TCF4

Transcription factor 4

bHLHb19, E2-2, ITF2, SEF2-1B

This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]

Ensembl	UniProt	RefSeq	Entrez
ENST00000354452 ENSP00000346440	P15884.216 P15884	NP_001356497.1 NP_001356497 NP_001077431.1 NP_001077431 NP_001317533.1 NP_001317533 NP_001356498.1 NP_001356498 NP_001356499.1 NP_001356499	TCF4 6925
ENST00000356073 ENSP00000348374	P15884.216 P15884 A0A024R2C0	NP_001356500.1 NP_001356500 NP_001356501.1 NP_001356501 NP_003190.1 NP_003190 NP_001356503.1 NP_001356503 NP_001356502.1 NP_001356502	TCF4 6925
ENST00000398339 ENSP00000381382	E9PH57	NP_001230155.2 NP_001230155	TCF4 6925
ENST00000457482 ENSP00000409447	P15884.216 P15884	NP_001230163.1 NP_001230163	TCF4 6925
ENST00000537578 ENSP00000440731	P15884.216 P15884	NP_001230156.1 NP_001230156 NP_001356506.1 NP_001356506 NP_001356505.1 NP_001356505 NP_001356515.1 NP_001356515	TCF4 6925
ENST00000537856 ENSP00000439827	P15884.216 P15884		TCF4 6925
ENST00000540999 ENSP00000445202	P15884.216 P15884	NP_001356511.1 NP_001356511 NP_001356512.1 NP_001356512 NP_001335148.1 NP_001335148 NP_001293136.1 NP_001293136	TCF4 6925
ENST00000543082 ENSP00000439656	P15884.216 P15884	NP_001230160.1 NP_001230160 NP_001335140.1 NP_001335140	TCF4 6925
ENST00000544241 ENSP00000441562	P15884.216 P15884	NP_001230161.1 NP_001230161	TCF4 6925
ENST00000561831 ENSP00000457765	P15884.216 P15884	NP_001230165.1 NP_001230165 NP_001335145.1 NP_001335145	TCF4 6925
ENST00000561992 ENSP00000455179	P15884.216 P15884	NP_001335141.1 NP_001335141 NP_001230162.1 NP_001230162	TCF4 6925
ENST00000562030 ENSP00000456220	H3BRF7		TCF4 6925
ENST00000562543 ENSP00000455450	G0LNT4		TCF4 6925
ENST00000562607 ENSP00000455071	H3BNZ2		TCF4 6925
ENST00000562638 ENSP00000456802	A0A1B0GXH5		TCF4 6925
ENST00000562847 ENSP00000454866	H3BNI2		TCF4 6925
ENST00000563824 ENSP00000457113	H3BTC3		TCF4 6925
ENST00000563888 ENSP00000457747	H3BUQ3		TCF4 6925
ENST00000564228 ENSP00000455261	P15884.216 P15884	NP_001293137.1 NP_001293137	TCF4 6925
ENST00000564343 ENSP00000454328	H3BMC8		TCF4 6925
ENST00000564403 ENSP00000457263	H3BTP3	NP_001230157.1 NP_001230157	TCF4 6925
ENST00000564999 ENSP00000457649	P15884.216 P15884 A0A024R2C0		TCF4 6925
ENST00000565018 ENSP00000455984	P15884.216 P15884		TCF4 6925
ENST00000565124 ENSP00000457082	H3BT95		TCF4 6925
ENST00000565908 ENSP00000454584	A0A075B723		TCF4 6925
ENST00000566279 ENSP00000456125	P15884.216 P15884		TCF4 6925
ENST00000566286 ENSP00000455418	P15884.216 P15884	NP_001230159.1 NP_001230159	TCF4 6925
ENST00000566514 ENSP00000456983	H3BT24		TCF4 6925
ENST00000566777 ENSP00000457245	H3BTM9		TCF4 6925
ENST00000567880 ENSP00000454366	P15884.216 P15884		TCF4 6925
ENST00000568147 ENSP00000455163	H3BP59		TCF4 6925
ENST00000568169 ENSP00000457392	H3BTZ0		TCF4 6925
ENST00000568186 ENSP00000458122	G0LNT7		TCF4 6925
ENST00000568673 ENSP00000455135	P15884.216 P15884	NP_001356504.1 NP_001356504 NP_001335147.1 NP_001335147 NP_001335146.1 NP_001335146 NP_001356507.1 NP_001356507 NP_001356509.1 NP_001356509 NP_001356508.1 NP_001356508 NP_001356510.1 NP_001356510	TCF4 6925
ENST00000568740 ENSP00000455346	H3BPJ7	NP_001356513.1 NP_001356513 NP_001356514.1 NP_001356514 NP_001335149.1 NP_001335149	TCF4 6925
ENST00000569012 ENSP00000455304	H3BPG3		TCF4 6925
ENST00000570146 ENSP00000468729	K7ESI6		TCF4 6925
ENST00000570177 ENSP00000454647	P15884.216 P15884		TCF4 6925
ENST00000570287 ENSP00000455763	P15884.216 P15884	NP_001230164.1 NP_001230164 NP_001335143.1 NP_001335143	TCF4 6925
ENST00000590810 ENSP00000468277	A0A0E3D6N2		TCF4 6925
ENST00000616053 ENSP00000478549	P15884.216 P15884		TCF4 6925
ENST00000625925 ENSP00000487413	A0A0D9SGE4		TCF4 6925
ENST00000626425 ENSP00000486111	A0A0D9SEX8		TCF4 6925
ENST00000626584 ENSP00000486072	P15884.216 P15884		TCF4 6925
ENST00000626595 ENSP00000487415	A0A0D9SGE5		TCF4 6925
ENST00000626631 ENSP00000487505	A0A0D9SGH7		TCF4 6925
ENST00000627685 ENSP00000487171	A0A0D9SG61		TCF4 6925
ENST00000627784 ENSP00000487150	A0A0D9SG55		TCF4 6925
ENST00000628078 ENSP00000486909	A0A0D9SFU5		TCF4 6925
ENST00000628636 ENSP00000485755	A0A0D9SEK1		TCF4 6925
ENST00000629343 ENSP00000486148	A0A0D9SEZ3		TCF4 6925
ENST00000629387 ENSP00000486670	P15884.216 P15884	NP_001356496.1 NP_001356496	TCF4 6925
ENST00000630268 ENSP00000486405	A0A0D9SF97		TCF4 6925
ENST00000630319 ENSP00000486215	A0A0D9SF18		TCF4 6925
ENST00000630712 ENSP00000487419	A0A0D9SGE7		TCF4 6925
ENST00000630720 ENSP00000487218	A0A0D9SG78		TCF4 6925
ENST00000630828 ENSP00000486974	A0A0D9SFX5		TCF4 6925
ENST00000635822 ENSP00000490451	A0A1B0GVB8		TCF4 6925
ENST00000636400 ENSP00000490006	P15884.216 P15884		TCF4 6925
ENST00000636822 ENSP00000490883	A0A1B0GWD5		TCF4 6925
ENST00000637169 ENSP00000490832	A0A1B0GW91	NP_001335144.1 NP_001335144	TCF4 6925
ENST00000638154 ENSP00000490625	A0A1B0GVR6		TCF4 6925
ENST00000643689 ENSP00000494380	A0A1B0GWD5	NP_001317534.1 NP_001317534	TCF4 6925
ENST00000675707 ENSP00000501758		NP_001335142.1 NP_001335142	TCF4 6925

Ensembl	UniProt	RefSeq	Entrez
ENSMUST00000066717 ENSMUSP00000067318	E9Q8G4		Tcf4 21413
ENSMUST00000078486 ENSMUSP00000077577	Q60722.182 Q60722	NP_001348056.1 NP_001348056 NP_001348058.1 NP_001348058	Tcf4 21413
ENSMUST00000114977 ENSMUSP00000110628	Q91YV0		Tcf4 21413
ENSMUST00000114978 ENSMUSP00000110629	Q60722.182 Q60722 Q91XK1		Tcf4 21413
ENSMUST00000114980 ENSMUSP00000110631	Q60722.182 Q60722	NP_001348057.1 NP_001348057	Tcf4 21413
ENSMUST00000114982 ENSMUSP00000110633	Q60722.182 Q60722	NP_001077436.1 NP_001077436	Tcf4 21413
ENSMUST00000114985 ENSMUSP00000110636	Q60722.182 Q60722	NP_038713.1 NP_038713	Tcf4 21413
ENSMUST00000128706 ENSMUSP00000144519	Q8BPX7		Tcf4 21413
ENSMUST00000145918 ENSMUSP00000144298	A0A0J9YUR0		Tcf4 21413
ENSMUST00000200703 ENSMUSP00000144583	A0A0J9YVB3		Tcf4 21413
ENSMUST00000200813 ENSMUSP00000144397	A0A0J9YUY3		Tcf4 21413
ENSMUST00000200862 ENSMUSP00000144338	A0A0J9YUT7		Tcf4 21413
ENSMUST00000200921 ENSMUSP00000143892	A0A0J9YTX3		Tcf4 21413
ENSMUST00000200966 ENSMUSP00000144045	A0A0J9YU75		Tcf4 21413
ENSMUST00000201037 ENSMUSP00000144488	A0A0J9YV50		Tcf4 21413
ENSMUST00000201091 ENSMUSP00000144386	A0A0J9YUX6		Tcf4 21413
ENSMUST00000201094 ENSMUSP00000144169	A0A0J9YUG4		Tcf4 21413
ENSMUST00000201124 ENSMUSP00000144080	A0A0J9YU99		Tcf4 21413
ENSMUST00000201181 ENSMUSP00000144376	A0A0J9YUW9		Tcf4 21413
ENSMUST00000201205 ENSMUSP00000144273	A0A0J9YTU7		Tcf4 21413
ENSMUST00000201235 ENSMUSP00000144473	A0A0J9YV39		Tcf4 21413
ENSMUST00000201288 ENSMUSP00000144494	A0A0J9YV54		Tcf4 21413
ENSMUST00000201299 ENSMUSP00000144599	A0A0J9YVC6		Tcf4 21413
ENSMUST00000201410 ENSMUSP00000143950	A0A0J9YUG4		Tcf4 21413
ENSMUST00000201537 ENSMUSP00000144655	A0A0J9YVG8		Tcf4 21413
ENSMUST00000201627 ENSMUSP00000144649	A0A1B0GXC8		Tcf4 21413
ENSMUST00000201631 ENSMUSP00000144285	A0A0J9YUP9		Tcf4 21413
ENSMUST00000201781 ENSMUSP00000144209	A0A0J9YUZ0		Tcf4 21413
ENSMUST00000201964 ENSMUSP00000144070	A0A0J9YU91		Tcf4 21413
ENSMUST00000202057 ENSMUSP00000144647	A0A0J9YUG4		Tcf4 21413
ENSMUST00000202074 ENSMUSP00000144544	A0A0J9YV88		Tcf4 21413
ENSMUST00000202116 ENSMUSP00000144512	Q60722.182 Q60722	NP_001348055.1 NP_001348055	Tcf4 21413
ENSMUST00000202350 ENSMUSP00000144154	A0A0J9YUF5		Tcf4 21413
ENSMUST00000202354 ENSMUSP00000144646	A0A0J9YVG2		Tcf4 21413
ENSMUST00000202435 ENSMUSP00000144407	A0A0J9YUZ0		Tcf4 21413
ENSMUST00000202458 ENSMUSP00000143875	A0A0J9YTW1		Tcf4 21413
ENSMUST00000202474 ENSMUSP00000143820	A0A0J9YTR9		Tcf4 21413
ENSMUST00000202477 ENSMUSP00000144219	A0A0J9YUG4		Tcf4 21413
ENSMUST00000202610 ENSMUSP00000144670	A0A0J9YVI1		Tcf4 21413
ENSMUST00000202674 ENSMUSP00000144221	A0A0J9YUK1		Tcf4 21413
ENSMUST00000202751 ENSMUSP00000144064	A0A0J9YU89		Tcf4 21413
ENSMUST00000202765 ENSMUSP00000144332	A0A0J9YUT3		Tcf4 21413
ENSMUST00000202772 ENSMUSP00000143987	A0A0J9YU37		Tcf4 21413
ENSMUST00000202937 ENSMUSP00000143857	A0A0J9YTU7		Tcf4 21413
ENSMUST00000203002 ENSMUSP00000144315	A0A0J9YUS2		Tcf4 21413
ENSMUST00000207214 ENSMUSP00000146869	A0A140LIL4		Tcf4 21413
ENSMUST00000209116 ENSMUSP00000147136	A0A140LJA2		Tcf4 21413
ENSMUST00000209174 ENSMUSP00000147155	A0A140LJC0		Tcf4 21413

More gene data

Top validated antibodies
Proteintech Group	22337-1-AP	56 references	Polyclonal	WB EL ICC IP IHC
Novus Biologicals	H00006925-M03	6 references	Monoclonal	WB EL ICC IP IHC
Biorbyt	orb2561791		Recombinant	WB ICC IP IHC FC ChIP
NSJ Bioreagents	V3887		Monoclonal	WB EL IHC PA OA
GeneTex	GTX54531	1 references	Polyclonal	WB ICC IP IHC

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447 antibodies from 36 providers.

Show Additional Columns

	Antibody	Refs	Type
Proteintech Group 1 antibody
	22337-1-AP	56	Polyclonal

Novus Biologicals 10 antibodies
	H00006925-M03	6	Monoclonal
	NBP1-88633	2	Polyclonal

Biorbyt 35 antibodies
	orb2561791		Recombinant
	orb1726878		Recombinant

NSJ Bioreagents 5 antibodies
	V3887		Monoclonal
	F49318		Polyclonal

GeneTex 4 antibodies
	GTX54531	1	Polyclonal
	GTX52873		Monoclonal

Abnova Corporation 5 antibodies
	H00006925-M03	2	Monoclonal
	MAB1812	3	Monoclonal

antibodies-online 122 antibodies
	ABIN520754	3	Monoclonal
	ABIN393964	1	Monoclonal

Invitrogen Antibodies 23 antibodies
	22337-1-AP		Polyclonal
	MA5-31923		Monoclonal

LSBio 65 antibodies
	LS-C806071		Polyclonal
	LS-B8267		Polyclonal

Acris Antibodies GmbH 4 antibodies
	AM05272PU-N	2	Monoclonal
	AM05271PU-N	3	Monoclonal

Antibodies.com 12 antibodies
	A86329		Polyclonal
	A29422		Polyclonal

NovoPro Bioscience Inc. 5 antibodies
	115905		Polyclonal
	127648		Monoclonal

FineTest Biotech 2 antibodies
	FNab08553		Polyclonal
	FNab10727		Polyclonal

Atlas Antibodies 1 antibody
	HPA025958	2	Polyclonal

Bioworld Technology, Inc 2 antibodies
	BS6172		Polyclonal
	BS1934		Polyclonal

Cusabio Biotech Co., Ltd 6 antibodies
	CSB-PA004249		Polyclonal
	CSB-PA023302HA01HU		Polyclonal

Affinity Biosciences 2 antibodies
	DF4572		Polyclonal
	DF6275		Polyclonal

Abcepta 5 antibodies
	AT4188a		Monoclonal
	AP5756a		Polyclonal

OriGene 8 antibodies
	RA18033-100		Polyclonal
	TA326945		Polyclonal

St John's Laboratory 5 antibodies
	STJ25793		Polyclonal
	STJ11102820		Polyclonal

Boster Biological Technology 3 antibodies
	A00674-1		Polyclonal
	A00674S616		Polyclonal

Aviva Systems Biology 4 antibodies
	OAAB03163		Polyclonal
	OAAF04379		Polyclonal

Everest Biotech 1 antibody
	EB08727		Polyclonal

Abbexa 20 antibodies
	abx224330		Monoclonal
	abx224442		Monoclonal

Abbkine Scientific Co.Ltd. 1 antibody
	ABP52575		Polyclonal

Creative Biolabs 18 antibodies
	MRO-2212-CN		Polyclonal
	CBMAB-T1375-YJ		Recombinant

ProSci 4 antibodies
	62-039		Polyclonal
	31-178		Polyclonal

Creative Diagnostics 4 antibodies
	DCABH-1264		Monoclonal
	DPABH-11648		Polyclonal

United States Biological 49 antibodies
	213716		Polyclonal
	213716-AP		Polyclonal

MyBioSource 6 antibodies
	MBS127288		Polyclonal
	MBS395015		Monoclonal

MilliporeSigma / Merck KGaA 6 antibodies
	SAB1404449		Monoclonal
	SAB1412620		Monoclonal

Abiocode, Inc. 1 antibody
	R3266-2		Polyclonal

Leading Biology 4 antibodies
	AMM08131G		Monoclonal
	AMM08132G		Monoclonal

EMD Millipore 1 antibody
	MABE361		Monoclonal

GenWay 2 antibodies
	18-003-43009		Polyclonal
	18-003-44336		Polyclonal

MedChemExpress LLC 1 antibody
	HY-P83064		Monoclonal

TCF4

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TCF4

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