF-1α stimulates pathological cardiac changes in streptozotocin-induced diabetic mice.
Bohuslavova R, Kolar F, Sedmera D, Skvorova L, Papousek F, Neckar J, Pavlinkova G
BMC endocrine disorders 2014 Feb 6;14:11
BMC endocrine disorders 2014 Feb 6;14:11
MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells.
He M, Lu Y, Xu S, Mao L, Zhang L, Duan W, Liu C, Pi H, Zhang Y, Zhong M, Yu Z, Zhou Z
Cell death & disease 2014 Feb 27;5:e1090
Cell death & disease 2014 Feb 27;5:e1090
A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection.
Ganapathy S, Xiao S, Yang M, Qi M, Choi DE, Ha CS, Little JB, Yuan ZM
The Journal of biological chemistry 2014 Feb 21;289(8):5340-7
The Journal of biological chemistry 2014 Feb 21;289(8):5340-7
Anthrax lethal toxin inhibits translation of hypoxia-inducible factor 1α and causes decreased tolerance to hypoxic stress.
Ouyang W, Torigoe C, Fang H, Xie T, Frucht DM
The Journal of biological chemistry 2014 Feb 14;289(7):4180-90
The Journal of biological chemistry 2014 Feb 14;289(7):4180-90
Upregulation of HIF-1α via activation of ERK and PI3K pathway mediated protective response to microwave-induced mitochondrial injury in neuron-like cells.
Zhao L, Yang YF, Gao YB, Wang SM, Wang LF, Zuo HY, Dong J, Xu XP, Su ZT, Zhou HM, Zhu LL, Peng RY
Molecular neurobiology 2014 Dec;50(3):1024-34
Molecular neurobiology 2014 Dec;50(3):1024-34
Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells.
Bordji K, Grandval A, Cuhna-Alves L, Lechapt-Zalcman E, Bernaudin M
The FEBS journal 2014 Dec;281(23):5220-36
The FEBS journal 2014 Dec;281(23):5220-36
Connexin 43 suppresses tumor angiogenesis by down-regulation of vascular endothelial growth factor via hypoxic-induced factor-1α.
Wang WK, Chen MC, Leong HF, Kuo YL, Kuo CY, Lee CH
International journal of molecular sciences 2014 Dec 26;16(1):439-51
International journal of molecular sciences 2014 Dec 26;16(1):439-51
Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells.
Samanta D, Gilkes DM, Chaturvedi P, Xiang L, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 16;111(50):E5429-38
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 16;111(50):E5429-38
Expression of HIF-1α and MDR1/P-glycoprotein in refractory mesial temporal lobe epilepsy patients and pharmacoresistant temporal lobe epilepsy rat model kindled by coriaria lactone.
Li Y, Chen J, Zeng T, Lei D, Chen L, Zhou D
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2014 Aug;35(8):1203-8
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2014 Aug;35(8):1203-8
Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1) dependent mechanism.
Engelhardt S, Al-Ahmad AJ, Gassmann M, Ogunshola OO
Journal of cellular physiology 2014 Aug;229(8):1096-105
Journal of cellular physiology 2014 Aug;229(8):1096-105
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
Salman S, Holloway AC, Nurse CA
American journal of physiology. Cell physiology 2014 Aug 1;307(3):C266-77
American journal of physiology. Cell physiology 2014 Aug 1;307(3):C266-77
Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α.
Ji X, Wang H, Zhu J, Zhu L, Pan H, Li W, Zhou Y, Cong Z, Yan F, Chen S
International journal of cancer 2014 Aug 1;135(3):574-84
International journal of cancer 2014 Aug 1;135(3):574-84
Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency.
Williamson DL, Li Z, Tuder RM, Feinstein E, Kimball SR, Dungan CM
Journal of applied physiology (Bethesda, Md. : 1985) 2014 Aug 1;117(3):246-56
Journal of applied physiology (Bethesda, Md. : 1985) 2014 Aug 1;117(3):246-56
Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 α in lung tumor.
Shiau AL, Shen YT, Hsieh JL, Wu CL, Lee CH
Environmental toxicology 2014 Apr;29(4):363-70
Environmental toxicology 2014 Apr;29(4):363-70
Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling.
Weisel FC, Kloepping C, Pichl A, Sydykov A, Kojonazarov B, Wilhelm J, Roth M, Ridge KM, Igarashi K, Nishimura K, Maison W, Wackendorff C, Klepetko W, Jaksch P, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G
Circulation 2014 Apr 8;129(14):1510-23
Circulation 2014 Apr 8;129(14):1510-23
Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α.
Zhao W, Chang C, Cui Y, Zhao X, Yang J, Shen L, Zhou J, Hou Z, Zhang Z, Ye C, Hasenmayer D, Perkins R, Huang X, Yao X, Yu L, Huang R, Zhang D, Guo H, Yan J
The Journal of biological chemistry 2014 Apr 18;289(16):11219-29
The Journal of biological chemistry 2014 Apr 18;289(16):11219-29
Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype.
Watson CJ, Collier P, Tea I, Neary R, Watson JA, Robinson C, Phelan D, Ledwidge MT, McDonald KM, McCann A, Sharaf O, Baugh JA
Human molecular genetics 2014 Apr 15;23(8):2176-88
Human molecular genetics 2014 Apr 15;23(8):2176-88
Proteomic screening of human targets of viral microRNAs reveals functions associated with immune evasion and angiogenesis.
Gallaher AM, Das S, Xiao Z, Andresson T, Kieffer-Kwon P, Happel C, Ziegelbauer J
PLoS pathogens 2013;9(9):e1003584
PLoS pathogens 2013;9(9):e1003584
Convergent RANK- and c-Met-mediated signaling components predict survival of patients with prostate cancer: an interracial comparative study.
Hu P, Chung LW, Berel D, Frierson HF, Yang H, Liu C, Wang R, Li Q, Rogatko A, Zhau HE
PloS one 2013;8(9):e73081
PloS one 2013;8(9):e73081
Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort.
Lin WP, Wang XJ, Wang CR, Zhang LQ, Li N, Wang FS, Lin JH
PloS one 2013;8(8):e73158
PloS one 2013;8(8):e73158
STAT3 or USF2 contributes to HIF target gene specificity.
Pawlus MR, Wang L, Murakami A, Dai G, Hu CJ
PloS one 2013;8(8):e72358
PloS one 2013;8(8):e72358
Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis.
Wang SC, Yu CF, Hong JH, Tsai CS, Chiang CS
PloS one 2013;8(8):e69182
PloS one 2013;8(8):e69182
Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma.
Al-Greene NT, Means AL, Lu P, Jiang A, Schmidt CR, Chakravarthy AB, Merchant NB, Washington MK, Zhang B, Shyr Y, Deane NG, Beauchamp RD
PloS one 2013;8(7):e69660
PloS one 2013;8(7):e69660
Melittin suppresses HIF-1α/VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical carcinoma cells.
Shin JM, Jeong YJ, Cho HJ, Park KK, Chung IK, Lee IK, Kwak JY, Chang HW, Kim CH, Moon SK, Kim WJ, Choi YH, Chang YC
PloS one 2013;8(7):e69380
PloS one 2013;8(7):e69380
Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.
Sun YY, Lin SH, Lin HC, Hung CC, Wang CY, Lin YC, Hung KS, Lien CC, Kuan CY, Lee YH
PloS one 2013;8(7):e69019
PloS one 2013;8(7):e69019
Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells.
Ma Z, Moruzzi N, Catrina SB, Hals I, Oberholzer J, Grill V, Björklund A
PloS one 2013;8(7):e67498
PloS one 2013;8(7):e67498
Hypoxia and hypoxia mimetics decrease aquaporin 5 (AQP5) expression through both hypoxia inducible factor-1α and proteasome-mediated pathways.
Kawedia JD, Yang F, Sartor MA, Gozal D, Czyzyk-Krzeska M, Menon AG
PloS one 2013;8(3):e57541
PloS one 2013;8(3):e57541
Metformin as an adjuvant drug against pediatric sarcomas: hypoxia limits therapeutic effects of the drug.
Garofalo C, Capristo M, Manara MC, Mancarella C, Landuzzi L, Belfiore A, Lollini PL, Picci P, Scotlandi K
PloS one 2013;8(12):e83832
PloS one 2013;8(12):e83832
Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1α.
Park HJ, Kim MK, Kim SR, Bae SK, Bae MK
PloS one 2013;8(12):e82868
PloS one 2013;8(12):e82868
Hyperoxia exposure impairs nephrogenesis in the neonatal rat: role of HIF-1α.
Popescu CR, Sutherland MR, Cloutier A, Benoît G, Bertagnolli M, Yzydorczyk C, Germain N, Phan V, Lelièvre-Pegorier M, Sartelet H, Nuyt AM
PloS one 2013;8(12):e82421
PloS one 2013;8(12):e82421
Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis.
Chen Z, He X, Xia W, Huang Q, Zhang Z, Ye J, Ni C, Wu P, Wu D, Xu J, Qiu F, Huang J
PloS one 2013;8(12):e80337
PloS one 2013;8(12):e80337
Mitochondrial respiration regulates adipogenic differentiation of human mesenchymal stem cells.
Zhang Y, Marsboom G, Toth PT, Rehman J
PloS one 2013;8(10):e77077
PloS one 2013;8(10):e77077
Clinicopathological implications of the expression of hypoxia-related proteins in gastric cancer.
Jung JH, Im S, Jung ES, Kang CS
International journal of medical sciences 2013;10(9):1217-23
International journal of medical sciences 2013;10(9):1217-23
Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation.
Coudyzer P, Lemoine P, Jordan BF, Gallez B, Galant C, Nisolle M, Courtoy PJ, Henriet P, Marbaix E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Sep;27(9):3711-9
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Sep;27(9):3711-9
Impaired cytoplasmic-nuclear transport of hypoxia-inducible factor-1α in amyotrophic lateral sclerosis.
Nagara Y, Tateishi T, Yamasaki R, Hayashi S, Kawamura M, Kikuchi H, Iinuma KM, Tanaka M, Iwaki T, Matsushita T, Ohyagi Y, Kira J
Brain pathology (Zurich, Switzerland) 2013 Sep;23(5):534-46
Brain pathology (Zurich, Switzerland) 2013 Sep;23(5):534-46
HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK
PLoS biology 2013 Sep;11(9):e1001665
PLoS biology 2013 Sep;11(9):e1001665
Measurement of cell respiration and oxygenation in standard multichannel biochips using phosphorescent O2-sensitive probes.
Kondrashina AV, Papkovsky DB, Dmitriev RI
The Analyst 2013 Sep 7;138(17):4915-21
The Analyst 2013 Sep 7;138(17):4915-21
Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells.
Park YK, Park B, Lee S, Choi K, Moon Y, Park H
The Journal of biological chemistry 2013 Sep 6;288(36):26311-22
The Journal of biological chemistry 2013 Sep 6;288(36):26311-22
MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors.
Kitamoto S, Yokoyama S, Higashi M, Yamada N, Takao S, Yonezawa S
Oncogene 2013 Sep 26;32(39):4614-21
Oncogene 2013 Sep 26;32(39):4614-21
Role of hepatic resident and infiltrating macrophages in liver repair after acute injury.
You Q, Holt M, Yin H, Li G, Hu CJ, Ju C
Biochemical pharmacology 2013 Sep 15;86(6):836-43
Biochemical pharmacology 2013 Sep 15;86(6):836-43
Correlation between ¹⁸F-FDG uptake and the expression of glucose transporter-1 and hypoxia-inducible factor-1α in transplanted VX2 tumors.
Xu H, Li B, Yu W, Wang H, Zhao X, Yao Y, Huang D
Nuclear medicine communications 2013 Oct;34(10):953-8
Nuclear medicine communications 2013 Oct;34(10):953-8
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis.
Miyauchi Y, Sato Y, Kobayashi T, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Miyamoto K, Tando T, Morioka H, Matsumoto M, Chambon P, Johnson RS, Kato S, Toyama Y, Miyamoto T
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 8;110(41):16568-73
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 8;110(41):16568-73
Expression of hypoxia-inducible factor-1α and vascular density in mammary adenomas and adenocarcinomas in bitches.
Madej JA, Madej JP, Dziegiel P, Pula B, Nowak M
Acta veterinaria Scandinavica 2013 Oct 24;55:73
Acta veterinaria Scandinavica 2013 Oct 24;55:73
Tumor cells upregulate normoxic HIF-1α in response to doxorubicin.
Cao Y, Eble JM, Moon E, Yuan H, Weitzel DH, Landon CD, Nien CY, Hanna G, Rich JN, Provenzale JM, Dewhirst MW
Cancer research 2013 Oct 15;73(20):6230-42
Cancer research 2013 Oct 15;73(20):6230-42
Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells.
Wu C, Zhou Y, Chang J, Xiao Y
Acta biomaterialia 2013 Nov;9(11):9159-68
Acta biomaterialia 2013 Nov;9(11):9159-68
Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics.
Fujimura A, Michiue H, Cheng Y, Uneda A, Tani Y, Nishiki T, Ichikawa T, Wei FY, Tomizawa K, Matsui H
Neoplasia (New York, N.Y.) 2013 Nov;15(11):1272-81
Neoplasia (New York, N.Y.) 2013 Nov;15(11):1272-81
Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics.
Fujimura A, Michiue H, Cheng Y, Uneda A, Tani Y, Nishiki T, Ichikawa T, Wei FY, Tomizawa K, Matsui H
Neoplasia (New York, N.Y.) 2013 Nov;15(11):1272-81
Neoplasia (New York, N.Y.) 2013 Nov;15(11):1272-81
Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo.
Yang X, Yang B, Cai J, Zhang C, Zhang Q, Xu L, Qin Q, Zhu H, Ma J, Tao G, Cheng H, Sun X
Cancer biology & therapy 2013 Nov;14(11):1068-73
Cancer biology & therapy 2013 Nov;14(11):1068-73
Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype.
Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama-Sorimachi N, Kikkawa Y, Takenaga K, Hayashi J
Mitochondrion 2013 Nov;13(6):881-7
Mitochondrion 2013 Nov;13(6):881-7
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function.
Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H Jr, Johnson RS, Broide DH, Nizet V
Journal of molecular medicine (Berlin, Germany) 2013 May;91(5):637-44
Journal of molecular medicine (Berlin, Germany) 2013 May;91(5):637-44
EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate.
Matsumoto S, Saito K, Yasui H, Morris HD, Munasinghe JP, Lizak M, Merkle H, Ardenkjaer-Larsen JH, Choudhuri R, Devasahayam N, Subramanian S, Koretsky AP, Mitchell JB, Krishna MC
Magnetic resonance in medicine 2013 May;69(5):1443-50
Magnetic resonance in medicine 2013 May;69(5):1443-50
Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma.
Liang Y, Zheng T, Song R, Wang J, Yin D, Wang L, Liu H, Tian L, Fang X, Meng X, Jiang H, Liu J, Liu L
Hepatology (Baltimore, Md.) 2013 May;57(5):1847-57
Hepatology (Baltimore, Md.) 2013 May;57(5):1847-57
Effect of advanced glycation end products on the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor proteins in RF/6A cells.
Zhang H, Tang L, Chen S, Yang Y, Chen M, Luo J
Experimental and therapeutic medicine 2013 May;5(5):1519-1522
Experimental and therapeutic medicine 2013 May;5(5):1519-1522
Siah2-deficient mice show impaired skin wound repair.
Musyoka JN, Liu MC, Pouniotis DS, Wong CS, Bowtell DD, Little PJ, Getachew R, Möller A, Darby IA
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2013 May-Jun;21(3):437-47
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2013 May-Jun;21(3):437-47
Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression.
Shizu R, Shindo S, Yoshida T, Numazawa S
Toxicology letters 2013 May 23;219(2):143-50
Toxicology letters 2013 May 23;219(2):143-50
The histone demethylase JMJD1A regulates adrenomedullin-mediated cell proliferation in hepatocellular carcinoma under hypoxia.
Park SJ, Kim JG, Son TG, Yi JM, Kim ND, Yang K, Heo K
Biochemical and biophysical research communications 2013 May 17;434(4):722-7
Biochemical and biophysical research communications 2013 May 17;434(4):722-7
Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex.
Feliciano DM, Zhang S, Quon JL, Bordey A
Human molecular genetics 2013 May 1;22(9):1725-34
Human molecular genetics 2013 May 1;22(9):1725-34
Glucose transporter 1 (GLUT1) of anaerobic glycolysis as predictive and prognostic values in neoadjuvant chemoradiotherapy and laparoscopic surgery for locally advanced rectal cancer.
Shim BY, Jung JH, Lee KM, Kim HJ, Hong SH, Kim SH, Sun DS, Cho HM
International journal of colorectal disease 2013 Mar;28(3):375-83
International journal of colorectal disease 2013 Mar;28(3):375-83
Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007.
Towner RA, Gillespie DL, Schwager A, Saunders DG, Smith N, Njoku CE, Krysiak RS 3rd, Larabee C, Iqbal H, Floyd RA, Bourne DW, Abdullah O, Hsu EW, Jensen RL
Neuro-oncology 2013 Mar;15(3):330-40
Neuro-oncology 2013 Mar;15(3):330-40
Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice.
Albers J, Rajski M, Schönenberger D, Harlander S, Schraml P, von Teichman A, Georgiev S, Wild PJ, Moch H, Krek W, Frew IJ
EMBO molecular medicine 2013 Jun;5(6):949-64
EMBO molecular medicine 2013 Jun;5(6):949-64
Protective role of growth hormone against hyperhomocysteinemia-induced glomerular injury.
Li C, Xia M, Abais JM, Liu X, Li N, Boini KM, Li PL
Naunyn-Schmiedeberg's archives of pharmacology 2013 Jun;386(6):551-61
Naunyn-Schmiedeberg's archives of pharmacology 2013 Jun;386(6):551-61
Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes.
Bohuslavova R, Skvorova L, Sedmera D, Semenza GL, Pavlinkova G
Journal of molecular and cellular cardiology 2013 Jul;60:129-41
Journal of molecular and cellular cardiology 2013 Jul;60:129-41
Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer.
Bendinelli P, Maroni P, Matteucci E, Luzzati A, Perrucchini G, Desiderio MA
European journal of cancer (Oxford, England : 1990) 2013 Jul;49(11):2608-18
European journal of cancer (Oxford, England : 1990) 2013 Jul;49(11):2608-18
Hypoxia-induced regulation of the very low density lipoprotein receptor.
Sundelin JP, Lidberg U, Nik AM, Carlsson P, Borén J
Biochemical and biophysical research communications 2013 Jul 26;437(2):274-9
Biochemical and biophysical research communications 2013 Jul 26;437(2):274-9
Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues.
Wang W, McKinnie SM, Patel VB, Haddad G, Wang Z, Zhabyeyev P, Das SK, Basu R, McLean B, Kandalam V, Penninger JM, Kassiri Z, Vederas JC, Murray AG, Oudit GY
Journal of the American Heart Association 2013 Jul 1;2(4):e000249
Journal of the American Heart Association 2013 Jul 1;2(4):e000249
Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.
Chiabrando D, Fiorito V, Marro S, Silengo L, Altruda F, Tolosano E
Blood cells, molecules & diseases 2013 Jan;50(1):25-30
Blood cells, molecules & diseases 2013 Jan;50(1):25-30
Effects of oxygen tension and IGF-I on HIF-1α protein expression in mouse blastocysts.
Yoon J, Juhn KM, Ko JK, Yoon SH, Ko Y, Lee CY, Lim JH
Journal of assisted reproduction and genetics 2013 Jan;30(1):99-105
Journal of assisted reproduction and genetics 2013 Jan;30(1):99-105
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.
Chaturvedi P, Gilkes DM, Wong CC, Kshitiz., Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL
The Journal of clinical investigation 2013 Jan;123(1):189-205
The Journal of clinical investigation 2013 Jan;123(1):189-205
Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1α-related defense mechanisms.
Kakinuma Y, Tsuda M, Okazaki K, Akiyama T, Arikawa M, Noguchi T, Sato T
Journal of the American Heart Association 2013 Jan 18;2(1):e004887
Journal of the American Heart Association 2013 Jan 18;2(1):e004887
The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb.
Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, Jefferson LS
American journal of physiology. Endocrinology and metabolism 2013 Jan 15;304(2):E229-36
American journal of physiology. Endocrinology and metabolism 2013 Jan 15;304(2):E229-36
Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α.
Kim YJ, Lee HJ, Kim TM, Eisinger-Mathason TS, Zhang AY, Schmidt B, Karl DL, Nakazawa MS, Park PJ, Simon MC, Yoon SS
International journal of cancer 2013 Jan 1;132(1):29-41
International journal of cancer 2013 Jan 1;132(1):29-41
Hypoxia inducible factor-1α-mediated activation of survivin in cervical cancer cells.
Bai H, Ge S, Lu J, Qian G, Xu R
The journal of obstetrics and gynaecology research 2013 Feb;39(2):555-63
The journal of obstetrics and gynaecology research 2013 Feb;39(2):555-63
Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells.
Kurt B, Paliege A, Willam C, Schwarzensteiner I, Schucht K, Neymeyer H, Sequeira-Lopez ML, Bachmann S, Gomez RA, Eckardt KU, Kurtz A
Journal of the American Society of Nephrology : JASN 2013 Feb;24(3):433-44
Journal of the American Society of Nephrology : JASN 2013 Feb;24(3):433-44
MicroRNA-183 upregulates HIF-1α by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells.
Tanaka H, Sasayama T, Tanaka K, Nakamizo S, Nishihara M, Mizukawa K, Kohta M, Koyama J, Miyake S, Taniguchi M, Hosoda K, Kohmura E
Journal of neuro-oncology 2013 Feb;111(3):273-83
Journal of neuro-oncology 2013 Feb;111(3):273-83
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
Hebron ML, Lonskaya I, Sharpe K, Weerasinghe PP, Algarzae NK, Shekoyan AR, Moussa CE
The Journal of biological chemistry 2013 Feb 8;288(6):4103-15
The Journal of biological chemistry 2013 Feb 8;288(6):4103-15
Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients.
Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 26;110(9):3483-8
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 26;110(9):3483-8
HNF4α contributes to glucose formation in aged rat hepatocytes.
Park EY, Lee CH, Lee EK, Kim JH, Cova A, Lee SK, Cho SC, Kwak CS, Song KY, Park SC, Jun HS, Kim KT
Experimental gerontology 2013 Dec;48(12):1518-25
Experimental gerontology 2013 Dec;48(12):1518-25
MiR-199a suppresses the hypoxia-induced proliferation of non-small cell lung cancer cells through targeting HIF1α.
Ding G, Huang G, Liu HD, Liang HX, Ni YF, Ding ZH, Ni GY, Hua HW
Molecular and cellular biochemistry 2013 Dec;384(1-2):173-80
Molecular and cellular biochemistry 2013 Dec;384(1-2):173-80
Overexpression of hypoxia inducible factor-1 alpha is an independent risk factor for recurrence after curative resection of colorectal liver metastases.
Shimomura M, Hinoi T, Kuroda S, Adachi T, Kawaguchi Y, Sasada T, Takakura Y, Egi H, Okajima M, Tashiro H, Nishizaka T, Ohdan H
Annals of surgical oncology 2013 Dec;20 Suppl 3:S527-36
Annals of surgical oncology 2013 Dec;20 Suppl 3:S527-36
Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas.
Minoia C, Quero C, Asselti M, Galise I, Marzano AL, Iacobazzi A, Rana A, Merchionne F, Serratì S, De Tullio G, Quintana G, Casiello M, Maiorano E, Simone G, Zito FA, Iacopino P, Guarini A
British journal of haematology 2013 Dec;163(5):640-5
British journal of haematology 2013 Dec;163(5):640-5
The presence of adenosine A2a receptor in thyrocytes and its involvement in Graves' IgG-induced VEGF expression.
Zhang L, Xu J, Sun N, Cai H, Ren M, Zhang J, Yu C, Wang Z, Gao L, Zhao J
Endocrinology 2013 Dec;154(12):4927-38
Endocrinology 2013 Dec;154(12):4927-38
Simvastatin reduces venous stenosis formation in a murine hemodialysis vascular access model.
Janardhanan R, Yang B, Vohra P, Roy B, Withers S, Bhattacharya S, Mandrekar J, Kong H, Leof EB, Mukhopadhyay D, Misra S
Kidney international 2013 Aug;84(2):338-52
Kidney international 2013 Aug;84(2):338-52
Macrophages transmit potent proangiogenic effects of oxLDL in vitro and in vivo involving HIF-1α activation: a novel aspect of angiogenesis in atherosclerosis.
Hutter R, Speidl WS, Valdiviezo C, Sauter B, Corti R, Fuster V, Badimon JJ
Journal of cardiovascular translational research 2013 Aug;6(4):558-69
Journal of cardiovascular translational research 2013 Aug;6(4):558-69
Integrated molecular analysis of clear-cell renal cell carcinoma.
Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, Shimamura T, Sato-Otsubo A, Nagae G, Suzuki H, Nagata Y, Yoshida K, Kon A, Suzuki Y, Chiba K, Tanaka H, Niida A, Fujimoto A, Tsunoda T, Morikawa T, Maeda D, Kume H, Sugano S, Fukayama M, Aburatani H, Sanada M, Miyano S, Homma Y, Ogawa S
Nature genetics 2013 Aug;45(8):860-7
Nature genetics 2013 Aug;45(8):860-7
Characterization of biological features of a rat F98 GBM model: a PET-MRI study with [18F]FAZA and [18F]FDG.
Belloli S, Brioschi A, Politi LS, Ronchetti F, Calderoni S, Raccagni I, Pagani A, Monterisi C, Zenga F, Zara G, Fazio F, Mauro A, Moresco RM
Nuclear medicine and biology 2013 Aug;40(6):831-40
Nuclear medicine and biology 2013 Aug;40(6):831-40
Phospho-Rb (Ser780) as a biomarker in patients with cervical lymph node metastases from an unknown primary tumour: a retrospective cohort study.
Park GC, Lee M, Roh JL, Choi SH, Nam SY, Kim SY, Cho KJ
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 2013 Aug;38(4):313-21
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 2013 Aug;38(4):313-21
miR-210 regulates the interaction between pancreatic cancer cells and stellate cells.
Takikawa T, Masamune A, Hamada S, Nakano E, Yoshida N, Shimosegawa T
Biochemical and biophysical research communications 2013 Aug 2;437(3):433-9
Biochemical and biophysical research communications 2013 Aug 2;437(3):433-9
Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia.
Xie L, Collins JF
The Journal of biological chemistry 2013 Aug 16;288(33):23943-52
The Journal of biological chemistry 2013 Aug 16;288(33):23943-52
MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α.
Yeh YM, Chuang CM, Chao KC, Wang LH
International journal of cancer 2013 Aug 15;133(4):867-78
International journal of cancer 2013 Aug 15;133(4):867-78
Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model.
Kim KJ, Choi JS, Kang I, Kim KW, Jeong CH, Jeong JW
Journal of pineal research 2013 Apr;54(3):264-70
Journal of pineal research 2013 Apr;54(3):264-70
Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis.
Tamaki Y, Nakade Y, Yamauchi T, Makino Y, Yokohama S, Okada M, Aso K, Kanamori H, Ohashi T, Sato K, Nakao H, Haneda M, Yoneda M
Journal of gastroenterology 2013 Apr;48(4):491-503
Journal of gastroenterology 2013 Apr;48(4):491-503
Echinomycin in the prevention of heterotopic ossification - an experimental antibiotic agent shows promising results in a murine model.
Zimmermann SM, Würgler-Hauri CC, Wanner GA, Simmen HP, Werner CM
Injury 2013 Apr;44(4):570-5
Injury 2013 Apr;44(4):570-5
In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli.
Nechemia-Arbely Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, Geva C, Shriki A, Klaus S, Rosen S, Rose-John S, Galun E, Axelrod JH, Heyman SN
Clinical and experimental pharmacology & physiology 2013 Apr;40(4):262-72
Clinical and experimental pharmacology & physiology 2013 Apr;40(4):262-72
DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.
Heir P, Sufan RI, Greer SN, Poon BP, Lee JE, Ohh M
Molecular and cellular biology 2013 Apr;33(8):1621-31
Molecular and cellular biology 2013 Apr;33(8):1621-31
Hyperglycaemia is associated with impaired vasa vasorum neovascularization and accelerated atherosclerosis in apolipoprotein-E deficient mice.
Veerman KJ, Venegas-Pino DE, Shi Y, Khan MI, Gerstein HC, Werstuck GH
Atherosclerosis 2013 Apr;227(2):250-8
Atherosclerosis 2013 Apr;227(2):250-8
C/EBP homologous binding protein (CHOP) underlies neural injury in sleep apnea model.
Chou YT, Zhan G, Zhu Y, Fenik P, Panossian L, Li Y, Zhang J, Veasey S
Sleep 2013 Apr 1;36(4):481-92
Sleep 2013 Apr 1;36(4):481-92
Epo deficiency alters cardiac adaptation to chronic hypoxia.
El Hasnaoui-Saadani R, Marchant D, Pichon A, Escoubet B, Pezet M, Hilfiker-Kleiner D, Hoch M, Pham I, Quidu P, Voituron N, Journé C, Richalet JP, Favret F
Respiratory physiology & neurobiology 2013 Apr 1;186(2):146-54
Respiratory physiology & neurobiology 2013 Apr 1;186(2):146-54
Expression of MUC17 is regulated by HIF1α-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer.
Kitamoto S, Yokoyama S, Higashi M, Yamada N, Matsubara S, Takao S, Batra SK, Yonezawa S
PloS one 2012;7(9):e44108
PloS one 2012;7(9):e44108
Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.
Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM
PloS one 2012;7(8):e44078
PloS one 2012;7(8):e44078
The importance of GLUT3 for de novo lipogenesis in hypoxia-induced lipid loading of human macrophages.
Li L, Liu B, Håversen L, Lu E, Magnusson LU, Ståhlman M, Borén J, Bergström G, Levin MC, Hultén LM
PloS one 2012;7(8):e42360
PloS one 2012;7(8):e42360
Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage.
Singh AK, Mukhopadhyay C, Biswas S, Singh VK, Mukhopadhyay CK
PloS one 2012;7(6):e38489
PloS one 2012;7(6):e38489
Soluble epoxide hydrolase activity determines the severity of ischemia-reperfusion injury in kidney.
Lee JP, Yang SH, Lee HY, Kim B, Cho JY, Paik JH, Oh YJ, Kim DK, Lim CS, Kim YS
PloS one 2012;7(5):e37075
PloS one 2012;7(5):e37075
Suppression of experimental choroidal neovascularization by curcumin in mice.
Xie P, Zhang W, Yuan S, Chen Z, Yang Q, Yuan D, Wang F, Liu Q
PloS one 2012;7(12):e53329
PloS one 2012;7(12):e53329
A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer.
Menon J, Doebele RC, Gomes S, Bevilacqua E, Reindl KM, Rosner MR
PloS one 2012;7(11):e49893
PloS one 2012;7(11):e49893
HIF-1α inhibition reduces nasal inflammation in a murine allergic rhinitis model.
Zhou H, Chen X, Zhang WM, Zhu LP, Cheng L
PloS one 2012;7(11):e48618
PloS one 2012;7(11):e48618
Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process.
Ortiz-Masià D, Díez I, Calatayud S, Hernández C, Cosín-Roger J, Hinojosa J, Esplugues JV, Barrachina MD
PloS one 2012;7(10):e48535
PloS one 2012;7(10):e48535
The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells.
Rider P, Kaplanov I, Romzova M, Bernardis L, Braiman A, Voronov E, Apte RN
Frontiers in immunology 2012;3:290
Frontiers in immunology 2012;3:290
Dry needling at myofascial trigger spots of rabbit skeletal muscles modulates the biochemicals associated with pain, inflammation, and hypoxia.
Hsieh YL, Yang SA, Yang CC, Chou LW
Evidence-based complementary and alternative medicine : eCAM 2012;2012:342165
Evidence-based complementary and alternative medicine : eCAM 2012;2012:342165
Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors.
Takeda T, Okuyama H, Nishizawa Y, Tomita S, Inoue M
Scientific reports 2012;2:494
Scientific reports 2012;2:494
The role of androgens on hypoxia-inducible factor (HIF)-1α-induced angiogenesis and on the survival of ischemically challenged skin flaps in a rat model.
Shafighi M, Olariu R, Brun C, Fathi AR, Djafarzadeh S, Jakob SM, Hunger RE, Banic A, Constantinescu MA
Microsurgery 2012 Sep;32(6):475-81
Microsurgery 2012 Sep;32(6):475-81
Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG.
Tsukamoto S, Yamashita S, Kim YH, Kumazoe M, Huang Y, Yamada K, Tachibana H
FEBS letters 2012 Sep 21;586(19):3441-7
FEBS letters 2012 Sep 21;586(19):3441-7
Impaired response of hypoxic sensor protein HIF-1α and its downstream proteins in the spinal motor neurons of ALS model mice.
Sato K, Morimoto N, Kurata T, Mimoto T, Miyazaki K, Ikeda Y, Abe K
Brain research 2012 Sep 14;1473:55-62
Brain research 2012 Sep 14;1473:55-62
Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury: possible involvements in hypoxia-inducible factor 1α (HIF-1α).
Hsieh YL, Chou LW, Chang PL, Yang CC, Kao MJ, Hong CZ
The Journal of comparative neurology 2012 Sep 1;520(13):2903-16
The Journal of comparative neurology 2012 Sep 1;520(13):2903-16
Glucotoxicity induces glucose-6-phosphatase catalytic unit expression by acting on the interaction of HIF-1α with CREB-binding protein.
Gautier-Stein A, Soty M, Chilloux J, Zitoun C, Rajas F, Mithieux G
Diabetes 2012 Oct;61(10):2451-60
Diabetes 2012 Oct;61(10):2451-60
Role of FDG-PET as a biological marker for predicting the hypoxic status of tongue cancer.
Han MW, Lee HJ, Cho KJ, Kim JS, Roh JL, Choi SH, Nam SY, Kim SY
Head & neck 2012 Oct;34(10):1395-402
Head & neck 2012 Oct;34(10):1395-402
Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1.
Chou CW, Wang CC, Wu CP, Lin YJ, Lee YC, Cheng YW, Hsieh CH
Neuro-oncology 2012 Oct;14(10):1227-38
Neuro-oncology 2012 Oct;14(10):1227-38
IL-1β-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway.
Bhawal UK, Ito Y, Tanimoto K, Sato F, Fujimoto K, Kawamoto T, Sasahira T, Hamada N, Kuniyasu H, Arakawa H, Kato Y, Abiko Y
Journal of cellular biochemistry 2012 Oct;113(10):3246-53
Journal of cellular biochemistry 2012 Oct;113(10):3246-53
The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1α mRNA stability.
Zhang D, Li J, Zhang M, Gao G, Zuo Z, Yu Y, Zhu L, Gao J, Huang C
The Journal of biological chemistry 2012 Oct 5;287(41):34361-71
The Journal of biological chemistry 2012 Oct 5;287(41):34361-71
Effect of trifluoperazine on toxicity, HIF-1α induction and hepatocyte regeneration in acetaminophen toxicity in mice.
Chaudhuri S, McCullough SS, Hennings L, Brown AT, Li SH, Simpson PM, Hinson JA, James LP
Toxicology and applied pharmacology 2012 Oct 15;264(2):192-201
Toxicology and applied pharmacology 2012 Oct 15;264(2):192-201
A validated regulatory network for Th17 cell specification.
Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkhurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, Kirigin FK, Birchmeier C, Wagner EF, Murphy KM, Myers RM, Bonneau R, Littman DR
Cell 2012 Oct 12;151(2):289-303
Cell 2012 Oct 12;151(2):289-303
N-acetylcysteine protects against hypoxia mimetic-induced autophagy by targeting the HIF-1α pathway in retinal ganglion cells.
Yang L, Tan P, Zhou W, Zhu X, Cui Y, Zhu L, Feng X, Qi H, Zheng J, Gu P, Fan X, Chen H
Cellular and molecular neurobiology 2012 Nov;32(8):1275-85
Cellular and molecular neurobiology 2012 Nov;32(8):1275-85
Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.
Pawlus MR, Wang L, Ware K, Hu CJ
Molecular and cellular biology 2012 Nov;32(22):4595-610
Molecular and cellular biology 2012 Nov;32(22):4595-610
Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle.
Roudier E, Forn P, Perry ME, Birot O
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Nov;26(11):4530-9
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Nov;26(11):4530-9
Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension.
Zhu Q, Liu M, Han WQ, Li PL, Wang Z, Li N
Journal of cellular and molecular medicine 2012 Nov;16(11):2701-7
Journal of cellular and molecular medicine 2012 Nov;16(11):2701-7
Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy.
Yamasaki T, Kamba T, Kanno T, Inoue T, Shibasaki N, Arakaki R, Yamada T, Kondo K, Kamoto T, Nishiyama H, Ogawa O, Nakamura E
Cancer science 2012 Nov;103(11):2027-37
Cancer science 2012 Nov;103(11):2027-37
Increased activation of the hypoxia-inducible factor pathway in varicose veins.
Lim CS, Kiriakidis S, Paleolog EM, Davies AH
Journal of vascular surgery 2012 May;55(5):1427-39
Journal of vascular surgery 2012 May;55(5):1427-39
Effects of oxygen on zonal marker expression in human articular chondrocytes.
Schrobback K, Malda J, Crawford RW, Upton Z, Leavesley DI, Klein TJ
Tissue engineering. Part A 2012 May;18(9-10):920-33
Tissue engineering. Part A 2012 May;18(9-10):920-33
Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis.
Xue X, Taylor M, Anderson E, Hao C, Qu A, Greenson JK, Zimmermann EM, Gonzalez FJ, Shah YM
Cancer research 2012 May 1;72(9):2285-93
Cancer research 2012 May 1;72(9):2285-93
Effects of hypoxic preconditioning on the expression of iron influx and efflux proteins in primary neuron culture.
Du F, Fan M, Gong Q, Zhu LL, Zhu ZJ, Lu L, Ke Y
Neurochemistry international 2012 Mar;60(4):335-43
Neurochemistry international 2012 Mar;60(4):335-43
Role of histone deacetylase expression in intrahepatic cholangiocarcinoma.
Morine Y, Shimada M, Iwahashi S, Utsunomiya T, Imura S, Ikemoto T, Mori H, Hanaoka J, Miyake H
Surgery 2012 Mar;151(3):412-9
Surgery 2012 Mar;151(3):412-9
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.
Wang Y, Roche O, Xu C, Moriyama EH, Heir P, Chung J, Roos FC, Chen Y, Finak G, Milosevic M, Wilson BC, Teh BT, Park M, Irwin MS, Ohh M
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 27;109(13):4892-7
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 27;109(13):4892-7
Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through HIF-1α pathway.
Song ZC, Zhou W, Shu R, Ni J
Cell proliferation 2012 Jun;45(3):239-48
Cell proliferation 2012 Jun;45(3):239-48
Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis.
Natsuizaka M, Naganuma S, Kagawa S, Ohashi S, Ahmadi A, Subramanian H, Chang S, Nakagawa KJ, Ji X, Liebhaber SA, Klein-Szanto AJ, Nakagawa H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jun;26(6):2620-30
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jun;26(6):2620-30
HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function.
Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jun;26(6):2306-17
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jun;26(6):2306-17
Expression of cardiac GATA4 and downstream genes after exercise training in the db/db mouse.
Broderick TL, Parrott CR, Wang D, Jankowski M, Gutkowska J
Pathophysiology : the official journal of the International Society for Pathophysiology 2012 Jun;19(3):193-203
Pathophysiology : the official journal of the International Society for Pathophysiology 2012 Jun;19(3):193-203
Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma.
Boysen G, Bausch-Fluck D, Thoma CR, Nowicka AM, Stiehl DP, Cima I, Luu VD, von Teichman A, Hermanns T, Sulser T, Ingold-Heppner B, Fankhauser N, Wenger RH, Krek W, Schraml P, Wollscheid B, Moch H
Neoplasia (New York, N.Y.) 2012 Jun;14(6):535-46
Neoplasia (New York, N.Y.) 2012 Jun;14(6):535-46
Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma.
Boysen G, Bausch-Fluck D, Thoma CR, Nowicka AM, Stiehl DP, Cima I, Luu VD, von Teichman A, Hermanns T, Sulser T, Ingold-Heppner B, Fankhauser N, Wenger RH, Krek W, Schraml P, Wollscheid B, Moch H
Neoplasia (New York, N.Y.) 2012 Jun;14(6):535-46
Neoplasia (New York, N.Y.) 2012 Jun;14(6):535-46
Angiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats.
Giani JF, Burghi V, Veiras LC, Tomat A, Muñoz MC, Cao G, Turyn D, Toblli JE, Dominici FP
American journal of physiology. Renal physiology 2012 Jun 15;302(12):F1606-15
American journal of physiology. Renal physiology 2012 Jun 15;302(12):F1606-15
Predicting outcomes of patients with intracranial meningiomas using molecular markers of hypoxia, vascularity, and proliferation.
Jensen R, Lee J
Neurosurgery 2012 Jul;71(1):146-56
Neurosurgery 2012 Jul;71(1):146-56
Hypoxia-inducible factor-1-regulated protein expression and oligodendroglioma patient outcome: comparison with established biomarkers and preoperative UCSF low-grade scoring system.
Abraham S, Hu N, Jensen R
Journal of neuro-oncology 2012 Jul;108(3):459-68
Journal of neuro-oncology 2012 Jul;108(3):459-68
Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α.
Pourvali K, Matak P, Latunde-Dada GO, Solomou S, Mastrogiannaki M, Peyssonnaux C, Sharp PA
FEBS letters 2012 Jul 30;586(16):2423-7
FEBS letters 2012 Jul 30;586(16):2423-7
Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
Chintala S, Najrana T, Toth K, Cao S, Durrani FA, Pili R, Rustum YM
BMC cancer 2012 Jul 17;12:293
BMC cancer 2012 Jul 17;12:293
Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung.
Jackson IL, Zhang X, Hadley C, Rabbani ZN, Zhang Y, Marks S, Vujaskovic Z
Free radical biology & medicine 2012 Jul 15;53(2):337-46
Free radical biology & medicine 2012 Jul 15;53(2):337-46
Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury.
Sakamoto K, Hashimoto N, Kondoh Y, Imaizumi K, Aoyama D, Kohnoh T, Kusunose M, Kimura M, Kawabe T, Taniguchi H, Hasegawa Y
American journal of physiology. Lung cellular and molecular physiology 2012 Jul 1;303(1):L43-53
American journal of physiology. Lung cellular and molecular physiology 2012 Jul 1;303(1):L43-53
Rapamycin decreases survivin expression to induce NSCLC cell apoptosis under hypoxia through inhibiting HIF-1α induction.
Chen B, Yuping S, Ni J
Molecular biology reports 2012 Jan;39(1):185-91
Molecular biology reports 2012 Jan;39(1):185-91
Uremia induces functional incompetence of bone marrow-derived stromal cells.
Noh H, Yu MR, Kim HJ, Jeon JS, Kwon SH, Jin SY, Lee J, Jang J, Park JO, Ziyadeh F, Han DC, Lee HB
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012 Jan;27(1):218-25
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012 Jan;27(1):218-25
Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury.
Liu C, Tsai AL, Chen YC, Fan SC, Huang CH, Wu CC, Chang CH
Journal of cellular biochemistry 2012 Jan;113(1):148-55
Journal of cellular biochemistry 2012 Jan;113(1):148-55
A myeloid hypoxia-inducible factor 1α-Krüppel-like factor 2 pathway regulates gram-positive endotoxin-mediated sepsis.
Mahabeleshwar GH, Qureshi MA, Takami Y, Sharma N, Lingrel JB, Jain MK
The Journal of biological chemistry 2012 Jan 6;287(2):1448-57
The Journal of biological chemistry 2012 Jan 6;287(2):1448-57
Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.
Tang X, Lucas JE, Chen JL, LaMonte G, Wu J, Wang MC, Koumenis C, Chi JT
Cancer research 2012 Jan 15;72(2):491-502
Cancer research 2012 Jan 15;72(2):491-502
Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism.
Cartee TV, White KJ, Newton-West M, Swerlick RA
Journal of dermatological science 2012 Feb;65(2):86-94
Journal of dermatological science 2012 Feb;65(2):86-94
Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis.
Xu Y, Li Q, Li XY, Yang QY, Xu WW, Liu GL
Journal of experimental & clinical cancer research : CR 2012 Feb 23;31:16
Journal of experimental & clinical cancer research : CR 2012 Feb 23;31:16
Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells.
Doe MR, Ascano JM, Kaur M, Cole MD
Cancer research 2012 Feb 15;72(4):949-57
Cancer research 2012 Feb 15;72(4):949-57
Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21.
Xu X, Kriegel AJ, Liu Y, Usa K, Mladinov D, Liu H, Fang Y, Ding X, Liang M
Kidney international 2012 Dec;82(11):1167-75
Kidney international 2012 Dec;82(11):1167-75
Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling.
Zhdanov AV, Dmitriev RI, Papkovsky DB
Bioscience reports 2012 Dec;32(6):587-95
Bioscience reports 2012 Dec;32(6):587-95
Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1α via activation of PGE(2)-cAMP signaling.
Lee J, Jung E, Hyun JW, Park D
Journal of cellular biochemistry 2012 Dec;113(12):3681-91
Journal of cellular biochemistry 2012 Dec;113(12):3681-91
Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts.
Sirvent A, Vigy O, Orsetti B, Urbach S, Roche S
Molecular & cellular proteomics : MCP 2012 Dec;11(12):1937-50
Molecular & cellular proteomics : MCP 2012 Dec;11(12):1937-50
Hypoxia-inducible factor 1-α induces miR-210 in normoxic differentiating myoblasts.
Cicchillitti L, Di Stefano V, Isaia E, Crimaldi L, Fasanaro P, Ambrosino V, Antonini A, Capogrossi MC, Gaetano C, Piaggio G, Martelli F
The Journal of biological chemistry 2012 Dec 28;287(53):44761-71
The Journal of biological chemistry 2012 Dec 28;287(53):44761-71
Hypoxia and HIF-1 increase S100A8 and S100A9 expression in prostate cancer.
Grebhardt S, Veltkamp C, Ströbel P, Mayer D
International journal of cancer 2012 Dec 15;131(12):2785-94
International journal of cancer 2012 Dec 15;131(12):2785-94
Nicotinic modulation of therapeutic response in vitro and in vivo.
Warren GW, Romano MA, Kudrimoti MR, Randall ME, McGarry RC, Singh AK, Rangnekar VM
International journal of cancer 2012 Dec 1;131(11):2519-27
International journal of cancer 2012 Dec 1;131(11):2519-27
Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensing.
Koch Y, van Fürden B, Kaiser S, Klein D, Kibschull M, Schorle H, Carpinteiro A, Gellhaus A, Winterhager E
Biology of reproduction 2012 Aug;87(2):37
Biology of reproduction 2012 Aug;87(2):37
Correlation of a priori DCE-MRI and (1)H-MRS data with molecular markers in neck nodal metastases: Initial analysis.
Jansen JF, Carlson DL, Lu Y, Stambuk HE, Moreira AL, Singh B, Patel SG, Kraus DH, Wong RJ, Shaha AR, Shah JP, Shukla-Dave A
Oral oncology 2012 Aug;48(8):717-22
Oral oncology 2012 Aug;48(8):717-22
Liposome-encapsulated hemoglobin attenuates cardiac dysfunction and sympathetic activity during hypohemoglobinemic shock.
Nogami Y, Takase B, Kinoshita M, Shono S, Kaneda S, Tanaka Y, Kishimoto S, Hattori H, Ishihara M
Shock (Augusta, Ga.) 2012 Aug;38(2):159-64
Shock (Augusta, Ga.) 2012 Aug;38(2):159-64
Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors.
Ke X, Fei F, Chen Y, Xu L, Zhang Z, Huang Q, Zhang H, Yang H, Chen Z, Xing J
Carcinogenesis 2012 Aug;33(8):1598-607
Carcinogenesis 2012 Aug;33(8):1598-607
Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging.
Wang H, Chen Q, Lee SH, Choi Y, Johnson FB, Pignolo RJ
Aging cell 2012 Aug;11(4):704-13
Aging cell 2012 Aug;11(4):704-13
Low density lipoprotein receptor-related protein 1 expression correlates with cholesteryl ester accumulation in the myocardium of ischemic cardiomyopathy patients.
Cal R, Juan-Babot O, Brossa V, Roura S, Gálvez-Montón C, Portoles M, Rivera M, Cinca J, Badimon L, Llorente-Cortés V
Journal of translational medicine 2012 Aug 8;10:160
Journal of translational medicine 2012 Aug 8;10:160
NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme.
Hsieh CH, Wu CP, Lee HT, Liang JA, Yu CY, Lin YJ
Free radical biology & medicine 2012 Aug 15;53(4):649-58
Free radical biology & medicine 2012 Aug 15;53(4):649-58
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.
Kiss J, Mollenhauer M, Walmsley SR, Kirchberg J, Radhakrishnan P, Niemietz T, Dudda J, Steinert G, Whyte MK, Carmeliet P, Mazzone M, Weitz J, Schneider M
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 15;189(4):1955-65
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 15;189(4):1955-65
A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration.
Wilson GK, Brimacombe CL, Rowe IA, Reynolds GM, Fletcher NF, Stamataki Z, Bhogal RH, Simões ML, Ashcroft M, Afford SC, Mitry RR, Dhawan A, Mee CJ, Hübscher SG, Balfe P, McKeating JA
Journal of hepatology 2012 Apr;56(4):803-9
Journal of hepatology 2012 Apr;56(4):803-9
Assessment of stanniocalcin-1 as a prognostic marker in human esophageal squamous cell carcinoma.
Shirakawa M, Fujiwara Y, Sugita Y, Moon JH, Takiguchi S, Nakajima K, Miyata H, Yamasaki M, Mori M, Doki Y
Oncology reports 2012 Apr;27(4):940-6
Oncology reports 2012 Apr;27(4):940-6
Hypoxic preconditioning increases iron transport rate in astrocytes.
Yang L, Fan M, Du F, Gong Q, Bi ZG, Zhu ZJ, Zhu LL, Ke Y
Biochimica et biophysica acta 2012 Apr;1822(4):500-8
Biochimica et biophysica acta 2012 Apr;1822(4):500-8
Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas.
Yamada T, Uchida M, Kwang-Lee K, Kitamura N, Yoshimura T, Sasabe E, Yamamoto T
Oral surgery, oral medicine, oral pathology and oral radiology 2012 Apr;113(4):464-71
Oral surgery, oral medicine, oral pathology and oral radiology 2012 Apr;113(4):464-71
Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice.
Milesi-Hallé A, McCullough S, Hinson JA, Kurten RC, Lamps LW, Brown A, James LP
Basic & clinical pharmacology & toxicology 2012 Apr;110(4):327-34
Basic & clinical pharmacology & toxicology 2012 Apr;110(4):327-34
Iron facilitator LS081 reduces hypoxia-inducible factor-1α protein and functions as anticancer agent in hepatocellular carcinoma.
Tanaka H, Li Z, Ikuta K, Addo L, Akutsu H, Nakamura M, Sasaki K, Ohtake T, Fujiya M, Torimoto Y, Glass J, Kohgo Y
Cancer science 2012 Apr;103(4):767-74
Cancer science 2012 Apr;103(4):767-74
Differential impact of EGFR-targeted therapies on hypoxia responses: implications for treatment sensitivity in triple-negative metastatic breast cancer.
El Guerrab A, Zegrour R, Nemlin CC, Vigier F, Cayre A, Penault-Llorca F, Rossignol F, Bignon YJ
PloS one 2011;6(9):e25080
PloS one 2011;6(9):e25080
NADPH oxidase subunit 4-mediated reactive oxygen species contribute to cycling hypoxia-promoted tumor progression in glioblastoma multiforme.
Hsieh CH, Shyu WC, Chiang CY, Kuo JW, Shen WC, Liu RS
PloS one 2011;6(9):e23945
PloS one 2011;6(9):e23945
Intermittent hypoxia after transient focal ischemia induces hippocampal neurogenesis and c-Fos expression and reverses spatial memory deficits in rats.
Tsai YW, Yang YR, Wang PS, Wang RY
PloS one 2011;6(8):e24001
PloS one 2011;6(8):e24001
Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis.
Sengupta T, Abraham G, Xu Y, Clurman BE, Minella AC
Molecular and cellular biology 2011 Sep;31(18):3885-95
Molecular and cellular biology 2011 Sep;31(18):3885-95
Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation.
Kumar P, Mendelson CR
Molecular endocrinology (Baltimore, Md.) 2011 Sep;25(9):1513-26
Molecular endocrinology (Baltimore, Md.) 2011 Sep;25(9):1513-26
EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate.
Pascal LE, Ai J, Rigatti LH, Lipton AK, Xiao W, Gnarra JR, Wang Z
Angiogenesis 2011 Sep;14(3):331-43
Angiogenesis 2011 Sep;14(3):331-43
Hypoxia inducible factor expression in intrahepatic cholangiocarcinoma.
Morine Y, Shimada M, Utsunomiya T, Imura S, Ikemoto T, Mori H, Hanaoka J, Kanamoto M, Iwahashi S, Miyake H
Hepato-gastroenterology 2011 Sep-Oct;58(110-111):1439-44
Hepato-gastroenterology 2011 Sep-Oct;58(110-111):1439-44
Trichinella spiralis infection induces angiogenic factor thymosin β4 expression.
Kang YJ, Jo JO, Cho MK, Yu HS, Ock MS, Cha HJ
Veterinary parasitology 2011 Sep 27;181(2-4):222-8
Veterinary parasitology 2011 Sep 27;181(2-4):222-8
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM, Pan F
Cell 2011 Sep 2;146(5):772-84
Cell 2011 Sep 2;146(5):772-84
Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis.
Hattori H, Okuda K, Murase T, Shigetsura Y, Narise K, Semenza GL, Nagasawa H
Bioorganic & medicinal chemistry 2011 Sep 15;19(18):5392-401
Bioorganic & medicinal chemistry 2011 Sep 15;19(18):5392-401
Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds.
Zhang X, Sarkar K, Rey S, Sebastian R, Andrikopoulou E, Marti GP, Fox-Talbot K, Semenza GL, Harmon JW
Journal of molecular medicine (Berlin, Germany) 2011 Oct;89(10):985-95
Journal of molecular medicine (Berlin, Germany) 2011 Oct;89(10):985-95
The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: pathological consideration of their potential roles.
Nonoguchi N, Miyatake S, Fukumoto M, Furuse M, Hiramatsu R, Kawabata S, Kuroiwa T, Tsuji M, Fukumoto M, Ono K
Journal of neuro-oncology 2011 Nov;105(2):423-31
Journal of neuro-oncology 2011 Nov;105(2):423-31
Crohn disease-associated Escherichia coli promote gastrointestinal inflammatory disorders by activation of HIF-dependent responses.
Mimouna S, Gonçalvès D, Barnich N, Darfeuille-Michaud A, Hofman P, Vouret-Craviari V
Gut microbes 2011 Nov-Dec;2(6):335-46
Gut microbes 2011 Nov-Dec;2(6):335-46
Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD).
Belibi F, Zafar I, Ravichandran K, Segvic AB, Jani A, Ljubanovic DG, Edelstein CL
American journal of physiology. Renal physiology 2011 May;300(5):F1235-43
American journal of physiology. Renal physiology 2011 May;300(5):F1235-43
Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia.
He Q, Gao Z, Yin J, Zhang J, Yun Z, Ye J
American journal of physiology. Endocrinology and metabolism 2011 May;300(5):E877-85
American journal of physiology. Endocrinology and metabolism 2011 May;300(5):E877-85
Role of hypoxia-inducible factors in the dexrazoxane-mediated protection of cardiomyocytes from doxorubicin-induced toxicity.
Spagnuolo RD, Recalcati S, Tacchini L, Cairo G
British journal of pharmacology 2011 May;163(2):299-312
British journal of pharmacology 2011 May;163(2):299-312
Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells.
Higashimura Y, Nakajima Y, Yamaji R, Harada N, Shibasaki F, Nakano Y, Inui H
Archives of biochemistry and biophysics 2011 May 1;509(1):1-8
Archives of biochemistry and biophysics 2011 May 1;509(1):1-8
Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.
Chaudhuri S, McCullough SS, Hennings L, Letzig L, Simpson PM, Hinson JA, James LP
Toxicology and applied pharmacology 2011 May 1;252(3):211-20
Toxicology and applied pharmacology 2011 May 1;252(3):211-20
NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.
Valsecchi V, Pignataro G, Del Prete A, Sirabella R, Matrone C, Boscia F, Scorziello A, Sisalli MJ, Esposito E, Zambrano N, Di Renzo G, Annunziato L
Stroke 2011 Mar;42(3):754-63
Stroke 2011 Mar;42(3):754-63
Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition.
Tamama K, Kawasaki H, Kerpedjieva SS, Guan J, Ganju RK, Sen CK
Journal of cellular biochemistry 2011 Mar;112(3):804-17
Journal of cellular biochemistry 2011 Mar;112(3):804-17
Hypoxia-inducible factor 1α expression is a prognostic biomarker in patients with astrocytic tumors associated with necrosis on MR image.
Mashiko R, Takano S, Ishikawa E, Yamamoto T, Nakai K, Matsumura A
Journal of neuro-oncology 2011 Mar;102(1):43-50
Journal of neuro-oncology 2011 Mar;102(1):43-50
Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats.
Lunde IG, Anton SL, Bruusgaard JC, Rana ZA, Ellefsen S, Gundersen K
The Journal of physiology 2011 Mar 15;589(Pt 6):1443-54
The Journal of physiology 2011 Mar 15;589(Pt 6):1443-54
Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells.
Trisciuoglio D, Gabellini C, Desideri M, Ragazzoni Y, De Luca T, Ziparo E, Del Bufalo D
Cell death and differentiation 2011 Jun;18(6):1024-35
Cell death and differentiation 2011 Jun;18(6):1024-35
Shedding of Epstein-Barr virus and cytomegalovirus from the genital tract of women in a periurban community in Andhra Pradesh, India.
Silver MI, Paul P, Sowjanya P, Ramakrishna G, Vedantham H, Kalpana B, Shah KV, Gravitt PE
Journal of clinical microbiology 2011 Jul;49(7):2435-9
Journal of clinical microbiology 2011 Jul;49(7):2435-9
Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats.
Leh S, Hultström M, Rosenberger C, Iversen BM
Virchows Archiv : an international journal of pathology 2011 Jul;459(1):99-108
Virchows Archiv : an international journal of pathology 2011 Jul;459(1):99-108
Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?
Kim JA, Kim SJ, Do IG, Jin J, Nam DH, Ko YH, Kim K, Kim WS
Leukemia & lymphoma 2011 Feb;52(2):205-13
Leukemia & lymphoma 2011 Feb;52(2):205-13
NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α.
Nakamura K, Tan F, Li Z, Thiele CJ
Molecular and cellular neurosciences 2011 Feb;46(2):498-506
Molecular and cellular neurosciences 2011 Feb;46(2):498-506
Identification of a mechanism underlying regulation of the anti-angiogenic forkhead transcription factor FoxO1 in cultured endothelial cells and ischemic muscle.
Milkiewicz M, Roudier E, Doyle JL, Trifonova A, Birot O, Haas TL
The American journal of pathology 2011 Feb;178(2):935-44
The American journal of pathology 2011 Feb;178(2):935-44
Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase.
Zhang XL, Yan ZW, Sheng WW, Xiao J, Zhang ZX, Ye ZB
Molecular and cellular biochemistry 2011 Dec;358(1-2):287-95
Molecular and cellular biochemistry 2011 Dec;358(1-2):287-95
Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression.
Kwon TG, Zhao X, Yang Q, Li Y, Ge C, Zhao G, Franceschi RT
Journal of cellular biochemistry 2011 Dec;112(12):3582-93
Journal of cellular biochemistry 2011 Dec;112(12):3582-93
Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss.
Ly A, Yee P, Vessey KA, Phipps JA, Jobling AI, Fletcher EL
Investigative ophthalmology & visual science 2011 Dec 2;52(13):9316-26
Investigative ophthalmology & visual science 2011 Dec 2;52(13):9316-26
Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse.
Rezvani HR, Ali N, Serrano-Sanchez M, Dubus P, Varon C, Ged C, Pain C, Cario-André M, Seneschal J, Taïeb A, de Verneuil H, Mazurier F
Journal of cell science 2011 Dec 15;124(Pt 24):4172-83
Journal of cell science 2011 Dec 15;124(Pt 24):4172-83
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.
Bohonowych JE, Peng S, Gopal U, Hance MW, Wing SB, Argraves KM, Lundgren K, Isaacs JS
BMC cancer 2011 Dec 15;11:520
BMC cancer 2011 Dec 15;11:520
Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1α in mouse hepatocytes.
Namas RA, Metukuri MR, Dhupar R, Velosa C, Jefferson BS, Myer E, Constantine GM, Billiar TR, Vodovotz Y, Zamora R
Shock (Augusta, Ga.) 2011 Aug;36(2):196-202
Shock (Augusta, Ga.) 2011 Aug;36(2):196-202
Wnt-β-catenin signaling protects against hepatic ischemia and reperfusion injury in mice.
Lehwald N, Tao GZ, Jang KY, Sorkin M, Knoefel WT, Sylvester KG
Gastroenterology 2011 Aug;141(2):707-18, 718.e1-5
Gastroenterology 2011 Aug;141(2):707-18, 718.e1-5
Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors.
Kummar S, Raffeld M, Juwara L, Horneffer Y, Strassberger A, Allen D, Steinberg SM, Rapisarda A, Spencer SD, Figg WD, Chen X, Turkbey IB, Choyke P, Murgo AJ, Doroshow JH, Melillo G
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Aug 1;17(15):5123-31
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Aug 1;17(15):5123-31
Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94.
Baek JH, Reiter CE, Manalo DJ, Buehler PW, Hider RC, Alayash AI
Biochimica et biophysica acta 2011 Apr-Jun;1809(4-6):262-8
Biochimica et biophysica acta 2011 Apr-Jun;1809(4-6):262-8
Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro.
Sato Y, Endo H, Okuyama H, Takeda T, Iwahashi H, Imagawa A, Yamagata K, Shimomura I, Inoue M
The Journal of biological chemistry 2011 Apr 8;286(14):12524-32
The Journal of biological chemistry 2011 Apr 8;286(14):12524-32
Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer.
Jian J, Yang Q, Dai J, Eckard J, Axelrod D, Smith J, Huang X
Free radical biology & medicine 2011 Apr 1;50(7):841-7
Free radical biology & medicine 2011 Apr 1;50(7):841-7
Hypoxia-inducible factors: post-translational crosstalk of signaling pathways.
Dimova EY, Kietzmann T
Methods in molecular biology (Clifton, N.J.) 2010;647:215-36
Methods in molecular biology (Clifton, N.J.) 2010;647:215-36
Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2α.
Manisterski M, Golan M, Amir S, Weisman Y, Mabjeesh NJ
Cell cycle (Georgetown, Tex.) 2010 Sep 15;9(18):3723-9
Cell cycle (Georgetown, Tex.) 2010 Sep 15;9(18):3723-9
HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy.
Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, Miyazaki K
International journal of cancer 2010 Sep 1;127(5):1158-71
International journal of cancer 2010 Sep 1;127(5):1158-71
Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role.
Espinosa I, José Carnicer M, Catasus L, Canet B, D'angelo E, Zannoni GF, Prat J
The American journal of surgical pathology 2010 Nov;34(11):1708-14
The American journal of surgical pathology 2010 Nov;34(11):1708-14
Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis.
Lee JJ, Natsuizaka M, Ohashi S, Wong GS, Takaoka M, Michaylira CZ, Budo D, Tobias JW, Kanai M, Shirakawa Y, Naomoto Y, Klein-Szanto AJ, Haase VH, Nakagawa H
Carcinogenesis 2010 Mar;31(3):427-34
Carcinogenesis 2010 Mar;31(3):427-34
Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression.
Tanaka T, Wakamatsu T, Daijo H, Oda S, Kai S, Adachi T, Kizaka-Kondoh S, Fukuda K, Hirota K
American journal of physiology. Regulatory, integrative and comparative physiology 2010 Mar;298(3):R661-71
American journal of physiology. Regulatory, integrative and comparative physiology 2010 Mar;298(3):R661-71
PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2.
Choy MK, Movassagh M, Bennett MR, Foo RS
Journal of cellular physiology 2010 Mar;222(3):635-9
Journal of cellular physiology 2010 Mar;222(3):635-9
Suppression of cyclin D1 by hypoxia-inducible factor-1 via direct mechanism inhibits the proliferation and 5-fluorouracil-induced apoptosis of A549 cells.
Wen W, Ding J, Sun W, Wu K, Ning B, Gong W, He G, Huang S, Ding X, Yin P, Chen L, Liu Q, Xie W, Wang H
Cancer research 2010 Mar 1;70(5):2010-9
Cancer research 2010 Mar 1;70(5):2010-9
Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study.
Hammers HJ, Verheul HM, Salumbides B, Sharma R, Rudek M, Jaspers J, Shah P, Ellis L, Shen L, Paesante S, Dykema K, Furge K, Teh BT, Netto G, Pili R
Molecular cancer therapeutics 2010 Jun;9(6):1525-35
Molecular cancer therapeutics 2010 Jun;9(6):1525-35
Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization.
Yoshida T, Zhang H, Iwase T, Shen J, Semenza GL, Campochiaro PA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jun;24(6):1759-67
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jun;24(6):1759-67
Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia.
Wu DC, Paulson RF
PloS one 2010 Jun 24;5(6):e11303
PloS one 2010 Jun 24;5(6):e11303
p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast cancer cells.
Zhang J, Lu A, Li L, Yue J, Lu Y
Cancer investigation 2010 Jul;28(6):588-97
Cancer investigation 2010 Jul;28(6):588-97
Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay.
Ioannou M, Mylonis I, Kouvaras E, Papamichali R, Daponte A, Paraskeva E, Simos G, Koukoulis GK
Oncology reports 2010 Jul;24(1):161-9
Oncology reports 2010 Jul;24(1):161-9
Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay.
Ioannou M, Mylonis I, Kouvaras E, Papamichali R, Daponte A, Paraskeva E, Simos G, Koukoulis GK
Oncology reports 2010 Jul;24(1):161-9
Oncology reports 2010 Jul;24(1):161-9
Double immunohistochemical staining method for HIF-1alpha and its regulators PHD2 and PHD3 in formalin-fixed paraffin-embedded tissues.
Vaughan MM, Toth K, Chintala S, Rustum YM
Applied immunohistochemistry & molecular morphology : AIMM 2010 Jul;18(4):375-81
Applied immunohistochemistry & molecular morphology : AIMM 2010 Jul;18(4):375-81
Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury.
Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL
Gastroenterology 2010 Jul;139(1):259-69.e3
Gastroenterology 2010 Jul;139(1):259-69.e3
Hypoxia-inducible factor-1alpha regulates the expression of nucleotide excision repair proteins in keratinocytes.
Rezvani HR, Mahfouf W, Ali N, Chemin C, Ged C, Kim AL, de Verneuil H, Taïeb A, Bickers DR, Mazurier F
Nucleic acids research 2010 Jan;38(3):797-809
Nucleic acids research 2010 Jan;38(3):797-809
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, Lambin P, van der Kogel AJ, Koritzinsky M, Wouters BG
The Journal of clinical investigation 2010 Jan;120(1):127-41
The Journal of clinical investigation 2010 Jan;120(1):127-41
HIF-1α Promotes A Hypoxia-Independent Cell Migration.
Li L, Madu CO, Lu A, Lu Y
The open biology journal 2010 Jan 1;3:8-14
The open biology journal 2010 Jan 1;3:8-14
Hypoxia is important for establishing vascularization during corpus luteum formation in cattle.
Nishimura R, Okuda K
The Journal of reproduction and development 2010 Feb;56(1):110-6
The Journal of reproduction and development 2010 Feb;56(1):110-6
Hypoxia is important for establishing vascularization during corpus luteum formation in cattle.
Nishimura R, Okuda K
The Journal of reproduction and development 2010 Feb;56(1):110-6
The Journal of reproduction and development 2010 Feb;56(1):110-6
Human nephrosclerosis triggers a hypoxia-related glomerulopathy.
Neusser MA, Lindenmeyer MT, Moll AG, Segerer S, Edenhofer I, Sen K, Stiehl DP, Kretzler M, Gröne HJ, Schlöndorff D, Cohen CD
The American journal of pathology 2010 Feb;176(2):594-607
The American journal of pathology 2010 Feb;176(2):594-607
Clinicopathological implications of expressions of hypoxia-related molecules in esophageal superficial squamous cell carcinoma.
Ogane N, Yasuda M, Shimizu M, Miyazawa M, Kamoshida S, Ueda A, Takata K, Sakuma Y, Miyagi Y, Kameda Y
Annals of diagnostic pathology 2010 Feb;14(1):23-9
Annals of diagnostic pathology 2010 Feb;14(1):23-9
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.
Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL
The Journal of biological chemistry 2010 Feb 5;285(6):3651-63
The Journal of biological chemistry 2010 Feb 5;285(6):3651-63
Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP.
Evens AM, Sehn LH, Farinha P, Nelson BP, Raji A, Lu Y, Brakman A, Parimi V, Winter JN, Schumacker PT, Gascoyne RD, Gordon LI
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010 Feb 20;28(6):1017-24
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010 Feb 20;28(6):1017-24
Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes.
Regazzetti C, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S
The Journal of biological chemistry 2010 Feb 19;285(8):5157-64
The Journal of biological chemistry 2010 Feb 19;285(8):5157-64
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells.
Chen H, Kluz T, Zhang R, Costa M
Carcinogenesis 2010 Dec;31(12):2136-44
Carcinogenesis 2010 Dec;31(12):2136-44
Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade.
Deng A, Arndt MA, Satriano J, Singh P, Rieg T, Thomson S, Tang T, Blantz RC
American journal of physiology. Renal physiology 2010 Dec;299(6):F1365-73
American journal of physiology. Renal physiology 2010 Dec;299(6):F1365-73
Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage.
Gauter-Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Rebouças JS, Batinic-Haberle I, Vujaskovic Z
Free radical biology & medicine 2010 Apr 15;48(8):1034-43
Free radical biology & medicine 2010 Apr 15;48(8):1034-43
mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition.
Bhaskar PT, Nogueira V, Patra KC, Jeon SM, Park Y, Robey RB, Hay N
Molecular and cellular biology 2009 Sep;29(18):5136-47
Molecular and cellular biology 2009 Sep;29(18):5136-47
Pharmacological stimulation of soluble guanylate cyclase modulates hypoxia-inducible factor-1alpha in rat heart.
Tsuruda T, Hatakeyama K, Masuyama H, Sekita Y, Imamura T, Asada Y, Kitamura K
American journal of physiology. Heart and circulatory physiology 2009 Oct;297(4):H1274-80
American journal of physiology. Heart and circulatory physiology 2009 Oct;297(4):H1274-80
Hypoxia-inducible factor-1alpha expression predicts the response to 5-fluorouracil-based adjuvant chemotherapy in advanced gastric cancer.
Nakamura J, Kitajima Y, Kai K, Mitsuno M, Ide T, Hashiguchi K, Hiraki M, Miyazaki K
Oncology reports 2009 Oct;22(4):693-9
Oncology reports 2009 Oct;22(4):693-9
Hypoxia-inducible factor-1alpha expression predicts the response to 5-fluorouracil-based adjuvant chemotherapy in advanced gastric cancer.
Nakamura J, Kitajima Y, Kai K, Mitsuno M, Ide T, Hashiguchi K, Hiraki M, Miyazaki K
Oncology reports 2009 Oct;22(4):693-9
Oncology reports 2009 Oct;22(4):693-9
TSC2 deficiency increases PTEN via HIF1alpha.
Mahimainathan L, Ghosh-Choudhury N, Venkatesan B, Das F, Mandal CC, Dey N, Habib SL, Kasinath BS, Abboud HE, Ghosh Choudhury G
The Journal of biological chemistry 2009 Oct 9;284(41):27790-8
The Journal of biological chemistry 2009 Oct 9;284(41):27790-8
Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response.
Doroudgar S, Thuerauf DJ, Marcinko MC, Belmont PJ, Glembotski CC
The Journal of biological chemistry 2009 Oct 23;284(43):29735-45
The Journal of biological chemistry 2009 Oct 23;284(43):29735-45
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization.
Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2009 Oct 20;106(42):17910-5
Proceedings of the National Academy of Sciences of the United States of America 2009 Oct 20;106(42):17910-5
Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation.
Sims JR, Lee SW, Topalkara K, Qiu J, Xu J, Zhou Z, Moskowitz MA
Stroke 2009 Nov;40(11):3618-26
Stroke 2009 Nov;40(11):3618-26
Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury.
Hammerschmidt E, Loeffler I, Wolf G
American journal of physiology. Renal physiology 2009 Nov;297(5):F1273-87
American journal of physiology. Renal physiology 2009 Nov;297(5):F1273-87
Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance.
Nomura M, Ishii H, Kawakami A, Yoshida M
American journal of physiology. Endocrinology and metabolism 2009 Nov;297(5):E1030-8
American journal of physiology. Endocrinology and metabolism 2009 Nov;297(5):E1030-8
Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons.
Lomb DJ, Desouza LA, Franklin JL, Freeman RS
Molecular pharmacology 2009 May;75(5):1198-209
Molecular pharmacology 2009 May;75(5):1198-209
Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing.
Keely S, Glover LE, MacManus CF, Campbell EL, Scully MM, Furuta GT, Colgan SP
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 May;23(5):1338-46
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 May;23(5):1338-46
The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity.
Kimbrel EA, Kung AL
The Journal of biological chemistry 2009 May 8;284(19):13033-44
The Journal of biological chemistry 2009 May 8;284(19):13033-44
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells.
Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE
Blood 2009 May 28;113(22):5568-74
Blood 2009 May 28;113(22):5568-74
Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression.
Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M
Proceedings of the National Academy of Sciences of the United States of America 2009 May 26;106(21):8760-5
Proceedings of the National Academy of Sciences of the United States of America 2009 May 26;106(21):8760-5
Regulation of thioredoxin by ceramide in retinal pigment epithelial cells.
Sreekumar PG, Ding Y, Ryan SJ, Kannan R, Hinton DR
Experimental eye research 2009 Mar;88(3):410-7
Experimental eye research 2009 Mar;88(3):410-7
Hypoxia-regulated activity of PKCepsilon in the lens.
Akoyev V, Das S, Jena S, Grauer L, Takemoto DJ
Investigative ophthalmology & visual science 2009 Mar;50(3):1271-82
Investigative ophthalmology & visual science 2009 Mar;50(3):1271-82
Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia.
El Hasnaoui-Saadani R, Pichon A, Marchant D, Olivier P, Launay T, Quidu P, Beaudry M, Duvallet A, Richalet JP, Favret F
American journal of physiology. Regulatory, integrative and comparative physiology 2009 Mar;296(3):R801-11
American journal of physiology. Regulatory, integrative and comparative physiology 2009 Mar;296(3):R801-11
Molecular signatures of localized clear cell renal cell carcinoma to predict disease-free survival after nephrectomy.
Klatte T, Seligson DB, LaRochelle J, Shuch B, Said JW, Riggs SB, Zomorodian N, Kabbinavar FF, Pantuck AJ, Belldegrun AS
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 Mar;18(3):894-900
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 Mar;18(3):894-900
Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity.
Lysiak JJ, Kirby JL, Tremblay JJ, Woodson RI, Reardon MA, Palmer LA, Turner TT
Journal of andrology 2009 Mar-Apr;30(2):146-56
Journal of andrology 2009 Mar-Apr;30(2):146-56
Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression.
Zhu K, Chan W, Heymach J, Wilkinson M, McConkey DJ
Cancer research 2009 Mar 1;69(5):1836-43
Cancer research 2009 Mar 1;69(5):1836-43
Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible factor pathway.
Rhoads RP, Johnson RM, Rathbone CR, Liu X, Temm-Grove C, Sheehan SM, Hoying JB, Allen RE
American journal of physiology. Cell physiology 2009 Jun;296(6):C1321-8
American journal of physiology. Cell physiology 2009 Jun;296(6):C1321-8
Hyperglycemia-enhanced ischemic brain damage in mutant manganese SOD mice is associated with suppression of HIF-1alpha.
Bullock JJ, Mehta SL, Lin Y, Lolla P, Li PA
Neuroscience letters 2009 Jun 5;456(2):89-92
Neuroscience letters 2009 Jun 5;456(2):89-92
Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition.
Rapisarda A, Hollingshead M, Uranchimeg B, Bonomi CA, Borgel SD, Carter JP, Gehrs B, Raffeld M, Kinders RJ, Parchment R, Anver MR, Shoemaker RH, Melillo G
Molecular cancer therapeutics 2009 Jul;8(7):1867-77
Molecular cancer therapeutics 2009 Jul;8(7):1867-77
Signaling by hypoxia-inducible factors is critical for ovulation in mice.
Kim J, Bagchi IC, Bagchi MK
Endocrinology 2009 Jul;150(7):3392-400
Endocrinology 2009 Jul;150(7):3392-400
Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.
Loinard C, Ginouvès A, Vilar J, Cochain C, Zouggari Y, Recalde A, Duriez M, Lévy BI, Pouysségur J, Berra E, Silvestre JS
Circulation 2009 Jul 7;120(1):50-9
Circulation 2009 Jul 7;120(1):50-9
mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.
Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, Vera DR, Shaw RJ
Proceedings of the National Academy of Sciences of the United States of America 2009 Jul 7;106(27):11137-42
Proceedings of the National Academy of Sciences of the United States of America 2009 Jul 7;106(27):11137-42
Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium.
Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, Haldar SM, Maemura K, Lamanna JC, Jain MK
The Journal of biological chemistry 2009 Jul 31;284(31):20522-30
The Journal of biological chemistry 2009 Jul 31;284(31):20522-30
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.
Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E, Greten FR, Rius J, Lewis CE
Blood 2009 Jul 23;114(4):844-59
Blood 2009 Jul 23;114(4):844-59
MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression.
Aubert S, Fauquette V, Hémon B, Lepoivre R, Briez N, Bernard D, Van Seuningen I, Leroy X, Perrais M
Cancer research 2009 Jul 15;69(14):5707-15
Cancer research 2009 Jul 15;69(14):5707-15
Magnesium deficiency causes loss of response to intermittent hypoxia in paraganglion cells.
Torii S, Kobayashi K, Takahashi M, Katahira K, Goryo K, Matsushita N, Yasumoto K, Fujii-Kuriyama Y, Sogawa K
The Journal of biological chemistry 2009 Jul 10;284(28):19077-89
The Journal of biological chemistry 2009 Jul 10;284(28):19077-89
A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak.
Irwin DC, McCord JM, Nozik-Grayck E, Beckly G, Foreman B, Sullivan T, White M, T Crossno J Jr, Bailey D, Flores SC, Majka S, Klemm D, van Patot MC
Free radical biology & medicine 2009 Jul 1;47(1):55-61
Free radical biology & medicine 2009 Jul 1;47(1):55-61
Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma.
Miyazawa M, Yasuda M, Fujita M, Kajiwara H, Hirabayashi K, Takekoshi S, Hirasawa T, Murakami M, Ogane N, Kiguchi K, Ishiwata I, Mikami M, Osamura RY
Pathology international 2009 Jan;59(1):19-27
Pathology international 2009 Jan;59(1):19-27
Hypoxia decreases insulin signaling pathways in adipocytes.
Regazzetti C, Peraldi P, Grémeaux T, Najem-Lendom R, Ben-Sahra I, Cormont M, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S
Diabetes 2009 Jan;58(1):95-103
Diabetes 2009 Jan;58(1):95-103
The prognostic value of hypoxia markers in T2-staged oral tongue cancer.
Roh JL, Cho KJ, Kwon GY, Ryu CH, Chang HW, Choi SH, Nam SY, Kim SY
Oral oncology 2009 Jan;45(1):63-8
Oral oncology 2009 Jan;45(1):63-8
Increased renal adrenomedullin expression in rats with ureteral obstruction.
Nørregaard R, Bødker T, Jensen BL, Stødkilde L, Nielsen S, Frøkiaer J
American journal of physiology. Regulatory, integrative and comparative physiology 2009 Jan;296(1):R185-92
American journal of physiology. Regulatory, integrative and comparative physiology 2009 Jan;296(1):R185-92
IFATS collection: Adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia.
Thangarajah H, Vial IN, Chang E, El-Ftesi S, Januszyk M, Chang EI, Paterno J, Neofytou E, Longaker MT, Gurtner GC
Stem cells (Dayton, Ohio) 2009 Jan;27(1):266-74
Stem cells (Dayton, Ohio) 2009 Jan;27(1):266-74
Adventitial transplantation of blood outgrowth endothelial cells in porcine haemodialysis grafts alleviates hypoxia and decreases neointimal proliferation through a matrix metalloproteinase-9-mediated pathway--a pilot study.
Hughes D, Fu AA, Puggioni A, Glockner JF, Anwer B, McGuire AM, Mukhopadhyay D, Misra S
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009 Jan;24(1):85-96
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009 Jan;24(1):85-96
Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.
Tyagi A, Singh RP, Ramasamy K, Raina K, Redente EF, Dwyer-Nield LD, Radcliffe RA, Malkinson AM, Agarwal R
Cancer prevention research (Philadelphia, Pa.) 2009 Jan;2(1):74-83
Cancer prevention research (Philadelphia, Pa.) 2009 Jan;2(1):74-83
Effect of hypoxia on the expression of phosphoglycerate kinase and antitumor activity of troxacitabine and gemcitabine in non-small cell lung carcinoma.
Lam W, Bussom S, Cheng YC
Molecular cancer therapeutics 2009 Feb;8(2):415-23
Molecular cancer therapeutics 2009 Feb;8(2):415-23
Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression.
Gilbert JS, Gilbert SA, Arany M, Granger JP
Hypertension (Dallas, Tex. : 1979) 2009 Feb;53(2):399-403
Hypertension (Dallas, Tex. : 1979) 2009 Feb;53(2):399-403
Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone.
Alam H, Weck J, Maizels E, Park Y, Lee EJ, Ashcroft M, Hunzicker-Dunn M
Endocrinology 2009 Feb;150(2):915-28
Endocrinology 2009 Feb;150(2):915-28
HIF-1alpha-dependent gene expression program during the nucleic acid-triggered antiviral innate immune responses.
Hong SW, Yoo JW, Kang HS, Kim S, Lee DK
Molecules and cells 2009 Feb 28;27(2):243-50
Molecules and cells 2009 Feb 28;27(2):243-50
IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain.
Shen F, Li N, Gade P, Kalvakolanu DV, Weibley T, Doble B, Woodgett JR, Wood TD, Gaffen SL
Science signaling 2009 Feb 24;2(59):ra8
Science signaling 2009 Feb 24;2(59):ra8
A HIF-1alpha-dependent autocrine feedback loop promotes survival of serum-deprived prostate cancer cells.
Thomas R, Kim MH
The Prostate 2009 Feb 15;69(3):263-75
The Prostate 2009 Feb 15;69(3):263-75
Cytogenetic and molecular tumor profiling for type 1 and type 2 papillary renal cell carcinoma.
Klatte T, Pantuck AJ, Said JW, Seligson DB, Rao NP, LaRochelle JC, Shuch B, Zisman A, Kabbinavar FF, Belldegrun AS
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Feb 15;15(4):1162-9
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Feb 15;15(4):1162-9
Construction of mutant TKGFP for real-time imaging of temporal dynamics of HIF-1 signal transduction activity mediated by hypoxia and reoxygenation in tumors in living mice.
Hsieh CH, Kuo JW, Lee YJ, Chang CW, Gelovani JG, Liu RS
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009 Dec;50(12):2049-57
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009 Dec;50(12):2049-57
Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia.
Rey S, Lee K, Wang CJ, Gupta K, Chen S, McMillan A, Bhise N, Levchenko A, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2009 Dec 1;106(48):20399-404
Proceedings of the National Academy of Sciences of the United States of America 2009 Dec 1;106(48):20399-404
Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan.
Hu Y, Kirito K, Yoshida K, Mitsumori T, Nakajima K, Nozaki Y, Hamanaka S, Nagashima T, Kunitama M, Sakoe K, Komatsu N
Molecular cancer therapeutics 2009 Aug;8(8):2329-38
Molecular cancer therapeutics 2009 Aug;8(8):2329-38
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.
Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ
Nucleic acids research 2009 Aug;37(14):4587-602
Nucleic acids research 2009 Aug;37(14):4587-602
Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.
Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA, Scherer PE
Molecular and cellular biology 2009 Aug;29(16):4467-83
Molecular and cellular biology 2009 Aug;29(16):4467-83
Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3.
Hsu K, Chi N, Gucek M, Van Eyk JE, Cole RN, Lin M, Foster DB
Blood 2009 Aug 27;114(9):1919-28
Blood 2009 Aug 27;114(9):1919-28
Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity.
Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell MJ, Boudreau N
Cancer research 2009 Aug 15;69(16):6721-9
Cancer research 2009 Aug 15;69(16):6721-9
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Thangarajah H, Yao D, Chang EI, Shi Y, Jazayeri L, Vial IN, Galiano RD, Du XL, Grogan R, Galvez MG, Januszyk M, Brownlee M, Gurtner GC
Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 11;106(32):13505-10
Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 11;106(32):13505-10
Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy.
Shibata R, Ueda S, Yamagishi S, Kaida Y, Matsumoto Y, Fukami K, Hayashida A, Matsuoka H, Kato S, Kimoto M, Okuda S
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009 Apr;24(4):1162-9
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009 Apr;24(4):1162-9
GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis.
Amann T, Maegdefrau U, Hartmann A, Agaimy A, Marienhagen J, Weiss TS, Stoeltzing O, Warnecke C, Schölmerich J, Oefner PJ, Kreutz M, Bosserhoff AK, Hellerbrand C
The American journal of pathology 2009 Apr;174(4):1544-52
The American journal of pathology 2009 Apr;174(4):1544-52
Hypoxia stimulates via separate pathways ERK phosphorylation and NF-kappaB activation in skeletal muscle cells in primary culture.
Osorio-Fuentealba C, Valdés JA, Riquelme D, Hidalgo J, Hidalgo C, Carrasco MA
Journal of applied physiology (Bethesda, Md. : 1985) 2009 Apr;106(4):1301-10
Journal of applied physiology (Bethesda, Md. : 1985) 2009 Apr;106(4):1301-10
Protection of retinal cells from ischemia by a novel gap junction inhibitor.
Das S, Lin D, Jena S, Shi A, Battina S, Hua DH, Allbaugh R, Takemoto DJ
Biochemical and biophysical research communications 2008 Sep 5;373(4):504-8
Biochemical and biophysical research communications 2008 Sep 5;373(4):504-8
Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.
Kimura K, Iwano M, Higgins DF, Yamaguchi Y, Nakatani K, Harada K, Kubo A, Akai Y, Rankin EB, Neilson EG, Haase VH, Saito Y
American journal of physiology. Renal physiology 2008 Oct;295(4):F1023-9
American journal of physiology. Renal physiology 2008 Oct;295(4):F1023-9
Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation.
Hlushchuk R, Riesterer O, Baum O, Wood J, Gruber G, Pruschy M, Djonov V
The American journal of pathology 2008 Oct;173(4):1173-85
The American journal of pathology 2008 Oct;173(4):1173-85
Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney.
Rosenberger C, Rosen S, Shina A, Frei U, Eckardt KU, Flippin LA, Arend M, Klaus SJ, Heyman SN
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Nov;23(11):3472-8
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Nov;23(11):3472-8
The C1772T genetic polymorphism in human HIF-1alpha gene associates with expression of HIF-1alpha protein in breast cancer.
Kim HO, Jo YH, Lee J, Lee SS, Yoon KS
Oncology reports 2008 Nov;20(5):1181-7
Oncology reports 2008 Nov;20(5):1181-7
PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress.
Yang G, Sun Q, Teng Y, Li F, Weng T, Yang X
Development (Cambridge, England) 2008 Nov;135(21):3587-97
Development (Cambridge, England) 2008 Nov;135(21):3587-97
Molecular angiogenic signaling in angiofibromas after embolization: implications for therapy.
Ngan BY, Forte V, Campisi P
Archives of otolaryngology--head & neck surgery 2008 Nov;134(11):1170-6
Archives of otolaryngology--head & neck surgery 2008 Nov;134(11):1170-6
Divergent effects of hypoxia on dendritic cell functions.
Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A
Blood 2008 Nov 1;112(9):3723-34
Blood 2008 Nov 1;112(9):3723-34
HIV-1 upregulates VEGF in podocytes.
Korgaonkar SN, Feng X, Ross MD, Lu TC, D'Agati V, Iyengar R, Klotman PE, He JC
Journal of the American Society of Nephrology : JASN 2008 May;19(5):877-83
Journal of the American Society of Nephrology : JASN 2008 May;19(5):877-83
Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family.
Evens AM, Schumacker PT, Helenowski IB, Singh AT, Dokic D, Keswani A, Kordeluk E, Raji A, Winter JN, Jovanovic BD, Holmgren A, Nelson BP, Gordon LI
British journal of haematology 2008 May;141(5):676-80
British journal of haematology 2008 May;141(5):676-80
Hypoxia-stimulated vascular endothelial growth factor production in human nasal polyp fibroblasts: effect of epigallocatechin-3-gallate on hypoxia-inducible factor-1 alpha synthesis.
Lin SK, Shun CT, Kok SH, Wang CC, Hsiao TY, Liu CM
Archives of otolaryngology--head & neck surgery 2008 May;134(5):522-7
Archives of otolaryngology--head & neck surgery 2008 May;134(5):522-7
Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1alpha in the renal medulla.
Li N, Chen L, Yi F, Xia M, Li PL
Circulation research 2008 May 9;102(9):1101-8
Circulation research 2008 May 9;102(9):1101-8
AMP-activated protein kinase is essential for survival in chronic hypoxia.
Borger DR, Gavrilescu LC, Bucur MC, Ivan M, Decaprio JA
Biochemical and biophysical research communications 2008 May 30;370(2):230-4
Biochemical and biophysical research communications 2008 May 30;370(2):230-4
Clinicopathologic significance of HIF-1alpha, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer.
Oh SY, Kwon HC, Kim SH, Jang JS, Kim MC, Kim KH, Han JY, Kim CO, Kim SJ, Jeong JS, Kim HJ
BMC cancer 2008 May 1;8:123
BMC cancer 2008 May 1;8:123
Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia.
Ryu J, Lee CW, Hong KH, Shin JA, Lim SH, Park CS, Shim J, Nam KB, Choi KJ, Kim YH, Han KH
Cardiovascular research 2008 May 1;78(2):333-40
Cardiovascular research 2008 May 1;78(2):333-40
Metallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1alpha.
Murphy BJ, Kimura T, Sato BG, Shi Y, Andrews GK
Molecular cancer research : MCR 2008 Mar;6(3):483-90
Molecular cancer research : MCR 2008 Mar;6(3):483-90
Spironolactone suppresses peritubular capillary loss and prevents deoxycorticosterone acetate/salt-induced tubulointerstitial fibrosis.
Iwazu Y, Muto S, Fujisawa G, Nakazawa E, Okada K, Ishibashi S, Kusano E
Hypertension (Dallas, Tex. : 1979) 2008 Mar;51(3):749-54
Hypertension (Dallas, Tex. : 1979) 2008 Mar;51(3):749-54
Inhibition of bFGF-receptor type 2 increases kidney damage and suppresses nephrogenic protein expression after ischemic acute renal failure.
Villanueva S, Cespedes C, Gonzalez AA, Roessler E, Vio CP
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Mar;294(3):R819-28
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Mar;294(3):R819-28
HIF activation protects from acute kidney injury.
Weidemann A, Bernhardt WM, Klanke B, Daniel C, Buchholz B, Câmpean V, Amann K, Warnecke C, Wiesener MS, Eckardt KU, Willam C
Journal of the American Society of Nephrology : JASN 2008 Mar;19(3):486-94
Journal of the American Society of Nephrology : JASN 2008 Mar;19(3):486-94
Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection.
Gauter-Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Batinic-Haberle I, Vujaskovic Z
Free radical biology & medicine 2008 Mar 15;44(6):982-9
Free radical biology & medicine 2008 Mar 15;44(6):982-9
A possible role for hypoxia-induced apelin expression in enteric cell proliferation.
Han S, Wang G, Qi X, Lee HM, Englander EW, Greeley GH Jr
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Jun;294(6):R1832-9
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Jun;294(6):R1832-9
Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor.
Rimon E, Chen B, Shanks AL, Nelson DM, Sadovsky Y
Endocrinology 2008 Jun;149(6):2952-8
Endocrinology 2008 Jun;149(6):2952-8
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
Frew IJ, Thoma CR, Georgiev S, Minola A, Hitz M, Montani M, Moch H, Krek W
The EMBO journal 2008 Jun 18;27(12):1747-57
The EMBO journal 2008 Jun 18;27(12):1747-57
Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling.
Champion KJ, Guinea M, Dammai V, Hsu T
Cancer research 2008 Jun 15;68(12):4649-57
Cancer research 2008 Jun 15;68(12):4649-57
Prognostic values of pathologic findings and hypoxia markers in 21 patients with salivary duct carcinoma.
Roh JL, Cho KJ, Kwon GY, Choi SH, Nam SY, Kim SY
Journal of surgical oncology 2008 Jun 1;97(7):596-600
Journal of surgical oncology 2008 Jun 1;97(7):596-600
Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia.
Frew IJ, Minola A, Georgiev S, Hitz M, Moch H, Richard S, Vortmeyer AO, Krek W
Molecular and cellular biology 2008 Jul;28(14):4536-48
Molecular and cellular biology 2008 Jul;28(14):4536-48
Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia.
Wang Y, Luo J, Chen X, Chen H, Cramer SW, Sun D
The European journal of neuroscience 2008 Jul;28(1):51-61
The European journal of neuroscience 2008 Jul;28(1):51-61
Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals.
Tacchini L, Gammella E, De Ponti C, Recalcati S, Cairo G
The Journal of biological chemistry 2008 Jul 25;283(30):20674-86
The Journal of biological chemistry 2008 Jul 25;283(30):20674-86
ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo.
Moser C, Lang SA, Mori A, Hellerbrand C, Schlitt HJ, Geissler EK, Fogler WE, Stoeltzing O
BMC cancer 2008 Jul 23;8:206
BMC cancer 2008 Jul 23;8:206
The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma.
Miyazaki Y, Hara A, Kato K, Oyama T, Yamada Y, Mori H, Shibata T
International journal of oncology 2008 Jan;32(1):145-51
International journal of oncology 2008 Jan;32(1):145-51
Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation.
Black SM, DeVol JM, Wedgwood S
American journal of physiology. Cell physiology 2008 Jan;294(1):C345-54
American journal of physiology. Cell physiology 2008 Jan;294(1):C345-54
Placental HIFs as markers of cerebral hypoxic distress in fetal mice.
Trollmann R, Strasser K, Keller S, Antoniou X, Grenacher B, Ogunshola OO, Dötsch J, Rascher W, Gassmann M
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Dec;295(6):R1973-81
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Dec;295(6):R1973-81
Hypoxia-inducible factor-1alpha protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression.
Yeh SH, Hung JJ, Gean PW, Chang WC
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Dec 24;28(52):14259-70
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Dec 24;28(52):14259-70
mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha.
Wong W, Goehring AS, Kapiloff MS, Langeberg LK, Scott JD
Science signaling 2008 Dec 23;1(51):ra18
Science signaling 2008 Dec 23;1(51):ra18
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.
Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 16;105(50):19579-86
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 16;105(50):19579-86
The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells.
Yamashita T, Ohneda O, Sakiyama A, Iwata F, Ohneda K, Fujii-Kuriyama Y
Blood 2008 Aug 15;112(4):1482-92
Blood 2008 Aug 15;112(4):1482-92
Glomerular endothelium in kidneys with congenital nephrotic syndrome of the Finnish type (NPHS1).
Kaukinen A, Kuusniemi AM, Lautenschlager I, Jalanko H
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Apr;23(4):1224-32
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Apr;23(4):1224-32
Evidence for sustained renal hypoxia and transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury.
Rosenberger C, Goldfarb M, Shina A, Bachmann S, Frei U, Eckardt KU, Schrader T, Rosen S, Heyman SN
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Apr;23(4):1135-43
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Apr;23(4):1135-43
HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus.
Nagao K, Taniyama Y, Kietzmann T, Doi T, Komuro I, Morishita R
The Journal of biological chemistry 2008 Apr 25;283(17):11841-9
The Journal of biological chemistry 2008 Apr 25;283(17):11841-9
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL
The Journal of biological chemistry 2008 Apr 18;283(16):10892-903
The Journal of biological chemistry 2008 Apr 18;283(16):10892-903
High-fat, high-sucrose, and high-cholesterol diets accelerate tumor growth and metastasis in tumor-bearing mice.
Kimura Y, Sumiyoshi M
Nutrition and cancer 2007;59(2):207-16
Nutrition and cancer 2007;59(2):207-16
Improved nuclear localization of DNA-binding polyamides.
Nickols NG, Jacobs CS, Farkas ME, Dervan PB
Nucleic acids research 2007;35(2):363-70
Nucleic acids research 2007;35(2):363-70
Acute hypobaric hypoxia (5486 m) induces greater pulmonary HIF-1 activation in hilltop compared to madison rats.
Engebretsen BJ, Irwin D, Valdez ME, O'Donovan MK, Tucker A, van Patot MT
High altitude medicine & biology 2007 Winter;8(4):312-21
High altitude medicine & biology 2007 Winter;8(4):312-21
The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine.
Lam W, Leung CH, Bussom S, Cheng YC
Molecular pharmacology 2007 Sep;72(3):536-44
Molecular pharmacology 2007 Sep;72(3):536-44
The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling.
Ide T, Kitajima Y, Miyoshi A, Ohtsuka T, Mitsuno M, Ohtaka K, Miyazaki K
Annals of surgical oncology 2007 Sep;14(9):2600-7
Annals of surgical oncology 2007 Sep;14(9):2600-7
Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair.
Mace KA, Yu DH, Paydar KZ, Boudreau N, Young DM
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2007 Sep-Oct;15(5):636-45
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2007 Sep-Oct;15(5):636-45
Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells.
Cheng G, Shao Z, Chaudhari B, Agrawal DK
American journal of physiology. Lung cellular and molecular physiology 2007 Nov;293(5):L1339-47
American journal of physiology. Lung cellular and molecular physiology 2007 Nov;293(5):L1339-47
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.
Hu CJ, Sataur A, Wang L, Chen H, Simon MC
Molecular biology of the cell 2007 Nov;18(11):4528-42
Molecular biology of the cell 2007 Nov;18(11):4528-42
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL
The Journal of biological chemistry 2007 Nov 16;282(46):33358-66
The Journal of biological chemistry 2007 Nov 16;282(46):33358-66
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.
Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL
Cancer cell 2007 May;11(5):407-20
Cancer cell 2007 May;11(5):407-20
Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway.
Jeong CH, Lee HJ, Cha JH, Kim JH, Kim KR, Kim JH, Yoon DK, Kim KW
The Journal of biological chemistry 2007 May 4;282(18):13672-9
The Journal of biological chemistry 2007 May 4;282(18):13672-9
Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo.
Lang SA, Klein D, Moser C, Gaumann A, Glockzin G, Dahlke MH, Dietmaier W, Bolder U, Schlitt HJ, Geissler EK, Stoeltzing O
Molecular cancer therapeutics 2007 Mar;6(3):1123-32
Molecular cancer therapeutics 2007 Mar;6(3):1123-32
Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model.
Jayle C, Favreau F, Zhang K, Doucet C, Goujon JM, Hebrard W, Carretier M, Eugene M, Mauco G, Tillement JP, Hauet T
American journal of physiology. Renal physiology 2007 Mar;292(3):F1082-93
American journal of physiology. Renal physiology 2007 Mar;292(3):F1082-93
Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency.
Komatsu DE, Bosch-Marce M, Semenza GL, Hadjiargyrou M
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007 Mar;22(3):366-74
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007 Mar;22(3):366-74
Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1alpha, and C/EBPalpha.
Liao H, Hyman MC, Lawrence DA, Pinsky DJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 Mar;21(3):935-49
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 Mar;21(3):935-49
Involvement of hypoxia-inducible transcription factors in polycystic kidney disease.
Bernhardt WM, Wiesener MS, Weidemann A, Schmitt R, Weichert W, Lechler P, Campean V, Ong AC, Willam C, Gretz N, Eckardt KU
The American journal of pathology 2007 Mar;170(3):830-42
The American journal of pathology 2007 Mar;170(3):830-42
Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning.
Chin BY, Jiang G, Wegiel B, Wang HJ, Macdonald T, Zhang XC, Gallo D, Cszimadia E, Bach FH, Lee PJ, Otterbein LE
Proceedings of the National Academy of Sciences of the United States of America 2007 Mar 20;104(12):5109-14
Proceedings of the National Academy of Sciences of the United States of America 2007 Mar 20;104(12):5109-14
Hypoxia-inducible transcription factor-1 alpha determines sensitivity of endothelial cells to the proteosome inhibitor bortezomib.
Veschini L, Belloni D, Foglieni C, Cangi MG, Ferrarini M, Caligaris-Cappio F, Ferrero E
Blood 2007 Mar 15;109(6):2565-70
Blood 2007 Mar 15;109(6):2565-70
Hypoxia inducible factor regulates the cardiac expression and secretion of apelin.
Ronkainen VP, Ronkainen JJ, Hänninen SL, Leskinen H, Ruas JL, Pereira T, Poellinger L, Vuolteenaho O, Tavi P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 Jun;21(8):1821-30
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 Jun;21(8):1821-30
The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.
Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL
The Journal of clinical investigation 2007 Jun;117(6):1616-26
The Journal of clinical investigation 2007 Jun;117(6):1616-26
Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy.
Shimojo N, Jesmin S, Zaedi S, Otsuki T, Maeda S, Yamaguchi N, Aonuma K, Hattori Y, Miyauchi T
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H474-81
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H474-81
Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia.
Bateman RM, Tokunaga C, Kareco T, Dorscheid DR, Walley KR
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H448-56
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H448-56
Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats.
McLaren AT, Marsden PA, Mazer CD, Baker AJ, Stewart DJ, Tsui AK, Li X, Yucel Y, Robb M, Boyd SR, Liu E, Yu J, Hare GM
American journal of physiology. Regulatory, integrative and comparative physiology 2007 Jan;292(1):R403-14
American journal of physiology. Regulatory, integrative and comparative physiology 2007 Jan;292(1):R403-14
Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells.
Brooks C, Wang J, Yang T, Dong Z
American journal of physiology. Renal physiology 2007 Jan;292(1):F243-52
American journal of physiology. Renal physiology 2007 Jan;292(1):F243-52
Immunohistochemical detection of hypoxia-inducible factor-1alpha in human renal allograft biopsies.
Rosenberger C, Pratschke J, Rudolph B, Heyman SN, Schindler R, Babel N, Eckardt KU, Frei U, Rosen S, Reinke P
Journal of the American Society of Nephrology : JASN 2007 Jan;18(1):343-51
Journal of the American Society of Nephrology : JASN 2007 Jan;18(1):343-51
Hypoxic regulation of Id-1 and activation of the unfolded protein response are aberrant in neuroblastoma.
Nemetski SM, Gardner LB
The Journal of biological chemistry 2007 Jan 5;282(1):240-8
The Journal of biological chemistry 2007 Jan 5;282(1):240-8
Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2.
LaRusch GA, Jackson MW, Dunbar JD, Warren RS, Donner DB, Mayo LD
Cancer research 2007 Jan 15;67(2):450-4
Cancer research 2007 Jan 15;67(2):450-4
Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization.
Winner M, Koong AC, Rendon BE, Zundel W, Mitchell RA
Cancer research 2007 Jan 1;67(1):186-93
Cancer research 2007 Jan 1;67(1):186-93
Insulin-induced activation of hypoxia-inducible factor-1 requires generation of reactive oxygen species by NADPH oxidase.
Biswas S, Gupta MK, Chattopadhyay D, Mukhopadhyay CK
American journal of physiology. Heart and circulatory physiology 2007 Feb;292(2):H758-66
American journal of physiology. Heart and circulatory physiology 2007 Feb;292(2):H758-66
Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221.
Creighton-Gutteridge M, Cardellina JH 2nd, Stephen AG, Rapisarda A, Uranchimeg B, Hite K, Denny WA, Shoemaker RH, Melillo G
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Feb 1;13(3):1010-8
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Feb 1;13(3):1010-8
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.
Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson RS, Kretzler M, Cohen CD, Eckardt KU, Iwano M, Haase VH
The Journal of clinical investigation 2007 Dec;117(12):3810-20
The Journal of clinical investigation 2007 Dec;117(12):3810-20
Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization.
Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL
The Journal of biological chemistry 2007 Dec 21;282(51):37064-73
The Journal of biological chemistry 2007 Dec 21;282(51):37064-73
Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms.
Hunt TK, Aslam RS, Beckert S, Wagner S, Ghani QP, Hussain MZ, Roy S, Sen CK
Antioxidants & redox signaling 2007 Aug;9(8):1115-24
Antioxidants & redox signaling 2007 Aug;9(8):1115-24
Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.
Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL
The Journal of biological chemistry 2007 Aug 10;282(32):23572-80
The Journal of biological chemistry 2007 Aug 10;282(32):23572-80
Hypoxia-inducible factors in the first trimester human lung.
Groenman F, Rutter M, Caniggia I, Tibboel D, Post M
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 Apr;55(4):355-63
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 Apr;55(4):355-63
Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney.
Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, Ohneda O, Takeda N, Sata M, Miyata T, Fujita T, Nangaku M
Journal of the American Society of Nephrology : JASN 2007 Apr;18(4):1218-26
Journal of the American Society of Nephrology : JASN 2007 Apr;18(4):1218-26
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.
Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH
The Journal of clinical investigation 2007 Apr;117(4):1068-77
The Journal of clinical investigation 2007 Apr;117(4):1068-77
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang YW
The Journal of biological chemistry 2007 Apr 13;282(15):10873-80
The Journal of biological chemistry 2007 Apr 13;282(15):10873-80
Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer.
Schoppmann SF, Fenzl A, Schindl M, Bachleitner-Hofmann T, Nagy K, Gnant M, Horvat R, Jakesz R, Birner P
Breast cancer research and treatment 2006 Sep;99(2):135-41
Breast cancer research and treatment 2006 Sep;99(2):135-41
Pressure gradients and transport in the murine femur upon hindlimb suspension.
Stevens HY, Meays DR, Frangos JA
Bone 2006 Sep;39(3):565-72
Bone 2006 Sep;39(3):565-72
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, Wentzel E, Furth EE, Lee WM, Enders GH, Mendell JT, Thomas-Tikhonenko A
Nature genetics 2006 Sep;38(9):1060-5
Nature genetics 2006 Sep;38(9):1060-5
Oxygen concentration is an important factor for modulating progesterone synthesis in bovine corpus luteum.
Nishimura R, Sakumoto R, Tatsukawa Y, Acosta TJ, Okuda K
Endocrinology 2006 Sep;147(9):4273-80
Endocrinology 2006 Sep;147(9):4273-80
Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy.
Pore N, Gupta AK, Cerniglia GJ, Jiang Z, Bernhard EJ, Evans SM, Koch CJ, Hahn SM, Maity A
Cancer research 2006 Sep 15;66(18):9252-9
Cancer research 2006 Sep 15;66(18):9252-9
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells.
Chen H, Yan Y, Davidson TL, Shinkai Y, Costa M
Cancer research 2006 Sep 15;66(18):9009-16
Cancer research 2006 Sep 15;66(18):9009-16
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.
Chavez JC, Baranova O, Lin J, Pichiule P
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Sep 13;26(37):9471-81
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Sep 13;26(37):9471-81
Overexpression of hypoxia-inducible factor 1alpha and p53 is a marker for an unfavorable prognosis in gastric cancer.
Sumiyoshi Y, Kakeji Y, Egashira A, Mizokami K, Orita H, Maehara Y
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Sep 1;12(17):5112-7
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Sep 1;12(17):5112-7
Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone.
Makino H, Miyamoto Y, Sawai K, Mori K, Mukoyama M, Nakao K, Yoshimasa Y, Suga S
Diabetes 2006 Oct;55(10):2747-56
Diabetes 2006 Oct;55(10):2747-56
Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice.
Shen F, Su H, Fan Y, Chen Y, Zhu Y, Liu W, Young WL, Yang GY
Stroke 2006 Oct;37(10):2601-6
Stroke 2006 Oct;37(10):2601-6
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Khan Z, Michalopoulos GK, Stolz DB
The American journal of pathology 2006 Oct;169(4):1251-69
The American journal of pathology 2006 Oct;169(4):1251-69
Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes.
Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, Wenger RH, Ohta A, Sitkovsky M
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 15;177(8):4962-5
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 15;177(8):4962-5
Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes.
Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, Wenger RH, Ohta A, Sitkovsky M
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 15;177(8):4962-5
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 15;177(8):4962-5
Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response.
Hwang II, Watson IR, Der SD, Ohh M
Journal of virology 2006 Nov;80(21):10712-23
Journal of virology 2006 Nov;80(21):10712-23
HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells.
Pore N, Gupta AK, Cerniglia GJ, Maity A
Neoplasia (New York, N.Y.) 2006 Nov;8(11):889-95
Neoplasia (New York, N.Y.) 2006 Nov;8(11):889-95
Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.
Khurana A, Nakayama K, Williams S, Davis RJ, Mustelin T, Ronai Z
The Journal of biological chemistry 2006 Nov 17;281(46):35316-26
The Journal of biological chemistry 2006 Nov 17;281(46):35316-26
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.
Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC
Molecular and cellular biology 2006 May;26(9):3514-26
Molecular and cellular biology 2006 May;26(9):3514-26
Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures.
Zhang W, Petrovic JM, Callaghan D, Jones A, Cui H, Howlett C, Stanimirovic D
Journal of neuroimmunology 2006 May;174(1-2):63-73
Journal of neuroimmunology 2006 May;174(1-2):63-73
Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha.
Fath DM, Kong X, Liang D, Lin Z, Chou A, Jiang Y, Fang J, Caro J, Sang N
The Journal of biological chemistry 2006 May 12;281(19):13612-9
The Journal of biological chemistry 2006 May 12;281(19):13612-9
Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis.
Grammas P, Samany PG, Thirumangalakudi L
Journal of Alzheimer's disease : JAD 2006 Mar;9(1):51-8
Journal of Alzheimer's disease : JAD 2006 Mar;9(1):51-8
Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis.
Grammas P, Samany PG, Thirumangalakudi L
Journal of Alzheimer's disease : JAD 2006 Mar;9(1):51-8
Journal of Alzheimer's disease : JAD 2006 Mar;9(1):51-8
Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension.
Rodriguez-Porcel M, Zhu XY, Chade AR, Amores-Arriaga B, Caplice NM, Ritman EL, Lerman A, Lerman LO
American journal of physiology. Heart and circulatory physiology 2006 Mar;290(3):H978-84
American journal of physiology. Heart and circulatory physiology 2006 Mar;290(3):H978-84
Calcium signaling stimulates translation of HIF-alpha during hypoxia.
Hui AS, Bauer AL, Striet JB, Schnell PO, Czyzyk-Krzeska MF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Mar;20(3):466-75
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Mar;20(3):466-75
EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms.
Pore N, Jiang Z, Gupta A, Cerniglia G, Kao GD, Maity A
Cancer research 2006 Mar 15;66(6):3197-204
Cancer research 2006 Mar 15;66(6):3197-204
Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1.
Kato H, Inoue T, Asanoma K, Nishimura C, Matsuda T, Wake N
International journal of cancer 2006 Mar 1;118(5):1144-53
International journal of cancer 2006 Mar 1;118(5):1144-53
A constitutively active hypoxia-inducible factor-1alpha/VP16 hybrid factor activates expression of the human B-type natriuretic peptide gene.
Luo Y, Jiang C, Belanger AJ, Akita GY, Wadsworth SC, Gregory RJ, Vincent KA
Molecular pharmacology 2006 Jun;69(6):1953-62
Molecular pharmacology 2006 Jun;69(6):1953-62
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation.
Lee KS, Kim SR, Park SJ, Lee HK, Park HS, Min KH, Jin SM, Lee YC
Molecular pharmacology 2006 Jun;69(6):1829-39
Molecular pharmacology 2006 Jun;69(6):1829-39
White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.
Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB, Shaw PJ, O'Brien JT, Ince PG, MRC Cognitive Function and Ageing Neuropathology Study Group.
Stroke 2006 Jun;37(6):1391-8
Stroke 2006 Jun;37(6):1391-8
Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia.
Wang R, Zhang YW, Zhang X, Liu R, Zhang X, Hong S, Xia K, Xia J, Zhang Z, Xu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Jun;20(8):1275-7
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Jun;20(8):1275-7
Activation of hypoxia-inducible factor 1 during macrophage differentiation.
Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, Arai T, Fukuda K, Kita T, Adachi T, Semenza GL, Nohara R
American journal of physiology. Cell physiology 2006 Jul;291(1):C104-13
American journal of physiology. Cell physiology 2006 Jul;291(1):C104-13
Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure.
Bernhardt WM, Câmpean V, Kany S, Jürgensen JS, Weidemann A, Warnecke C, Arend M, Klaus S, Günzler V, Amann K, Willam C, Wiesener MS, Eckardt KU
Journal of the American Society of Nephrology : JASN 2006 Jul;17(7):1970-8
Journal of the American Society of Nephrology : JASN 2006 Jul;17(7):1970-8
Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
Tian YM, Mole DR, Ratcliffe PJ, Gleadle JM
The Biochemical journal 2006 Jul 1;397(1):179-86
The Biochemical journal 2006 Jul 1;397(1):179-86
Synergistic effects of CoCl(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells.
Pacary E, Legros H, Valable S, Duchatelle P, Lecocq M, Petit E, Nicole O, Bernaudin M
Journal of cell science 2006 Jul 1;119(Pt 13):2667-78
Journal of cell science 2006 Jul 1;119(Pt 13):2667-78
Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice.
Wang J, Hoshijima M, Lam J, Zhou Z, Jokiel A, Dalton ND, Hultenby K, Ruiz-Lozano P, Ross J Jr, Tryggvason K, Chien KR
The Journal of biological chemistry 2006 Jan 6;281(1):213-20
The Journal of biological chemistry 2006 Jan 6;281(1):213-20
Essential role of B-Raf in ERK activation during extraembryonic development.
Galabova-Kovacs G, Matzen D, Piazzolla D, Meissl K, Plyushch T, Chen AP, Silva A, Baccarini M
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 31;103(5):1325-30
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 31;103(5):1325-30
Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation.
Quintero M, Brennan PA, Thomas GJ, Moncada S
Cancer research 2006 Jan 15;66(2):770-4
Cancer research 2006 Jan 15;66(2):770-4
Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia.
Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ
Blood 2006 Jan 15;107(2):698-707
Blood 2006 Jan 15;107(2):698-707
Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.
Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, Weindruch R
The Journal of nutrition 2006 Feb;136(2):343-52
The Journal of nutrition 2006 Feb;136(2):343-52
Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1alpha variant for local induction of angiogenesis.
Trentin D, Hall H, Wechsler S, Hubbell JA
Proceedings of the National Academy of Sciences of the United States of America 2006 Feb 21;103(8):2506-11
Proceedings of the National Academy of Sciences of the United States of America 2006 Feb 21;103(8):2506-11
Expression of hypoxia-inducible factor (HIF)-1alpha as a biomarker of outcome in soft-tissue sarcomas.
Shintani K, Matsumine A, Kusuzaki K, Matsubara T, Satonaka H, Wakabayashi T, Hoki Y, Uchida A
Virchows Archiv : an international journal of pathology 2006 Dec;449(6):673-81
Virchows Archiv : an international journal of pathology 2006 Dec;449(6):673-81
bFGF induces an earlier expression of nephrogenic proteins after ischemic acute renal failure.
Villanueva S, Cespedes C, Gonzalez A, Vio CP
American journal of physiology. Regulatory, integrative and comparative physiology 2006 Dec;291(6):R1677-87
American journal of physiology. Regulatory, integrative and comparative physiology 2006 Dec;291(6):R1677-87
Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.
Kang SH, Cho HT, Devi S, Zhang Z, Escuin D, Liang Z, Mao H, Brat DJ, Olson JJ, Simons JW, Lavallee TM, Giannakakou P, Van Meir EG, Shim H
Cancer research 2006 Dec 15;66(24):11991-7
Cancer research 2006 Dec 15;66(24):11991-7
Relationship of hypoxia-inducible factor 1alpha and p21WAF1/CIP1 expression to cell apoptosis and clinical outcome in patients with gastric cancer.
Mizokami K, Kakeji Y, Oda S, Maehara Y
World journal of surgical oncology 2006 Dec 13;4:94
World journal of surgical oncology 2006 Dec 13;4:94
Hypoxia and expression of hypoxia-inducible factor in the aging kidney.
Tanaka T, Kato H, Kojima I, Ohse T, Son D, Tawakami T, Yatagawa T, Inagi R, Fujita T, Nangaku M
The journals of gerontology. Series A, Biological sciences and medical sciences 2006 Aug;61(8):795-805
The journals of gerontology. Series A, Biological sciences and medical sciences 2006 Aug;61(8):795-805
Hypoxia and expression of hypoxia-inducible factor in the aging kidney.
Tanaka T, Kato H, Kojima I, Ohse T, Son D, Tawakami T, Yatagawa T, Inagi R, Fujita T, Nangaku M
The journals of gerontology. Series A, Biological sciences and medical sciences 2006 Aug;61(8):795-805
The journals of gerontology. Series A, Biological sciences and medical sciences 2006 Aug;61(8):795-805
Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia.
Zampino M, Yuzhakova M, Hansen J, McKinney RD, Goldspink PH, Geenen DL, Buttrick PM
American journal of physiology. Heart and circulatory physiology 2006 Aug;291(2):H957-64
American journal of physiology. Heart and circulatory physiology 2006 Aug;291(2):H957-64
Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic renal ischemia.
Chade AR, Zhu X, Mushin OP, Napoli C, Lerman A, Lerman LO
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Aug;20(10):1706-8
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Aug;20(10):1706-8
Estrogen induces angiogenesis of the female rabbit bladder.
Lin AD, Mannikarottu A, Kogan BA, Whitbeck C, Chichester P, Leggett RE, Levin RM
The Journal of endocrinology 2006 Aug;190(2):241-6
The Journal of endocrinology 2006 Aug;190(2):241-6
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels.
Grimmer C, Balbus N, Lang U, Aigner T, Cramer T, Müller L, Swoboda B, Pfander D
The American journal of pathology 2006 Aug;169(2):491-502
The American journal of pathology 2006 Aug;169(2):491-502
Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.
McMahon S, Charbonneau M, Grandmont S, Richard DE, Dubois CM
The Journal of biological chemistry 2006 Aug 25;281(34):24171-81
The Journal of biological chemistry 2006 Aug 25;281(34):24171-81
Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.
Bracken CP, Fedele AO, Linke S, Balrak W, Lisy K, Whitelaw ML, Peet DJ
The Journal of biological chemistry 2006 Aug 11;281(32):22575-85
The Journal of biological chemistry 2006 Aug 11;281(32):22575-85
Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins.
Villanueva S, Céspedes C, Vio CP
American journal of physiology. Regulatory, integrative and comparative physiology 2006 Apr;290(4):R861-70
American journal of physiology. Regulatory, integrative and comparative physiology 2006 Apr;290(4):R861-70
Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility.
Hsu T, Adereth Y, Kose N, Dammai V
The Journal of biological chemistry 2006 Apr 28;281(17):12069-80
The Journal of biological chemistry 2006 Apr 28;281(17):12069-80
Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia.
Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung AM, Brown AS, Hicklin DJ, Foster FS, Kerbel RS
Cancer research 2006 Apr 1;66(7):3639-48
Cancer research 2006 Apr 1;66(7):3639-48
Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer.
Kim SJ, Rabbani ZN, Dewhirst MW, Vujaskovic Z, Vollmer RT, Schreiber EG, Oosterwijk E, Kelley MJ
Lung cancer (Amsterdam, Netherlands) 2005 Sep;49(3):325-35
Lung cancer (Amsterdam, Netherlands) 2005 Sep;49(3):325-35
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity.
Kong D, Park EJ, Stephen AG, Calvani M, Cardellina JH, Monks A, Fisher RJ, Shoemaker RH, Melillo G
Cancer research 2005 Oct 1;65(19):9047-55
Cancer research 2005 Oct 1;65(19):9047-55
Up-regulation of c-met protooncogene product expression through hypoxia-inducible factor-1alpha is involved in trophoblast invasion under low-oxygen tension.
Hayashi M, Sakata M, Takeda T, Tahara M, Yamamoto T, Okamoto Y, Minekawa R, Isobe A, Ohmichi M, Tasaka K, Murata Y
Endocrinology 2005 Nov;146(11):4682-9
Endocrinology 2005 Nov;146(11):4682-9
Expression of hypoxia-inducible factor-1alpha in esophageal squamous cell carcinoma.
Matsuyama T, Nakanishi K, Hayashi T, Yoshizumi Y, Aiko S, Sugiura Y, Tanimoto T, Uenoyama M, Ozeki Y, Maehara T
Cancer science 2005 Mar;96(3):176-82
Cancer science 2005 Mar;96(3):176-82
Adaptive responses to mitochondrial dysfunction in the rho degrees Namalwa cell.
Behan A, Doyle S, Farrell M
Mitochondrion 2005 Jun;5(3):173-93
Mitochondrion 2005 Jun;5(3):173-93
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor.
Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL
Cancer research 2005 Jul 15;65(14):6178-88
Cancer research 2005 Jul 15;65(14):6178-88
Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line.
Aminova LR, Chavez JC, Lee J, Ryu H, Kung A, Lamanna JC, Ratan RR
The Journal of biological chemistry 2005 Feb 4;280(5):3996-4003
The Journal of biological chemistry 2005 Feb 4;280(5):3996-4003
Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo: estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter.
Kazi AA, Jones JM, Koos RD
Molecular endocrinology (Baltimore, Md.) 2005 Aug;19(8):2006-19
Molecular endocrinology (Baltimore, Md.) 2005 Aug;19(8):2006-19
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.
Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, Fisher SJ
Development (Cambridge, England) 2005 Aug;132(15):3393-403
Development (Cambridge, England) 2005 Aug;132(15):3393-403
Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells.
Alberghini A, Recalcati S, Tacchini L, Santambrogio P, Campanella A, Cairo G
The Journal of biological chemistry 2005 Aug 26;280(34):30120-8
The Journal of biological chemistry 2005 Aug 26;280(34):30120-8
Genistein inhibited retinal neovascularization and expression of vascular endothelial growth factor and hypoxia inducible factor 1alpha in a mouse model of oxygen-induced retinopathy.
Wang B, Zou Y, Li H, Yan H, Pan JS, Yuan ZL
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2005 Apr;21(2):107-13
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2005 Apr;21(2):107-13
A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells.
Li YM, Zhou BP, Deng J, Pan Y, Hay N, Hung MC
Cancer research 2005 Apr 15;65(8):3257-63
Cancer research 2005 Apr 15;65(8):3257-63
Determination of the role of hypoxia-inducible factor 1 in wound healing.
Reichner JS, Albina JE
Methods in enzymology 2004;381:527-38
Methods in enzymology 2004;381:527-38
Carotid chemodenervation approach to study oxygen sensing in brain stem catecholaminergic cells.
Pascual O, Roux JC, Soulage C, Morin-Surun MP, Denavit-Saubié M, Pequignot JM
Methods in enzymology 2004;381:422-49
Methods in enzymology 2004;381:422-49
Protocol of radiotherapy for glioblastoma according to the expression of HIF-1.
Irie N, Matsuo T, Nagata I
Brain tumor pathology 2004;21(1):1-6
Brain tumor pathology 2004;21(1):1-6
Protocol of radiotherapy for glioblastoma according to the expression of HIF-1.
Irie N, Matsuo T, Nagata I
Brain tumor pathology 2004;21(1):1-6
Brain tumor pathology 2004;21(1):1-6
Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia.
Tissot van Patot MC, Bendrick-Peart J, Beckey VE, Serkova N, Zwerdlinger L
American journal of physiology. Lung cellular and molecular physiology 2004 Sep;287(3):L525-32
American journal of physiology. Lung cellular and molecular physiology 2004 Sep;287(3):L525-32
Hypoxia-inducible factor-1 transactivates transforming growth factor-beta3 in trophoblast.
Nishi H, Nakada T, Hokamura M, Osakabe Y, Itokazu O, Huang LE, Isaka K
Endocrinology 2004 Sep;145(9):4113-8
Endocrinology 2004 Sep;145(9):4113-8
Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head.
Tezel G, Wax MB
Archives of ophthalmology (Chicago, Ill. : 1960) 2004 Sep;122(9):1348-56
Archives of ophthalmology (Chicago, Ill. : 1960) 2004 Sep;122(9):1348-56
c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism.
Knies-Bamforth UE, Fox SB, Poulsom R, Evan GI, Harris AL
Cancer research 2004 Sep 15;64(18):6563-70
Cancer research 2004 Sep 15;64(18):6563-70
Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species.
Mansfield KD, Simon MC, Keith B
Journal of applied physiology (Bethesda, Md. : 1985) 2004 Oct;97(4):1358-66
Journal of applied physiology (Bethesda, Md. : 1985) 2004 Oct;97(4):1358-66
Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene.
Wykoff CC, Sotiriou C, Cockman ME, Ratcliffe PJ, Maxwell P, Liu E, Harris AL
British journal of cancer 2004 Mar 22;90(6):1235-43
British journal of cancer 2004 Mar 22;90(6):1235-43
Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways.
Swinson DE, Jones JL, Cox G, Richardson D, Harris AL, O'Byrne KJ
International journal of cancer 2004 Aug 10;111(1):43-50
International journal of cancer 2004 Aug 10;111(1):43-50
Expression and localization of hypoxia-inducible factor-1 subunits in the adult rat epididymis.
Palladino MA, Powell JD, Korah N, Hermo L
Biology of reproduction 2004 Apr;70(4):1121-30
Biology of reproduction 2004 Apr;70(4):1121-30
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.
Erler JT, Cawthorne CJ, Williams KJ, Koritzinsky M, Wouters BG, Wilson C, Miller C, Demonacos C, Stratford IJ, Dive C
Molecular and cellular biology 2004 Apr;24(7):2875-89
Molecular and cellular biology 2004 Apr;24(7):2875-89
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.
Erler JT, Cawthorne CJ, Williams KJ, Koritzinsky M, Wouters BG, Wilson C, Miller C, Demonacos C, Stratford IJ, Dive C
Molecular and cellular biology 2004 Apr;24(7):2875-89
Molecular and cellular biology 2004 Apr;24(7):2875-89
HIF-1-mediated activation of telomerase in cervical cancer cells.
Yatabe N, Kyo S, Maida Y, Nishi H, Nakamura M, Kanaya T, Tanaka M, Isaka K, Ogawa S, Inoue M
Oncogene 2004 Apr 29;23(20):3708-15
Oncogene 2004 Apr 29;23(20):3708-15
Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.
Liu MY, Poellinger L, Walker CL
Cancer research 2003 May 15;63(10):2675-80
Cancer research 2003 May 15;63(10):2675-80
Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells.
Park JH, Kim TY, Jong HS, Kim TY, Chun YS, Park JW, Lee CT, Jung HC, Kim NK, Bang YJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Jan;9(1):433-40
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Jan;9(1):433-40
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC
Molecular and cellular biology 2003 Dec;23(24):9361-74
Molecular and cellular biology 2003 Dec;23(24):9361-74
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC
Molecular and cellular biology 2003 Dec;23(24):9361-74
Molecular and cellular biology 2003 Dec;23(24):9361-74
Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression.
Powell JD, Elshtein R, Forest DJ, Palladino MA
Biology of reproduction 2002 Sep;67(3):995-1002
Biology of reproduction 2002 Sep;67(3):995-1002
Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression.
Powell JD, Elshtein R, Forest DJ, Palladino MA
Biology of reproduction 2002 Sep;67(3):995-1002
Biology of reproduction 2002 Sep;67(3):995-1002
Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium.
Des Tombe AL, Van Beek-Harmsen BJ, Lee-De Groot MB, Van Der Laarse WJ
Microscopy research and technique 2002 Sep 1;58(5):412-20
Microscopy research and technique 2002 Sep 1;58(5):412-20
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
Ivan M, Haberberger T, Gervasi DC, Michelson KS, Günzler V, Kondo K, Yang H, Sorokina I, Conaway RC, Conaway JW, Kaelin WG Jr
Proceedings of the National Academy of Sciences of the United States of America 2002 Oct 15;99(21):13459-64
Proceedings of the National Academy of Sciences of the United States of America 2002 Oct 15;99(21):13459-64
Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer.
Schindl M, Schoppmann SF, Samonigg H, Hausmaninger H, Kwasny W, Gnant M, Jakesz R, Kubista E, Birner P, Oberhuber G, Austrian Breast and Colorectal Cancer Study Group.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002 Jun;8(6):1831-7
Clinical cancer research : an official journal of the American Association for Cancer Research 2002 Jun;8(6):1831-7
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Min JH, Yang H, Ivan M, Gertler F, Kaelin WG Jr, Pavletich NP
Science (New York, N.Y.) 2002 Jun 7;296(5574):1886-9
Science (New York, N.Y.) 2002 Jun 7;296(5574):1886-9
Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis.
Stokes DG, Liu G, Coimbra IB, Piera-Velazquez S, Crowl RM, Jiménez SA
Arthritis and rheumatism 2002 Feb;46(2):404-19
Arthritis and rheumatism 2002 Feb;46(2):404-19
Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis.
Stokes DG, Liu G, Coimbra IB, Piera-Velazquez S, Crowl RM, Jiménez SA
Arthritis and rheumatism 2002 Feb;46(2):404-19
Arthritis and rheumatism 2002 Feb;46(2):404-19
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.
Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, Gorodin S, Moshel Y, Elbaz S, Budanov A, Chajut A, Kalinski H, Kamer I, Rozen A, Mor O, Keshet E, Leshkowitz D, Einat P, Skaliter R, Feinstein E
Molecular and cellular biology 2002 Apr;22(7):2283-93
Molecular and cellular biology 2002 Apr;22(7):2283-93
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.
Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, Gorodin S, Moshel Y, Elbaz S, Budanov A, Chajut A, Kalinski H, Kamer I, Rozen A, Mor O, Keshet E, Leshkowitz D, Einat P, Skaliter R, Feinstein E
Molecular and cellular biology 2002 Apr;22(7):2283-93
Molecular and cellular biology 2002 Apr;22(7):2283-93
Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription.
Arsham AM, Plas DR, Thompson CB, Simon MC
The Journal of biological chemistry 2002 Apr 26;277(17):15162-70
The Journal of biological chemistry 2002 Apr 26;277(17):15162-70
Hypoxia reduces hormone responsiveness of human breast cancer cells.
Kurebayashi J, Otsuki T, Moriya T, Sonoo H
Japanese journal of cancer research : Gann 2001 Oct;92(10):1093-101
Japanese journal of cancer research : Gann 2001 Oct;92(10):1093-101
Hypoxia reduces hormone responsiveness of human breast cancer cells.
Kurebayashi J, Otsuki T, Moriya T, Sonoo H
Japanese journal of cancer research : Gann 2001 Oct;92(10):1093-101
Japanese journal of cancer research : Gann 2001 Oct;92(10):1093-101
DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance.
Schindl M, Oberhuber G, Pichlbauer EG, Obermair A, Birner P, Kelley MR
International journal of oncology 2001 Oct;19(4):799-802
International journal of oncology 2001 Oct;19(4):799-802
DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance.
Schindl M, Oberhuber G, Pichlbauer EG, Obermair A, Birner P, Kelley MR
International journal of oncology 2001 Oct;19(4):799-802
International journal of oncology 2001 Oct;19(4):799-802
Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy.
Birner P, Schindl M, Obermair A, Breitenecker G, Oberhuber G
Clinical cancer research : an official journal of the American Association for Cancer Research 2001 Jun;7(6):1661-8
Clinical cancer research : an official journal of the American Association for Cancer Research 2001 Jun;7(6):1661-8
Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis.
Birner P, Gatterbauer B, Oberhuber G, Schindl M, Rössler K, Prodinger A, Budka H, Hainfellner JA
Cancer 2001 Jul 1;92(1):165-71
Cancer 2001 Jul 1;92(1):165-71
Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis.
Birner P, Gatterbauer B, Oberhuber G, Schindl M, Rössler K, Prodinger A, Budka H, Hainfellner JA
Cancer 2001 Jul 1;92(1):165-71
Cancer 2001 Jul 1;92(1):165-71
HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha.
Albina JE, Mastrofrancesco B, Vessella JA, Louis CA, Henry WL Jr, Reichner JS
American journal of physiology. Cell physiology 2001 Dec;281(6):C1971-7
American journal of physiology. Cell physiology 2001 Dec;281(6):C1971-7
Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem.
Pascual O, Denavit-Saubié M, Dumas S, Kietzmann T, Ghilini G, Mallet J, Pequignot JM
The European journal of neuroscience 2001 Dec;14(12):1981-91
The European journal of neuroscience 2001 Dec;14(12):1981-91
Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem.
Pascual O, Denavit-Saubié M, Dumas S, Kietzmann T, Ghilini G, Mallet J, Pequignot JM
The European journal of neuroscience 2001 Dec;14(12):1981-91
The European journal of neuroscience 2001 Dec;14(12):1981-91
Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite.
Duyndam MC, Hulscher TM, Fontijn D, Pinedo HM, Boven E
The Journal of biological chemistry 2001 Dec 21;276(51):48066-76
The Journal of biological chemistry 2001 Dec 21;276(51):48066-76
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ
Science (New York, N.Y.) 2001 Apr 20;292(5516):468-72
Science (New York, N.Y.) 2001 Apr 20;292(5516):468-72
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr
Science (New York, N.Y.) 2001 Apr 20;292(5516):464-8
Science (New York, N.Y.) 2001 Apr 20;292(5516):464-8
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.
Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW
Proceedings of the National Academy of Sciences of the United States of America 2000 Sep 12;97(19):10430-5
Proceedings of the National Academy of Sciences of the United States of America 2000 Sep 12;97(19):10430-5
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer.
Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G
Cancer research 2000 Sep 1;60(17):4693-6
Cancer research 2000 Sep 1;60(17):4693-6
Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells.
Wang G, Hazra TK, Mitra S, Lee HM, Englander EW
Nucleic acids research 2000 May 15;28(10):2135-40
Nucleic acids research 2000 May 15;28(10):2135-40
Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells.
Wang G, Hazra TK, Mitra S, Lee HM, Englander EW
Nucleic acids research 2000 May 15;28(10):2135-40
Nucleic acids research 2000 May 15;28(10):2135-40
Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha.
Gothié E, Richard DE, Berra E, Pagès G, Pouysségur J
The Journal of biological chemistry 2000 Mar 10;275(10):6922-7
The Journal of biological chemistry 2000 Mar 10;275(10):6922-7
Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha.
Gothié E, Richard DE, Berra E, Pagès G, Pouysségur J
The Journal of biological chemistry 2000 Mar 10;275(10):6922-7
The Journal of biological chemistry 2000 Mar 10;275(10):6922-7
Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.
Sutter CH, Laughner E, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2000 Apr 25;97(9):4748-53
Proceedings of the National Academy of Sciences of the United States of America 2000 Apr 25;97(9):4748-53
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW
Cancer research 1999 Nov 15;59(22):5830-5
Cancer research 1999 Nov 15;59(22):5830-5
Aging persons' estimates of vehicular motion.
Schiff W, Oldak R, Shah V
Psychology and aging 1992 Dec;7(4):518-25
Psychology and aging 1992 Dec;7(4):518-25
Aging persons' estimates of vehicular motion.
Schiff W, Oldak R, Shah V
Psychology and aging 1992 Dec;7(4):518-25
Psychology and aging 1992 Dec;7(4):518-25
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Supportive validation
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- 53f61d28929e0
- Main image
- Experimental details
- 100 ug of total protein from BM was separated on a 7.5 % polyacrylamide gel and transferred to Immobilon-FL PVDF (Millipore). 1:500 diluted HIF1 (Novus, NB 100-105) antibody and 1:5000 diluted ActinB (Santa Cruz Biotechnology, SC-1616) were used as a primary antibody. For the secondary antibody IRDye 800CW Goat anti-Mouse IgG (1:5000 diluted), IRDye® 680RD Donkey anti-Goat IgG (1:5000 diluted) (LI-COR Biosciences) were used, respectively. The membrane was scanned using Odyssey laser scanner (LI-COR Biosciences).
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- Novus Biologicals (provider)
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- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - HIF-1 alpha induction by CoCl2 on Caki-1 cell lysate. Image from verified customer review.
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- Experimental details
- Caki-1 cells were treated with CoCl2 at indicated concentration for 4 and 6 hours. Then total cell lysate was prepared and 40 ug sample was loaded for western blot analysis. The same membrane was probed with anti-beta-actin antibody.
- Sample type
- Total cell lysate
- Validation comment
- Detected a specific band induced by CoCl2
- Primary Ab dilution
- 1:1000
- Conjugate
- Unconjugated
- Secondary Ab
- Secondary Ab
- Secondary Ab dilution
- 1:2000
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- Novus Biologicals (provider)
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- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Analysis using the HRP conjugate of NB100-105. Detection of 50ug cobalt chloride induced COS-7 nuclear extracts (NB800-PC26) using NB100-105.
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- Novus Biologicals (provider)
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- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Analysis of HIF-1 alpha in human hepatocytes from cancer patient using anti-HIF-1 alpha antibody NB100-105. Image from verified customer review.
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- Novus Biologicals (provider)
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- Experimental details
- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Naive CD4 T cells from WT, VHL-deficient (Vhl KO), or HIF-1 alpha-deficient (HIF-1 alpha KO) mice were differentiated under IL-22-skewing conditions for a total of 60 h. Some cells remained at normoxia for the duration of the culture (N); others were at normoxia for 35 h and then hypoxia (1% O2) for 24 h (H). At 60 h, nuclear extracts were harvested, and HIF-1 alpha and Lamin B1 levels were analyzed by Western blot. Image from verified customer review.
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- Novus Biologicals (provider)
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- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Detection of HIF-1 alpha in HeLa whole cell lysate using NB100-105. ECL solution 5 min, exposure 3-5 min. Image from verified customer review.
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- Novus Biologicals (provider)
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- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Upregulation of HIF-1alpha in human PCa. Protein expression of HIF-1alpha, VEGF, and GLUT4 were examined with western blot, in PC-3, DU145, and LNCaP cells after various treatments as indicated. Data are expressed as mean +/- SD of seven independent experiments. $p < 0.05 versus RWPE-1 or BPH1 cells or normal tissue. *p < 0.05 versus control group. #p < 0.05 versus si-HIF-1alpha or DDP group. Original blots are shown in Supplementary Figure 5. C: Ctrl; D: DDP; S: si-HIF-1alpha; D/S: DDP/si-HIF-1alpha. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/s41598-017-07973-4), licensed under a CC-BY licence.
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- Novus Biologicals (provider)
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- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - L. donovani infection induces HIF-1 alpha expression in CD11chi splenic DCs in an IRF-5 dependent manner.Mice were infected with 2x107 amastigotes intravenously. Immunoblot analysis of HIF-1 alpha expression in CD11c+ cells from C57BL/6 mice (upper panel) and densitometric analysis normalized to beta-actin expression and expressed as fold increase to results obtained with naive mice (lower panel). Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.ppat.1004938), licensed under a CC-BY licence.
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Upregulation of HIF-1alpha in human Pca. HIF-1alpha protein was detected by western blot in nonmalignant (RWPE-1 and BPH1) and PCa cell lines (PC-3, DU145, LNCaP, and 22RV1) as indicated. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/s41598-017-07973-4), licensed under a CC-BY licence.
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- Novus Biologicals (provider)
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- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - HIF1alpha/PFKFB3 is upregulated in beta-cells of HIP rats and humans with type 2 diabetes. Representative Western blot of PFKFB3 and HIF1alpha levels in nuclear-enriched- and whole cell extracts from non-diabetic (ND) and T2D donor islets. Data are presented as mean +/- SEM, n = 3 independent biological samples for each group. Statistical significance was analyzed by Student t-test (*p < 0.05, ***p < 0.001) Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/s41467-019-10444-1) licensed under a CC-BY licence.
Supportive validation
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- Novus Biologicals (provider)
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- Immunohistochemistry: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Staining of HIF-1 alpha in human kidney using NB100-105. Renal tubular epithelium showed moderate membranous, cytoplasmic and nuclear staining, and glomeruli showed faint to moderate nuclear staining.
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- Novus Biologicals (provider)
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- Immunohistochemistry-Paraffin: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Analysis using the biotin conjugate of NB100-105. Staining of human glioblastoma multiforme.
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- Novus Biologicals (provider)
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- Immunohistochemistry: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - HIF-1alpha expression in PDAC and adjacent normal pancreatic tissue. PDAC with weak (intensity 1) nuclear and cytoplasmic HIF-1alpha staining (left). PDAC with strong (intensity 3) nuclear and moderate (intensity 2) cytoplasmic HIF-1alpha staining (right). Image collected and cropped by CiteAb from the following publication (https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1432-4), licensed under a CC-BY licence.
Supportive validation
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- Flow Cytometry: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Analysis using the Alexa Fluor (R) 488 conjugate of NB100-105. Staining of HIF-1 alpha in multiple myeloma cells: H929 cells (0.5x10^6) were stained with Alexa Fluor 488 (R) conjugated HIF-1 alpha antibody (NB100-105AF488). Image courtesy of Dr. Barbara Muz at Washington University in St. Louis School of Medicine.
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- Novus Biologicals (provider)
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- Experimental details
- Flow Cytometry: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - Analysis using the Alexa Fluor (R) 488 conjugate of NB100-105. Staining of HIF-1 alpha in H929 cells using HIF-1 alpha antibody. Image from verified customer review.
