APR04234G

antibody from Leading Biology

Targeting: MYH7 CMD1S, CMH1, MPD1

Western blot (Recommended by provider)

Antibody Data

Product number

APR04234G

Provider

Leading Biology

Product name

MYH7 Antibody (N-term)

Antibody type

Polyclonal

Description

Muscle myosin is a hexameric protein containing 2 heavychain subunits, 2 alkali light chain subunits, and 2 regulatorylight chain subunits. This gene encodes the beta (or slow) heavychain subunit of cardiac myosin. It is expressed predominantly innormal human ventricle. It is also expressed in skeletal muscletissues rich in slow-twitch type I muscle fibers. Changes in therelative abundance of this protein and the alpha (or fast) heavysubunit of cardiac myosin correlate with the contractile velocityof cardiac muscle. Its expression is also altered during thyroidhormone depletion and hemodynamic overloading. Mutations in thisgene are associated with familial hypertrophic cardiomyopathy,myosin storage myopathy, dilated cardiomyopathy, and Laingearly-onset distal myopathy.

Reactivity

Human, Mouse

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.