BS60593

antibody from Bioworld Technology, Inc
Targeting: MAPRE2 EB1, EB2, RP1
Provider product page for BS60593

Antibody data

Product number
BS60593 - Provider product page
Provider
Bioworld Technology, Inc
Product name
MAPRE2 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human MAPRE2
Description
APC (adenomatous polyposis coli) is a tumor suppressor gene that is frequently mutated in colorectal cancers and is one of the earliest indicators of colorectal carcinogenesis. APC is widely expressed and is largely similar to the related brain-specific homolog APCL. These proteins both associate with ÉÇ-catenin and functionally regulate the levels of intracellular ÉÇ-catenin. Additionally, these homologs interact with the microtubule cytoskeletal protein EB1 to regulate cell cycle progression or growth control. EB1 family proteins (EB1, RP1 (EB2) and EB3) interact with cytoplasmic microtubules ininterphase cells, with mitotic spindles, and with the APC tumor suppressor gene. The functional inactivation of the APC gene product is a key event in colorectal tumorigenesis. RP1 is localized in the plus ends of microtubule networks in the presence or absence of APC. The gene which encodes RP1 maps to human chromosome 18q12.1.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MAPRE2 protein structure - BS60593 shown in red.