CRHR1

This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]

Description

Corticotropin releasing hormone receptor 1

Tissue specificity

Group enriched (brain, pituitary gland)

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Chromosome

17 (45784280 - 45835828)

Ensembl ID

ENSG00000120088  (ver. 103.38)

Orthologs

-

UniProt

P34998

neXtProt

NX_P34998

Human splice variants

Protein structure