BS7941

antibody from Bioworld Technology, Inc
Targeting: DAP
Provider product page for BS7941
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7941 - Provider product page
Provider
Bioworld Technology, Inc
Product name
DAP polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human DAP.
Description
In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved cytoplasmic region called the ¡ùdeath domain¡ì. DAP-1 (for death associated protein-1) interacts with the death domain of TNF-R1 and can trigger programmed cell death in a variety of cell lines, as well as suppress NF°ÙB/Rel activity. DAP-3 is a positive mediator of programmed cell death; overexpressed intact full-length protein is required in order to induce apoptosis. During apotosis, the caspase-activated DAP-5 can mediate CAP-independent translation at least from its own internal ribosome entry site, thus resulting in a positive feedback loop responsible for the continuous translation of DAP-5. DAP-5 is also required for cellular differentiation, as it controls specific gene expression pathways.
Reactivity
Human, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
DAP protein structure - BS7941 shown in red.