Tissue expression
Cell line expression
Protein structure
BCR
BCR activator of RhoGEF and GTPaseALL, BCR1, CML, D22S11, D22S662, PHL
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2020]
Top validated antibodies |
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Proteintech Group | 22585-1-AP | 1 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
|
Invitrogen Antibodies | 22585-1-AP | Polyclonal |
WB
ICC
IP
IHC
FC
OA |
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NovoPro Bioscience Inc. | 108436 | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
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Novus Biologicals | NBP1-19098 | Polyclonal |
WB
ICC
IP
IHC
FC
|
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antibodies-online | ABIN438927 | Polyclonal |
WB
ICC
IP
IHC
FC
|
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